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Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
Open accessAbstract
NF-kappa B, a heterodimeric transcription factor composed of p50 and p65 subunits, can be activated in many cell types and is thought to regulate a wide variety of genes involved in immune function and development. Mice lacking the p50 subunit of NF-kappa B show no developmental abnormalities, but exhibit multifocal defects in immune responses involving B lymphocytes and nonspecific responses to infection. B cells do not proliferate in response to bacterial lipopolysaccharide and are defective in basal and specific antibody production. Mice lacking p50 are unable effectively to clear L. monocytogenes and are more susceptible to infection with S. pneumoniae, but are more resistant to infection with murine encephalomyocarditis virus. These data support the role of NF-kappa B as a vital transcription factor for both specific and nonspecific immune responses, but do not indicate a developmental role for the factor.
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Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263
Cited by
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
Baldwin, A. S. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.649 · Cited by 4,979
Hayden, M. S., & Ghosh, S. (2004) · Genes & Development · doi:10.1101/gad.1228704 · Cited by 3,842
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047
Self-citationNF-κB at the crossroads of life and death
Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709
The two NF-κB activation pathways and their role in innate and adaptive immunity
Bonizzi, G., & Karin, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.03.008 · Cited by 2,535
Crosstalk in NF-κB Signaling Pathways
Oeckinghaus, A., Hayden, M. S., & Ghosh, S. (2011) · Nature Immunology · doi:10.1038/ni.2065 · Cited by 1,942
Tili, E., Michaille, J.-J., Cimino, A., Costinean, S., Dumitru, C. D., Adair, B., Fabbri, M., Alder, H., Liu, C. G., Calin, G. A., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5082 · Cited by 1,304
Hayden, M. S., West, A. P., & Ghosh, S. (2006) · Oncogene · doi:10.1038/sj.onc.1209943 · Cited by 1,178
Requirement for NF-κB in osteoclast and B-cell development
Franzoso, G., Carlson, L., Xing, L., Poljak, L., Shores, E. W., Brown, K. D., Leonardi, A., Tran, T., Boyce, B. F., & Siebenlist, U. (1997) · Genes & Development · doi:10.1101/gad.11.24.3482 · Cited by 996
Nuclear factor-?B: its role in health and disease
Kumar, A., Takada, Y., Boriek, A., & Aggarwal, B. (2004) · Journal of Molecular Medicine · doi:10.1007/s00109-004-0555-y · Cited by 933
McKay, L. I., & Cidlowski, J. A. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0375 · Cited by 805
The transcriptional control of hematopoiesis [see comments]
Shivdasani, R., & Orkin, S. (1996) · Blood · doi:10.1182/blood.v87.10.4025.bloodjournal87104025 · Cited by 560
Zonana, J., Elder, M. E., Schneider, L. C., Orlow, S. J., Moss, C., Golabi, M., Shapira, S. K., Farndon, P. A., Wara, D. W., Emmal, S. A., et al. (2000) · The American Journal of Human Genetics · doi:10.1086/316914 · Cited by 521
Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins
Perona, R., Montaner, S., Saniger, L., Sánchez-Pérez, I., Bravo, R., & Lacal, J. C. (1997) · Genes & Development · doi:10.1101/gad.11.4.463 · Cited by 519
Das, J., Chen, C.-H., Yang, L., Cohn, L., Ray, P., & Ray, A. (2001) · Nature Immunology · doi:10.1038/83158 · Cited by 518
Bouchon, A., Hernández-Munain, C., Cella, M., & Colonna, M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.8.1111 · Cited by 460
Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ
Yamamoto, M., Yamazaki, S., Uematsu, S., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Kuwata, H., Takeuchi, O., Takeshige, K., et al. (2004) · Nature · doi:10.1038/nature02738 · Cited by 460
Transcriptional control of granulocyte and monocyte development
Friedman, A. D. (2007) · Oncogene · doi:10.1038/sj.onc.1210764 · Cited by 427
NF-κB dysregulation in microRNA-146a–deficient mice drives the development of myeloid malignancies
Zhao, J. L., Rao, D. S., Boldin, M. P., Taganov, K. D., O'Connell, R. M., & Baltimore, D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105398108 · Cited by 386
Self-citationZhao, J. L., Ma, C., O’Connell, R. M., Mehta, A., DiLoreto, R., Heath, J. R., & Baltimore, D. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.01.007 · Cited by 327
Self-citationThymic regulatory T cells arise via two distinct developmental programs
Owen, D. L., Mahmud, S. A., Sjaastad, L. E., Williams, J. B., Spanier, J. A., Simeonov, D. R., Ruscher, R., Huang, W., Proekt, I., Miller, C. N., et al. (2019) · Nature Immunology · doi:10.1038/s41590-018-0289-6 · Cited by 225
The encephalomyocarditis virus
Carocci, M., & Bakkali-Kassimi, L. (2012) · Virulence · doi:10.4161/viru.20573 · Cited by 231
Defective B cell receptor‐mediated responses in mice lacking the Ets protein, Spi‐B
Su, G. H., Chen, H., Muthusamy, N., Garrett‐Sinha, L. A., Baunoch, D., Tenen, D. G., & Simon, M. C. (1997) · The EMBO Journal · doi:10.1093/emboj/16.23.7118 · Cited by 182
Crosstalk via the NF-κB signaling system
Basak, S., & Hoffmann, A. (2008) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2008.04.005 · Cited by 177
Distinct roles for the NF-κB1 (p50) and c-Rel transcription factors in inflammatory arthritis
Campbell, I. K., Gerondakis, S., O’Donnell, K., & Wicks, I. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8298 · Cited by 168
The pleiotropic effects of erythropoietin in infection and inflammation
Nairz, M., Sonnweber, T., Schroll, A., Theurl, I., & Weiss, G. (2012) · Microbes and Infection · doi:10.1016/j.micinf.2011.10.005 · Cited by 161
CD28: a signalling perspective
WARD, S. G. (1996) · Biochemical Journal · doi:10.1042/bj3180361 · Cited by 149
Androgens suppress osteoclast formation induced by RANKL and macrophage colony-stimulating factor.
Huber, D. M., Bendixen, A. C., Pathrose, P., Srivastava, S., Dienger, K. M., Shevde, N. K., & Pike, J. W. (2001) · Endocrinology · doi:10.1210/endo.142.9.8402 · Cited by 141
Sylla, B. S., Hung, S. C., Davidson, D. M., Hatzivassiliou, E., Malinin, N. L., Wallach, D., Gilmore, T. D., Kieff, E., & Mosialos, G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.10106 · Cited by 137
Nuclear Factor-κB1 (p50) Limits the Inflammatory and Fibrogenic Responses to Chronic Injury
Oakley, F., Mann, J., Nailard, S., Smart, D. E., Mungalsingh, N., Constandinou, C., Ali, S., Wilson, S. J., Millward-Sadler, H., Iredale, J. P., et al. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62291-2 · Cited by 123
CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling
Starokadomskyy, P., Gluck, N., Li, H., Chen, B., Wallis, M., Maine, G. N., Mao, X., Zaidi, I. W., Hein, M. Y., McDonald, F. J., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66466 · Cited by 115
Loss of Nfkb1 leads to early onset aging
Bernal, G. M., Wahlstrom, J. S., Crawley, C. D., Cahill, K. E., Pytel, P., Liang, H., Kang, S., Weichselbaum, R. R., & Yamini, B. (2014) · Aging · doi:10.18632/aging.100702 · Cited by 97
Edenberg, H. J., Xuei, X., Wetherill, L. F., Bierut, L., Bucholz, K., Dick, D. M., Hesselbrock, V., Kuperman, S., Porjesz, B., Schuckit, M. A., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm368 · Cited by 89
Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice
Kishi, N., MacDonald, J. L., Ye, J., Molyneaux, B. J., Azim, E., & Macklis, J. D. (2016) · Nature Communications · doi:10.1038/ncomms10520 · Cited by 69
Nuclear Factor-κB p50 Limits Inflammation and Prevents Lung Injury during Escherichia coli Pneumonia
Mizgerd, J. P., Lupa, M. M., Kogan, M. S., Warren, H. B., Kobzik, L., & Topulos, G. P. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200303-412oc · Cited by 66
The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate
Tortola, L., Nitsch, R., Bertrand, M. J. M., Kogler, M., Redouane, Y., Kozieradzki, I., Uribesalgo, I., Fennell, L. M., Daugaard, M., Klug, H., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.04.032 · Cited by 64
Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis
Bianchi, A., Marchetti, L., Hall, Z., Lemos, H., Vacca, M., Paish, H., Green, K., Elliott, B., Tiniakos, D., Passos, J. F., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2001022 · Cited by 45
“mouse lacks the p50 subunit of NF-kB, which classically heterodimerizes with RelA to positively regulate inflammatory gene transcription (11).”
BackgroundPhospholipase Cγ2 Provides Survival Signals via Bcl2 and A1 in Different Subpopulations of B Cells
Wen, R., Chen, Y., Xue, L., Schuman, J., Yang, S., Morris, S. W., & Wang, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307318200 · Cited by 41
Wnt Signaling Regulates Macrophage Mediated Immune Response to Pathogens
Jati, S., & Sen, M. (2020) · Macrophage Activation - Biology and Disease · doi:10.5772/intechopen.86433 · Cited by 4
Metadata
- Authors
- Sha, W. C., Liou, H.-C., Tuomanen, E. I., & Baltimore, D.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1995-01
- Volume
- 80
- Issue
- 2
- Pages
- 321-330
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2035616122
- Cited by
- 1,157
- References
- 1
- FWCI
- 32.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
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