Cited by 177Pain Mechanisms and TreatmentsNeuroscience and Neuropharmacology ResearchNeuropeptides and Animal Physiology

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Subpopulations of gabaergic neurons in laminae i–iii of rat spinal dorsal horn defined by coexistence with classical transmitters, peptides, nitric oxide synthase or parvalbumin

Laing, I., Todd, A.J., Heizmann, C.W., Schmidt, H.H.H.W.·1994·Neuroscience

DOI 10.1016/0306-4522(94)90065-5

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Abstract

GABAergic neurons in laminae I-III of the spinal dorsal horn may contain one or more of the following compounds: glycine, acetylcholine, neuropeptide Y, enkephalin, nitric oxide synthase or parvalbumin. Although the pattern of co-localization of some of these compounds is understood, it is not known which types of GABAergic neurons contain parvalbumin, or whether nitric oxide synthase coexists with peptides, acetylcholine or parvalbumin in any of these neurons, and in this study we have used immunocytochemistry and enzyme histochemistry to resolve these issues. Parvalbumin-immunoreactivity was restricted to those GABA-immunoreactive neurons that also showed glycine-immunoreactivity and was not co-localized with neuropeptide Y-immunoreactivity or NADPH diaphorase activity. By combining NADPH diaphorase histochemistry with immunocytochemistry with an antiserum to nitric oxide synthase, we were able to show that NADPH diaphorase activity was a reliable marker for nitric oxide synthase in the spinal cord. Neurons that possess GABA- but not glycine-immunoreactivity may contain neuropeptide Y, enkephalin, acetylcholine or NADPH diaphorase, and all of the cholinergic neurons appear to contain NADPH diaphorase. By combining immunofluorescent detection of neuropeptide Y or enkephalin with NADPH diaphorase histochemistry, we showed that peptide-immunoreactivity did not coexist with NADPH diaphorase. This suggests that neither of these peptides coexists with nitric oxide synthase or wit…

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Authors: Laing, I., Todd, A. J., Heizmann, C. W., & Schmidt, H. H. H. W.
Affiliations: University of Glasgow (GB)
University of Zurich (CH)
Universitätsklinikum Würzburg (DE)
Corresponding author: Todd, A.J.
ORCID: Todd, A.J.
Schmidt, H.H.H.W.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 1994-07
Volume: 61
Issue: 1
Pages: 123-132
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/0306-4522(94)90065-5
OpenAlex: W2029706214
Cited by: 177
References: 55
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 9 · 2020: 8 · 2019: 4 · 2018: 5 · 2017: 9 · 2016: 3 · 2015: 5 · 2014: 4 · 2013: 10 · 2012: 1
FWCI: 4.76
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: GABAergic neurons, dorsal horn, parvalbumin, nitric oxide synthase, NADPH-diaphorase, neuropeptide Y, enkephalin, acetylcholine, glycine, neuropeptide co-localization, inhibitory interneurons, cholinergic neurons, rats
MeSH terms: Acetylcholine, Amino Acid Oxidoreductases, Animals, Enkephalins, Female, gamma-Aminobutyric Acid, Glycine, Immunohistochemistry, Male, NADPH Dehydrogenase, Neurons, Neuropeptide Y, Neuropeptides, Parvalbumins, Spinal Cord, Biomarkers, Rats, Sprague-Dawley, Neurotransmitter Agents, Nitric Oxide Synthase, Mice, Rats

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Subpopulations of gabaergic neurons in laminae i–iii of rat spinal dorsal horn defined by coexistence with classical transmitters, peptides, nitric oxide synthase or parvalbumin

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