The neuroscience of affiliation: forging links between basic and clinical research on neuropeptides and social behavior
Abstract
Animal studies point to the role of two neuropeptides-oxytocin and vasopressin-in the regulation of affiliative behaviors including mating, pair-bond formation, maternal/parenting behavior, and attachment. These findings may have important implications for understanding and treating clinical disorders marked by social deficits and/or disrupted attachment. This review focuses on advances made to date in the effort to forge links between basic and clinical research in the area of neuropeptides and social behavior. The literature on oxytocin and its involvement in stress response, affiliation, and prosocial behavior is reviewed, and the implications of these findings for such disorders as autism as well as other social and stress-related disorders including social phobia, post-traumatic stress disorder, and some personality disorders are considered. Finally, unresolved issues and directions for future research are discussed.
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Both non-social and social stressors are associated with oxytocin release.
“In terms of stress-related oxytocin triggers, both non-social and social stressors are associated with oxytocin release (DeVries et al., 2003; Bartz and Hollander, 2006; Table 1).”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Bartz and Hollander, 2006
High oxytocin levels in conjunction with positive affiliative contact may serve to motivate approach behavior to seek new friendships and reinstate normal social functioning after conflicts.
“For example, there are some reports that in women, peripheral OT reactivity serves as a marker of relational distress (Tabak et al., 2011), and it has been suggested that these high OT levels in conjunction with positive affiliative contact may serve to motivate approach behavior to seek new friendships and reinstate normal social functioning after conflicts (Bartz and Hollander, 2006;Taylor, 2006”
From The effect of oxytocin on cooperation in a prisoner's dilemma depends on the social context and a person's social value orientation (2014) · cites this paper as Bartz and Hollander, 2006
Arginine vasopressin (AVP) and oxytocin (OT) are key neuropeptides that facilitate social communication, affiliative behaviors and social cognition across mammals.
“Our first studies of the role of the AVPR1a gene in social cognition exemplified by a simple laboratory paradigm converges with a wide range of both animal and human experimentation showing that arginine vasopressin (AVP) and the closely related oxytocin (OT) are key neuropeptides that facilitate social communication, affiliative behaviors and social cognition across mammals [6], [7] .”
From The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task (2009) · cites this paper as [6]
Extensive data indicate that oxytocin exerts prosocial properties such as enhancing affiliative behavior, trust, and warmth.
“Extensive data indicate that oxytocin exerts prosocial properties such as enhancing affiliative behavior, trust, and warmth (Bartz and Hollander, 2006; MacDonald and MacDonald, 2010).”
From Augmenting Prolonged Exposure therapy for PTSD with intranasal oxytocin: a randomized, placebo-controlled pilot trial (2018) · cites this paper as Bartz and Hollander, 2006
Evidence has supported the investigation of OT as a treatment for Fragile X syndrome.
“Evidence has supported the investigation of OT as a treatment for FXS (Bartz and Hollander, 2006; Hall et al., 2012; Hollander et al., 2007).”
From Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders (2014) · cites this paper as Bartz and Hollander, 2006
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Oxytocin and postpartum depression: Delivering on what's known and what's not
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Circumplex Measures of Interpersonal Constructs
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Oxytocin indexes relational distress following interpersonal harms in women
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Oxytocin and vasopressin support distinct configurations of social synchrony
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MDMA-assisted therapy: A new treatment model for social anxiety in autistic adults
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Attachment and Personality Disorders: A Short Review
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- Authors
- A. Bartz, J., & Hollander, E.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- ORCID
- Hollander, Eric
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2006-11
- Volume
- 50
- Issue
- 4
- Pages
- 518-528
- ISSN
- 0018-506X (ISSN-L)
- OpenAlex
- W2086586090
- Cited by
- 311
- References
- 120
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 8 · 2020: 9 · 2019: 9 · 2018: 5 · 2017: 12 · 2016: 17 · 2015: 21 · 2014: 32 · 2013: 28 · 2012: 27
- FWCI
- 31.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Beatrice and Samuel A. Seaver Foundation
- National Institutes of Health
- National Institute of Mental Health (U54MH066673)
- National Institute of Neurological Disorders and Stroke
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Keywords
- oxytocin, vasopressin, neuropeptides, affiliative behavior, social behavior, pair bonding, maternal behavior, attachment, stress response, prosocial behavior, autism spectrum disorder, social anxiety disorder, post-traumatic stress disorder, personality disorders, social dysfunction
- MeSH terms
- Animals, Autistic Disorder, Humans, Oxytocin, Personality Disorders, Phobic Disorders, Social Behavior, Stress Disorders, Post-Traumatic, Stress, Psychological, Vasopressins
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