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Cited by 110Hypothalamic control of reproductive hormonesHormonal and reproductive studiesSexual Differentiation and Disorders

Developmental processes in early adolescence

Nottelmann, Editha D., Susman, Elizabeth J., Dorn, Lorah D., Inoff-Germain, Gale, Loriaux, D.Lynn, Cutler, Gordon B., Chrousos, George P.·1987·Journal of Adolescent Health Care
DOI 10.1016/0197-0070(87)90428-1
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Abstract

Cross-sectional data are presented on 108 young adolescents (56 boys, 52 girls), ages 9 to 14 years. The measures were: for all subjects, pubertal stage (Tanner criteria for genital/breast and pubic hair stage); height and weight; serum hormone concentrations for gonadotropins (luteinizing hormone and follicle-stimulating hormone), sex steroids (testosterone, estradiol, and the computed testosterone to estradiol ratio), adrenal androgens (dehydroepiandrosterone, dehydroepiandrosterone sulfate, and androstenedione), and testosterone-estradiol binding globulin. In addition, testicular volume for boys and menarchial status for girls are reported. The study goal was to provide interrelations among these measures, based on the same sample, and examine their interchangeability. Results suggest that it would be reasonable to compare research across as well as within studies based on different markers. Multiple regression analysis showed that the strongest hormone correlates of pubertal development were androgen levels (primarily testosterone in boys and primarily dehydroepiandrosterone sulphate and androstenedione in girls). Estradiol level in girls was the strongest correlate only for menarchial status. Level of testosterone-estradiol binding globulin, which was lower at successive pubertal stages for boys and showed no consistent differences for girls, may be a useful measure for studying the developmental processes and gender differences during puberty.

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Authors
Nottelmann, E. D., Susman, E. J., Dorn, L. D., Inoff-Germain, G., Loriaux, D. L., Cutler, G. B., & Chrousos, G. P.
Affiliations
National Institutes of Health (US)
Corresponding author
Nottelmann, Editha D.
ORCID
Venue
Journal of Adolescent Health Care
Publisher
Elsevier BV
Published
1987-05
Volume
8
Issue
3
Pages
246-260
ISSN
0197-0070 (ISSN-L)
DOI
10.1016/0197-0070(87)90428-1
OpenAlex
W2065563218
Cited by
110
References
47
Citations by year
2025: 2 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 13 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 6
FWCI
5.76
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Adolescent Health Care (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords
puberty, pubertal development, early adolescence, sex steroids, testosterone, estradiol, testosterone-estradiol-binding globulin, adrenal androgens, dehydroepiandrosterone sulfate, androstenedione, gonadotropins, luteinizing hormone, follicle-stimulating hormone, testicular volume, menarche, Tanner stages, gender differences
MeSH terms
Adolescent, Age Factors, Androgens, Body Height, Body Weight, Child, Female, Gonadotropins, Humans, Male, Puberty, Gonadal Steroid Hormones, Testis

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