Cited by 196Neurogenesis and neuroplasticity mechanismsCircadian rhythm and melatoninSleep and Wakefulness Research

Experimental ‘Jet Lag’ Inhibits Adult Neurogenesis and Produces Long-Term Cognitive Deficits in Female Hamsters

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Gibson, Erin M., Wang, Connie, Tjho, Stephanie, Khattar, Neera, Kriegsfeld, Lance J.·2010·PLoS ONE

Abstract

BACKGROUND: Circadian disruptions through frequent transmeridian travel, rotating shift work, and poor sleep hygiene are associated with an array of physical and mental health maladies, including marked deficits in human cognitive function. Despite anecdotal and correlational reports suggesting a negative impact of circadian disruptions on brain function, this possibility has not been experimentally examined. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, we investigated whether experimental 'jet lag' (i.e., phase advances of the light:dark cycle) negatively impacts learning and memory and whether any deficits observed are associated with reductions in hippocampal cell proliferation and neurogenesis. Because insults to circadian timing alter circulating glucocorticoid and sex steroid concentrations, both of which influence neurogenesis and learning/memory, we assessed the contribution of these endocrine factors to any observed alterations. Circadian disruption resulted in pronounced deficits in learning and memory paralleled by marked reductions in hippocampal cell proliferation and neurogenesis. Significantly, deficits in hippocampal-dependent learning and memory were not only seen during the period of the circadian disruption, but also persisted well after the cessation of jet lag, suggesting long-lasting negative consequences on brain function. CONCLUSIONS/SIGNIFICANCE: Together, these findings support the view that circadian disruptions suppress hippocampal neurogenesis via a glucocorticoid-independent mechanism, imposing pronounced and persistent impairments on learning and memory.

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  1. [47]Orsini M 1961 The external vaginal phenomena characterizing the stages of the estrous cycle, pregnancy, pseudopregnancy, lactation and anestrous hamster, Mesocricetus auratus Waterhouse. Proceedings of Animal Care Panel 14 193 206

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Authors
Gibson, E. M., Wang, C., Tjho, S., Khattar, N., & Kriegsfeld, L. J.
Affiliations
University of California, Berkeley (US)
Corresponding author
Kriegsfeld, Lance J.
Venue
PLoS ONE
Published
2010-12-01
Volume
5
Issue
12
Pages
e15267
ISSN
1932-6203 (ISSN-L)
OpenAlex
W2116127629
Cited by
196
References
83
Citations by year
2026: 2 · 2025: 6 · 2024: 8 · 2023: 17 · 2022: 12 · 2021: 12 · 2020: 17 · 2019: 10 · 2018: 18 · 2017: 16 · 2016: 10 · 2015: 17 · 2014: 20 · 2013: 15 · 2012: 10
FWCI
3.14
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • eScholarship (California Digital Library) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
  • Figshare (submittedVersion, cc-by)
Funders
  • Northwestern University
  • National Institutes of Health (050470, HD 050470)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD050470, HD 050470)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
jet lag, circadian rhythm disruption, adult neurogenesis, hippocampal cell proliferation, learning and memory impairment, glucocorticoids, sex steroids, female hamsters, long-term cognitive deficits
MeSH terms
Animals, Brain, Cognition Disorders, Disease Models, Animal, Female, Glucocorticoids, Cricetinae, Hippocampus, Hypothalamo-Hypophyseal System, Memory, Neurons, Sleep, Jet Lag Syndrome, Cell Proliferation

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