The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Oxytocin induction of short-latency maternal behavior in nulliparous, estrogen-primed female rats
Abstract
This study was designed to test whether intracerebroventricular (icv) administration of oxytocin can shorten the latency of estrogen-treated virgin rats to respond to foster pups with maternal care. A secondary goal was a description of the behavioral effects of icv oxytocin in rats. Forty-eight hours before pup presentation female rats (Sprague-Dawley strain, obtained from Zivic-Miller Laboratories, Inc.) with chronic lateral ventricle cannulae were ovariectomized and treated with 100 micrograms/kg body wt estradiol benzoate (EB). Immediately before pup presentation either 400 ng oxytocin or the normal saline vehicle was infused. A second control group of noncannulated animals received the same surgery, EB treatment, and behavior tests without any icv infusion. Maternal behavior was scored on a scale from 0 to 5, one point each being given for licking pups, carrying pups, grouping pups, crouching over pups, and nest building. At the end of 1 hr of pup exposure 65% of the oxytocin-infused animals received scores of 4 or 5, while only 25% of the control animals attained these scores. Maternal behavior appeared as a unit in both spontaneously maternal and oxytocin-treated animals, with fewer than 10% in either group receiving scores of 1, 2, or 3. The oxytocin group also spent significantly more time grooming. In a second experiment in which oxytocin or normal saline was administered icv to oil-treated animals, this grooming effect was shown to be estrogen independent while the induction of maternal behavior required prior treatment with estrogen. Finally, a slight, transient hyperthermic effect of oxytocin on body temperature was observed in this test paradigm. These data suggest a role for oxytocin, acting with estrogen, in the onset of maternal behavior in rats.
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“The transition from juvenile to adult patterns of alloparental behavior in females does not appear to be related to changes in sex hormones [40].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [40]
In the citing paper
“However, as females reach puberty, only about 50% of the females will spontaneously retrieve, lick/groom, and hover over pups presented to them, with the remainder of the females either ignoring or attacking pups [38-40].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [40]
Citations
Cites
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Paraventricular Nucleus:A Site for the Integration of Neuroendocrine and Autonomic Mechanisms
Swanson, L. W., & Sawchenko, P. E. (2008) · Neuroendocrinology · doi:10.1159/000123111 · Cited by 1,001
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Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M. (1978) · Cell and Tissue Research · doi:10.1007/bf00212323 · Cited by 830
Oxytocin induces maternal behavior in virgin female rats
Pedersen, C. A., Ascher, J. A., Monroe, Y. L., & Prange, A. J. (1982) · Science · doi:10.1126/science.7071605 · Cited by 770
Nonhormonal basis of maternal behavior in the rat
Rosenblatt, J. S. (1967) · Science · doi:10.1126/science.156.3781.1512 · Cited by 721
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Oxytocin Receptors: Triggers for Parturition and Lactation?
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Insel, T. R. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.005 · Cited by 1,044
“Adult virgin females primed with estrogen and injected centrally with OT were reported to exhibit full maternal behavior, including nest building and crouching over pups in a nursing posture (Fahrbach et al., 1984; Pedersen et al., 1982; although also see Rubin et al., 1983).”
Beetz, A., Uvnäs-Moberg, K., Julius, H., & Kotrschal, K. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00234 · Cited by 904
“OT promotes maternal care behavior (Pedersen et al., 1982; Fahrbach et al., 1984) and bonding to the offspring (Kendrick et al.”
Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior
Ross, H. E., & Young, L. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.004 · Cited by 856
“It has been determined that along with OT, estrogen priming, as well as anosmia, will increase the probability of spontaneous maternal care in virgin rats [10,11].”
BackgroundOxytocin receptor distribution reflects social organization in monogamous and polygamous voles
Insel, T. R., & Shapiro, L. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5981 · Cited by 833
The neuroendocrine basis of social recognition
Ferguson, J. N., Young, L. J., & Insel, T. R. (2002) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2002.0229 · Cited by 494
Metadata
- Authors
- FAHRBACH, S.
- Affiliations
- Rockefeller University (US)
- Corresponding author
- FAHRBACH, S
- ORCID
- FAHRBACH, S
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 1984-09
- Volume
- 18
- Issue
- 3
- Pages
- 267-286
- ISSN
- 0018-506X (ISSN-L)
- OpenAlex
- W2018132730
- Cited by
- 187
- References
- 33
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 1 · 2020: 19 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 7 · 2012: 3
- FWCI
- 11.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Arizona
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- oxytocin, maternal behavior, estrogen, estradiol benzoate, nulliparous rats, intracerebroventricular administration, pup licking, grooming, body temperature, hyperthermia
- MeSH terms
- Animals, Brain, Estradiol, Female, Grooming, Injections, Intraventricular, Maternal Behavior, Motor Activity, Nesting Behavior, Oxytocin, Rats, Inbred Strains, Reaction Time, Rats
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