Cytokine signal transduction

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

Kawano, M., Hirano, T., Matsuda, T., Taga, T., Horii, Y., Iwato, K., Asaoku, H., Tang, B., Tanabe, O., Tanaka, H., et al. (1988) · Nature · doi:10.1038/332083a0 · Cited by 1,633

IL‐6 in inflammation, immunity, and disease

Tanaka, T., Narazaki, M., & Kishimoto, T. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016295 · Cited by 5,046

Identification and expression cloning of a leptin receptor, OB-R.

Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496

Abnormal splicing of the leptin receptor in diabetic mice

Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., & Friedman, J. M. (1996) · Nature · doi:10.1038/379632a0 · Cited by 2,327

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., More, K. J., Breitbart, R. E., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81294-5 · Cited by 2,214

STATs in oncogenesis

Bowman, T., Garcia, R., Turkson, J., & Jove, R. (2000) · Oncogene · doi:10.1038/sj.onc.1203527 · Cited by 1,743

Dimerization of cell surface receptors in signal transduction

Heldin, C.-H. (1995) · Cell · doi:10.1016/0092-8674(95)90404-2 · Cited by 1,634

Thematic review series: The Pathogenesis of Atherosclerosis. Effects of infection and inflammation on lipid and lipoprotein metabolism mechanisms and consequences to the host

Khovidhunkit, W., Kim, M.-S., Memon, R. A., Shigenaga, J. K., Moser, A. H., Feingold, K. R., & Grunfeld, C. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r300019-jlr200 · Cited by 1,481

Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action

TURNBULL, A. V., & RIVIER, C. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.1 · Cited by 1,297

The Leptin Receptor

Tartaglia, L. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6093 · Cited by 1,289

The role of STATs in transcriptional control and their impact on cellular function

Bromberg, J., & Darnell, J. E. (2000) · Oncogene · doi:10.1038/sj.onc.1203476 · Cited by 1,201

The Pathophysiologic Roles of Interleukin-6 in Human Disease

Papanicolaou, D. A., Wilder, R. L., Manolagas, S. C., & Chrousos, G. P. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-2-199801150-00009 · Cited by 1,146

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

Akira, S., Nishio, Y., Inoue, M., Wang, X.-J., We, S., Matsusaka, T., Yoshida, K., Sudo, T., Naruto, M., & Kishimoto, T. (1994) · Cell · doi:10.1016/0092-8674(94)90235-6 · Cited by 1,019

Leptin receptor missense mutation in the fatty Zucker rat

Phillips, M. S., Liu, Q., Hammond, H. A., Dugan, V., Hey, P. J., Caskey, C. T., & Hess, J. F. (1996) · Nature Genetics · doi:10.1038/ng0596-18 · Cited by 822

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.

Fei, H., Okano, H. J., Li, C., Lee, G.-H., Zhao, C., Darnell, R., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.7001 · Cited by 766

The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

Lin, J.-X., Migone, T.-S., Tseng, M., Friedmann, M., Weatherbee, J. A., Zhou, L., Yamauchi, A., Bloom, E. T., Mietz, J., John, S., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90141-8 · Cited by 752

Thrombopoietin: the primary regulator of platelet production [see comments]

Kaushansky, K. (1995) · Blood · doi:10.1182/blood.v86.2.419.bloodjournal862419 · Cited by 642

SOCS3 Mediates Feedback Inhibition of the Leptin Receptor via Tyr985

Bjørbæk, C., Lavery, H. J., Bates, S. H., Olson, R. K., Davis, S. M., Flier, J. S., & Myers, M. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007577200 · Cited by 537

Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity.

Seidel, H. M., Milocco, L. H., Lamb, P., Darnell, J. E., Stein, R. B., & Rosen, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.3041 · Cited by 415

Heregulin‐dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3.

Wallasch, C., Weiss, F. U., Niederfellner, G., Jallal, B., Issing, W., & Ullrich, A. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00101.x · Cited by 406

Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice

Saxena, N. K., Ikeda, K., Rockey, D. C., Friedman, S. L., & Anania, F. A. (2002) · Hepatology · doi:10.1053/jhep.2002.32029 · Cited by 382

Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells

Rahaman, S. O., Harbor, P. C., Chernova, O., Barnett, G. H., Vogelbaum, M. A., & Haque, S. J. (2002) · Oncogene · doi:10.1038/sj.onc.1206047 · Cited by 377

Role of cytokines in cardiovascular diseases: a focus on endothelial responses to inflammation

KOFLER, S., NICKEL, T., & WEIS, M. (2005) · Clinical Science · doi:10.1042/cs20040174 · Cited by 353

The Leptin Receptor Activates Janus Kinase 2 and Signals for Proliferation in a Factor-Dependent Cell Line

Ghilardi, N., & Skoda, R. C. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.4.9907 · Cited by 326

A primer on cytokines: sources, receptors, effects, and inducers

Curfs, J. H., Meis, J. F., & Hoogkamp-Korstanje, J. A. (1997) · Clinical Microbiology Reviews · doi:10.1128/cmr.10.4.742 · Cited by 317

Hematopoietic cytokine receptor signaling

Baker, S. J., Rane, S. G., & Reddy, E. P. (2007) · Oncogene · doi:10.1038/sj.onc.1210757 · Cited by 256

The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation

Yamamoto, T., Sekine, Y., Kashima, K., Kubota, A., Sato, N., Aoki, N., & Matsuda, T. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02291-x · Cited by 250

Components of a stat recognition code: Evidence for two layers of molecular selectivity

Schindler, U., Wu, P., Rothe, M., Brasseur, M., & McKnight, S. L. (1995) · Immunity · doi:10.1016/1074-7613(95)90013-6 · Cited by 246

15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia

Park, E. J., Park, S. Y., Joe, E.-H., & Jou, I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210819200 · Cited by 214

Tumor necrosis factor and interleukin 1 decrease RXRα, PPARα, PPARγ, LXRα, and the coactivators SRC-1, PGC-1α, and PGC-1β in liver cells

Kim, M. S., Sweeney, T. R., Shigenaga, J. K., Chui, L. G., Moser, A., Grunfeld, C., & Feingold, K. R. (2007) · Metabolism · doi:10.1016/j.metabol.2006.10.007 · Cited by 168

Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells

Linnekin, D., DeBerry, C. S., & Mou, S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.43.27450 · Cited by 161

Induction of Neurite Outgrowth by Interleukin-6 Is Accompanied by Activation of Stat3 Signaling Pathway in a Variant PC12 Cell (E2) Line

Wu, Y. Y., & Bradshaw, R. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.22.13023 · Cited by 100

Structural basis of STAT2 recognition by IRF9 reveals molecular insights into ISGF3 function

Rengachari, S., Groiss, S., Devos, J. M., Caron, E., Grandvaux, N., & Panne, D. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718426115 · Cited by 91

Regulated expression of gp130 and IL-6 receptor alpha chain in T cell maturation and activation.

Betz, U. (1998) · International Immunology · doi:10.1093/intimm/10.8.1175 · Cited by 70

Protein Kinase C-θ Promotes Th17 Differentiation via Upregulation of Stat3

Kwon, M.-J., Ma, J., Ding, Y., Wang, R., & Sun, Z. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102941 · Cited by 56

Design of Conditionally Active STATs: Insights into STAT Activation and Gene Regulatory Function

Milocco, L. H., Haslam, J. A., Rosen, J., & Seidel, H. M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2913 · Cited by 52

A new hepatocyte stimulating factor: cardiotrophin‐1 (CT‐1)

Peters, M., Roeb, E., Pennica, D., zum Büschenfelde, K.-H. M., & Rose-John, S. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00972-c · Cited by 39

Stress response to hepatectomy in patients with a healthy or a diseased liver

Lan, A. K., Luk, H., Goto, S., Chen, S. S., Eng, H., Chen, Y., de Villa, V. H., Wang, C. C., Cheng, Y., Chen, C., et al. (2003) · World Journal of Surgery · doi:10.1007/s00268-003-6955-2 · Cited by 29

Immunoexpression of interleukin-6 in drug-induced gingival overgrowth patients

Ganesh, P. (2016) · Contemporary Clinical Dentistry · doi:10.4103/0976-237x.183048 · Cited by 9