Does amyloid precede paired helical filaments in the senile plaque? A study of 15 cases with graded intellectual status in aging and Alzheimer disease
Open accessAbstract
The density of senile plaques in 15 women over 75 years of age was higher when evaluated by thioflavine S than by immunocytochemistry with a polyclonal antibody against paired helical filaments. Mental status had been prospectively assessed in this cohort by the test score of Blessed et al. A difference between the two methods was found whatever the degree of mental impairment. Senile plaques were exceptionally immunolabeled in the least affected cases. This could not be explained only by differences in sensitivity of the stains and suggests that the amyloid is surrounded by anti-PHF positive neurites only in the latest stages of the senile plaque.
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NPs represent a nidus in which extracellular plaque substance(s) seem to induce intracellular degenerative changes with tau pathology.
“The particular toxic substance(s) within NPs still have not been completely characterized (90, 103, 278), but NPs represent a nidus in which extracellular plaque substance(s) seem to induce intracellular degenerative changes with tau pathology (18, 50, 279-281).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [280]
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- Authors
- Duyckaerts, C., Delaère, P., Poulain, V., Brion, J.-P., & Hauw, J.-J.
- Affiliations
- Pitié-Salpêtrière Hospital (FR)
- Hôpital Charles-Foix (FR)
- Erasmus Hospital (BE)
- Corresponding author
- Duyckaerts, C.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1988-09
- Volume
- 91
- Issue
- 3
- Pages
- 354-359
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1999185673
- Cited by
- 65
- References
- 25
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2012: 1
- FWCI
- 5.49
- Type
- journal article
- Language
- en
- Open access
- green
- dipot.ulb.ac.be
- Licence
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyloid plaques, amyloid, paired helical filaments, Alzheimer's disease, aging, intellectual status, neurites
- MeSH terms
- Aged, Aging, Alzheimer Disease, Amyloid, Brain, Female, Humans, Immunohistochemistry, Intermediate Filaments, Staining and Labeling, Thiazoles, Benzothiazoles
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