Effects of Circadian Disruption on Mental and Physical Health
Abstract
Circadian (daily) rhythms in physiology and behavior are phylogenetically ancient and are present in almost all plants and animals. In mammals, these rhythms are generated by a master circadian clock in the suprachiasmatic nucleus of the hypothalamus, which in turn synchronizes "peripheral oscillators" throughout the brain and body in almost all cell types and organ systems. Although circadian rhythms are phylogenetically ancient, modern industrialized society and the ubiquity of electric lighting has resulted in a fundamental alteration in the relationship between an individual's endogenous circadian rhythmicity and the external environment. The ramifications of this desynchronization for mental and physical health are not fully understood, although numerous lines of evidence are emerging that link defects in circadian timing with negative health outcomes. This article explores the function of the circadian system, the effects of disrupted clocks on the brain and body, and how these effects impact mental and physical health.
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In adult mammals, chronic circadian disruption has diverse negative impacts on physical and mental health, including a shortened lifespan.
“In adult mammals, chronic circadian disruption has diverse negative impacts on physical and mental health6, 7, including a shortened lifespan8.”
From Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice (2017) · cites this paper as [6]
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- Authors
- Karatsoreos, I. N.
- Affiliations
- Washington State University (US)
- Corresponding author
- Karatsoreos, Ilia N.
- ORCID
- Karatsoreos, Ilia N.
- Venue
- Current Neurology and Neuroscience Reports
- Published
- 2012-02-10
- Volume
- 12
- Issue
- 2
- Pages
- 218-225
- ISSN
- 1528-4042 (ISSN-L)
- 1534-6293
- OpenAlex
- W2042324782
- Cited by
- 85
- References
- 43
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 8 · 2023: 5 · 2022: 9 · 2021: 11 · 2020: 5 · 2019: 9 · 2018: 7 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 8 · 2013: 4
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Neurology and Neuroscience Reports (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- circadian rhythm, circadian rhythm disruption, suprachiasmatic nucleus, peripheral oscillators, light pollution, electric lighting, mental health, physical health, circadian misalignment, circadian clock
- MeSH terms
- Cognition Disorders, Humans, Metabolic Diseases, Obesity, Chronobiology Disorders, Circadian Clocks
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