Cited by 140Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsInflammasome and immune disorders

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Imbalance of microglial TLR4/TREM2 in LPS-treated APP/PS1 transgenic mice: a potential Link between Alzheimer's disease and systemic inflammation

Zhou, Jian, Yu, Weihua, Zhang, Man, Tian, Xin, Li, Yu, Lü, Yang·2019·Neurochemical Research

DOI 10.1007/s11064-019-02748-x

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Abstract

Clinically, superimposed systemic inflammation generally has significant deleterious effects on the Alzheimer's disease (AD) progression. However, the related molecular mechanisms remain poorly understood. Microglial toll-like receptor 4 (TLR4) and triggering receptor expressed on myeloid cells 2 (TREM2) are two key regulators of inflammation that may play an essential role in this complex pathophysiological process. In this study, intraperitoneal injection of lipopolysaccharide (LPS) into APP/PS1 transgenic AD model was used to mimic systemic inflammation in the development of AD. Initial results from the cortex showed that compared with wild-type mice, APP/PS1 mice exhibited elevated gene and protein expression levels of both TLR4 and TREM2 with different degree. Interestingly, after LPS treatment, TLR4 expression was persistently up-regulated, while TREM2 expression was significantly down-regulated in APP/PS1 mice, suggesting that the negative regulatory effect of TREM2 on inflammation might be suppressed by LPS-induced hyperactive TLR4. This imbalance of TLR4/TREM2 contributed to microglial over-activation, followed by increased neuronal apoptosis in the cortex of APP/PS1 mice; these changes did not alter the expression level of Aβ 1-42. Similar alterations were observed in our in vitro experiment with β-amyloid 1-42 (Aβ 1-42)-treated N9 microglia. Further, Morris water maze (MWM) testing data indicated that LPS administration acutely aggravated cognitive impairment in APP/PS1 mice, suggesting that the addition of systemic inflammation can potentially accelerate the progression of AD. Collectively, we conclude that an imbalance of TLR4/TREM2 may be a potential link between AD and systemic inflammation. TREM2 can serve as a potential therapeutic target for treating systemic inflammation in AD progression.

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Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226
Mechanisms underlying inflammation in neurodegeneration
Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580
TREM2 Variants in Alzheimer's Disease
Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020
Variant of TREM2 Associated with the Risk of Alzheimer's Disease
Jonsson, T., Stefansson, H., Steinberg, S., Jonsdottir, I., Jonsson, P. V., Snaedal, J., Bjornsson, S., Huttenlocher, J., Levey, A. I., Lah, J. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211103 · Cited by 2,558
Signaling to NF-κB by Toll-like receptors
Kawai, T., & Akira, S. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.09.002 · Cited by 2,468
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease
Ulland, T. K., Song, W. M., Huang, S. C.-C., Ulrich, J. D., Sergushichev, A., Beatty, W. L., Loboda, A. A., Zhou, Y., Cairns, N. J., Kambal, A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.023 · Cited by 1,263
Systemic inflammation and disease progression in Alzheimer disease
Holmes, C., Cunningham, C., Zotova, E., Woolford, J., Dean, C., Kerr, S., Culliford, D., & Perry, V. H. (2009) · Neurology · doi:10.1212/wnl.0b013e3181b6bb95 · Cited by 1,139
Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2
Takahashi, K., Rochford, C. D. P., & Neumann, H. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041611 · Cited by 1,124
Systemic infections and inflammation affect chronic neurodegeneration
Perry, V. H., Cunningham, C., & Holmes, C. (2007) · Nature Reviews Immunology · doi:10.1038/nri2015 · Cited by 1,027
Regulation of innate immune responses in the brain
Rivest, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2565 · Cited by 843
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
Wang, Y., Ulland, T. K., Ulrich, J. D., Song, W., Tzaferis, J. A., Hole, J. T., Yuan, P., Mahan, T. E., Shi, Y., Gilfillan, S., et al. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20151948 · Cited by 840
Lipopolysaccharide-Induced Inflammation Exacerbates Tau Pathology by a Cyclin-Dependent Kinase 5-Mediated Pathway in a Transgenic Model of Alzheimer's Disease
Kitazawa, M., Oddo, S., Yamasaki, T. R., Green, K. N., & LaFerla, F. M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2868-05.2005 · Cited by 697
Cutting Edge: TREM-2 Attenuates Macrophage Activation
Turnbull, I. R., Gilfillan, S., Cella, M., Aoshi, T., Miller, M., Piccio, L., Hernandez, M., & Colonna, M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.6.3520 · Cited by 688
Neuroinflammation Induces Neurodegeneration.
Kempuraj, D., Thangavel, R., Natteru, P., Selvakumar, G. P., Saeed, D., Zahoor, H., Zaheer, S., Iyer, S. S., & Zaheer, A. (2016) · PubMed · Cited by 675
Microglial dysfunction in brain aging and Alzheimer's disease
Mosher, K. I., & Wyss-Coray, T. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.008 · Cited by 618
APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases
Lanoiselée, H.-M., Nicolas, G., Wallon, D., Rovelet-Lecrux, A., Lacour, M., Rousseau, S., Richard, A.-C., Pasquier, F., Rollin-Sillaire, A., Martinaud, O., et al. (2017) · PLOS Medicine · doi:10.1371/journal.pmed.1002270 · Cited by 616
Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll‐like receptor‐mediated neuronal injury
Lehnardt, S. (2009) · Glia · doi:10.1002/glia.20928 · Cited by 612
Role of the Toll-Like Receptor 4 in Neuroinflammation in Alzheimer’s Disease
Walter, S., Letiembre, M., Liu, Y., Heine, H., Penke, B., Hao, W., Bode, B., Manietta, N., Walter, J., Schulz-Schüffer, W., et al. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000110455 · Cited by 543
Role of toll-like receptor signalling in A uptake and clearance
Tahara, K., Kim, H.-D., Jin, J.-J., Maxwell, J. A., Li, L., & Fukuchi, K.-I. (2006) · Brain · doi:10.1093/brain/awl249 · Cited by 493
Inflammation, microglia, and alzheimer's disease
Cameron, B., & Landreth, G. E. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.10.006 · Cited by 452
TREM and TREM-like receptors in inflammation and disease
Ford, J. W., & McVicar, D. W. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.01.009 · Cited by 434
Lipopolysaccharide-induced microglial activation and neuroprotection against experimental brain injury is independent of hematogenous TLR4
Chen, Z., Jalabi, W., Shpargel, K. B., Farabaugh, K. T., Dutta, R., Yin, X., Kidd, G. J., Bergmann, C. C., Stohlman, S. A., & Trapp, B. D. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0730-12.2012 · Cited by 432
Molecular Pathogenesis of Alzheimer's Disease: An Update
Sanabria‐Castro, A., Echeverría, I. A., & Bonilla, C. M. (2017) · Annals of Neurosciences · doi:10.1159/000464422 · Cited by 427
TREM2 in Neurodegenerative Diseases
Jay, T. R., von Saucken, V. E., & Landreth, G. E. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0197-5 · Cited by 427
Resveratrol Mitigates Lipopolysaccharide- and Aβ-Mediated Microglial Inflammation by Inhibiting the TLR4/NF-Κb/STAT Signaling cascade
Capiralla, H., Vingtdeux, V., Zhao, H., Sankowski, R., Al‐Abed, Y., Davies, P., & Marambaud, P. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07594.x · Cited by 426
GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer’s Disease
Cruchaga, C., Kauwe, J. S. K., Harari, O., Jin, S. C., Cai, Y., Karch, C. M., Benitez, B. A., Jeng, A. T., Skorupa, T., Carrell, D., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.026 · Cited by 383
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury
Mazaheri, F., Snaidero, N., Kleinberger, G., Madore, C., Daria, A., Werner, G., Krasemann, S., Capell, A., Trümbach, D., Wurst, W., et al. (2017) · The EMBO Reports · doi:10.15252/embr.201743922 · Cited by 351
Toll‐like receptor 4 in CNS pathologies
Buchanan, M. M., Hutchinson, M. R., Watkins, L. R., & Yin, H. H. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06736.x · Cited by 334
Elucidating the Role of TREM2 in Alzheimer’s Disease
Ulrich, J. D., Ulland, T. K., Colonna, M., & Holtzman, D. M. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.042 · Cited by 325
Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease
Jiang, T., Tan, L., Zhu, X.-C., Zhang, Q.-Q., Cao, L., Tan, M.-S., Gu, L.-Z., Wang, H.-F., Ding, Z.-Z., Zhang, Y.-D., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.164 · Cited by 320
Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer’s disease
Heslegrave, A., Heywood, W., Paterson, R., Magdalinou, N., Svensson, J., Johansson, P., Öhrfelt, A., Blennow, K., Hardy, J., Schott, J., et al. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0071-x · Cited by 303
Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2
Ulrich, J. D., Finn, M. B., Wang, Y., Shen, A., Mahan, T. E., Jiang, H., Stewart, F. R., Piccio, L., Colonna, M., & Holtzman, D. M. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-20 · Cited by 302
Effects of Hydroxyurea and 1‐β‐D‐Arabinofuranosyl‐cytosine on Deoxyribonucleotide Pools in Mouse Embryo Cells
Skoog, L. K., & Nordenskjöld, B. A. (1971) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1971.tb01290.x · Cited by 277
TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice
Frank, S., Burbach, G. J., Bonin, M., Walter, M., Streit, W., Bechmann, I., & Deller, T. (2008) · Glia · doi:10.1002/glia.20710 · Cited by 247
Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease
Yin, Z., Raj, D., Saiepour, N., Van Dam, D., Brouwer, N., Holtman, I. R., Eggen, B. J. L., Möller, T., Tamm, J. A., Abdourahman, A., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.03.021 · Cited by 238
The Development of Amyloid β Protein Deposits in the Aged Brain
Thal, D. R., Capetillo-Zarate, E., Del Tredici, K., & Braak, H. (2006) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2006.6.re1 · Cited by 234
TREM2 and the neuroimmunology of Alzheimer's disease
Hickman, S. E., & El Khoury, J. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.11.021 · Cited by 221
Aβ-Induced Inflammatory Processes in Microglia Cells of APP23 Transgenic Mice
Bornemann, K. D., Wiederhold, K., Pauli, C., Ermini, F., Stalder, M., Schnell, L., Sommer, B., Jucker, M., & Staufenbiel, M. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63945-4 · Cited by 206
Neuroinflammation in Alzheimer’s disease; A source of heterogeneity and target for personalized therapy
Latta, C. H., Brothers, H. M., & Wilcock, D. M. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.061 · Cited by 188
TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
Xiang, X., Werner, G., Bohrmann, B., Liesz, A., Mazaheri, F., Capell, A., Feederle, R., Knuesel, I., Kleinberger, G., & Haass, C. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606370 · Cited by 183
Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer’s disease
Sly, L. M., KRZESICKI, R. F., Brashler, J. R., Buhl, A.-L., McKinley, D. D., Carter, D. B., & Chin, J. E. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00730-4 · Cited by 180
TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells
Ito, H., & Hamerman, J. A. (2012) · European Journal of Immunology · doi:10.1002/eji.201141679 · Cited by 173
TREM 2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post‐Mortem Temporal Cortices
Lue, L., Schmitz, C. T., Serrano, G., Sue, L. I., Beach, T. G., & Walker, D. G. (2015) · Brain Pathology · doi:10.1111/bpa.12190 · Cited by 154
R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study
Korvatska, O., Leverenz, J. B., Jayadev, S., McMillan, P., Kurtz, I., Guo, X., Rumbaugh, M., Matsushita, M., Girirajan, S., Dorschner, M. O., et al. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.0979 · Cited by 137
DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro-inflammatory response
Zhong, L., Chen, X.-F., Zhang, Z.-L., Wang, Z., Shi, X.-Z., Xu, K., Zhang, Y.-W., Xu, H., & Bu, G. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.645986 · Cited by 133
Neural stem cell transplantation decreases neuroinflammation in a transgenic mouse model of Alzheimer's disease
Zhang, Q., Wu, H., Wang, Y., Gu, G., Zhang, W., & Xia, R. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13413 · Cited by 127
TREM2 in Alzheimer’s disease
Jiang, T., Yu, J., Zhu, X., & Tan, L. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8424-8 · Cited by 122
TLR4 is a link between diabetes and Alzheimer’s disease
Huang, N., Jin, H. D., Zhou, S., Shi, J., & Jin, F. J. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.08.047 · Cited by 122
Tau: The Center of a Signaling Nexus in Alzheimer's Disease
Khan, S. S., & Bloom, G. S. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00031 · Cited by 121
Osmotin-loaded magnetic nanoparticles with electromagnetic guidance for the treatment of Alzheimer's disease
Amin, F. U., Hoshiar, A. K., Duc, T., Noh, Y., Shah, S. A., Khan, M. S., Yoon, J., & Kim, M. O. (2017) · Nanoscale · doi:10.1039/c7nr00772h · Cited by 120
Toll-like receptors are key players in neurodegeneration
Arroyo, D. S., Soria, J. A., Gaviglio, E. A., Rodriguez‐Galán, M. C., & Iribarren, P. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.05.006 · Cited by 117
Myeloid microvesicles in cerebrospinal fluid are associated with myelin damage and neuronal loss in mild cognitive impairment and Alzheimer disease
Agosta, F., Dalla Libera, D., Spinelli, E. G., Finardi, A., Canu, E., Bergami, A., Bocchio Chiavetto, L., Baronio, M., Comi, G., Martino, G., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24235 · Cited by 113
Increased Expression of TREM2 in Peripheral Blood of Alzheimer's Disease Patients
Hu, N., Tan, M., Yu, J., Sun, L., Tan, L., Wang, Y.-L., Jiang, T., & Tan, L. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130854 · Cited by 108
The triggering receptor expressed on myeloid cells 2 ( TREM2 ) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia
Roussos, P., Katsel, P., Fam, P., Tan, W., Purohit, D. P., & Haroutunian, V. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.10.013 · Cited by 103
The Anti-neuroinflammatory Activity of Tectorigenin Pretreatment via Downregulated NF-κB and ERK/JNK Pathways in BV-2 Microglial and Microglia Inactivation in Mice With Lipopolysaccharide
Lim, H.-S., Kim, Y. J., Kim, B., Park, G., & Jeong, S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00462 · Cited by 103
Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1β and IL-6
Murray, C., Skelly, D., & Cunningham, C. M. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-50 · Cited by 100
Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice
Jiang, T., Yu, J., Zhu, X., Tan, M., Gu, L.-Z., Zhang, Y., & Tan, L. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.11.026 · Cited by 97
Gx‐50 reduces β‐amyloid‐induced TNF‐α, IL‐1β, NO, and PGE2 expression and inhibits NF‐κB signaling in a mouse model of Alzheimer's disease
Shi, S., Liang, D., Chen, Y., Xie, Y., Wang, Y., Wang, L., Wang, Z., & Qiao, Z. (2015) · European Journal of Immunology · doi:10.1002/eji.201545855 · Cited by 93
Microglial MyD88 signaling regulates acute neuronal toxicity of LPS-stimulated microglia in vitro
Dean, J. M., Wang, X., Kaindl, A. M., Gressèns, P., Fleiss, B., Hagberg, H., & Mallard, C. E. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.10.018 · Cited by 87
Triggering receptor expressed on myeloid cells‐2 fine‐tunes inflammatory responses in murine Gram‐negative sepsis
Gawish, R., Martins, R., Boehm, B., Wimberger, T., Sharif, O., Lakovits, K., Schmidt, M., & Knapp, S. (2014) · The FASEB Journal · doi:10.1096/fj.14-260067 · Cited by 73
Honokiol Attenuates Oligomeric Amyloid β1-42-Induced Alzheimer’s Disease in Mice Through Attenuating Mitochondrial Apoptosis and Inhibiting the Nuclear Factor Kappa-B Signaling Pathway
Wang, M., Li, Y., Ni, C., & Song, G. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000480320 · Cited by 63
Electroacupuncture prevents cognitive impairment induced by lipopolysaccharide via inhibition of oxidative stress and neuroinflammation
Han, Y.-G., Qin, X., Zhang, T., Lei, M., Sun, F., Sun, J., & Yuan, W. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.06.003 · Cited by 62
N9 microglial cells polarized by LPS and IL4 show differential responses to secondary environmental stimuli
Liu, H., Zheng, M., Du, Y., Wang, L., Kuang, F., Qin, H., Zhang, B., & Han, H. (2012) · Cellular Immunology · doi:10.1016/j.cellimm.2012.06.001 · Cited by 59
A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression
Carrasquillo, M. M., Allen, M., Burgess, J. D., Wang, X., Strickland, S. L., Aryal, S., Siuda, J., Kachadoorian, M. L., Medway, C., Younkin, C. S., et al. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.10.005 · Cited by 58
The Molecular Epidemiology of the Highly Virulent ST93 Australian Community Staphylococcus aureus Strain
Coombs, G. W., Goering, R. V., Chua, K., Monecke, S., Howden, B. P., Stinear, T. P., Ehricht, R., O’Brien, F. G., & Christiansen, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043037 · Cited by 57
Over-Expressed Pathogenic miRNAs in Alzheimer’s Disease (AD) and Prion Disease (PrD) Drive Deficits in TREM2-Mediated Aβ42 Peptide Clearance
Zhao, Y., Jaber, V. R., & Lukiw, W. J. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00140 · Cited by 56
Peripheral Immune Signatures in Alzheimer Disease
Goldeck, D., Witkowski, J. M., Fülöp, T., & Pawelec, G. (2016) · Current Alzheimer Research · doi:10.2174/1567205013666160222112444 · Cited by 55
The effects of age and lipopolysaccharide (LPS)-mediated peripheral inflammation on numbers of central catecholaminergic neurons
Mouton, P. R., Kelley-Bell, B., Tweedie, D., Spangler, E. L., Perez, E., Carlson, O. D., Short, R. G., de Cabo, R., Chang, J. P., Ingram, D. K., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.09.025 · Cited by 48
Rapamycin suppresses Aβ 25–35 - or LPS-induced neuronal inflammation via modulation of NF-κB signaling
Liu, Y., Gao, X., Chen, L., & You, X.-Q. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.05.005 · Cited by 45
Sequence Variants of Toll Like Receptor 4 and Late-Onset Alzheimer's Disease
Chen, Y.-C., Yip, P.-K., Huang, Y.-L., Sun, Y., Wen, L.-L., Chu, Y.-M., & Chen, T.-F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050771 · Cited by 38
The Linker for Activation of B Cells (LAB)/Non-T Cell Activation Linker (NTAL) Regulates Triggering Receptor Expressed on Myeloid Cells (TREM)-2 Signaling and Macrophage Inflammatory Responses Independently of the Linker for Activation of T Cells
Whittaker, G. C., Orr, S. J., Quigley, L., Hughes, L., Francischetti, I. M. B., Zhang, W., & McVicar, D. W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.038398 · Cited by 33
Chitinase1 contributed to a potential protection via microglia polarization and Aβ oligomer reduction in D-galactose and aluminum-induced rat model with cognitive impairments
Xiao, Q., Yu, W., Tian, Q., Fu, X. L., Wang, X., Gu, M., & Lü, Y. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.050 · Cited by 30
Regulating amyloidogenesis through the natural triggering receptor expressed in myeloid/microglial cells 2 (TREM2)
Jones, B. M., Bhattacharjee, S., Dua, P., Hill, J. M., Zhao, Y., & Lukiw, W. J. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00094 · Cited by 26
In-depth analysis of the synaptic plasma membrane proteome of small hippocampal slices using an integrated approach
Qiao, R., Li, S., Zhou, M., Chen, P., Liu, Z., Tang, M., & Zhou, J. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.015 · Cited by 16
Studies on cholesterol esterase in rat adipose tissue: Comparison of substrates and regulation of the activity
Nakamura, K., Inoue, Y., Watanabe, N., & Tomita, T. (1988) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(88)90297-4 · Cited by 11
Effects of somatostatin on plasma ammonia and amino acid profile during fasting and after protein feeding in cirrhotic patients.
Trevisani, F., Bernardi, M., Palma, R. D., Servadei, D., Piazzi, S., Capelli, M., & Gasbarrini, A. (1986) · PubMed · Cited by 5
Hypoxia-Up-Regulated Mitochondrial Movement Regulator Does Not Contribute to the APP/PS1 Double Transgenic Mouse Model of Alzheimer's Disease
Zou, Y., Yu, L., Yu, W., Du, Y., Shi, R., Zhang, M., Duan, J., Deng, Y., Tu, Q., Dai, R., et al. (2013) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000351669 · Cited by 3
[Use of the metallographic microscope in endodontic therapy].
Bagnol, J., Gm, C., Pieri, J. C., & Regord, C. (1972) · PubMed · Cited by 1

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See all 140

Authors: Zhou, J., Yu, W., Zhang, M., Tian, X., Li, Y., & Lü, Y.
Affiliations: The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
Chongqing Medical University (CN)
Corresponding author: Lü, Yang
ORCID: Zhou, Jian
Yu, Weihua
Zhang, Man
Tian, Xin
Li, Yu
Lü, Yang
Venue: Neurochemical Research
Publisher: Springer Science and Business Media LLC
Published: 2019-02-12
Volume: 44
Issue: 5
Pages: 1138-1151
ISSN: 0364-3190 (ISSN-L)
1573-6903
DOI: 10.1007/s11064-019-02748-x
OpenAlex: W2913512944
Cited by: 139
References: 78
Citations by year: 2026: 14 · 2025: 17 · 2024: 17 · 2023: 15 · 2022: 28 · 2021: 30 · 2020: 16 · 2019: 2
FWCI: 8.48
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Neurochemical Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: Alzheimer's disease, systemic inflammation, microglia, TLR4, TREM2, lipopolysaccharide, APP/PS1 mice, microglial activation, neuronal apoptosis, amyloid-beta 42, cognitive impairment
MeSH terms: Alzheimer Disease, Animals, Brain, Disease Models, Animal, Inflammation, Lipopolysaccharides, Male, Membrane Glycoproteins, Mice, Transgenic, Receptors, Immunologic, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Microglia, Toll-Like Receptor 4

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Imbalance of microglial TLR4/TREM2 in LPS-treated APP/PS1 transgenic mice: a potential Link between Alzheimer's disease and systemic inflammation

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