Cited by 177Antioxidant Activity and Oxidative StressCancer and biochemical researchRedox biology and oxidative stress

Oxidative and antioxidative mechanisms in oral cancer and precancer: A review

Choudhari, Sheetal Korde, Chaudhary, Minal, Gadbail, Amol R., Sharma, Aparna, Tekade, Satyajit·2014·Oral Oncology

Abstract

Development of cancer in humans is a multistep process. Complex series of cellular and molecular changes participating in cancer development are mediated by a diversity of endogenous and exogenous stimuli and important amongst this is generation of reactive oxygen species (ROS). Reactive radicals and non-radicals are collectively known as ROS. These can produce oxidative damage to the tissues and hence are known as oxidants in biological system. Many researchers have documented the role of ROS in both initiation and promotion of multistep carcinogenesis. To mitigate the harmful effects of free radicals, all aerobic cells are endowed with extensive antioxidant defence mechanisms. Lowered antioxidant capacity or the oxidant-antioxidant imbalance can lead to oxidative damage to cellular macromolecules leading to cancer. Oral cavity cancer is an important cancer globally and tobacco is the primary etiological factor in its development. Tobacco consumption exposes the oral epithelium to toxic oxygen and nitrogen free radicals that can affect host antioxidant defence mechanisms. Elevated levels of ROS and Reactive Nitrogen Species (RNS) and lowered antioxidants are found in oral precancer and cancer. Protection can be provided by various antioxidants against deleterious action of these free radicals. Treatment with antioxidants has the potential to prevent, inhibit and reverse the multiple steps involved in oral carcinogenesis. This review is an attempt to understand the interesting correlation between ROS and RNS mediated cell damage and enzymatic and non-enzymatic defence mechanisms involved in oral cancer development and its progression and the use of antioxidants in oral cancer prevention and treatment.

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Crossref · 10.1016/j.oraloncology.2013.09.011

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  • The relationship between coffee consumption, antioxidant activity, and brewing methods is largely uncharacterized.

    “The role of antioxidant compounds as radical-scavengers in the body is well-researched24–26, but the relationship between coffee consumption, antioxidant activity, and brewing methods is largely uncharacterized.”

    From Acidity and Antioxidant Activity of Cold Brew Coffee (2018) · cites this paper as [25]

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Authors
Choudhari, S. K., Chaudhary, M., Gadbail, A. R., Sharma, A., & Tekade, S.
Corresponding author
Choudhari, Sheetal Korde
Venue
Oral Oncology
Publisher
Elsevier BV
Published
2014-01
Volume
50
Issue
1
Pages
10-18
ISSN
1368-8375 (ISSN-L)
OpenAlex
W1969775662
Cited by
177
References
133
Citations by year
2026: 4 · 2025: 12 · 2024: 15 · 2023: 16 · 2022: 20 · 2021: 16 · 2020: 18 · 2019: 12 · 2018: 20 · 2017: 7 · 2016: 14 · 2015: 14 · 2014: 9
FWCI
1.20
Type
journal article
Language
en
Open access
closed
Locations
  • Oral Oncology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
oral cancer, oral precancer, reactive oxygen species, reactive nitrogen species, oxidative stress, antioxidant defense, free radicals, oxidative DNA damage, tobacco, oral carcinogenesis, antioxidant therapy, oral cancer prevention
MeSH terms
Antioxidants, Humans, Mouth Neoplasms, Precancerous Conditions, Reactive Oxygen Species, Oxidative Stress, Carcinogenesis

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