Fast dopamine release events in the nucleus accumbens of early adolescent rats
Open accessAbstract
Subsecond fluctuations in dopamine (dopamine transients) in the nucleus accumbens are often time-locked to rewards and cues and provide an important learning signal during reward processing. As the mesolimbic dopamine system undergoes dynamic changes during adolescence in the rat, it is possible that dopamine transients encode reward and stimulus presentations differently in adolescents. However, to date no measurements of dopamine transients in awake adolescents have been made. Thus, we used fast scan cyclic voltammetry to measure dopamine transients in the nucleus accumbens core of male rats (29-30 days of age) at baseline and with the presentation of various stimuli that have been shown to trigger dopamine release in adult rats. We found that dopamine transients were detectable in adolescent rats and occurred at a baseline rate similar to adult rats (71-72 days of age). However, unlike adults, adolescent rats did not reliably exhibit dopamine transients at the unexpected presentation of visual, audible and odorous stimuli. In contrast, brief interaction with another rat increased dopamine transients in both adolescent and adult rats. While this effect habituated in adults at a second interaction, it persisted in the adolescents. These data are the first demonstration of dopamine transients in adolescent rats and reveal an important divergence from adults in the occurrence of these transients that may result in differential learning about rewards.
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In laboratory animals, voltammetry studies show that the type of reward can affect age differences in ventral striatal response.
“In laboratory animals, studies using voltammetry to assess subsecond, phasic DA release in the ventral striatum of rats have shown that, as in human imaging studies, the nature of the reward can influence age differences in the ventral striatal response to reward.”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Robinson et al, 2011
In laboratory animals, adolescent rats exhibit attenuated DA transients in ventral striatum to novel sensory stimuli compared with adults, but greater DA release to highly palatable food reward.
“In response to a variety of types of novel sensory (visual, olfactory and auditory) stimuli, adolescent rats were found to exhibit attenuated DA transients in the ventral striatum when compared with adults, whereas they exhibited greater DA release to a highly palatable food reward (Ung et al, 2010; Robinson et al, 2011).”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Robinson et al, 2011
A brief interaction with another animal induces a more sustained release of dopamine in adolescent rats than in adult rats.
“In addition, a brief interaction with another animal induces a more sustained release of dopamine in adolescent rats than in adult rats, suggesting a diminished habituation to rewarding stimuli in adolescents [17].”
From Is there heightened sensitivity to social reward in adolescence? (2016) · cites this paper as [17]
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- Authors
- Robinson, D. L., Zitzman, D. L., Smith, K. J., & Spear, L. P.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Binghamton University (US)
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 176
- Pages
- 296-307
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC3061289
- OpenAlex
- W2132896051
- Cited by
- 94
- References
- 59
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 17 · 2017: 4 · 2016: 10 · 2015: 3 · 2014: 9 · 2013: 11 · 2012: 3
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- NIH (R01DA019071)
- Bowles Center for Alcohol Studies at the University of North Carolina
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nucleus accumbens, adolescence, mesolimbic dopamine system, reward processing, social interaction, habituation, dopamine release
- MeSH terms
- Aging, Animals, Brain Chemistry, Dopamine, Learning, Male, Nucleus Accumbens, Reward, Rats, Long-Evans, Rats
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