Autism and Oxytocin: New Developments in Translational Approaches to Therapeutics
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Autism is a neurodevelopmental disorder characterized by dysfunction in three core symptom domains: speech and communication deficits, repetitive or compulsive behaviors with restricted interests, and social impairment. The neuropeptide oxytocin, along with the structurally similar peptide arginine vasopressin, may play a role in the etiology of autism, and especially in the social impairment domain. Oxytocin is a nonapeptide (i.e., it has nine amino acids). It is synthesized in magnocellular neurons in the paraventricular nucleus and the supraoptic nucleus of the hypothalamus and is released into the bloodstream by way of axon terminals in the posterior pituitary. Oxytocin is released both peripherally, where it is involved in milk letdown and the facilitation of uterine contractions, and centrally, where it acts as a neuromodulator along with arginine vasopressin. Here, we discuss relevant translational research pertaining to the role of oxytocin in social and repetitive behaviors and consider clinical implications. We also discuss current research limitations, review recent preliminary findings from studies involving oxytocin in autism spectrum disorder patient populations, and point to possible directions for future research.
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In subjects diagnosed with autism, a single intranasal administration of OXT might improve, at least temporarily, emotion recognition abilities in the Reading the Mind in the Eyes test and the patients' ability to process socially relevant cues in a computer-based game.
“Moreover, in subjects diagnosed with autism, a single intranasal administration of OXT might be able to improve, at least temporarily, emotion recognition abilities in the Reading the Mind in the Eyes test and the patients' ability to process socially relevant cues in a computer-based game (Andari et al, 2010;Green and Hollander, 2010;Guastella et al, 2010).”
From Chronic and acute intranasal oxytocin produce divergent social effects in mice (2014) · cites this paper as Green and Hollander, 2010
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Kenkel, W. M., Yee, J. R., & Carter, C. S. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12186 · Cited by 70 · see citing works
Gillberg, C., Fernell, E., Kočovská, E., Minnis, H., Bourgeron, T., Thompson, L., & Allely, C. S. (2017) · Autism Research · doi:10.1002/aur.1777 · Cited by 65 · see citing works
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- Authors
- Green, J. J., & Hollander, E.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Hollander, Eric
- ORCID
- Hollander, Eric
- Venue
- Neurotherapeutics
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 7
- Issue
- 3
- Pages
- 250-257
- ISSN
- 1878-7479 (ISSN-L)
- PMC
- PMC5084228
- OpenAlex
- W2030809876
- Cited by
- 124
- References
- 86
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 7 · 2022: 8 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 8 · 2017: 5 · 2016: 9 · 2015: 10 · 2014: 16 · 2013: 11 · 2012: 16
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neurotherapeutics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health
- National Institute of Mental Health
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, oxytocin, vasopressin, social dysfunction, repetitive behavior, social behavior, hypothalamic neuropeptides, paraventricular nucleus, supraoptic nucleus, milk let-down, uterine contraction, neuromodulation
- MeSH terms
- Animals, Arginine Vasopressin, Autistic Disorder, Humans, Oxytocin, Social Behavior
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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