Chronic Stress Causes Amygdala Hyperexcitability in Rodents
Open accessAbstract
Background Chronic stress is a major health concern, often leading to depression, anxiety, or when severe enough, posttraumatic stress disorder. While many studies demonstrate that the amygdala is hyperresponsive in patients with these disorders, the cellular neurophysiological effects of chronic stress on the systems that underlie psychiatric disorders, such as the amygdala, are relatively unknown.Methods In this study, we examined the effects of chronic stress on the activity and excitability of amygdala neurons in vivo in rats. We used in vivo intracellular recordings from single neurons of the lateral amygdala (LAT) to measure neuronal properties and determine the cellular mechanism for the effects of chronic stress on LAT neurons.Results We found a mechanism for the effects of chronic stress on amygdala activity, specifically that chronic stress increased excitability of LAT pyramidal neurons recorded in vivo. This hyperexcitability was caused by a reduction of a regulatory influence during action potential firing, facilitating LAT neuronal activity. The effects of stress on excitability were occluded by agents that block calcium-activated potassium channels and reversed by pharmacological enhancement of calcium-activated potassium channels.Conclusions These data demonstrate a specific channelopathy that occurs in the amygdala after chronic stress. This enhanced excitability of amygdala neurons after chronic stress may explain the observed hyperresponsiveness of the amygdala in patients with posttraumatic stress disorder and may facilitate the emergence of depression or anxiety in other patients.
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The BLA is generally hyperactive following chronic stress.
“The stress-induced attenuation of BLA→DMS activity was surprising because the BLA is, generally, hyperactive following chronic stress54–61 (c.f.62).”
From A dual-pathway architecture for stress to disrupt agency and promote habit (2025) · cites this paper as [56]
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- Authors
- Rosenkranz, J. A., Venheim, E. R., & Padival, M.
- Affiliations
- Rosalind Franklin University of Medicine and Science (US)
- Corresponding author
- Rosenkranz, J. Amiel
- ORCID
- Rosenkranz, J. Amiel
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 67
- Issue
- 12
- Pages
- 1128-1136
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC2882519
- OpenAlex
- W2084070063
- Cited by
- 284
- References
- 71
- Citations by year
- 2026: 14 · 2025: 23 · 2024: 15 · 2023: 17 · 2022: 24 · 2021: 29 · 2020: 19 · 2019: 20 · 2018: 10 · 2017: 22 · 2016: 14 · 2015: 16 · 2014: 13 · 2013: 19 · 2012: 17
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Brain Research Foundation
- National Institutes of Health (MH084970)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- chronic stress, lateral amygdala, pyramidal neurons, neuronal excitability, calcium-activated potassium channels, channelopathies, post-traumatic stress disorder, depression, anxiety, action potential firing, single-unit recording
- MeSH terms
- Action Potentials, Adrenal Glands, Amygdala, Animals, Calcium Channel Agonists, Calcium Channel Blockers, Chronic Disease, Male, Neurons, Stilbenes, Stress, Psychological, Rats, Sprague-Dawley, Maze Learning, Potassium Channels, Calcium-Activated, Potassium Channel Blockers, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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