The Leptin Receptor Activates Janus Kinase 2 and Signals for Proliferation in a Factor-Dependent Cell Line

Ghilardi, Nico; Skoda, Radek C.

doi:10.1210/mend.11.4.9907

Cited by 326Regulation of Appetite and ObesityCytokine Signaling Pathways and InteractionsAdipokines, Inflammation, and Metabolic Diseases

The Leptin Receptor Activates Janus Kinase 2 and Signals for Proliferation in a Factor-Dependent Cell Line

Ghilardi, Nico, Skoda, Radek C.·1997·Molecular Endocrinology

DOI 10.1210/mend.11.4.9907

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Abstract

The antiobesity effects of leptin are mediated by the obese receptor (OB-R), a member of the cytokine receptor superfamily. Several isoforms of OB-R that differ in the length of the cytoplasmic domain have been described. An isoform with a long cytoplasmic domain of 302 amino acids, termed OB-Rb, contains the conserved box 1 and box 2 motifs and is likely to be responsible for leptin-induced signaling. A point mutation in the OB-R gene of diabetes (db) mice generates a new splice donor that interferes with the correct splicing of the OB-Rb mRNA and is predicted to cause absence of the OB-Rb protein in db/db mice. Here we examined the signaling potential of the long isoform, OB-Rb, and of a short isoform, OB-Ra, in BaF3 cells, a factor-dependent hematopoietic cell line. The long isoform was able to generate a proliferative signal and upon leptin binding, activated janus kinase 2 (Jak2). Consistently, antibodies directed against the extracellular domain of OB-R coprecipitated Jak2. The short isoform, OB-Ra, was inactive in both proliferation and Jak activation. These results provide further support for the long isoform, OB-Rb, being the principal mediator of the effects of leptin and help to explain why db/db mice are resistant to leptin, despite the presence of the short OB-R isoforms.

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Upon leptin binding to LepRb, Jak2 is activated and phosphorylates three tyrosine residues on LepRb (Tyr985, Tyr1077, Tyr1138), which recruit and activate downstream signaling proteins.
“Upon leptin binding to LepRb, the tyrosine kinase Janus kinase-2 (Jak2) is activated (69), resulting in the phosphorylation of three tyrosine residues on LepRb (Tyr985, Tyr1077, Tyr1138) that in turn recruit and activate a distinct set of downstream signaling proteins.”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [69]

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“Upon leptin binding to LepRb, the tyrosine kinase Janus kinase-2 (Jak2) is activated (69), resulting in the phosphorylation of three tyrosine residues on LepRb (Tyr985, Tyr1077, Tyr1138) that in turn recruit and activate a distinct set of downstream signaling proteins.”
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Authors: Ghilardi, N., & Skoda, R. C.
Affiliations: University of Basel (CH)
Corresponding author: Skoda, Radek C.
ORCID: Ghilardi, Nico
Skoda, Radek C.
Venue: Molecular Endocrinology
Publisher: The Endocrine Society
Published: 1997-04-01
Volume: 11
Issue: 4
Pages: 393-399
ISSN: 0888-8809 (ISSN-L)
1944-9917
DOI: 10.1210/mend.11.4.9907
OpenAlex: W2029999922
Cited by: 326
References: 43
Citations by year: 2026: 1 · 2025: 3 · 2024: 1 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 13 · 2015: 11 · 2014: 16 · 2013: 18 · 2012: 7
FWCI: 8.56
Type: journal article
Language: en
Open access: closed
Locations: Molecular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords: leptin, leptin receptor, Ob-Rb, Ob-Ra, JAK2, receptor isoforms, leptin signaling, cell proliferation, Ba/F3 cells, db/db mice, leptin resistance, cytokine receptor superfamily
MeSH terms: Amino Acid Sequence, Animals, Carrier Proteins, Cell Division, Enzyme Activation, Hematopoietic Stem Cells, Molecular Sequence Data, Precipitin Tests, Protein-Tyrosine Kinases, Proteins, Proto-Oncogene Proteins, Receptors, Cell Surface, Transfection, Signal Transduction, Sequence Homology, Amino Acid, Alternative Splicing, Receptors, Cytokine, Leptin, Mice, Janus Kinase 2, Receptors, Leptin

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The Leptin Receptor Activates Janus Kinase 2 and Signals for Proliferation in a Factor-Dependent Cell Line

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