Cited by 165Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsCholinesterase and Neurodegenerative Diseases

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Neuroprotective Effects of Resveratrol Against Aβ Administration in Rats are Improved by Lipid-Core Nanocapsules

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Frozza, Rudimar L., Bernardi, Andressa, Hoppe, Juliana B., Meneghetti, André B., Matté, Aline, Battastini, Ana M. O., Pohlmann, Adriana R., Guterres, Sílvia S., Salbego, Christianne·2013·Molecular Neurobiology

DOI 10.1007/s12035-013-8401-2

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Abstract

Alzheimer's disease (AD), a neurodegenerative disorder exhibiting a gradual decline in cognitive function, is characterized by the presence of neuritic plaques composed of neurofibrillary tangles and amyloid-β (Aβ) peptide. Available drugs for AD therapy have small effect sizes and do not alter disease progression. Several studies have been shown that resveratrol is associated with anti-amyloidogenic properties, but therapeutic application of its beneficial effects is limited. Here we compared the neuroprotective effects of free resveratrol treatment with those of resveratrol-loaded lipid-core nanocapsule treatment against intracerebroventricular injection of Aβ1-42 in rats. Animals received a single intracerebroventricular injection of Aβ1-42 (2 nmol), and 1 day after Aβ infusion, they were administered either free resveratrol (RSV) or resveratrol-loaded lipid-core nanocapsules (5 mg/kg, each 12 h, intraperitoneally), for 14 days. Aβ1-42-infused animals showed a significant impairment on learning memory ability, which was paralleled by a significant decrease in hippocampal synaptophysin levels. Furthermore, animals exhibited activated astrocytes and microglial cells, as well as disturbance in c-Jun N-terminal kinase (JNK) and glycogen synthase kinase-3β (GSK-3β) activation, beyond destabilization of β-catenin levels. Our results clearly show that by using lipid-core nanocapsules, resveratrol was able to rescue the deleterious effects of Aβ1-42 while treatment with RSV presented only partial beneficial effects. These findings might be explained by the robust increase of resveratrol concentration in the brain tissue achieved by lipid-core nanocapsules. Our data not only confirm the potential of resveratrol in treating AD but also offer an effective way to improve the efficiency of resveratrol through the use of nanodrug delivery systems.

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Gomes, B. A. Q., Silva, J. P. B., Romeiro, C. F. R., dos Santos, S. M., Rodrigues, C. A., Gonçalves, P. R., Sakai, J. T., Mendes, P. F. S., Varela, E. L. P., & Monteiro, M. C. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8152373 · Cited by 403
Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights
Coutinho, D. D. S., Pacheco, M. T., Frozza, R. L., & Bernardi, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061812 · Cited by 308
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Authors: Frozza, R. L., Bernardi, A., Hoppe, J. B., Meneghetti, A. B., Matté, A., Battastini, A. M. O., Pohlmann, A. R., Guterres, S. S., & Salbego, C.
Affiliations: Universidade Federal do Rio Grande do Sul (BR)
Corresponding author: Frozza, Rudimar L.
ORCID: Frozza, Rudimar L.
Bernardi, Andressa
Hoppe, Juliana B.
Meneghetti, André B.
Matté, Aline
Battastini, Ana M. O.
Pohlmann, Adriana R.
Venue: Molecular Neurobiology
Publisher: Springer Science and Business Media LLC
Published: 2013-01-12
Volume: 47
Issue: 3
Pages: 1066-1080
ISSN: 0893-7648 (ISSN-L)
1559-1182
DOI: 10.1007/s12035-013-8401-2
OpenAlex: W2037132719
Cited by: 165
References: 81
Citations by year: 2026: 2 · 2025: 9 · 2024: 10 · 2023: 17 · 2022: 18 · 2021: 9 · 2020: 17 · 2019: 17 · 2018: 14 · 2017: 13 · 2016: 11 · 2015: 12 · 2014: 12 · 2013: 4
FWCI: 9.03
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by-nc-sa
www.springer.com/tdm (tdm)
Locations: Molecular Neurobiology (publishedVersion)
PubMed (publishedVersion)
Lume (Universidade Federal do Rio Grande do Sul) (submittedVersion, cc-by-nc-sa)
Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Keywords: resveratrol, amyloid-beta 42, Alzheimer's disease, lipid-core nanocapsules, nanoparticle drug delivery, neuroprotection, learning and memory impairment, astrocyte activation, microglial activation, JNK, GSK3β, β-catenin, intracerebroventricular administration
MeSH terms: Glycogen Synthase Kinase 3 beta, Resveratrol, Animals, Astrocytes, Enzyme Activation, Hippocampus, Injections, Intraventricular, Lipids, Male, Memory Disorders, Stilbenes, Synapses, Tissue Distribution, Signal Transduction, Amyloid beta-Peptides, Rats, Wistar, Microglia, Neuroprotective Agents, Cytoprotection, Glycogen Synthase Kinase 3, JNK Mitogen-Activated Protein Kinases, beta Catenin, Rats, Nanocapsules, Protein Stability

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Neuroprotective Effects of Resveratrol Against Aβ Administration in Rats are Improved by Lipid-Core Nanocapsules

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