Facilitation and attenuation of social recognition in rats by different oxytocin-related peptides
Abstract
The memory-modulating effects of subcutaneously administered oxytocin and related peptides were investigated in the social recognition paradigm in rats. The attenuation of social recognition by 0.6 and 6 micrograms/kg of oxytocin was mimicked by the same doses of des-Gly8-oxytocin, [pGlu4, Cyt6]oxytocin-(4-9) and prolyl-leucyl-glycinamide (PLG) and by 0.6 micrograms/kg of oxytocin-(1-6) and [pGlu4,Cyt6]oxytocin-(4-8). The peptide leucyl-glycinamide (LG) was not active in this respect. The facilitation of social recognition by 0.6 and 6 ng/kg of oxytocin was mimicked by the same doses of PLG and LG but not by the other peptides and the amino acid glycine. It is concluded that the active moieties for attenuation and facilitation of social memory reside in different parts of the oxytocin molecule, e.g. the 5-7 and 8-9 region, respectively.
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The role of the OXT system has been investigated in rodent models, but uniquely using OXT-related mutant mice and giving OXT through intracerebroventricular (ICV), intraperitoneal (IP) and subcutaneous (SC) injections.
“The role of the OXT system has been investigated in rodent models, but uniquely using OXT-related mutant mice and giving OXT through intracerebroventricular (ICV), intraperitoneal (IP) and subcutaneous (SC) injections (Bielsky and Young, 2004;Jin et al, 2007;Popik et al, 1996;Sala et al, 2012;Sala et al, 2011;Takayanagi et al, 2005;Winslow and Insel, 2002).”
From Chronic and acute intranasal oxytocin produce divergent social effects in mice (2014) · cites this paper as Popik et al, 1996
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- Authors
- Popik, P., Vetulani, J., & Van Ree, J. M.
- Affiliations
- Maj Institute of Pharmacology (PL)
- Corresponding author
- Popik, Piotr
- ORCID
- Popik, Piotr
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 1996-07
- Volume
- 308
- Issue
- 2
- Pages
- 113-116
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2068648002
- Cited by
- 42
- References
- 19
- Citations by year
- 2024: 1 · 2023: 1 · 2018: 1 · 2017: 2 · 2015: 3 · 2013: 2 · 2012: 2
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, social recognition memory, peptide fragments, memory enhancement, rats
- MeSH terms
- Animals, Behavior, Animal, Male, Oxytocin, Peptides, Social Behavior, Rats, Wistar, Rats
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