Cited by 11Mindfulness and Compassion InterventionsFunctional Brain Connectivity StudiesDementia and Cognitive Impairment Research

Reduced age-related gray matter loss in the subgenual cingulate cortex in long-term meditators.

Kurth, Florian, Zsadanyi, Sára E., Luders, Eileen·2021·Brain Imaging and Behavior

Abstract

Accumulating evidence suggests that meditation practices have positive effects on brain ageing overall. The cingulate is known to be recruited during meditation, but research into possible effects of meditation on the ageing of the cingulate is currently missing. Thus, the present study was designed to help close this knowledge gap, with particular focus on the subgenual cingulate, a region involved in emotional regulation and autonomic and endocrine functions, making it potentially relevant for meditation. Here, we investigated differences in age-related gray matter loss between 50 long-term meditation practitioners (28 male, 22 female), aged between 24 and 77, and 50 age- and sex-matched controls. Areas of interest were four subregions of the subgenual cingulate gyrus (areas 25, 33, s24, and s32) defined as per the Julich-Brain atlas. Our study revealed a significant age-related decline in all subregions in both meditators and controls, but with significantly lower rates of annual tissue loss in meditators, specifically in left and right area s32 and right area 25. These regions have been shown to play a role in mood regulation, autonomic processing, and the integration of emotion and cognitive processes, which are all involved in and impacted by meditation. Overall, the results add further evidence to the emerging notion that meditation may slow the effects of ageing on the brain.

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Crossref · 10.1007/s11682-021-00578-6

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Authors
Kurth, F., Zsadanyi, S. E., & Luders, E.
Affiliations
University of Auckland (NZ)
Corresponding author
Kurth, Florian
Venue
Brain Imaging and Behavior
Published
2021-10-23
Volume
15
Issue
6
Pages
2824-2832
ISSN
  • 1931-7557 (ISSN-L)
  • 1931-7565
OpenAlex
W3207768953
Cited by
11
References
80
Citations by year
2025: 4 · 2024: 4 · 2023: 2 · 2022: 1
FWCI
1.20
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Imaging and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
meditation, brain aging, subgenual anterior cingulate cortex, gray matter loss, long-term meditators, emotion regulation, mood regulation, neuroplasticity
MeSH terms
Adult, Cerebral Cortex, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Meditation, Young Adult, Gray Matter

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