Cited by 85Circadian rhythm and melatoninSleep and Work-Related FatigueSleep and related disorders

Effects of Circadian Disruption on Mental and Physical Health

Karatsoreos, Ilia N.·2012·Current Neurology and Neuroscience Reports

Abstract

Circadian (daily) rhythms in physiology and behavior are phylogenetically ancient and are present in almost all plants and animals. In mammals, these rhythms are generated by a master circadian clock in the suprachiasmatic nucleus of the hypothalamus, which in turn synchronizes "peripheral oscillators" throughout the brain and body in almost all cell types and organ systems. Although circadian rhythms are phylogenetically ancient, modern industrialized society and the ubiquity of electric lighting has resulted in a fundamental alteration in the relationship between an individual's endogenous circadian rhythmicity and the external environment. The ramifications of this desynchronization for mental and physical health are not fully understood, although numerous lines of evidence are emerging that link defects in circadian timing with negative health outcomes. This article explores the function of the circadian system, the effects of disrupted clocks on the brain and body, and how these effects impact mental and physical health.

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Crossref · 10.1007/s11910-012-0252-0

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Authors
Karatsoreos, I. N.
Affiliations
Washington State University (US)
Corresponding author
Karatsoreos, Ilia N.
Venue
Current Neurology and Neuroscience Reports
Published
2012-02-10
Volume
12
Issue
2
Pages
218-225
ISSN
  • 1528-4042 (ISSN-L)
  • 1534-6293
OpenAlex
W2042324782
Cited by
85
References
43
Citations by year
2026: 3 · 2025: 2 · 2024: 8 · 2023: 5 · 2022: 9 · 2021: 11 · 2020: 5 · 2019: 9 · 2018: 7 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 8 · 2013: 4
FWCI
0.62
Type
journal article
Language
en
Open access
closed
Locations
  • Current Neurology and Neuroscience Reports (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
circadian rhythm, circadian rhythm disruption, suprachiasmatic nucleus, peripheral oscillators, light pollution, electric lighting, mental health, physical health, circadian misalignment, circadian clock
MeSH terms
Cognition Disorders, Humans, Metabolic Diseases, Obesity, Chronobiology Disorders, Circadian Clocks

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