The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Non-enzymatic template-directed synthesis on RNA random copolymers
Abstract
Poly(C, U) random copolymer templates direct the oligomerization of 2-MeImpG and 2-MeImpA, resulting in the production of a variety of oligo/(G,A)s. The efficiency of monomer incorporation into newly synthesized oligomers is greater for 2-MeImpG than for 2-MeImpA, and decreases for both monomers as the uracil content of the template increases. The relatively poor incorporation of adenine is partly due to an intrinsically less efficient incorporation reaction, and partly due to the masking of uracil sites by G X U non-complementary pairing. The efficiency of adenine incorporation can be improved by decreasing the concentration of 2-MeImpG and increasing the concentration of 2-MeImpA in the reaction mixture. The oligomeric product distribution can be characterized in detail using high-pressure liquid chromatography on an RPC-5 column. Oligomers are separated on the basis of chain length, base composition, and phospho-diester-linkage isomerism. The 3'----5' regiospecificity of monomer addition to template-bound oligomers is lower for 2-MeImpA than for 2-MeImpG. The presence of an adenine residue at the 2'(3') terminus of the acceptor strand lowers the regiospecificity of 2-MeImpA addition even further.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Non-enzymatic RNA polymerization allows synthesis of short RNA oligonucleotides under prebiotic conditions (Joyce et al., 1984; Adamala and Szostak, 2013b).”
From The Astrobiology Primer v2.0 (2016) · cites this paper as Joyce et al., 1984
In the citing paper
“The prebiotic replication of RNA could have occurred non-enzymatically inside protocells via chemically activated nucleotides (Joyce et al., 1984; Mansy et al., 2008; Adamala and Szostak, 2013b).”
From The Astrobiology Primer v2.0 (2016) · cites this paper as Joyce et al., 1984
Citations
Cites
Selforganization of matter and the evolution of biological macromolecules
Eigen, M. (1971) · Die Naturwissenschaften · doi:10.1007/bf00623322 · Cited by 3,788
Improved Estimation of Secondary Structure in Ribonucleic Acids
Tinoco, I., Borer, P. N., Dengler, B., Levine, M., Uhlenbeck, O. C., Crothers, D. M., & Gralla, J. D. (1973) · Nature New Biology · doi:10.1038/newbio246040a0 · Cited by 2,270
Structure of a B-DNA dodecamer
Dickerson, R. E., & Drew, H. R. (1981) · Journal of Molecular Biology · doi:10.1016/0022-2836(81)90357-0 · Cited by 893
Evidence for Extraterrestrial Amino-acids and Hydrocarbons in the Murchison Meteorite
Kvenvolden, K. A., Lawless, J. G., Pering, K. L., Peterson, E., Flores, J. J. A., Ponnamperuma, C., Kaplan, I. R., & MOORE, C. B. (1970) · Nature · doi:10.1038/228923a0 · Cited by 867
Pearson, R. L., Weiss, J. F., & Kelmers, A. D. (1971) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(71)90748-9 · Cited by 504
A Nonenzymatic RNA Polymerase Model
Inoue, T., & Orgel, L. E. (1983) · Science · doi:10.1126/science.6186026 · Cited by 273
Self-citationPrebiotic chemistry and nucleic acid replication
Orgel, L. E., & Lohrmann, R. (1974) · Accounts of Chemical Research · doi:10.1021/ar50083a002 · Cited by 247
Self-citationOligomerization of (guanosine 5′-phosphor)-2-methylimidazolide on poly(C)
Inoue, T., & Orgel, L. E. (1982) · Journal of Molecular Biology · doi:10.1016/0022-2836(82)90169-3 · Cited by 209
Self-citationThermodynamics and kinetics of the helix‐coil transition of oligomers containing GC base pairs
Pörschke, D., Uhlenbeck, O. C., & Martin, F. H. (1973) · Biopolymers · doi:10.1002/bip.1973.360120609 · Cited by 188
Non-enzymic template-directed synthesis on RNA random copolymers
Joyce, G. F., & Orgel, L. E. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90166-x · Cited by 176
Self-citation
Research works printed but not linked: 4
- Chu, 1984, Biochim. Biophys. Acta
- Grzeskowiak, 1984, J. Mol. Evol
- Lohrmann, 1979, Errata, Tetrahedron, 35, 566
- Sulston, 1968, 59, 726
Cited by
Sorted by citations
RNA evolution and the origins of life
Joyce, G. F. (1989) · Nature · doi:10.1038/338217a0 · Cited by 658
Self-citationOrgel, L. E. (1992) · Nature · doi:10.1038/358203a0 · Cited by 535
Self-citationNonenzymatic template-directed RNA synthesis inside model protocells
Adamala, K., & Szostak, J. W. (2013) · Science · doi:10.1126/science.1241888 · Cited by 367
Progress Toward Synthetic Cells
Blain, J. C., & Szostak, J. W. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-080411-124036 · Cited by 323
Poudyal, R. R., Guth-Metzler, R., Veenis, A. J., Frankel, E. A., Keating, C. D., & Bevilacqua, P. C. (2019) · Nature Communications · doi:10.1038/s41467-019-08353-4 · Cited by 300
In-ice evolution of RNA polymerase ribozyme activity
Attwater, J., Wochner, A., & Holliger, P. (2013) · Nature Chemistry · doi:10.1038/nchem.1781 · Cited by 279
RNA catalysis and the origins of life
Orgel, L. E. (1986) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(86)80149-7 · Cited by 251
Self-citationTemplate switching between PNA and RNA oligonucleotides
Böhler, C., Nielsen, P. E., & Orgel, L. E. (1995) · Nature · doi:10.1038/376578a0 · Cited by 255
Self-citationFerris, J. P. (2002) · Origins of life and evolution of the biosphere · doi:10.1023/a:1020543312109 · Cited by 183
Non-enzymic template-directed synthesis on RNA random copolymers
Joyce, G. F., & Orgel, L. E. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90166-x · Cited by 176
Self-citationPrywes, N., Blain, J. C., Del Frate, F., & Szostak, J. W. (2016) · eLife · doi:10.7554/elife.17756 · Cited by 141
The Road to Non‐Enzymatic Molecular Networks
Dadon, Z., Wagner, N., & Ashkenasy, G. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200702552 · Cited by 143
Nucleoside Phosphorylation by Phosphate Minerals
Costanzo, G., Saladino, R., Crestini, C., Ciciriello, F., & Mauro, E. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611346200 · Cited by 136
Domagal-Goldman, S. D., Wright, K. E., Domagal-Goldman, S. D., Wright, K. E., Adamala, K., Arina de la Rubia, L., Bond, J., Dartnell, L. R., Goldman, A. D., Lynch, K., et al. (2016) · Astrobiology · doi:10.1089/ast.2015.1460 · Cited by 136
“Non-enzymatic template-directed RNA synthesis ( Joyce et al., 1984).”
Formamide Chemistry and the Origin of Informational Polymers
Saladino, R., Crestini, C., Ciciriello, F., Costanzo, G., & Mauro, E. D. (2007) · Chemistry & Biodiversity · doi:10.1002/cbdv.200790059 · Cited by 134
Template-Directed Synthesis of Novel, Nucleic Acid-Like Structures
Schwartz, A. W., & Orgel, L. E. (1985) · Science · doi:10.1126/science.228.4699.585 · Cited by 129
Self-citationEutectic Phases in Ice Facilitate Nonenzymatic Nucleic Acid Synthesis
Kanavarioti, A., Monnard, P., & Deamer, D. W. (2001) · Astrobiology · doi:10.1089/15311070152757465 · Cited by 131
Trinks, H., Schröder, W., & Biebricher, C. K. (2005) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-005-5009-1 · Cited by 122
A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis
Doudna, J. A., Couture, S., & Szostak, J. W. (1991) · Science · doi:10.1126/science.1707185 · Cited by 117
Formamide as the main building block in the origin of nucleic acids
Costanzo, G., Saladino, R., Crestini, C., Ciciriello, F., & Mauro, E. D. (2007) · BMC Evolutionary Biology · doi:10.1186/1471-2148-7-s2-s1 · Cited by 111
Ertem, G., & Ferris, J. P. (1997) · Journal of the American Chemical Society · doi:10.1021/ja970422h · Cited by 104
A Highly Reactive Imidazolium-Bridged Dinucleotide Intermediate in Nonenzymatic RNA Primer Extension
Walton, T., & Szostak, J. W. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b07977 · Cited by 102
Catalysis and prebiotic RNA synthesis
Ferris, J. P. (1993) · Origins of Life and Evolution of Biospheres · doi:10.1007/bf01582081 · Cited by 97
Enantiomeric Cross-Inhibition in the Synthesis of Oligonucleotides on a Nonchiral Template
Schmidt, J. G., Nielsen, P. E., & Orgel, L. E. (1997) · Journal of the American Chemical Society · doi:10.1021/ja963563c · Cited by 94
Self-citationThe role of sugar-backbone heterogeneity and chimeras in the simultaneous emergence of RNA and DNA
Bhowmik, S., & Krishnamurthy, R. (2019) · Nature Chemistry · doi:10.1038/s41557-019-0322-x · Cited by 95
Template-directed synthesis on the pentanucleotide CpCpGpCpC
Inoue, T., Joyce, G. F., Grzeskowiak, K., Orgel, L. E., Brown, J. M., & Reese, C. B. (1984) · Journal of Molecular Biology · doi:10.1016/0022-2836(84)90244-4 · Cited by 80
Self-citationSequence- and regioselectivity in the montmorillonite-catalyzed synthesis of RNA
Miyakawa, S., & Ferris, J. P. (2003) · Journal of the American Chemical Society · doi:10.1021/ja034328e · Cited by 78
Glyoxylate as a Backbone Linkage for a Prebiotic Ancestor of RNA
Bean, H. D., Anet, F. A. L., Gould, I. R., & Hud, N. V. (2005) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-005-2082-4 · Cited by 79
In Search of an RNA Replicase Ribozyme
McGinness, K. E., & Joyce, G. F. (2003) · Chemistry & Biology · doi:10.1016/s1074-5521(03)00003-6 · Cited by 74
Self-citationMontmorillonite, Oligonucleotides, RNA and Origin of Life
Ertem, G. (2004) · Origins of Life and Evolution of Biospheres · doi:10.1023/b:orig.0000043130.49790.a7 · Cited by 76
Houlihan, G., Arangundy‐Franklin, S., & Holliger, P. (2017) · Accounts of Chemical Research · doi:10.1021/acs.accounts.7b00056 · Cited by 75
Copying of RNA Sequences without Pre‐Activation
Jauker, M., Griesser, H., & Richert, C. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201506592 · Cited by 72
Isolation of novel ribozymes that ligate AMP-activated RNA substrates
Hager, A. J., & Szostak, J. W. (1997) · Chemistry & Biology · doi:10.1016/s1074-5521(97)90246-5 · Cited by 71
The binding and reactions of nucleotides and polynucleotides on iron oxide hydroxide polymorphs
Holm, N. G., Ertem, G., & Ferris, J. P. (1993) · Origins of Life and Evolution of Biospheres · doi:10.1007/bf01581839 · Cited by 71
Phenomenon of life: Between equilibrium and non-linearity. Origin and principles of evolution
Галимов, Э. М. (2006) · Geochemistry International · doi:10.1134/s0016702906130015 · Cited by 65
polymerization on the Rocks: β-amino Acids and Arginine
Liu, R., & Orgel, L. E. (1998) · Origins of Life and Evolution of Biospheres · doi:10.1023/a:1006576213220 · Cited by 64
Self-citationThe effect of leaving groups on binding and reactivity in enzyme-free copying of DNA and RNA
Kervio, E., Sosson, M., & Richert, C. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw476 · Cited by 63
The virtual circular genome model for primordial RNA replication
Zhou, L., Ding, D., & Szostak, J. W. (2020) · RNA · doi:10.1261/rna.077693.120 · Cited by 61
Horowitz, E. D., Engelhart, A. E., Chen, M. C., Quarles, K. A., Smith, M. W., Lynn, D. G., & Hud, N. V. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914172107 · Cited by 62
Ia, K., Politis, P. K., Aerschot, A. A. V., Busson, R. H., Herdewijn, P. A., & Orgel, L. E. (1999) · Journal of the American Chemical Society · doi:10.1021/ja983958r · Cited by 63
Self-citationKawamura, K., & Ferris, J. P. (1999) · Origins of life and evolution of the biosphere · doi:10.1023/a:1006648524187 · Cited by 61
Sequence- and Regio-Selectivity in the Montmorillonite-Catalyzed Synthesis of RNA
Ertem, G., & Ferris, J. P. (2000) · Origins of Life and Evolution of Biospheres · doi:10.1023/a:1006767019897 · Cited by 63
Gröb, T., Seybert, G., Massa, W., Weller, F., Palaniswami, R., Greiner, A., & Dehnicke, K. (2000) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20001201)39:23 · Cited by 33
Self-citationThe Story of RNA Folding, as Told in EpochsPreprint
Herschlag, D., Bonilla, S. L., & Bisaria, N. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a032433 · Cited by 57
Ferris, J. P., & Ertem, G. (1992) · Origins of Life and Evolution of Biospheres · doi:10.1007/bf01809373 · Cited by 58
Ding, P. Z., Kawamura, K., & Ferris, J. P. (1996) · Origins of Life and Evolution of Biospheres · doi:10.1007/bf01809853 · Cited by 56
Template-directed oligonucleotide ligation on hydroxylapatite
Acevedo, O. L., & Orgel, L. E. (1986) · Nature · doi:10.1038/321790a0 · Cited by 55
Self-citationRNA-Catalyzed RNA Ligation on an External RNA Template
McGinness, K. E., & Joyce, G. F. (2002) · Chemistry & Biology · doi:10.1016/s1074-5521(02)00110-2 · Cited by 52
Self-citationIa, K., Bouvere, B. D., Aerschot, A. A. V., Herdewijn, P. A., & Orgel, L. E. (1999) · Journal of the American Chemical Society · doi:10.1021/ja990440u · Cited by 52
Self-citationSurprising fidelity of template-directed chemical ligation of oligonucleotides
James, K. D., & Ellington, A. D. (1997) · Chemistry & Biology · doi:10.1016/s1074-5521(97)90245-3 · Cited by 50
From Prelife to Life: How Chemical Kinetics Become Evolutionary Dynamics
Chen, I. A., & Nowak, M. A. (2012) · Accounts of Chemical Research · doi:10.1021/ar2002683 · Cited by 50
Nucleoside Phosphorylation: A Feasible Step in the Prebiotic Pathway to RNA
Reimann, R., & Zubay, G. (1999) · Origins of Life and Evolution of Biospheres · doi:10.1023/a:1006580009791 · Cited by 50
Nonenzymatic Oligomerization of RNA by TNA Templates
Heuberger, B. D., & Switzer, C. (2006) · Organic Letters · doi:10.1021/ol062368s · Cited by 50
Homochirality in Life: Two Equal Runners, One Tripped
Green, M. M., & Jain, V. (2009) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-009-9180-7 · Cited by 50
Mace, D. C., & Alberts, B. (1984) · Journal of Molecular Biology · doi:10.1016/0022-2836(84)90459-5 · Cited by 48
Polymerization of β-amino Acids in Aqueous Solution
Liu, R., & Orgel, L. E. (1998) · Origins of Life and Evolution of Biospheres · doi:10.1023/a:1006580918298 · Cited by 47
Self-citationA Highly Enantio-Selective Hexitol Nucleic Acid Template for Nonenzymatic Oligoguanylate Synthesis
Ia, K., Politis, P. K., Pitsch, S., Herdewijn, P. A., & Orgel, L. E. (1999) · Journal of the American Chemical Society · doi:10.1021/ja9836489 · Cited by 46
Self-citationHomochiral selection in the montmorillonite-catalyzed and uncatalyzed Prebiotic synthesis of RNA
Joshi, P. C., Ferris, J. P., & Pitsch, S. (2000) · Chemical Communications · doi:10.1039/b007444f · Cited by 45
DNA renaturation at the water-phenol interface
Goldar, A., & Sikorav, J. (2004) · The European Physical Journal E · doi:10.1140/epje/i2004-10011-7 · Cited by 45
Sismour, A. M., & Benner, S. A. (2005) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.5.11.1409 · Cited by 44
Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication
Jia, T. Z., Fahrenbach, A. C., Kamat, N. P., Adamala, K. P., & Szostak, J. W. (2016) · Nature Chemistry · doi:10.1038/nchem.2551 · Cited by 44
RetractedSimultaneous origin of homochirality, the genetic code and its directionality
Root-Bernstein, R. S. (2007) · BioEssays · doi:10.1002/bies.20602 · Cited by 42
Non-enzymatic transcription of an oligodeoxynucleotide 14 residues long
Acevedo, O. L., & Orgel, L. E. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90117-3 · Cited by 42
Self-citationInfluence of Surface Chemistry and Charge on Mineral–RNA Interactions
Swadling, J. B., Suter, J. L., Greenwell, H. C., & Coveney, P. V. (2013) · Langmuir · doi:10.1021/la303352g · Cited by 41
Chemical activity of simple basic peptides
Brack, A., & Barbier, B. (1990) · Origins of Life and Evolution of Biospheres · doi:10.1007/bf01808274 · Cited by 41
Template-directed synthesis on oligodeoxycytidylate and polydeoxycytidylate templates
Chen, C. B., Inoue, T., & Orgel, L. E. (1985) · Journal of Molecular Biology · doi:10.1016/0022-2836(85)90091-9 · Cited by 40
Self-citationTemplate-directed synthesis of oligonucleotides under eutectic conditions
Stribling, R., & Miller, S. L. (1991) · Journal of Molecular Evolution · doi:10.1007/bf02102186 · Cited by 38
Ia, K., Pitsch, S., & Orgel, L. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13448 · Cited by 39
Self-citationNon-enzymatic template-directed synthesis on RNA random copolymers
Joyce, G. F., & Orgel, L. E. (1988) · Journal of Molecular Biology · doi:10.1016/0022-2836(88)90297-5 · Cited by 36
Self-citationMonnard, P., & Ziock, H. J. (2008) · Chemistry & Biodiversity · doi:10.1002/cbdv.200890141 · Cited by 37
Oligomerization of α-Thioglutamic Acid
Maurel, M., & Orgel, L. E. (2000) · Origins of Life and Evolution of Biospheres · doi:10.1023/a:1006728514362 · Cited by 36
Self-citationDer Weg zu nichtenzymatischen molekularen Netzwerken
Dadon, Z., Wagner, N., & Ashkenasy, G. (2008) · Angewandte Chemie · doi:10.1002/ange.200702552 · Cited by 35
Nonrandomness in prebiotic peptide synthesis
Tyagi, S., & Ponnamperuma, C. (1990) · Journal of Molecular Evolution · doi:10.1007/bf02101111 · Cited by 35
Böhler, C., Hill, A. R., & Orgel, L. E. (1996) · Origins of Life and Evolution of Biospheres · doi:10.1007/bf01808155 · Cited by 35
Self-citationSynthetic Life with Alternative Nucleic Acids as Genetic Materials
Nie, P., Bai, Y., & Mei, H. (2020) · Molecules · doi:10.3390/molecules25153483 · Cited by 34
Duzdevich, D., Carr, C. E., Ding, D., Zhang, S. J., Walton, T., & Szostak, J. W. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab173 · Cited by 36
Synthesis and Nonenzymatic Template-Directed Polymerization of 2′-Amino-2′-deoxythreose Nucleotides
Blain, J. C., Ricardo, A., & Szostak, J. W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja411950n · Cited by 33
Template-directed polynucleotide synthesis on mineral surfaces
Schwartz, A. W., & Orgel, L. E. (1985) · Journal of Molecular Evolution · doi:10.1007/bf02102362 · Cited by 33
Self-citationMALDI analysis of oligonucleotides directly from montmorillonite
Zagorevskii, D. V., Aldersley, M. F., & Ferris, J. P. (2006) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2006.05.012 · Cited by 33
Ferris, J. P., Kamaluddin, K., & Ertem, G. (1990) · Origins of Life and Evolution of Biospheres · doi:10.1007/bf01808110 · Cited by 32
Darwinian chemistry: towards the synthesis of a simple cell
Loakes, D., & Holliger, P. (2009) · Molecular BioSystems · doi:10.1039/b904024b · Cited by 33
Studies in the Mineral and Salt-Catalyzed Formation of RNA Oligomers
Miyakawa, S., Joshi, P. C., Gaffey, M. J., González‐Toril, E., Hyland, C., Ross, T. L., Rybij, K., & Ferris, J. P. (2006) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-006-9009-6 · Cited by 33
Rojas Stütz, J. A., & Richert, C. (2001) · Journal of the American Chemical Society · doi:10.1021/ja011448i · Cited by 30
Adamala, K. P., Engelhart, A. E., & Szostak, J. W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja511564d · Cited by 30
Schwartz, A. W., Visscher, J., Bakker, C. G., & Niessen, J. (1987) · Origins of Life and Evolution of Biospheres · doi:10.1007/bf02386473 · Cited by 29
Acridine‐Labeled Primers as Tools for the Study of Nonenzymatic RNA Oligomerization
Kurz, M., Göbel, K., Hartel, C., & Göbel, M. (1998) · Helvetica Chimica Acta · doi:10.1002/hlca.19980810528 · Cited by 27
Polyphosphorylation and Non-Enzymatic Template-Directed Ligation of Oligonucleotides
Gao, K., & Orgel, L. E. (2000) · Origins of Life and Evolution of Biospheres · doi:10.1023/a:1006683507864 · Cited by 26
Self-citationTemplate-Directed Oligomerization Catalyzed by a Polynucleotide Analog
Visscher, J., Bakker, C. G., van der Woerd, R., & Schwartz, A. W. (1989) · Science · doi:10.1126/science.2540527 · Cited by 26
A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension
Giurgiu, C., Li, L., O’Flaherty, D. K., Tam, C. P., & Szostak, J. W. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b08784 · Cited by 25
Kaddour, H., Gerişlioğlu, S., Dalai, P., Miyoshi, T., Wesdemiotis, C., & Sahai, N. (2018) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.8b10288 · Cited by 24
Cyclization of nucleotide analogues as an obstacle to polymerization
Hill, A. R., Nord, L. D., Orgel, L. E., & Robins, R. K. (1988) · Journal of Molecular Evolution · doi:10.1007/bf02143509 · Cited by 24
Self-citationStribling, R., & Miller, S. L. (1991) · Journal of Molecular Evolution · doi:10.1007/bf02102185 · Cited by 24
Tran, Q. P., Yi, R., & Fahrenbach, A. C. (2023) · Chemical Science · doi:10.1039/d3sc03185c · Cited by 24
5-Propynyluracil·diaminopurine: an efficient base-pair for non-enzymatic transcription of DNA
Chaput, J. C., Sinha, S., & Switzer, C. (2002) · Chemical Communications · doi:10.1039/b204535d · Cited by 23
Chirality and the equation of “biological big bang”
Аветисов, В. А., & Gol'danskiĭ, V. I. (1993) · Physics Letters A · doi:10.1016/0375-9601(93)90230-w · Cited by 21
Ferris, J. P., & Eetem, G. (1993) · Origins of Life and Evolution of Biospheres · doi:10.1007/bf01581901 · Cited by 22
Catalysis in abiotic structured media: an approach to selective synthesis of biopolymers
Monnard, P.-A. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4342-2 · Cited by 20
The chemistry of materials for artificial Darwinian systems
Cairns-smith, A. G. (1988) · International Reviews in Physical Chemistry · doi:10.1080/01442358809353213 · Cited by 20
Kopieren von RNA‐Sequenzen ohne Voraktivierung
Jauker, M., Griesser, H., & Richert, C. (2015) · Angewandte Chemie · doi:10.1002/ange.201506592 · Cited by 19
The progene hypothesis: the nucleoprotein world and how life began
Altstein, A. D. (2015) · Biology Direct · doi:10.1186/s13062-015-0096-z · Cited by 20
Metadata
- Authors
- Joyce, G. F., Inoue, T., & Orgel, L. E.
- Affiliations
- Salk Institute for Biological Studies (US)
- ORCID
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 1984-06
- Volume
- 176
- Issue
- 2
- Pages
- 279-306
- ISSN
- 0022-2836 (ISSN-L)
- OpenAlex
- W3184228035
- Cited by
- 178
- References
- 34
- Citations by year
- 2026: 1 · 2025: 4 · 2023: 3 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 2 · 2017: 4 · 2016: 8 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 5
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular Biology (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Keywords
- oligonucleotide synthesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
