What is the function of hippocampal theta rhythm?--Linking behavioral data to phasic properties of field potential and unit recording data
Abstract
The extensive physiological data on hippocampal theta rhythm provide an opportunity to evaluate hypotheses about the role of theta rhythm for hippocampal network function. Computational models based on these hypotheses help to link behavioral data with physiological measurements of different variables during theta rhythm. This paper reviews work on network models in which theta rhythm contributes to the following functions: (1) separating the dynamics of encoding and retrieval, (2) enhancing the context-dependent retrieval of sequences, (3) buffering of novel information in entorhinal cortex (EC) for episodic encoding, and (4) timing interactions between prefrontal cortex and hippocampus for memory-guided action selection. Modeling shows how these functional mechanisms are related to physiological data from the hippocampal formation, including (1) the phase relationships of synaptic currents during theta rhythm measured by current source density analysis of electroencephalographic data from region CA1 and dentate gyrus, (2) the timing of action potentials, including the theta phase precession of single place cells during running on a linear track, the context-dependent changes in theta phase precession across trials on each day, and the context-dependent firing properties of hippocampal neurons in spatial alternation (e.g., "splitter cells"), (3) the cholinergic regulation of sustained activity in entorhinal cortical neurons, and (4) the phasic timing of prefrontal cortical neurons relative to hippocampal theta rhythm.
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The theta rhythm is thought to be important for organizing disparate memory tasks.
“The theta rhythm is thought to be important for organizing disparate memory tasks (Lisman and Idiart, 1995; Hasselmo et al., 2002; Hasselmo, 2005; Lisman and Jensen, 2013; Siegle and Wilson, 2014)”
From Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit (2016) · cites this paper as Hasselmo, 2005
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- Authors
- Hasselmo, M. E.
- Affiliations
- Boston University (US)
- Corresponding author
- Hasselmo, Michael E.
- ORCID
- Hasselmo, Michael E.
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2005-01
- Volume
- 15
- Issue
- 7
- Pages
- 936-949
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- OpenAlex
- W2163909553
- Cited by
- 502
- References
- 129
- Citations by year
- 2026: 19 · 2025: 31 · 2024: 22 · 2023: 27 · 2022: 32 · 2021: 24 · 2020: 22 · 2019: 24 · 2018: 25 · 2017: 27 · 2016: 29 · 2015: 27 · 2014: 26 · 2013: 25 · 2012: 26
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (P50MH060450, MH 60013, MH-60450, MH61492, R01MH061492)
- National Institute on Drug Abuse (DA 16454, R01DA016454)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampal theta rhythm, theta phase precession, place cells, spatial alternation, entorhinal cortex, cholinergic modulation, prefrontal cortex, current source density, CA1, dentate gyrus
- MeSH terms
- Action Potentials, Animals, Hippocampus, Humans, Neural Pathways, Synaptic Transmission, Neurons, Theta Rhythm, Neural Networks, Computer
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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