Relationships among estrogen receptor, oxytocin and vasopressin gene expression and social interaction in male mice
Abstract
The incidence of social disorders such as autism and schizophrenia is significantly higher in males, and the presentation more severe, than in females. This suggests the possible contribution of sex hormones to the development of these psychiatric disorders. There is also evidence that these disorders are highly heritable. To contribute toward our understanding of the mechanisms underlying social behaviors, particularly social interaction, we assessed the relationship of social interaction with gene expression for two neuropeptides, oxytocin (OT) and arginine vasopressin (AVP), using adult male mice. Social interaction was positively correlated with: oxytocin receptor (OTR) and vasopressin receptor (V1aR) mRNA expression in the medial amygdala; and OT and AVP mRNA expression in the paraventricular nucleus of the hypothalamus (PVN). When mice representing extremes of social interaction were compared, all of these mRNAs were more highly expressed in high social interaction mice than in low social interaction mice. OTR and V1aR mRNAs were highly correlated with estrogen receptor α (ERα) mRNA in the medial amygdala, and OT and AVP mRNAs with estrogen receptor β (ERβ) mRNA in the PVN, indicating that OT and AVP systems are tightly regulated by estrogen receptors. A significant difference in the level of ERα mRNA in the medial amygdala between high and low social interaction mice was also observed. These results support the hypothesis that variations of estrogen receptor levels are…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the PVN, AVP mRNA expression is altered by experimental manipulations that impact agonistic and affiliative interactions, including play.
“In the PVN, AVP mRNA expression is altered by experimental manipulations that impact agonistic and affiliative interactions, including play (Veenema et al., 2006; Veenema and Neumann, 2009; Murakami et al., 2011; De Souza et al., 2013).”
From Sexually dimorphic role for vasopressin in the development of social play (2014) · cites this paper as Murakami et al., 2011
Cites
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · cited 3× · see citing works
“Social interaction and ethologically inspired behavioral analysis The social interaction analysis was performed according to modified methods utilized by Olivier Berton (Berton et al., 2006; Krishnan et al., 2007).”
BackgroundMethodSwanson, L. W., & Kuypers, H. G. J. M. (1980) · Journal of Comparative Neurology · doi:10.1002/cne.901940306 · Cited by 1,413 · see citing works
Champagne, F. A., Francis, D. D., Mar, A., & Meaney, M. J. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00149-5 · Cited by 1,021 · see citing works
Francis, D. D., Young, L. J., Meaney, M. J., & Insel, T. R. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.0007-1331.2002.00776.x · Cited by 415 · see citing works
Bielsky, I. F., Hu, S.-B., Ren, X., Terwilliger, E. F., & Young, L. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.031 · Cited by 367 · see citing works
Central vasopressin and oxytocin release: regulation of complex social behaviours
VEENEMA, A., & NEUMANN, I. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00422-6 · Cited by 338 · see citing works
Possible Role for Endogenous Oxytocin in Estrogen-Facilitated Maternal Behavior in Rats
Fahrbach, S. E., Morrell, J. I., & Pfaff, D. W. (2008) · Neuroendocrinology · doi:10.1159/000124125 · Cited by 322 · see citing works
Self-citationTopical Review: Fetal Testosterone and Sex Differences in Typical Social Development and in Autism
Knickmeyer, R. C., & Baron-Cohen, S. (2006) · Journal of Child Neurology · doi:10.1177/08830738060210101601 · Cited by 230 · see citing works
Examination of AVPR1a as an autism susceptibility gene
Wassink, T. H., Piven, J., Vieland, V. J., Pietila, J., Goedken, R. J., Folstein, S. E., & Sheffield, V. C. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001503 · Cited by 212 · see citing works
Low doses of oxytocin facilitate social recognition in rats
Popik, P., Vetulani, J., & van Ree, J. M. (1992) · Psychopharmacology · doi:10.1007/bf02253591 · Cited by 212 · see citing works
Veenema, A. H., Beiderbeck, D. I., Lukas, M., & Neumann, I. D. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.03.006 · Cited by 180 · see citing works
Lubin, D. A., Elliot, J. C., Black, M. C., & Johns, J. M. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.2.195 · Cited by 145 · see citing works
Neuropeptides and the social brain: potential rodent models of autism
Lim, M. M., Bielsky, I. F., & Young, L. J. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.05.006 · Cited by 129 · see citing works
Facilitation and attenuation of social recognition in rats by different oxytocin-related peptides
Popik, P., Vetulani, J., & Van Ree, J. M. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00215-4 · Cited by 42 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Autism, oxytocin and interoception
Quattrocki, E., & Friston, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.012 · Cited by 393 · see citing works
Dumais, K. M., Bredewold, R., Mayer, T. E., & Veenema, A. H. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.08.012 · Cited by 201 · see citing works
Brain oxytocin in social fear conditioning and its extinction: involvement of the lateral septum
Zoicas, I., Slattery, D. A., & Neumann, I. D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.156 · Cited by 189 · see citing works
Kudwa, A. E., McGivern, R. F., & Handa, R. J. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.03.004 · Cited by 73 · see citing works
Kompier, N. F., Keysers, C., Gazzola, V., Lucassen, P. J., & Krugers, H. J. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00143 · Cited by 53 · see citing works
Sexually dimorphic role for vasopressin in the development of social play
Paul, M. J., Terranova, J. I., Probst, C. K., Murray, E. K., Ismail, N. I., & de Vries, G. J. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00058 · Cited by 51 · see citing works
“1 Neuroscience Institute, Georgia State University, Atlanta, GA, USA 2 Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA, USA 3 Northern Ireland Centre for Stratified Medicine, University of Ulster, Ulster, UK 4 School of Psychology, University of Ottawa, Ottawa, ON, Canada Edited by: Regina…”
BackgroundInfluentialRigney, N., Whylings, J., de Vries, G. J., & Petrulis, A. (2021) · Neuroendocrinology · doi:10.1159/000509421 · Cited by 42 · see citing works
Neuroendocrine underpinning of social recognition in males and females
Aspesi, D., & Choleris, E. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13070 · Cited by 41 · see citing works
O’Tuathaigh, C. M. P., Fumagalli, F., Desbonnet, L., Perez-Branguli, F., Moloney, G., Loftus, S., O’Leary, C., Petit, E., Cox, R., Tighe, O., et al. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw120 · Cited by 22 · see citing works
Chun, E. K., Donovan, M., Liu, Y., & Wang, Z. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100427 · Cited by 18 · see citing works
- Authors
- Murakami, G., Hunter, R. G., Fontaine, C., Ribeiro, A., & Pfaff, D.
- Affiliations
- Rockefeller University (US)
- Corresponding author
- Murakami, G.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2011-07-12
- Volume
- 34
- Issue
- 3
- Pages
- 469-477
- ISSN
- 0953-816X (ISSN-L)
- OpenAlex
- W1939470521
- Cited by
- 99
- References
- 14
- Citations by year
- 2025: 3 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 10 · 2017: 10 · 2016: 8 · 2015: 8 · 2014: 12 · 2013: 7 · 2012: 7
- FWCI
- 12.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R37HD005751, HD05751)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- social interaction, oxytocin, vasopressin, estrogen receptor alpha, estrogen receptor beta, oxytocin receptor, vasopressin V1a receptor, medial amygdala, paraventricular nucleus, sex differences in social behavior, autism spectrum disorder, schizophrenia, sex hormones, gene expression, mice
- MeSH terms
- Animals, Arginine Vasopressin, Behavior, Animal, Mental Disorders, Female, Interpersonal Relations, Male, Mice, Inbred C57BL, Neuropsychological Tests, Oxytocin, Paraventricular Hypothalamic Nucleus, Social Behavior, Gene Expression, Receptors, Vasopressin, Receptors, Oxytocin, Estrogen Receptor alpha, Estrogen Receptor beta, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
