Cited by 502Memory and Neural MechanismsNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

What is the function of hippocampal theta rhythm?--Linking behavioral data to phasic properties of field potential and unit recording data

Hasselmo, Michael E.·2005·Hippocampus

Abstract

The extensive physiological data on hippocampal theta rhythm provide an opportunity to evaluate hypotheses about the role of theta rhythm for hippocampal network function. Computational models based on these hypotheses help to link behavioral data with physiological measurements of different variables during theta rhythm. This paper reviews work on network models in which theta rhythm contributes to the following functions: (1) separating the dynamics of encoding and retrieval, (2) enhancing the context-dependent retrieval of sequences, (3) buffering of novel information in entorhinal cortex (EC) for episodic encoding, and (4) timing interactions between prefrontal cortex and hippocampus for memory-guided action selection. Modeling shows how these functional mechanisms are related to physiological data from the hippocampal formation, including (1) the phase relationships of synaptic currents during theta rhythm measured by current source density analysis of electroencephalographic data from region CA1 and dentate gyrus, (2) the timing of action potentials, including the theta phase precession of single place cells during running on a linear track, the context-dependent changes in theta phase precession across trials on each day, and the context-dependent firing properties of hippocampal neurons in spatial alternation (e.g., "splitter cells"), (3) the cholinergic regulation of sustained activity in entorhinal cortical neurons, and (4) the phasic timing of prefrontal cortical neurons relative to hippocampal theta rhythm.

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  1. Sutton RS, Barto AG. 1998. Reinforcement learning (adaptive computation and machine learning). Cambridge MA: MIT Press.

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Authors
Hasselmo, M. E.
Affiliations
Boston University (US)
Corresponding author
Hasselmo, Michael E.
Venue
Hippocampus
Publisher
Wiley
Published
2005-01
Volume
15
Issue
7
Pages
936-949
ISSN
  • 1050-9631 (ISSN-L)
  • 1098-1063
OpenAlex
W2163909553
Cited by
502
References
129
Citations by year
2026: 19 · 2025: 31 · 2024: 22 · 2023: 27 · 2022: 32 · 2021: 24 · 2020: 22 · 2019: 24 · 2018: 25 · 2017: 27 · 2016: 29 · 2015: 27 · 2014: 26 · 2013: 25 · 2012: 26
FWCI
1.57
Type
journal article
Language
en
Open access
closed
Locations
  • Hippocampus (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (P50MH060450, MH 60013, MH-60450, MH61492, R01MH061492)
  • National Institute on Drug Abuse (DA 16454, R01DA016454)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
hippocampal theta rhythm, theta phase precession, place cells, spatial alternation, entorhinal cortex, cholinergic modulation, prefrontal cortex, current source density, CA1, dentate gyrus
MeSH terms
Action Potentials, Animals, Hippocampus, Humans, Neural Pathways, Synaptic Transmission, Neurons, Theta Rhythm, Neural Networks, Computer

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