Reduced age-related gray matter loss in the subgenual cingulate cortex in long-term meditators.
Abstract
Accumulating evidence suggests that meditation practices have positive effects on brain ageing overall. The cingulate is known to be recruited during meditation, but research into possible effects of meditation on the ageing of the cingulate is currently missing. Thus, the present study was designed to help close this knowledge gap, with particular focus on the subgenual cingulate, a region involved in emotional regulation and autonomic and endocrine functions, making it potentially relevant for meditation. Here, we investigated differences in age-related gray matter loss between 50 long-term meditation practitioners (28 male, 22 female), aged between 24 and 77, and 50 age- and sex-matched controls. Areas of interest were four subregions of the subgenual cingulate gyrus (areas 25, 33, s24, and s32) defined as per the Julich-Brain atlas. Our study revealed a significant age-related decline in all subregions in both meditators and controls, but with significantly lower rates of annual tissue loss in meditators, specifically in left and right area s32 and right area 25. These regions have been shown to play a role in mood regulation, autonomic processing, and the integration of emotion and cognitive processes, which are all involved in and impacted by meditation. Overall, the results add further evidence to the emerging notion that meditation may slow the effects of ageing on the brain.
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Subgenual cingulate cortex was observed with lower rates of annual tissue loss in long-term meditators, suggesting a protective effect of meditation on emotional and cognitive function.
“the subgenual cingulate cortex was observed with lower rates of annual tissue loss in long-term meditators, suggesting a protective effect of meditation on the emotional and cognitive function (Kurth et al., 2021).”
From Enhanced Resting-State Functional Connectivity With Decreased Amplitude of Low-Frequency Fluctuations of the Salience Network in Mindfulness Novices (2022) · cites this paper as Kurth et al., 2021
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- Authors
- Kurth, F., Zsadanyi, S. E., & Luders, E.
- Affiliations
- University of Auckland (NZ)
- Corresponding author
- Kurth, Florian
- ORCID
- Kurth, Florian
- Venue
- Brain Imaging and Behavior
- Published
- 2021-10-23
- Volume
- 15
- Issue
- 6
- Pages
- 2824-2832
- ISSN
- 1931-7557 (ISSN-L)
- 1931-7565
- OpenAlex
- W3207768953
- Cited by
- 11
- References
- 80
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 2 · 2022: 1
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Imaging and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- meditation, brain aging, subgenual anterior cingulate cortex, gray matter loss, long-term meditators, emotion regulation, mood regulation, neuroplasticity
- MeSH terms
- Adult, Cerebral Cortex, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Meditation, Young Adult, Gray Matter
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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