Cited by 2,753Birth, Development, and HealthPregnancy and preeclampsia studiesPrenatal Substance Exposure Effects

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Fetal nutrition and cardiovascular disease in adult life

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Barker, D.J.P, Godfrey, K.M, Gluckman, P.D, Harding, J.E, Owens, J.A, Robinson, J.S·1993·The Lancet

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Abstract

Babies who are small at birth or during infancy have increased rates of cardiovascular disease and non-insulin-dependent diabetes as adults. Some of these babies have low birthweights, some are small in relation to the size of their placentas, some are thin at birth, and some are short at birth and fail to gain weight in infancy. This paper shows how fetal undernutrition at different stages of gestation can be linked to these patterns of early growth. The fetuses' adaptations to undernutrition are associated with changes in the concentrations of fetal and placental hormones. Persisting changes in the levels of hormone secretion, and in the sensitivity of tissues to them, may link fetal undernutrition with abnormal structure, function, and disease in adult life.

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Self-citation

Authors: Barker, D. J. P., Godfrey, K. M., Gluckman, P. D., Harding, J. E., Owens, J. A., & Robinson, J. S.
Affiliations: Southampton General Hospital (GB)
University of Auckland (NZ)
The University of Adelaide (AU)
ORCID: Godfrey, K.M
Gluckman, P.D
Harding, J.E
Owens, J.A
Robinson, J.S
Venue: The Lancet
Publisher: Elsevier BV
Published: 1993-04
Volume: 341
Issue: 8850
Pages: 938-941
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/0140-6736(93)91224-a
OpenAlex: W2096601431
Cited by: 2,753
References: 53
Citations by year: 2026: 39 · 2025: 47 · 2024: 68 · 2023: 81 · 2022: 108 · 2021: 103 · 2020: 113 · 2019: 98 · 2018: 142 · 2017: 121 · 2016: 111 · 2015: 115 · 2014: 126 · 2013: 100 · 2012: 107
FWCI: 14.76
Type: journal article
Language: en
Open access: green
figshare.com
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Figshare (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords: fetal malnutrition, fetal programming, cardiovascular disease, type 2 diabetes, low birth weight, small for gestational age, placental hormones, fetal growth, developmental origins of health and disease, hormone sensitivity
MeSH terms: Adult, Birth Weight, Body Height, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Fetal Growth Retardation, Humans, Hydrocortisone, Infant Nutrition Disorders, Infant, Low Birth Weight, Infant, Newborn, Infant, Small for Gestational Age, Insulin, Insulin Resistance, Insulin-Like Growth Factor I, Male, Nutrition Disorders, Pregnancy, Pregnancy Complications, Risk Factors

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Fetal nutrition and cardiovascular disease in adult life

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