Cited by 128Stress Responses and CortisolNeuroinflammation and Neurodegeneration MechanismsAdrenal Hormones and Disorders

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Adrenalectomy enhances pro-inflammatory cytokines gene expression, in the spleen, pituitary and brain of mice in response to lipopolysaccharide

Goujon, Emmanuelle, Parnet, Patricia, Layé, Sophie, Combe, Chantal, Dantzer, Robert·1996·Molecular Brain Research

DOI 10.1016/0169-328x(95)00242-k

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Abstract

To assess the possible influence of endogenous glucocorticoids on cytokine expression in the brain, adrenalectomized mice and sham operated mice were injected with saline or lipopolysaccharide (LPS, 10 micrograms/mouse, subcutaneously) and the levels of transcripts for IL-1 alpha, IL-1 beta, IL-1ra, IL-6 and tumor necrosis factor-alpha (TNF alpha) were determined 2 h after treatment in the spleen, pituitary, hypothalamus, hippocampus and striatum, using semi-quantitative reverse transcription polymerase chain reaction (RT-PCR). Levels of IL-1 beta were measured by ELISA in plasma and tissues of mice sacrificed after the administration of LPS or saline. LPS induced the expression of pro-inflammatory cytokines at the mRNA level in all tissues under investigation, except for TNF alpha in the hippocampus. This effect was potentiated by adrenalectomy in the spleen for IL-1 alpha and IL-1ra, the pituitary for cytokines other than IL-1ra, the hypothalamus for all cytokines, the hippocampus for cytokines other than TNF alpha, and the striatum for IL-1 alpha and IL-6. In saline-treated mice, adrenalectomy increased IL-1 alpha and IL-1 beta gene expression in the hypothalamus and IL-1 alpha gene expression in the hippocampus and striatum. LPS increased plasma and tissue levels of IL-1 beta, as determined by ELISA, and this effect was potentiated by adrenalectomy in plasma and tissues other than the spleen. These results can be interpreted to suggest that endogenous glucocorticoids regulate the neural components of the host response to infection and inflammation by inhibiting cytokine expression in peripheral organs and the brain.

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Authors: Goujon, E., Parnet, P., Layé, S., Combe, C., & Dantzer, R.
Affiliations: Inserm (FR)
Corresponding author: Dantzer, Robert
ORCID: Parnet, Patricia
Layé, Sophie
Dantzer, Robert
Venue: Molecular Brain Research
Publisher: Elsevier BV
Published: 1996-02
Volume: 36
Issue: 1
Pages: 53-62
ISSN: 0169-328X (ISSN-L)
DOI: 10.1016/0169-328x(95)00242-k
OpenAlex: W2010946024
Cited by: 128
References: 47
Citations by year: 2026: 1 · 2024: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 7 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 7
FWCI: 3.85
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular Brain Research (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: adrenalectomy, endogenous glucocorticoids, inflammatory cytokines, lipopolysaccharide, IL-1α, IL-1β, interleukin-1 receptor antagonist, interleukin-6, TNF-α, hypothalamus, hippocampus, striatum, pituitary gland, spleen, neuroimmune regulation, inflammation, infection
MeSH terms: Adrenal Glands, Adrenalectomy, Animals, Base Sequence, Brain, Corticosterone, Gene Expression Regulation, Inflammation, Interleukins, Lipopolysaccharides, Male, Mice, Inbred ICR, Molecular Sequence Data, Pituitary Gland, Spleen, Tumor Necrosis Factor-alpha, Cytokines, Mice

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Adrenalectomy enhances pro-inflammatory cytokines gene expression, in the spleen, pituitary and brain of mice in response to lipopolysaccharide

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