Post-learning intranasal oxytocin modulates human memory for facial identity
Open accessAbstract
The nanopeptide oxytocin has physiological functions during labour and lactation. In addition, oxytocin is known to modulate aggression, anxiety, social behaviour and cognition. Little is known about its effects on memory for emotional stimuli. In the present single-blind, placebo-controlled, randomised study we have investigated the short- and long-term effects of a single post-learning dose (20 IU) of intranasal oxytocin on memory for facial identity and expression in 36 healthy young females and males using a face portrait recognition test. In the acquisition phase of the test, 60 different male faces with happy, angry or neutral expressions were presented to the volunteers. Thirty minutes and 24h after oxytocin administration, recognition memory tests were performed using portraits with neutral facial expressions, only. Oxytocin improved identity recognition memory independently of participant's gender, for neutral and angry faces, whereas this effect was not present for happy faces. Oxytocin-treated subjects had a lower bias to judge not previously seen faces as being previously seen. Oxytocin had no effect on facial expression memory. In conclusion, oxytocin has distinct effects on memory performance for facial identity and may contribute to the modulation of social behaviour.
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Peptide specificity is achieved through a high binding affinity for the receptors, about 1000× higher than classical neurotransmitters.
“Peptide specificity is achieved through a high binding affinity for the receptors, about 1000× higher than classical neurotransmitters [119, 132].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [119]
OT increases the accuracy of people's perceptual judgments of others' emotions and intentions, improves recognition memory, and stimulates eye contact.
“It increases the accuracy of people's perceptual judgments of others' emotions and intentions (Domes et al., 2007), improves recognition memory (Savaskan et al., 2008) and stimulates eye contact (Guastella et al., 2008).”
From The effect of oxytocin on cooperation in a prisoner's dilemma depends on the social context and a person's social value orientation (2014) · cites this paper as Savaskan et al., 2008
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- Authors
- Savaskan, E., Ehrhardt, R., Schulz, A., Walter, M., & Schächinger, H.
- Affiliations
- University Hospital Zurich (CH)
- Universität Trier (DE)
- Universitäre Psychiatrische Kliniken Basel (CH)
- Corresponding author
- Savaskan, Egemen
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 33
- Issue
- 3
- Pages
- 368-374
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2147868789
- Cited by
- 262
- References
- 53
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 15 · 2020: 11 · 2019: 7 · 2018: 13 · 2017: 13 · 2016: 16 · 2015: 18 · 2014: 23 · 2013: 30 · 2012: 22
- FWCI
- 31.20
- Type
- journal article
- Language
- en
- Open access
- green
- orbilu.uni.lu
- Licence
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Open Repository and Bibliography (University of Luxembourg) (submittedVersion, cc-by-nc-sa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, intranasal administration, face identification, face memory, emotional valence, happy and angry faces, social cognition, social behavior
- MeSH terms
- Administration, Intranasal, Adolescent, Adult, Data Interpretation, Statistical, Face, Facial Expression, Female, Humans, Male, Memory, Oxytocin, Psychomotor Performance, Sex Characteristics, Single-Blind Method, Recognition, Psychology
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