Cited by 187Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyStress Responses and Cortisol

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Oxytocin induction of short-latency maternal behavior in nulliparous, estrogen-primed female rats

FAHRBACH, S·1984·Hormones and Behavior

Open this paper in CoChat — free account

Abstract

This study was designed to test whether intracerebroventricular (icv) administration of oxytocin can shorten the latency of estrogen-treated virgin rats to respond to foster pups with maternal care. A secondary goal was a description of the behavioral effects of icv oxytocin in rats. Forty-eight hours before pup presentation female rats (Sprague-Dawley strain, obtained from Zivic-Miller Laboratories, Inc.) with chronic lateral ventricle cannulae were ovariectomized and treated with 100 micrograms/kg body wt estradiol benzoate (EB). Immediately before pup presentation either 400 ng oxytocin or the normal saline vehicle was infused. A second control group of noncannulated animals received the same surgery, EB treatment, and behavior tests without any icv infusion. Maternal behavior was scored on a scale from 0 to 5, one point each being given for licking pups, carrying pups, grouping pups, crouching over pups, and nest building. At the end of 1 hr of pup exposure 65% of the oxytocin-infused animals received scores of 4 or 5, while only 25% of the control animals attained these scores. Maternal behavior appeared as a unit in both spontaneously maternal and oxytocin-treated animals, with fewer than 10% in either group receiving scores of 1, 2, or 3. The oxytocin group also spent significantly more time grooming. In a second experiment in which oxytocin or normal saline was administered icv to oil-treated animals, this grooming effect was shown to be estrogen independent while the induction of maternal behavior required prior treatment with estrogen. Finally, a slight, transient hyperthermic effect of oxytocin on body temperature was observed in this test paradigm. These data suggest a role for oxytocin, acting with estrogen, in the onset of maternal behavior in rats.

Integrity signals

Registry

Crossref · 10.1016/0018-506x(84)90016-3

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Hypothalamic integration: organization of the paraventricular and supraoptic nuclei
Swanson, L. W., & Sawchenko, P. E. (1983) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.06.030183.001413 · Cited by 1,991
Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat
Sawchenko, P. E., & Swanson, L. W. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902050306 · Cited by 1,150
Paraventricular Nucleus:A Site for the Integration of Neuroendocrine and Autonomic Mechanisms
Swanson, L. W., & Sawchenko, P. E. (2008) · Neuroendocrinology · doi:10.1159/000123111 · Cited by 1,001
Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin
Pedersen, C. A., & Prange, A. J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.12.6661 · Cited by 841
Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M. (1978) · Cell and Tissue Research · doi:10.1007/bf00212323 · Cited by 830
Oxytocin induces maternal behavior in virgin female rats
Pedersen, C. A., Ascher, J. A., Monroe, Y. L., & Prange, A. J. (1982) · Science · doi:10.1126/science.7071605 · Cited by 770
Nonhormonal basis of maternal behavior in the rat
Rosenblatt, J. S. (1967) · Science · doi:10.1126/science.156.3781.1512 · Cited by 721
Immunohistochemical analysis of magnocellular elements in rat hypothalamus: Distribution and numbers of cells containing neurophysin, oxytocin, and vasopressin
Rhodes, C. H., Morriell, J. I., & Pfaff, D. W. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.901980106 · Cited by 536
Oxytocin Receptors: Triggers for Parturition and Lactation?
Soloff, M. S., Alexandrová, M., & Fernström, M. J. (1979) · Science · doi:10.1126/science.221972 · Cited by 394
Projections from vasopressin, oxytocin, and neurophysin neurons to neural targets in the rat and human
Sofroniew, M. V. (1980) · Journal of Histochemistry & Cytochemistry · doi:10.1177/28.5.7381192 · Cited by 317

Show all 33 references

Sorted by citations

The Challenge of Translation in Social Neuroscience: A Review of Oxytocin, Vasopressin, and Affiliative Behavior
Insel, T. R. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.005 · Cited by 1,044
“Adult virgin females primed with estrogen and injected centrally with OT were reported to exhibit full maternal behavior, including nest building and crouching over pups in a nursing posture (Fahrbach et al., 1984; Pedersen et al., 1982; although also see Rubin et al., 1983).”
Psychosocial and psychophysiological effects of human-animal interactions: the possible role of oxytocin
Beetz, A., Uvnäs-Moberg, K., Julius, H., & Kotrschal, K. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00234 · Cited by 904
“OT promotes maternal care behavior (Pedersen et al., 1982; Fahrbach et al., 1984) and bonding to the offspring (Kendrick et al.”
Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior
Ross, H. E., & Young, L. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.004 · Cited by 856
“It has been determined that along with OT, estrogen priming, as well as anosmia, will increase the probability of spontaneous maternal care in virgin rats [10,11].”
Background
Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles
Insel, T. R., & Shapiro, L. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5981 · Cited by 833
The neuroendocrine basis of social recognition
Ferguson, J. N., Young, L. J., & Insel, T. R. (2002) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2002.0229 · Cited by 494
Oxytocin — A neuropeptide for affiliation: Evidence from behavioral, receptor autoradiographic, and comparative studies
Insel, T. R. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90073-g · Cited by 487
Oxytocin activates the postpartum onset of rat maternal behavior in the ventral tegmental and medial preoptic areas.
Pedersen, C. A., Caldwell, J. D., Walker, C., Ayers, G., & Mason, G. A. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.6.1163 · Cited by 475
CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior
Bale, T. L., Davis, A. M., Auger, A. P., Dorsa, D. M., & McCarthy, M. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-07-02546.2001 · Cited by 446
“Oxytocin has been reported to have anxiolytic (McC arthy et al., 1996) and antidepressant (Arletti and Bertolini, 1987) actions, as well as facilitating pair-bonding (Williams et al., 1994; Insel and Hulihan, 1995) and mother‐infant interactions (Pedersen and Prange, 1979; Fahrbach et al., 1984 ).”
Background
Lust, attraction, and attachment in mammalian reproduction
Fisher, H. E. (1998) · Human Nature · doi:10.1007/s12110-998-1010-5 · Cited by 429
“Several studies report that oxytocin administered centrally to virgin female rats induces maternal behaviors within minutes ( Fahrbach et al. 1984a, 1984b, 1985; Pedersen and Prange 1979; Pedersen et al. 1982; Wamboldt and Insel 1987), but the response is dependent on priming with gonadal steroids (Leckman and Mayes,…”
Background
The neurobiology of pair bonding: Insights from a socially monogamous rodent
Young, K. A., Gobrogge, K. L., Liu, Y., & Wang, Z. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.07.006 · Cited by 389
“Further, some neuropeptides, such as AVP and OT, may have gender specific roles in certain behaviors related to pair bonding: AVP regulates selective aggression [99,100,201] and paternal behavior [149,213] in males, while OT regulates maternal care in females [16,76,165,173,178].”
Central functions of oxytocin
Argiolas, A., & GESSA, G. L. (1991) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80002-8 · Cited by 366
Medial preoptic area interactions with dopamine neural systems in the control of the onset and maintenance of maternal behavior in rats
Numan, M., & Stolzenberg, D. S. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.10.002 · Cited by 361
Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat
Szyf, M., Weaver, I. C. G., Champagne, F. A., Diorio, J., & Meaney, M. J. (2005) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2005.10.002 · Cited by 348
The programming of individual differences in defensive responses and reproductive strategies in the rat through variations in maternal care
Cameron, N. M., Champagne, F. A., Parent, C., Fish, E. W., Ozaki-Kuroda, K., & Meaney, M. J. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.022 · Cited by 320
“ICV administration of oxytocin rapidly stimulates maternal behavior in virgin rats (Pedersen and Prange, 1979; Fahrbach et al., 1984) and the MPOA appears to be a critical site.”
Background
The social deficits of the oxytocin knockout mouse
Winslow, J. T., & Insel, T. R. (2002) · Neuropeptides · doi:10.1054/npep.2002.0909 · Cited by 307
Behavioral Consequences of Intracerebral Vasopressin and Oxytocin: Focus on Learning and Memory **This paper is dedicated to our friend and scientific teacher Prof. Dr Armin Ermisch (1935–1995).
Engelmann, M., Wotjak, C. T., Neumann, I. D., Ludwig, M., & Landgraf, R. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00059-3 · Cited by 269
The genetic basis of parental care evolution in monogamous mice
Bendesky, A., Kwon, Y.-M., Lassance, J.-M., Lewarch, C. L., Yao, S., Peterson, B. K., He, M. X., Dulac, C., & Hoekstra, H. E. (2017) · Nature · doi:10.1038/nature22074 · Cited by 268
Lesions of the hypothalamic paraventricular nucleus disrupt the initiation of maternal behavior
Insel, T. R., & Harbaugh, C. R. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90234-5 · Cited by 250
Hypothalamic Neural Circuits Regulating Maternal Responsiveness Toward Infants
Numan, M. (2006) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582306288790 · Cited by 258
Hormonal basis during pregnancy for the onset of maternal behavior in the rat
Rosenblatt, J. S. (1988) · Psychoneuroendocrinology · doi:10.1016/0306-4530(88)90005-4 · Cited by 227
“Oxytocin may play some role in maternal behavior only when a certain moderate level of stress produced by the new cage is involved, a suggestion made by Fahrbach et al. (1985b). Another study explored the role of oxytocin ICV in the onset of maternal behavior in a Sprague-Dawley strain from Zivic-Miller.”
Background
Neuronal–glial interactions and behaviour
Laming, P. R., Kimelberg, H. K., Robinson, S. R., Salm, A. K., Hawrylak, N., Müller, C. M., Roots, B. I., & Ng, K. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00080-9 · Cited by 220
Intracranial dialysis measurement of oxytoxin, monoamine and uric acid release from the olfactory bulb and substantia nigra of sheep during parturition, suckling, separation from lambs and eating
Kendrick, K. M., Keverne, E. B., Chapman, C., & Baldwin, B. A. (1988) · Brain Research · doi:10.1016/0006-8993(88)91455-2 · Cited by 175
Oxytocin Control of Maternal Behavior Regulation by Sex Steroids and Offspring Stimulia
PEDERSEN, C. A. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51916.x · Cited by 172
Ewe–lamb bonding behaviours at birth are affected by maternal undernutrition in pregnancy
Dwyer, C. M., Lawrence, A. B., Bishop, S. C., & Lewis, M. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2002743 · Cited by 171
“In both rats and sheep, maternal behaviour is then induced by the central release of oxytocin (Fahrbach et al. 1984; Keverne & Kendrick, 1992).”
Background
Microdialysis measurement of oxytocin, aspartate, γ-aminobutyric acid and glutamate release from the olfactory bulb of the sheep during vaginocervical stimulation
Kendrick, K. M., Keverne, E. B., Chapman, C., & Baldwin, B. A. (1988) · Brain Research · doi:10.1016/0006-8993(88)91447-3 · Cited by 168
Epigenetic Programming of Phenotypic Variations in Reproductive Strategies in the Rat Through Maternal Care
Cameron, N. M., Shahrokh, D. K., Corpo, A. D., Dhir, S. K., Szyf, M., Champagne, F. A., & Meaney, M. J. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01725.x · Cited by 171
Regional Changes in Brain Oxytocin Receptors Post‐Partum: Time‐Course and Relationship to Maternal Behaviour
Insel, T. R. (1990) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1990.tb00445.x · Cited by 164
“4. Competition studies of [1251]OTA binding (50 pM) with increasing concentrations of unlabelled OTA ( 5 to 500 pM) added to adjacent sections of the bed nucleus of the stria terminalis (BNST) in brains from post-partum Day 1 , pregnant and post-lactating females.”
Background
Toward understanding how early-life social experiences alter oxytocin- and vasopressin-regulated social behaviors
Veenema, A. H. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.002 · Cited by 172
“For example, OT promotes maternal care (Fahrbach et al., 1984), social recognition (Ferguson et al., 2001), and social trust (Kosfeld et al., 2005).”
Background
Oxytocin, amino acid and monoamine release in the region of the medial preoptic area and bed nucleus of the stria terminalis of the sheep during parturition and suckling
Kendrick, K. M., Keverne, E. B., Hinton, M. R., & Goode, J. A. (1992) · Brain Research · doi:10.1016/0006-8993(92)90631-i · Cited by 150
Developmental Timing of the Effects of Maternal Care on Gene Expression and Epigenetic Regulation of Hormone Receptor Levels in Female Rats
Peña, C. J., Neugut, Y. D., & Champagne, F. A. (2013) · Endocrinology · doi:10.1210/en.2013-1595 · Cited by 150
Oxytocin: a parenting hormone
Feldman, R., & Bakermans-Kranenburg, M. J. (2017) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2017.02.011 · Cited by 160
“After OT injection, however, virgin females display all essential aspects of maternal behavior, including nest building and assuming a nursing posture [35,36].”
Social status in pairs of male squirrel monkeys determines the behavioral response to central oxytocin administration
Winslow, J., & Insel, T. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-07-02032.1991 · Cited by 145
“At a behavioral level, OT’s effects on maternal and female sexual behavior require priming with gonadal steroids (Pedersen and Prange, 1979; Fahrbach et al., 1984; Caldwell et al., 1986; Gorzalka and Lester, 1987; Kendrick et al., 1987).”
Background
Oxytocin antiserum delays onset of ovarian steroid-induced maternal behavior
Pedersen, C. A., Caldwell, J. D., Johnson, M. F., Fort, S. A., & Prange, A. J. (1985) · Neuropeptides · doi:10.1016/0143-4179(85)90108-8 · Cited by 137
Neuromolecular basis of parental behavior in laboratory mice and rats: With special emphasis on technical issues of using mouse genetics
Kuroda, K. O., Tachikawa, K., Yoshida, S., Tsuneoka, Y., & Numan, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.02.008 · Cited by 139
“As a result, each pup remains in contact with other pups (Fahrbach et al., 1984).”
Background
The role of central oxytocin in obsessive compulsive disorder and related normal behavior
Leckman, J. F., Goodman, W. K., North, W. G., Chappell, P. B., Price, L. H., Pauls, D. L., Anderson, G. M., Riddle, M. A., McDougle, C. J., Barr, L. C., et al. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90021-3 · Cited by 133
Maternal Behavior: Sensory, Hormonal, and Neural Determinants
Stern, J. M. (1989) · Elsevier eBooks · doi:10.1016/b978-0-12-137952-0.50008-2 · Cited by 133
The olfactory bulb: A critical site of action for oxytocin in the induction of maternal behaviour in the rat
Yu, G.-Z., Kaba, H., Okutani, F., Takahashi, S., & Higuchi, T. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00600-1 · Cited by 129
Love is more than just a kiss: a neurobiological perspective on love and affection
de Boer, A., van Buel, E. M., & Ter Horst, G. J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.017 · Cited by 123
“The effects of oxytocin on attachment and sexual behavior are estrogen dependent (Keverne and Kendrick, 1994; Fahrbach et al., 1984) and gender specific.”
Effect of preoptic region implants of dilute estradiol on the maternal behavior of ovariectomized, nulliparous rats
Fahrbach, S. E., & Pfaff, D. W. (1986) · Hormones and Behavior · doi:10.1016/0018-506x(86)90043-7 · Cited by 124
Haloperidol-induced disruption of retrieval behavior and reversal with apomorphine in lactating rats
Giordano, A. L., Johnson, A. E., & Rosenblatt, J. S. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90288-f · Cited by 123
A relationship between oxytocin and anxiety of romantic attachment
Marazziti (2006) · Clinical Practice and Epidemiology in Mental Health · doi:10.1186/1745-0179-2-28 · Cited by 124
Genital, olfactory, and endocrine interactions in the development of maternal behaviour in the parturient ewe
Poindron, P. (1988) · Psychoneuroendocrinology · doi:10.1016/0306-4530(88)90009-1 · Cited by 121
The effects of paraventricular hypothalamic lesions on maternal behavior in rats
Numan, M., & Corodimas, K. P. (1985) · Physiology & Behavior · doi:10.1016/0031-9384(85)90318-x · Cited by 118
Oxytocin inhibits infanticide in female house mice (Mus domesticus)
McCarthy, M. J. (1990) · Hormones and Behavior · doi:10.1016/0018-506x(90)90015-p · Cited by 119
Effects of oxytocin microinjected into the central amygdaloid nucleus and bed nucleus of stria terminalis on maternal aggressive behavior in rats
Consiglio, A. R., Borsoi, A., Pereira, G. A. M., & Lucion, A. B. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.05.002 · Cited by 106
Oxytocin Activation of Maternal Behavior in the Rata
Pedersen, C. A., Caldwell, J. D., Peterson, G. W., Walker, C. H., & Mason, G. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34346.x · Cited by 106
Neural basis of maternal behavior in the rat
Numan, M. J. (1988) · Psychoneuroendocrinology · doi:10.1016/0306-4530(88)90006-6 · Cited by 104
“The evidence concerning oxytocin's facilitation of maternal behavior is the following: (1) Intraventricular injections of oxytocin facilitate maternal behavior in estrogen-primed virgin female rats (Pedersen & Prange, 1979; Pedersen et al. , 1982; Fahrbach et al., 1984; 1986b; Wamboldt & Insel, 1986).”
Background
Previous maternal experience potentiates the effect of parturition on oxytocin receptor mRNA expression in the paraventricular nucleus
Broad, K. D., Lévy, F., Evans, G., Kimura, T., Keverne, E. B., & Kendrick, K. M. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00782.x · Cited by 100
Effects of chronic and acute cocaine treatment on the onset of maternal behavior and aggression in Sprague-Dawley rats.
Johns, J. M., Noonan, L. R., Zimmerman, L. I., Li, L., & al, E. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.1.107 · Cited by 100
Oxytocin is associated with infant-care behavior and motivation in cooperatively breeding marmoset monkeys
Finkenwirth, C., Martins, E. G., Deschner, T., & Burkart, J. M. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.01.008 · Cited by 98
“…in motivational priming during mother-infant bonding in mammals (Carter, 1998; Maestripieri, 2001b) and it is positively involved in maternal behavior in rats (Fahrbach et al., 1984; Pedersen et al., 1994) and sheep (Kendrick et al., 1987), but such effects have not been studied in primates yet.”
Background
Oxytocin and Parental Behaviors
Yoshihara, C., Numan, M., & Kuroda, K. O. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_11 · Cited by 104
Flexibility and adaptation of the neural substrate that supports maternal behavior in mammals
Olazábal, D. E., Pereira, M., Agrati, D., Ferreira, A., Fleming, A. S., González-Mariscal, G., Lévy, F., Lucion, A. B., Morrell, J. I., Numan, M., et al. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.004 · Cited by 97
Peridural anesthesia disturbs maternal behavior in primiparous and multiparous parturient ewes
Krehbiel, D., Poindron, P., Lévy, F., & Prud'homme, M.-J. (1987) · Physiology & Behavior · doi:10.1016/0031-9384(87)90031-x · Cited by 96
Changes in Oxytocin Immunoreactivity and mRNA Expression in the Sheep Brain during Pregnancy, Parturition and Lactation and in Response to Oestrogen and Progesterone
Broad, K. D., Kendrick, K. M., SIRINATHSINGHJI, D. J. S., & Keverne, E. B. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00505.x · Cited by 90
Endocrine Responses in Cows Milked by Hand and Machine
Gorewit, R. C., Svennersten, K., Butler, W. R., & UVNÄS‐MOBERG, K. (1992) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(92)77780-7 · Cited by 90
Oxytocin receptors in the nucleus accumbens shell are involved in the consolidation of maternal memory in postpartum rats
D'Cunha, T. M., King, S. J., Fleming, A. S., & Lévy, F. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.09.007 · Cited by 81
“Studies have also found that intraventricular or site-specific administration of OT can induce maternal behavior in virigin female rats (Fahrbach et al., 1984; Yu et al., 1996).”
Background
The regulation of maternal behaviour in marmosets and tamarins
Pryce, C. R. (1993) · Behavioural Processes · doi:10.1016/0376-6357(93)90133-c · Cited by 82
Preoccupations and Behaviors Associated with Romantic and Parental Love: Perspectives on the Origin of Obsessive-Compulsive Disorder
Leckman, J. F., & Mayes, L. C. (1999) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/s1056-4993(18)30172-x · Cited by 79
Oxytocin Receptors and Maternal Behavior
Insel, T. R., & SHAPIRO, L. E. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34350.x · Cited by 79
Social bonding: regulation by neuropeptides
Lieberwirth, C., & Wang, Z. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00171 · Cited by 86
“Central OT administration reduces the latency of female rats to show maternal behavior when exposed to pups (Pedersen and Prange, 1979; Pedersen et al., 1982; Fahrbach et al., 1984) and increases maternal behavior in mice (McCarthy, 1990).”
Background
Central mechanisms underlying the neural and neuroendocrine determinants of maternal behaviour
Keverne, E. B. (1988) · Psychoneuroendocrinology · doi:10.1016/0306-4530(88)90010-8 · Cited by 78
Ovarian steroids and sexual interaction alter oxytocinergic content and distribution in the basal forebrain
Caldwell, J. D., Jirikowski, G. F., Greer, E. R., Stumpf, W. E., & Pedersen, C. A. (1988) · Brain Research · doi:10.1016/0006-8993(88)90882-7 · Cited by 76
Neuroendocrine control of maternal behavior in non-human and human mammals
Lévy, F. (2016) · Annales d Endocrinologie · doi:10.1016/j.ando.2016.04.002 · Cited by 77
Foster Mother–Infant Bonding: Associations Between Foster Mothers' Oxytocin Production, Electrophysiological Brain Activity, Feelings of Commitment, and Caregiving Quality
Bick, J. R., Dozier, M., Bernard, K., Grasso, D. J., & Simons, R. F. (2012) · Child Development · doi:10.1111/cdev.12008 · Cited by 76
Expression and Region-Specific Regulation of the Oxytocin Receptor Gene in Rat Brain
Breton, C., & Zingg, H. H. (1997) · Endocrinology · doi:10.1210/endo.138.5.5127 · Cited by 78
The importance of vaginal-cervical stimulation for maternal behaviour in the rat
Yeo, J. A. G., & Keverne, E. B. (1986) · Physiology & Behavior · doi:10.1016/0031-9384(86)90378-1 · Cited by 74
The Parental Brain
Numan, M. (2020) · doi:10.1093/oso/9780190848675.001.0001 · Cited by 106
A comparative systems model of the regulation of maternal motivation in mammals
Pryce, C. R. (1992) · Animal Behaviour · doi:10.1016/s0003-3472(05)80102-2 · Cited by 71
Parental Behavior in Rodents
Pereira, M., Smiley, K. O., & Lonstein, J. S. (2022) · Advances in neurobiology · doi:10.1007/978-3-030-97762-7_1 · Cited by 72
Oxytocin and vasopressin enhance responsiveness to infant stimuli in adult marmosets
Taylor, J. H., & French, J. A. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.10.002 · Cited by 68
“…rat, Francis et al., 2000; macaque, Maestripieri et al., 2009), and females that would not ordinarily engage in parental behavior can be induced to do so with exogenous OT infusions (rat, Fahrbach et al., 1984; sheep, Kendrick et al., 1987; mouse, McCarthy et al., 1986; rat, Pedersen et al., 1982).”
Background
Maternal Behavior among the Nonprimate Mammals
Rosenblatt, J. S., Mayer, A. D., & Siegel, H. I. (1985) · Springer eBooks · doi:10.1007/978-1-4684-4832-0_7 · Cited by 69
The Role of Oxytocin Release in the Mediobasal Hypothalamus of the Sheep in Relation to Female Sexual Receptivity
Kendrick, K. M., Fabre‐Nys, C., Blache, D., Goode, J. A., & Broad, K. D. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00359.x · Cited by 67
“central release of the peptide hormone oxytocin (OXY) has been implicated both in the control of maternal behaviour in rats (1, 2) and sheep (3) and sexual receptivity in rats (4-7) and prairie voles (8), although the proposed role for OXY in controlling sexual receptivity in these two latter species is opposite.”
Background
Maternal Behavior
Numan, M. J., FLEMING, A., & Lévy, F. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50040-3 · Cited by 63
The role of lactogenic hormones in maternal behavior in female rats
Bridges, R. S. (1994) · Acta Paediatrica · doi:10.1111/j.1651-2227.1994.tb13263.x · Cited by 62
Chapter 4 Oxytocin: who needs it?
Insel, T. R., Gingrich, B., & Young, L. J. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)33005-4 · Cited by 62
Effect of varying the duration of pre-test cage habituation on oxytocin induction of short-latency maternal behavior
Fahrbach, S. E., Morrell, J. I., & Pfaff, D. W. (1986) · Physiology & Behavior · doi:10.1016/0031-9384(86)90396-3 · Cited by 60
The habenular complex mediates hormonal stimulation of maternal behavior in rats.
Corodimas, K. P., Rosenblatt, J. S., & Morrell, J. I. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.5.853 · Cited by 59
Infanticide and parental behavior in wild female house mice: Effects of ovariectomy, adrenalectomy and administration of oxytocin and prostaglandin F2α
McCarthy, M. M., Bare, J. E., & Saal, F. S. V. (1986) · Physiology & Behavior · doi:10.1016/0031-9384(86)90066-1 · Cited by 58
Chronic intracerebroventricular morphine and lactation in rats: Dependence and tolerance in relation to oxytocin neurones
Rayner, V. C., Robinson, I. C., & Russell, J. A. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp016964 · Cited by 58
Dose-Dependent Effects of Multiple Acute Cocaine Injections on Maternal Behavior and Aggression in Sprague-Dawley Rats
Johns, J. M., Nelson, C. J., Meter, K. E., Lubin, D. A., Couch, C. D., Ayers, A., & Walker, C. H. (1998) · Developmental Neuroscience · doi:10.1159/000017353 · Cited by 57
“The distinction between the onset and maintenance periods of maternal behavior is particularly important because these two periods are apparently regulated by different underlying hormonal states (oxytocin is essential for the normal onset of maternal behavior but not essential for its maintenance once maternal behavi…”
Background
Role of oxytocin in the medial preoptic area (MPOA) in the modulation of paternal behavior in mandarin voles
Yuan, W., He, Z., Hou, W., Wang, L., Li, L., Zhang, J., Yang, Y., Jia, R., Qiao, H., & Tai, F. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.02.014 · Cited by 56
Chronic gestational cocaine treatment decreases oxytocin levels in the medial preoptic area, ventral tegmental area and hippocampus in Sprague-Dawley rats
Johns, J. M., Lubin, D. A., Walker, C. H., Meter, K. E., & Mason, G. (1997) · Neuropeptides · doi:10.1016/s0143-4179(97)90037-8 · Cited by 53
Hormonal influences on the duration of postpartum maternal responsiveness in the rat
Orpen, B. G., Furman, N., Wong, P. Y., & Fleming, A. S. (1987) · Physiology & Behavior · doi:10.1016/0031-9384(87)90052-7 · Cited by 53
The interplay of oxytocin and sex hormones
Quintana, D. S., Glaser, B. D., Kang, H., Kildal, E. S.-M., Audunsdottir, K., Sartorius, A. M., & Barth, C. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105765 · Cited by 54
“…via intracerebroventricular oxytocin administration that effects on the onset of parenting behaviors were demonstrated in virgin rodents, which was dependent on the presence of estrogens (Fahrbach et al., 1984; Pedersen et al., 1982; Pedersen and Prange, 1979) and the environment (McCarthy, 1995).”
Pain, Parental Involvement, and Oxytocin in the Neonatal Intensive Care Unit
Filippa, M., Poisbeau, P., Mairesse, J., Monaci, M. G., Baud, O., Hüppi, P. S., Grandjean, D., & Kuhn, P. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00715 · Cited by 56
Speculations Concerning the Physiological Significance of Central Oxytocin in Maternal Behavior
McCarthy, M. M., Kow, L., & Pfaff, D. W. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34347.x · Cited by 50
The Contribution of Oxytocin and Vasopressin to Mammalian Social Behavior: Potential Role in Autism Spectrum Disorder
Harony, H., & Wagner, S. (2010) · Neurosignals · doi:10.1159/000321035 · Cited by 62
“Indeed, following priming with estrogen, virgin female rats centrally infused with OT display full maternal behavior [”
Background
Innate and learned aspects of pheromone-mediated social behaviours
Beny, Y., & Kimchi, T. (2014) · Animal Behaviour · doi:10.1016/j.anbehav.2014.09.014 · Cited by 55
“It has been suggested that oxytocin release in the brain might be part of an array of neuroendocrine events, mediated by the pup's odours, that together determine the initial aversion to pups observed in nulliparous females (Fahrbach, Morrell, & Pfaff,1984).”
Background
Maternal care boosted by paternal imprinting in mammals
Creeth, H., McNamara, G. I., Tunster, S. J., Boqué-Sastre, R., Allen, B., Sumption, L. A., Eddy, J. B., Isles, A. R., & John, R. M. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2006599 · Cited by 52
Oxytocin—a social peptide? Deconstructing the evidence
Leng, G., Leng, R., & Ludwig, M. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0055 · Cited by 51
Role of oxytocin in parental behaviour
Olazábal, D. E. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12594 · Cited by 49
A Role for Nonapeptides and Dopamine in Nest‐Building Behaviour
Hall, Z. J., Healy, S. D., & Meddle, S. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12250 · Cited by 45
“oxytocin infusions induce maternal behaviour in rats and mice [23,24] and oxytocin signalling appears to be involved in nest-building behaviour in rodents [25,26].”
The Regulation of Oxytocin Receptor Binding in the Ventromedial Hypothalamic Nucleus by Gonadal Steroids
Johnson, A. E. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34367.x · Cited by 44
Oxytocin and mothering behavior in the rat
Pedersen, C. A., & Prange, A. J. (1985) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(85)90056-7 · Cited by 40
Oxytocin mediates the acquisition of filial, odor-guided huddling for maternally-associated odor in preweanling rats
Kojima, S., & Alberts, J. R. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.08.003 · Cited by 39
“, 2000; Popik and van Ree, 1998), pair bonding (Carter, 1998; Young and Wang, 2004), and maternal behavior (Fahrbach et al., 1984; Keverne and Kendrick, 1992; Pedersen, 1997; Pedersen and Boccia, 2003) in rodents and ungulates, as well as love (Bartels and Zeki, 2004), trust (Kosfeld et al.”
Background
Sex-specific activity and function of hypothalamic nonapeptide neurons during nest-building in zebra finches
Klatt, J. D., & Goodson, J. L. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.10.001 · Cited by 38
The ventromedial hypothalamic circuitry and male alloparental behaviour in a socially monogamous rodent species
Liu, Y., Donovan, M. L., Jia, X., & Wang, Z. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14550 · Cited by 38
Thermal control of mother-young contact in Norway rats: Factors mediating the chronic elevation of maternal temperature
Adels, L. E., & Leon, M. (1986) · Physiology & Behavior · doi:10.1016/0031-9384(86)90094-6 · Cited by 38
Modulating the Oxytocin System During the Perinatal Period: A New Strategy for Neuroprotection of the Immature Brain?
Zinni, M., Colella, M., Novais, A. R. B., Baud, O., & Mairesse, J. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00229 · Cited by 35
“Indeed, the authors demonstrated that intracerebral administration of OTX to virgin female rats reduced the latency to develop maternal care in response to exposure to forest pups (75, 76).”
Background
Alterations in supraoptic nucleus ultrastructure of maternally behaving virgin rats
Salm, A. K., Modney, B. K., & Hatton, G. I. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90209-2 · Cited by 34

Authors: FAHRBACH, S.
Affiliations: Rockefeller University (US)
Corresponding author: FAHRBACH, S
ORCID: FAHRBACH, S
Venue: Hormones and Behavior
Publisher: Elsevier BV
Published: 1984-09
Volume: 18
Issue: 3
Pages: 267-286
ISSN: 0018-506X (ISSN-L)
DOI: 10.1016/0018-506x(84)90016-3
OpenAlex: W2018132730
Cited by: 187
References: 33
Citations by year: 2026: 4 · 2025: 1 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 1 · 2020: 19 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 7 · 2012: 3
FWCI: 11.67
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Hormones and Behavior (publishedVersion)
PubMed (publishedVersion)
Funders: University of Arizona
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: oxytocin, maternal behavior, estrogen, estradiol benzoate, nulliparous rats, intracerebroventricular administration, pup licking, grooming, body temperature, hyperthermia
MeSH terms: Animals, Brain, Estradiol, Female, Grooming, Injections, Intraventricular, Maternal Behavior, Motor Activity, Nesting Behavior, Oxytocin, Rats, Inbred Strains, Reaction Time, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oxytocin induction of short-latency maternal behavior in nulliparous, estrogen-primed female rats

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks