The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Fetal nutrition and cardiovascular disease in adult life
Open accessAbstract
Babies who are small at birth or during infancy have increased rates of cardiovascular disease and non-insulin-dependent diabetes as adults. Some of these babies have low birthweights, some are small in relation to the size of their placentas, some are thin at birth, and some are short at birth and fail to gain weight in infancy. This paper shows how fetal undernutrition at different stages of gestation can be linked to these patterns of early growth. The fetuses' adaptations to undernutrition are associated with changes in the concentrations of fetal and placental hormones. Persisting changes in the levels of hormone secretion, and in the sensitivity of tissues to them, may link fetal undernutrition with abnormal structure, function, and disease in adult life.
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“Barker’s foundational work identified associations between undernutrition during gestation, low birth weight and higher rates of ischemic heart and coronary artery disease mortality in adulthood in British children born in the 1920s [38,39,40,41].”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [41]
In the citing paper
“Thus, the DOHaD theory proposed that nutrient restriction during specific periods of development (e.g., conception, gestation and the first few years of life), when tissues and organs are particularly sensitive to environmental exposures, as a consequence influence the susceptibility for cardiovascular and metabolic diseases in adulthood [41,42,43].”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [41]
Citations
Cites
WEIGHT IN INFANCY AND DEATH FROM ISCHAEMIC HEART DISEASE
Barker, D. J. P., Osmond, C., Winter, P. D., Margetts, B., & Simmonds, S. J. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90710-1 · Cited by 3,574
Self-citationType 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis
Hales, C. N., & Barker, D. J. P. (1992) · Diabetologia · doi:10.1007/bf00400248 · Cited by 3,294
Self-citationFetal and infant growth and impaired glucose tolerance at age 64
Hales, C. N., Barker, D. J., Clark, P. M., Cox, L. J., Fall, C., Osmond, C., & Winter, P. D. (1991) · BMJ · doi:10.1136/bmj.303.6809.1019 · Cited by 2,708
Self-citationBarker, D. J. P., Hales, C. N., Fall, C. H. D., Osmond, C., Phipps, K., & Clark, P. M. S. (1993) · Diabetologia · doi:10.1007/bf00399095 · Cited by 2,468
Self-citationBarker, D. J., Osmond, C., Golding, J., Kuh, D., & Wadsworth, M. E. (1989) · BMJ · doi:10.1136/bmj.298.6673.564 · Cited by 2,415
Self-citationFetal and placental size and risk of hypertension in adult life.
Barker, D. J., Bull, A. R., Osmond, C., & Simmonds, S. J. (1990) · BMJ · doi:10.1136/bmj.301.6746.259 · Cited by 1,728
Self-citationPremature mortality due to cardiovascular disease in hypopituitarism
Rosén, T., & Bengtsson, B.-Å. (1990) · The Lancet · doi:10.1016/0140-6736(90)91812-o · Cited by 1,402
Cellular Response in Rats during Malnutrition at Various Ages
Winick, M., & Noble, A. (1966) · Journal of Nutrition · doi:10.1093/jn/89.3.300 · Cited by 959
Programming by Early Nutrition in Man
Lucas, A. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514047.ch4 · Cited by 911
Glucocorticoid exposure in utero: new model for adult hypertension
Benediktsson, R., Lindsay, R. S., Noble, J., Seckl, J. R., & Edwards, C. R. W. (1993) · The Lancet · doi:10.1016/0140-6736(93)90138-7 · Cited by 862
Research works printed but not linked: 1
- Mh Oliver, Je Harding, Bh Breier, Pc Evans, PD. Gluckman, Glucose but not amino acids regulates plasma insulin-like growth factor (IGF)-I concentrations in fetal sheep, Ped Res ((in press)).
Cited by
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Items 1,001–1,007 of 1,007
Diagnosis and Management of Intrauterine Growth Retardation
Lepercq, J. A., & Mahieu‐Caputo, D. (1998) · Hormone Research in Paediatrics · doi:10.1159/000053081 · Cited by 34
Gross placental measures and childhood growth
Baptiste-Roberts, K., Salafia, C. M., Nicholson, W. K., Duggan, A., Wang, N.-Y., & Brancati, F. L. (2009) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050802415728 · Cited by 30
Tchoukalova, Y. D., Krishnapuram, R., White, U. A., Burk, D., Fang, X., Nijland, M. J., & Nathanielsz, P. W. (2014) · International Journal of Obesity · doi:10.1038/ijo.2013.106 · Cited by 19
High cotinine levels are persistent during the first days of life in newborn second hand smokers
Ivorra, C., García-Vicent, C., Ponce, F., Ortega-Evangelio, G., Fernández-Formoso, J. A., & Lurbe, E. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2013.10.017 · Cited by 18
Guillemette, L., Hay, J. L., Kehler, D. S., Hamm, N. C., Oldfield, C., McGavock, J. M., & Duhamel, T. A. (2018) · Sports Medicine - Open · doi:10.1186/s40798-018-0148-x · Cited by 18
Adherence to Mediterranean Diet and Its Association with Maternal and Newborn Outcomes
Di Renzo, L., Marchetti, M., Rizzo, G., Gualtieri, P., Monsignore, D., Dominici, F., Mappa, I., Cavicchioni, O., Aguzzoli, L., De Lorenzo, A., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19148497 · Cited by 13
Forsum, E., Forsberg, A. M., Nilsson, E., Bergström, J., & Hultman, E. (2000) · Annals of Nutrition and Metabolism · doi:10.1159/000012837 · Cited by 9
Metadata
- Authors
- Barker, D. J. P., Godfrey, K. M., Gluckman, P. D., Harding, J. E., Owens, J. A., & Robinson, J. S.
- Affiliations
- Southampton General Hospital (GB)
- University of Auckland (NZ)
- The University of Adelaide (AU)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1993-04
- Volume
- 341
- Issue
- 8850
- Pages
- 938-941
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2096601431
- Cited by
- 2,753
- References
- 53
- Citations by year
- 2026: 39 · 2025: 47 · 2024: 68 · 2023: 81 · 2022: 108 · 2021: 103 · 2020: 113 · 2019: 98 · 2018: 142 · 2017: 121 · 2016: 111 · 2015: 115 · 2014: 126 · 2013: 100 · 2012: 107
- FWCI
- 14.76
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- fetal malnutrition, fetal programming, cardiovascular disease, type 2 diabetes, low birth weight, small for gestational age, placental hormones, fetal growth, developmental origins of health and disease, hormone sensitivity
- MeSH terms
- Adult, Birth Weight, Body Height, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Fetal Growth Retardation, Humans, Hydrocortisone, Infant Nutrition Disorders, Infant, Low Birth Weight, Infant, Newborn, Infant, Small for Gestational Age, Insulin, Insulin Resistance, Insulin-Like Growth Factor I, Male, Nutrition Disorders, Pregnancy, Pregnancy Complications, Risk Factors
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