The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Chronic Wound Healing: A Review of Current Management and Treatments
Open accessAbstract
Wound healing is a complex, highly regulated process that is critical in maintaining the barrier function of skin. With numerous disease processes, the cascade of events involved in wound healing can be affected, resulting in chronic, non-healing wounds that subject the patient to significant discomfort and distress while draining the medical system of an enormous amount of resources. The healing of a superficial wound requires many factors to work in concert, and wound dressings and treatments have evolved considerably to address possible barriers to wound healing, ranging from infection to hypoxia. Even optimally, wound tissue never reaches its pre-injured strength and multiple aberrant healing states can result in chronic non-healing wounds. This article will review wound healing physiology and discuss current approaches for treating a wound.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Smiell, J. M., Wieman, T. J., Steed, D. L., Perry, B. H., Sampson, A. R., & Schwab, B. H. (1999) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.1999.00335.x · Cited by 454
Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes.
Löndahl, M., Katzman, P., Nilsson, A., & Hammarlund, C. (2010) · Diabetes Care · doi:10.2337/dc09-1754 · Cited by 441 · cited 1×
“This was in some ways underlined in a recent randomized controlled trial where hyperbaric oxygen as an adjunct did help wound healing but even the authors qualified their findings to be applicable only to ‘‘selected patients with diabetes’’ [61].”
ResultA clinical trial of Integra Template for diabetic foot ulcer treatment
Driver, V. R., Lavery, L. A., Reyzelman, A. M., Dutra, T. G., Dove, C. R., Kotsis, S. V., Kim, H. M., & Chung, K. C. (2015) · Wound Repair and Regeneration · doi:10.1111/wrr.12357 · Cited by 291
Cited by
Functional Hydrogels as Wound Dressing to Enhance Wound Healing
Liang, Y., He, J., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c04206 · Cited by 3,135
Gornik, H. L., Aronow, H. D., Goodney, P. P., Arya, S., Brewster, L. P., Byrd, L., Chandra, V., Drachman, D. E., Eaves, J. M., Ehrman, J. K., et al. (2024) · Circulation · doi:10.1161/cir.0000000000001251 · Cited by 771
Yin, M., Wu, J., Deng, M., Wang, P., Ji, G., Wang, M., Zhou, C., Blum, N. T., Zhang, W., Shi, H., et al. (2021) · ACS Nano · doi:10.1021/acsnano.1c06036 · Cited by 380
Chronic wounds: Current status, available strategies and emerging therapeutic solutions
Las Heras, K., Igartua, M., Santos-Vizcaino, E., & Hernandez, R. M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.039 · Cited by 370
Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets
Guan, F., Wang, R., Yi, Z., Luo, P., Liu, W., Xie, Y., Liu, Z., Xia, Z., Zhang, H., & Cheng, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02124-y · Cited by 371
Gornik, H. L., Aronow, H. D., Goodney, P. P., Arya, S., Brewster, L. P., Byrd, L., Chandra, V., Drachman, D. E., Eaves, J. M., Ehrman, J. K., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.02.013 · Cited by 294
Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases
Ahmad, S. S., Ahmad, K., Lee, E. J., Lee, Y.-H., & Choi, I. (2020) · Cells · doi:10.3390/cells9081773 · Cited by 202
In situ formation of injectable hydrogels for chronic wound healing
Gao, Y., Li, Z., Huang, J., Zhao, M., & Wu, J. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01074j · Cited by 189
Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds
Wilkinson, H. N., & Hardman, M. J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00773 · Cited by 173
Li, H., Li, B., Lv, D., Li, W., Lu, Y., & Luo, G. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114778 · Cited by 142
Conceição, M., Gushiken, L. F. S., Aldana-Mejía, J. A., Tanimoto, M. H., Ferreira, M. V. D. S., Alves, A. C. M., Miyashita, M. N., Bastos, J. K., Beserra, F. P., & Pellizzon, C. H. (2022) · Antioxidants · doi:10.3390/antiox11112188 · Cited by 34
The p-rpS6-zone delineates wounding responses and the healing process
Ring, N. A. R., Dworak, H., Bachmann, B., Schädl, B., Valdivieso, K., Rozmaric, T., Heimel, P., Fischer, I., Klinaki, E., Gutasi, A., et al. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.04.001 · Cited by 31
Kwon, T.-R., Han, S. W., Kim, J. H., Lee, B. C., Kim, J. M., Hong, J. Y., & Kim, B. J. (2019) · Annals of Dermatology · doi:10.5021/ad.2019.31.4.403 · Cited by 29
Aouji, M., Rkhaila, A., Bouhaddioui, B., Zirari, M., Harifi, H., Taboz, Y., Lrhorfi, L. A., & Bengueddour, R. (2023) · BioMedicine · doi:10.37796/2211-8039.1424 · Cited by 28
A highly stretchable smart dressing for wound infection monitoring and treatment
Su, R., Wang, L., Han, F., Bian, S., Meng, F., Qi, W., Zhai, X., Li, H., Wu, J., Pan, X., et al. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101107 · Cited by 24
Mesenchymal Stem Cells for Cutaneous Wound Healing
Camões, S. P., Santos, J. M., Carvalho, F., & Miranda, J. P. (2020) · Learning Materials in Biosciences · doi:10.1007/978-3-030-43939-2_13 · Cited by 6
How to Fight Acute Sun Damage? Current Skin Care Strategies
Jesus, A., Sousa, E., Cidade, H., Cruz, M. T., & Almeida, I. F. (2024) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-024-00641-3 · Cited by 3
Metadata
- Authors
- Han, G., & Ceilley, R.
- Venue
- Advances in Therapy
- Published
- 2017-01-21
- Volume
- 34
- Issue
- 3
- Pages
- 599-610
- ISSN
- 0741-238X (ISSN-L)
- 1865-8652
- OpenAlex
- W2574904481
- Cited by
- 2,096
- References
- 4
- FWCI
- 97.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.