Cited by 115Neuroendocrine regulation and behaviorOlfactory and Sensory Function StudiesNeuropeptides and Animal Physiology

Oxytocin but not vasopressin facilities social recognition following injection into the medial preoptic area of the rat brain

Popik, Piotr, van Ree, Jan M.·1991·European Neuropsychopharmacology

Abstract

Social recognition of juvenile rats by adult male residents has been shown to be modulated by peripheral administration of neurohypophyseal hormones vasopressin and oxytocin. In the present study, the effects of these peptides on social recognition were investigated after local injection into the medial preoptic area of the hypothalamus. It was found that oxytocin given in a wide range of doses (0.3-1000 pg) facilitated social recognition. This effect was not blocked by pretreatment with oxytocin receptor antagonist desGly(NH2)9-d(CH2)5[Tyr(Me)2Thr4]OVT. Oxytocin injected into the septum in doses of 0.03-3 pg was not effective. Administration of vasopressin (100 or 1000 pg), [pGlu4,Cyt6]AVP-(4-8) (200 pg) or [pGlu4,Cyt6]AVP-(4-9) (200 pg) into the medial preoptic area did not influence social recognition. It is concluded that the medial preoptic area is a sensitive brain site for the oxytocin-induced facilitation of social recognition in rats.

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Crossref · 10.1016/0924-977x(91)90010-r

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Authors
Popik, P., & van Ree, J. M.
Affiliations
Utrecht University (NL)
Corresponding author
Popik, Piotr
Venue
European Neuropsychopharmacology
Publisher
Elsevier BV
Published
1991-12
Volume
1
Issue
4
Pages
555-560
ISSN
0924-977X (ISSN-L)
OpenAlex
W2008312242
Cited by
114
References
24
Citations by year
2024: 1 · 2023: 4 · 2022: 2 · 2021: 1 · 2019: 7 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 10 · 2014: 9 · 2013: 9 · 2012: 3
FWCI
2.69
Type
journal article
Language
en
Open access
closed
Locations
  • European Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
oxytocin, vasopressin, social recognition, medial preoptic area, hypothalamus, neurohypophyseal hormones, oxytocin receptor antagonist, septum, young rats, social behavior
MeSH terms
Animals, Arginine Vasopressin, Cognition, Injections, Male, Oxytocin, Preoptic Area, Rats, Inbred Strains, Social Behavior, Stimulation, Chemical, Receptors, Oxytocin, Rats, Angiotensin Receptor Antagonists

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