Cited by 194Posttraumatic Stress Disorder ResearchTraumatic Brain Injury ResearchPsychoanalysis and Psychopathology Research

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Neuroimaging studies in post-traumatic stress disorder

Bremner, J. Douglas·2002·Current Psychiatry Reports

DOI 10.1007/s11920-996-0044-9

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Abstract

The past decade has seen a rapid advance in understanding of the neural circuits of post-traumatic stress disorder (PTSD), which has largely been due to the application of neuroimaging to the study of this disorder. Based on studies in animals of the effects of stress on the brain, dysfunction of the medial prefrontal cortex, hippocampus, and amygdala have been hypothesized to underlie symptoms of PTSD. Neuroimaging studies in PTSD have been consistent with these hypotheses, with the most replicated findings showing decreased medial prefrontal cortical function in PTSD. Other replicated findings include decreased inferior frontal gyrus function, decreased hippocampal function, increased posterior cingulate function, and, in some behavioral paradigms, increased amygdala function. Several studies have now shown changes in structure (smaller volume) of the hippocampus in PTSD. These studies are beginning to map out a neural circuitry of PTSD that may have future implications for diagnosis and treatment.

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Authors: Bremner, J. D.
Affiliations: Emory University (US)
Corresponding author: Bremner, J. Douglas
ORCID: Bremner, J. Douglas
Venue: Current Psychiatry Reports
Publisher: Springer Science and Business Media LLC
Published: 2002-08
Volume: 4
Issue: 4
Pages: 254-263
ISSN: 1523-3812 (ISSN-L)
1535-1645
DOI: 10.1007/s11920-996-0044-9
OpenAlex: W2138680553
Cited by: 194
References: 32
Citations by year: 2026: 1 · 2025: 2 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 9 · 2014: 11 · 2013: 5 · 2012: 9
FWCI: 22.12
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Current Psychiatry Reports (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (R01MH056120)
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords: post-traumatic stress disorder, neural circuits, medial prefrontal cortex, hippocampus, amygdala, inferior frontal gyrus, posterior cingulate cortex, hippocampal volume, brain structural changes
MeSH terms: Brain, Female, Humans, Male, Stress Disorders, Post-Traumatic, Tomography, Emission-Computed, Tomography, Emission-Computed, Single-Photon

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