Low doses of oxytocin facilitate social recognition in rats
Abstract
Social recognition of juveniles by adult male residents has been shown to be modulated by neurohypophyseal hormones. The decrease of social investigation behavior during a second encounter with the same juvenile serves as index for social recognition. In the present study it was found that low doses (0.09-6.0 ng.kg-1) of oxytocin (OXT) given subcutaneously dose dependently facilitated social recognition. The effect of OXT appeared specific, since no change in social investigation was found when a novel juvenile was tested during the second encounter. No disturbances of social recognition by the low doses of OXT could be detected, in contrast to higher doses of this hormone. Other neurohypophyseal hormones, vasopressin and vasotocin, did not facilitate social recognition when tested in the same range of low doses.
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Intranasal OT improves the ability to infer the emotional state of others based on subtle facial stimuli, a phenomenon referred to as "mind reading".
“Intranasal OT also improves the ability to infer the emotional state of others based on subtle facial stimuli, a phenomenon referred to as “mind reading” [105]; which could have profound effects on the maintenance of social groups.”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [105]
The OT system in the olfactory bulb, septum, and MPOA plays a role in social recognition.
“the OT system in the olfactory bulb, septum (Popik et al., 1992), and MPOA (Popik and Van Ree, 1991) plays a role in social recognition.”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Popik et al., 1992
There is both animal and human research to suggest systemic OT can influence social behavior and cognition.
“There is both animal (Popik et al., 1992) and human (Hollander et al., 2007(Hollander et al., , 2003) ) research to suggest systemic OT can influence social behavior and cognition”
From Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial (2016) · cites this paper as Popik et al., 1992
Dose-dependent effects of OT on social behavior in animals and humans indicate that lower doses of OT may be more efficacious.
“Dose-dependent effects of OT on social behavior in animals (Benelli et al., 1995;Popik et al., 1992) and humans (Cardoso et al., 2013;Hall et al., 2012;Quintana et al., 2015b) that indicate that lower doses of OT may be more efficacious warrants further research.”
From Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial (2016) · cites this paper as Popik et al., 1992
The data are in line with animal research that has associated a lower OT dose with stronger increases in social recognition.
“Furthermore, the data are in line with animal research that has associated a lower OT dose with stronger increases in social recognition (Benelli et al., 1995;Popik et al., 1992), which is pertinent given the crucial role of the amygdala in social cognition and behavior.”
From Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial (2016) · cites this paper as Popik et al., 1992
Pre-clinical research demonstrates that lower doses of oxytocin may be more efficacious.
“despite pre-clinical research demonstrating that lower doses may be more efficacious.36, 37”
Research is increasingly pointing towards lower oxytocin doses being more (or at least equivalently) efficacious than higher doses.
“Research is increasingly pointing towards lower oxytocin doses being more (or at least equivalently) efficacious than higher doses.36, 37, 72, 73”
Oxytocin has a well-established role in social behaviors and social recognition.
“and the well-established role of oxytocin in social behaviors and social recognition (13, 21, 34; 39-44).”
From Social Interaction Elicits Activity in Glutamatergic Neurons in the Posterior Intralaminar Complex of the Thalamus (2024) · cites this paper as [42]
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- Authors
- Popik, P., Vetulani, J., & van Ree, J. M.
- Affiliations
- Utrecht University (NL)
- ORCID
- Popik, Piotr
- Venue
- Psychopharmacology
- Published
- 1992-01
- Volume
- 106
- Issue
- 1
- Pages
- 71-74
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W1970134980
- Cited by
- 212
- References
- 24
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 9 · 2021: 5 · 2020: 6 · 2019: 9 · 2018: 9 · 2017: 10 · 2016: 12 · 2015: 11 · 2014: 6 · 2013: 9 · 2012: 7
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, social recognition, social investigation, neurohypophyseal hormones, vasopressin, arginine vasotocin, dose dependence, young rats, social behavior
- MeSH terms
- Animals, Arginine Vasopressin, Cognition, Male, Memory, Oxytocin, Rats, Inbred Strains, Social Behavior, Vasotocin, Rats
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