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Cited by 14

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Effects of Creatine Monohydrate Supplementation on Muscle, Bone and Brain- Hope or Hype for Older Adults?

Candow, Darren G., Moriarty, Terence·2025·Current Osteoporosis Reports
DOI 10.1007/s11914-024-00895-x
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Research works printed but not linked: 43

  1. Cruz-Jentof AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al. Writing Group for the European Working Group on Sarcopenia in Older people 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48:16–31. · DOI · Paper page
  2. Tournadre A, Vial G, Capel F, Soubrier M, Boirie Y, Sarcopenia. Joint Bone Spine. 2019;86:309–14. · DOI · Paper page
  3. Candow DG, Forbes SC, Kirk B, Duque G. Current evidence and possible future applications of creatine supplementation for older adults. Nutrients. 2021;13:745. · DOI · Paper page
  4. Kirk B, Phu S, Brennan-Olsen SL, Bani HE, Duque G. Associations between osteoporosis, the severity of Sarcopenia and fragility fractures in community-dwelling older adults. Eur Geriatr Med. 2020;11:443–50. · DOI
  5. Gurholt TP, German Borda M, Parker N, Fominykh V, Kjelkenes R, Linge J, et al. Linking Sarcopenia, brain structure and cognitive performance: a large-scale UK Biobank study. Brain Commun. 2024;6:fcae083. · DOI
  6. Tanabe C, Reed MJ, Pham TN, Penn K, Bentov I, Kaplan SJ. Association of Brain Atrophy and Masseter Sarcopenia with 1-Year mortality in older trauma patients. JAMA Surg. 2019;154:716–23. · DOI
  7. Shafiee G, Keshtkar A, Soltani A, Ahadi Z, Larijani B, Hesmat R. Prevalence of Sarcopenia in the world: a systematic review and meta-analysis of general population studies. J Diabetes Metab Disord. 2017;16:21. · DOI · Paper page
  8. Santilli V, Bernetti A, Mangone M, Paoloni M. Clinical definition of Sarcopenia. Clin Cases Min Bone Metab. 2014;11:177.
  9. Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev. 2000;80:1107–213. · DOI · Paper page
  10. Persky AM, Brazeau GA. Clinical pharmacology of the dietary supplement creatine monohydrate. Pharmacol Rev. 2001;53:161–76. · DOI · Paper page
  11. Candow DG, Chilibeck PD, Forbes SC. Creatine supplementation and aging musculoskeletal health. Endocrine. 2014;45:354–56. · DOI · Paper page
  12. Delpino FM, Figueiredo LM, Forbes SC, Candow DG, Santos HO. The influence of age, sex, and type of exercise on the efficacy of creatine supplementation on lean body mass: a systematic review and meta-analysis of randomized clinical trials. Nutrition. 2022;103–4:10111791. · DOI · Paper page
  13. Forbes SC, Candow DG, Ostojic SM, Roberts MD, Chilibeck PD. Meta-analysis examining the importance of creatine ingestion strategies on lean tissue mass and strength in older adults. Nutrients. 2021;13:1912. · DOI · Paper page
  14. Candow DG, Chilibeck PD, Forbes SC, Fairman CM, Gualano B, Roschel H. Creatine supplementation for older adults: focus on Sarcopenia, osteoporosis, frailty and cachexia. Bone. 2022;162:116467. · DOI · Paper page
  15. Forbes SC, Candow DG, Ferreira L, Souza-Junior T. Effects of creatine supplementation on properties of muscle, bone, and brain function in older adults: a narrative review. J Diet Suppl. 2022;19:318–35. · DOI
  16. Liu M, Zhang Z, Zhou C, Ye Z, He P, Zhang Y, et al. Predicted fat mass and lean mass in relation to all-cause and cause-specific mortality. J Cachexia Sarcopenia Muscle. 2022;13:1064–75. · DOI
  17. Spahillari A, Mukamal KJ, DeFilippi C, Kizer JR, Gottdiener JS, Djoussé L, et al. The association of lean and fat mass with all-cause mortality in older adults: the Cardiovascular Health Study. Nutr Metab Cardiovas Dis. 2016;26:1039–47. · DOI
  18. Taaffe DR, Henwood TR, Nalls MA, Walker DG, Lang TF, Harris TB. Alterations in muscle attenuation following detraining and retraining in resistance-trained older adults. Gerontology. 2009;55:217–23. · DOI · Paper page
  19. Bhasin S, Travison TG, Manini TM, Patel S, Pencina KM, Fielding RA, et al. Sarcopenia definition: the position statements of the Sarcopenia definition and outcomes consortium. J Am Geriatr Soc. 2020;68:1410–18. · DOI · Paper page
  20. Buckinx F, Landi F, Cesari M, Fielding RA, Visser M, Engelke K, et al. Pitfalls in the measurement of muscle mass: a need for a reference standard. J Cachexia Sarcopenia Muscle. 2018;9:269–78. · DOI · Paper page
  21. Candow DG, Chilibeck PD, Gordon JJ, Kontulainen S. Efficacy of creatine supplementation and supervised resistance training on area and density of bone and muscle in older adults. Med Sci Sports Exerc. 2021;53:2388–95. · DOI · Paper page
  22. Cawthon PM, Fox KM, Gandra SR, Delmonico MJ, Chiou CF, Anthony MS, et al. Clustering of strength, physical function, muscle, and adiposity characteristics and risk of disability in older adults. J Am Geriatr Soc. 2011;59:781–7. · DOI
  23. Gerber I, ap Gwynn I, Alini M, Wallimann T. Stimulatory effects of creatine on metabolic activity, differentiation and mineralization of primary osteoblast-like cells in monolayer and micromass cell cultures. Eur Cell Mater. 2005;10:8–22. · DOI
  24. Wallimann T, Hemmer W. Creatine kinase in non-muscle tissues and cells. Mol Cell Biochem. 1994;133–134:193–220. · DOI · Paper page
  25. Chilibeck PD, Chrusch MJ, Chad KE, Shawn Davison K, Burke DG. Creatine monohydrate and resistance training increase bone mineral content and density in older men. J Nutr Health Aging 2005;9:352–3.
  26. Chilibeck PD, Candow DG, Gordon JJ, Duff WRD, Mason R, Shaw K, et al. A 2-year randomized controlled trial on creatine supplementation during exercise for postmenopausal bone health. Med Sci Sports Exerc. 2023;55:1750–60. · DOI · Paper page
  27. Chilibeck PD, Candow DG, Landeryou T, Kaviani M, Paus-Jenssen L. Effects of creatine and resistance training on bone health in postmenopausal women. Med Sci Sports Exerc. 2015;47:1587–95. · DOI · Paper page
  28. Candow D, Chilibeck P, Gordon J, Vogt E, Landeryou T, Kaviani M, et al. Effect of 12 months of creatine supplementation and whole-body resistance training on measures of bone, muscle and strength in older males. Nutr Health. 2021;27(2):151–59. · DOI · Paper page
  29. Gualano B, Macedo AR, Alves CRR, Roschel H, Benatti FB, Takayama L, et al. Creatine supplementation and resistance training in vulnerable older women: a randomized double-blind placebo-controlled clinical trial. Exp Gerontol. 2014;53:7–15. · DOI · Paper page
  30. Candow DG, Forbes SC, Vogt E. Effect of pre-exercise and post-exercise creatine supplementation on bone mineral content and density in healthy aging adults. Exp Gerontol. 2019;119:89–92. · DOI · Paper page
  31. Pinto CL, Botelho PB, Carneiro JA, Mota JF. Impact of creatine supplementation in combination with resistance training on lean mass in the elderly. J Cachexia Sarcopenia Muscle. 2016;7:41–21. · DOI · Paper page
  32. Forbes SC, Chilibeck PD, Candow DG. Creatine Supplementation during Resistance Training does not lead to Greater Bone Mineral density in older humans: a brief Meta-analysis. Front Nutr. 2018;5:27. · DOI
  33. Sales LP, Pinto AJ, Rodrigues SF, Alvarenga JC, Goncalves N, Sampaio-Barros MM, et al. Creatine Supplementation (3 g/d) and Bone Health in Older women: a 2-Year, Randomized, Placebo-Controlled Trial. J Gerontol Biol Sci Med Sci. 2020;75:931–38. · DOI · Paper page
  34. Eshkoor SA, Hamid TA, Mun CY, Ng CK. Mild cognitive impairment and its management in older people. Clin Interv Aging. 2015;10:687–93. · DOI · Paper page
  35. Fernandes-Pires G, Braissant O. Current and potential new treatment strategies for creatine deficiency syndromes. Mol Genet Metab. 2022;135:15–26. · DOI · Paper page
  36. Dechent P, Pouwels PJ, Wilken B, Hanefeld F, Frahm J. Increase of total creatine in human brain after oral supplementation of creatine-monohydrate. Am J Physiol. 1999;277:698.
  37. Candow DG, Forbes SC, Ostojic SM, Prokopidis K, Stock MS, Harmon KK, et al. Heads-Up for Creatine Supplementation and its potential applications for Brain Health and function. Sports Med. 2023;53:49–65. · DOI · Paper page
  38. Turner CE, Byblow WD, Gant N. Creatine supplementation enhances corticomotor excitability and cognitive performance during oxygen deprivation. J Neurosci. 2015;35:1773–80. · DOI · Paper page
  39. Machado M, Pereira R. The potential and challenges of Creatine supplementation for Cognition/Memory in older adults. Eur J Geriatr Gerontol. 2023;5:1–5. · DOI
  40. McMorris T, Mielcarz G, Harris RC, Swain JP, Howard A. Creatine supplementation and cognitive performance in elderly individuals. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2007;14:517–28. · DOI · Paper page
  41. Xu C, Bi S, Zhang W, Luo L. The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis. Front Nutr. 2024;11:1424972. · DOI · Paper page
  42. Machado M, Masterson TD, Oliveira EF. Could dietary creatine intake modulate overweight elderly’s selective attention and inhibitory function? Nutr Health. 2022;2601060221127497. · DOI · Paper page
  43. Ostojic SM, Korovljev D, Stajer V. Dietary creatine and cognitive function in U.S. adults aged 60 years and over. Aging Clin Exp Res. 2021;33:3269–74. · DOI · Paper page

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Metadata

Authors
Candow, D. G., & Moriarty, T.
Venue
Current Osteoporosis Reports
Publisher
Springer Science and Business Media LLC
Published
2024-11-01
Volume
23
Issue
1
ISSN
  • 1544-1873
  • 1544-2241
DOI
10.1007/s11914-024-00895-x
Cited by
14
References
30
Language
en
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CoChat. (2026). Citation check: Effects of Creatine Monohydrate Supplementation on Muscle, Bone and Brain- Hope or Hype for Older Adults? https://app.cochat.ai/papers/10.1007/s11914-024-00895-x
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Candow, D. G., & Moriarty, T. (2025). Effects of Creatine Monohydrate Supplementation on Muscle, Bone and Brain- Hope or Hype for Older Adults? Current Osteoporosis Reports. https://doi.org/10.1007/s11914-024-00895-x

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