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Song, W., Kwak, H.-B., & Lawler, J. M. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.517 · Cited by 155 · see citing works

Mitochondrial Involvement and Impact in Aging Skeletal Muscle

Hepple, R. T. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00211 · Cited by 155 · see citing works

The Role of Apoptosis in Age-Related Skeletal Muscle Atrophy

Dirks, A. J., & Leeuwenburgh, C. (2005) · Sports Medicine · doi:10.2165/00007256-200535060-00002 · Cited by 153 · see citing works

Sarcopenia and cachexia: the adaptations of negative regulators of skeletal muscle mass

Sakuma, K., & Yamaguchi, A. (2012) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-011-0052-4 · Cited by 137 · see citing works

Destabilization of the neuromuscular junction by proteolytic cleavage of agrin results in precocious sarcopenia

Bütikofer, L., Zurlinden, A., Bolliger, M. F., Kunz, B., & Sonderegger, P. (2011) · The FASEB Journal · doi:10.1096/fj.11-191262 · Cited by 138 · see citing works

Discovering pathways of sarcopenia in older adults: a role for insulin resistance on mitochondria dysfunction

Abbatecola, A. M., Paolisso, G., Fattoretti, P., Evans, W. J., Fiore, V., Dicioccio, L., & Lattanzio, F. (2011) · The Journal of nutrition, health and aging · doi:10.1007/s12603-011-0366-0 · Cited by 137 · see citing works

Oxidative Stress and Severe Walking Disability among Older Women

Semba, R. D., Ferrucci, L., Sun, K., Walston, J. D., Varadhan, R., Guralnik, J. M., & Fried, L. P. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2007.07.028 · Cited by 132 · see citing works

Resistance Training With Creatine Monohydrate Improves Upper-Body Strength in Patients With Parkinson Disease: A Randomized Trial

Hass, C. J., Collins, M. A., & Juncos, J. L. (2007) · Neurorehabilitation and neural repair · doi:10.1177/1545968306293449 · Cited by 130 · see citing works

Age-dependent changes in mitochondrial morphology and volume are not predictors of lifespan

Regmi, S. G., Rolland, S. G. M., & Conradt, B. (2014) · Aging · doi:10.18632/aging.100639 · Cited by 124 · see citing works

Mitochondrial DNA deletion mutations

McKenzie, D. I., Bua, E. A., McKiernan, S. H., Cao, Z., Wanagat, J., & Aiken, J. M. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02867.x · Cited by 124 · see citing works

Aging related changes in determinants of muscle force generating capacity: a comparison of muscle aging in men and male rodents.

Ballak, S., Degens, H., de Haan, A. D., & Jaspers, R. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.01.005 · Cited by 117 · see citing works

Disruption of mitochondrial dynamics affects behaviour and lifespan in Caenorhabditis elegans

Byrne, J. J., Soh, M. S., Chandhok, G., Vijayaraghavan, T., Teoh, J.-S., Crawford, S., Cobham, A. E., Yapa, N. M. B., Mirth, C. K., & Neumann, B. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03024-5 · Cited by 116 · see citing works

The role of PGC‐1 coactivators in aging skeletal muscle and heart

Dillon, L. M., Rebelo, A. P., & Moraes, C. T. (2012) · IUBMB Life · doi:10.1002/iub.608 · Cited by 116 · see citing works

PGC-1α is required for training-induced prevention of age-associated decline in mitochondrial enzymes in mouse skeletal muscle

Leick, L., Lyngby, S. S., Wojtaszewski, J. F. P., & Pilegaard, H. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.01.011 · Cited by 116 · see citing works

Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle

Marzetti, E., Lawler, J. M., Hiona, A., Manini, T., Seo, A. Y., & Leeuwenburgh, C. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.028 · Cited by 113 · see citing works

Sarcopenia in Nursing Home Residents

Bauer, J. M., Kaiser, M. J., & Sieber, C. C. (2008) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2008.04.010 · Cited by 112 · see citing works

The role of mitochondria in aging of skeletal muscle

Figueiredo, P. A., Mota, M. P., Appell, H. J., & Duarte, J. A. (2008) · Biogerontology · doi:10.1007/s10522-007-9121-7 · Cited by 109 · see citing works

Apoptosis and necrosis mediate skeletal muscle fiber loss in age-induced mitochondrial enzymatic abnormalities

Cheema, N., Herbst, A., McKenzie, D., & Aiken, J. M. (2015) · Aging Cell · doi:10.1111/acel.12399 · Cited by 107 · see citing works

Lack of age-related increase of mitochondrial DNA amount in brain, skeletal muscle and human heart

Frahm, T., Mohamed, S. A., Bruse, P., Gemünd, C., Oehmichen, M., & Meißner, C. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.06.008 · Cited by 100 · see citing works

Mitochondrial Impairment in Sarcopenia

Bellanti, F., Buglio, A. L., & Vendemiale, G. (2021) · Biology · doi:10.3390/biology10010031 · Cited by 99 · see citing works

Dietary restriction attenuates age‐associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD

Jang, Y. C., Liu, Y., Hayworth, C. R., Bhattacharya, A., Lustgarten, M. S., Müller, F. L., Chaudhuri, A. R., Qi, W., Li, Y., Huang, J., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00843.x · Cited by 94 · see citing works

OPA1 mutations cause cytochrome c oxidase deficiency due to loss of wild-type mtDNA molecules

Yu‐Wai‐Man, P., Sitarz, K. S., Samuels, D. C., Griffiths, P. G., Reeve, A. K., Bindoff, L. A., Horváth, R., & Chinnery, P. F. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq209 · Cited by 93 · see citing works

Mitochondrial Dysfunction as an Underlying Cause of Skeletal Muscle Disorders

Chen, T., Koh, K.-Y., Lin, K. M.-C., & Chou, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112926 · Cited by 93 · see citing works

The ageing mitochondrial genome

Krishnan, K. J., Greaves, L. C., Reeve, A. K., & Turnbull, D. M. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm635 · Cited by 89 · see citing works

No decline in skeletal muscle oxidative capacity with aging in long-term calorically restricted rats: Effects are independent of mitochondrial DNA integrity

Baker, D. J., Betik, A. C., Krause, D. J., & Hepple, R. T. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.7.675 · Cited by 89 · see citing works

Early‐onset calorie restriction conserves fiber number in aging rat skeletal muscle

McKiernan, S. H., Bua, E. A., McGorray, J., & Aiken, J. M. (2004) · The FASEB Journal · doi:10.1096/fj.03-0667fje · Cited by 89 · see citing works

Low serum carotenoids are associated with a decline in walking speed in older women

Alipanah, N., Varadhan, R., Sun, K., Ferrucci, L., Fried, L. P., & Semba, R. D. (2009) · The journal of nutrition health & aging · doi:10.1007/s12603-009-0053-6 · Cited by 87 · see citing works

The role of SIRT1 in skeletal muscle function and repair of older mice

Myers, M. J., Shepherd, D. L., Durr, A. J., Stanton, D. S., Mohamed, J. S., Hollander, J. M., & Alway, S. E. (2019) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12437 · Cited by 85 · see citing works

Opposite pathobiochemical fate of pyruvate kinase and adenylate kinase in aged rat skeletal muscle as revealed by proteomic DIGE analysis

Doran, P., O’Connell, K. M., Gannon, J. M., Kavanagh, M., & Ohlendieck, K. (2007) · PROTEOMICS · doi:10.1002/pmic.200700475 · Cited by 83 · see citing works

Mitochondrial DNA mutations as a fundamental mechanism in physiological declines associated with aging

Pak, J. W., Herbst, A. J., Bua, E. A., Gokey, N. G., McKenzie, D. I., & Aiken, J. M. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00034.x · Cited by 83 · see citing works

Age-Related Changes in Speed and Mechanism of Adult Skeletal Muscle Stem Cell Migration

Collins‐Hooper, H., Woolley, T. E., Dyson, L., Patel, A. P., Potter, P. K., Baker, R. E., Gaffney, E. A., Maini, P. K., Dash, P. R., & Patel, K. (2012) · Stem Cells · doi:10.1002/stem.1088 · Cited by 82 · see citing works

Proteomics of skeletal muscle aging

Doran, P., Donoghue, P. M., O’Connell, K. M., Gannon, J. M., & Ohlendieck, K. (2009) · PROTEOMICS · doi:10.1002/pmic.200800365 · Cited by 81 · see citing works

Sarcopenia Accelerates at Advanced Ages in Fisher 344xBrown Norway Rats

Lushaj, E. B., Johnson, J. K., McKenzie, D. I., & Aiken, J. M. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.9.921 · Cited by 81 · see citing works

Angiotensin-Converting Enzyme Inhibition Intervention in Elderly Persons: Effects on Body Composition and Physical Performance

Carter, C. S., Onder, G., Kritchevsky, S. B., & Pahor, M. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.11.1437 · Cited by 80 · see citing works

Lifelong exercise and mild (8%) caloric restriction attenuate age-induced alterations in plantaris muscle morphology, oxidative stress and IGF-1 in the Fischer-344 rat

Kim, J.-H., Kwak, H., Leeuwenburgh, C., & Lawler, J. M. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2007.12.012 · Cited by 79 · see citing works

Mitochondrial DNA Mutations and Aging

Krishnan, K. J., Greaves, L. C., Reeve, A. K., & Turnbull, D. M. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1395.024 · Cited by 79 · see citing works

Muscle contractile activity regulates Sirt3 protein expression in rat skeletal muscles

Hokari, F., Kawasaki, E., Sakai, A., Koshinaka, K., Sakuma, K., & Kawanaka, K. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00335.2009 · Cited by 76 · see citing works

Vitamin d status modulates mitochondrial oxidative capacities in skeletal muscle: role in sarcopenia

Salles, J., Chanet, A., Guillet, C., Vaes, A. M., Brouwer-Brolsma, E. M., Rocher, C., Giraudet, C., Patrac, V., Meugnier, E., Montaurier, C., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-04246-3 · Cited by 73 · see citing works

Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans

Gaffney, C. J., Pollard, A. K., Barratt, T. F., Constantin‐Teodosiu, D., Greenhaff, P. L., & Szewczyk, N. J. (2018) · Aging · doi:10.18632/aging.101654 · Cited by 72 · see citing works

Life-long calorie restriction in Fischer 344 rats attenuates age-related loss in skeletal muscle-specific force and reduces extracellular space

Payne, A. M., Dodd, S. L., & Leeuwenburgh, C. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00758.2003 · Cited by 71 · see citing works

Synergistic effects of caloric restriction with maintained protein intake on skeletal muscle performance in 21‐month‐old rats: a mitochondria‐mediated pathway

Zangarelli‌, A., Chanséaume, E., Morio, B., Malpuech‐Brugère, C., Mosoni, L., Rousset, P., Giraudet, C., Patrac, V., Gachon, P., Boirie‌, Y., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-4544com · Cited by 70 · see citing works

Exercise improves mitochondrial and redox-regulated stress responses in the elderly: better late than never!

Cobley, J. N., Moult, P. R., Burniston, J. G., Morton, J. P., & Close, G. L. (2014) · Biogerontology · doi:10.1007/s10522-014-9546-8 · Cited by 69 · see citing works

Exercise Training Modulates the Nitric Oxide Synthase Profile in Skeletal Muscle From Old Rats

Song, W. J., Kwak, H.-B., Kim, J.-H., & Lawler, J. M. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp021 · Cited by 70 · see citing works

Aging Thyroarytenoid and Limb Skeletal Muscle: Lessons in Contrast

Thomas, L. B., Harrison, A. L., & Stemple, J. C. (2007) · Journal of Voice · doi:10.1016/j.jvoice.2006.11.006 · Cited by 70 · see citing works

The impact of age-related dysregulation of the angiotensin system on mitochondrial redox balance

Vajapey, R. S., Rini, D. A., Walston, J. D., & Abadir, P. M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00439 · Cited by 69 · see citing works

Impact of aging on mitochondrial function in cardiac and skeletal muscle

Hepple, R. T. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.03.017 · Cited by 68 · see citing works

Latent mitochondrial DNA deletion mutations drive muscle fiber loss at old age

Herbst, A. J., Wanagat, J., Cheema, N., Widjaja, K., McKenzie, D. I., & Aiken, J. M. (2016) · Aging Cell · doi:10.1111/acel.12520 · Cited by 66 · see citing works

The Role of NF‐κB in Protein Breakdown in Immobilization, Aging, and Exercise: From Basic Processes to Promotion of Health

BAR‐SHAI, M., CARMELI, E., & REZNICK, A. Z. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1356.034 · Cited by 67 · see citing works

Pathophysiological mechanisms explaining poor clinical outcome of older cancer patients with low skeletal muscle mass

Looijaard, S. M. L. M., Hekkert, M. L. T. L., Wüst, R. C. I., Otten, R. H. J., Meskers, C. G. M., & Maier, A. B. (2020) · Acta Physiologica · doi:10.1111/apha.13516 · Cited by 65 · see citing works

Proteomic profiling reveals a severely perturbed protein expression pattern in aged skeletal muscle

O’Connell, K. M., Gannon, J. M., Doran, P., & Ohlendieck, K. (2007) · International Journal of Molecular Medicine · doi:10.3892/ijmm.20.2.145 · Cited by 65 · see citing works

Mitochondrial function in vivo: Spectroscopy provides window on cellular energetics

Amara, C. E., Marcinek, D. J., Shankland, E. G., Schenkman, K. A., Arakaki, L. S. L., & Conley, K. E. (2008) · Methods · doi:10.1016/j.ymeth.2008.10.001 · Cited by 65 · see citing works

Muscle mass loss in Rhesus monkeys: Age of onset

Colman, R. J., McKiernan, S. H., Aiken, J. M., & Weindruch, R. H. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.05.001 · Cited by 64 · see citing works

Exercise rescues mitochondrial coupling in aged skeletal muscle: a comparison of different modalities in preventing sarcopenia

Harper, C., Gopalan, V., & Goh, J. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02737-1 · Cited by 62 · see citing works

Myonectin protects against skeletal muscle dysfunction in male mice through activation of AMPK/PGC1α pathway

Ozaki, Y., Ohashi, K., Otaka, N., Kawanishi, H., Takikawa, T., Fang, L., Takahara, K., Tatsumi, M., Ishihama, S., Takefuji, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40435-2 · Cited by 63 · see citing works

Accumulation of severely atrophic myofibers marks the acceleration of sarcopenia in slow and fast twitch muscles

Rowan, S. L., Purves-Smith, F. M., Solbak, N. M., & Hepple, R. T. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.03.005 · Cited by 61 · see citing works

Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone

Fraysse, B., Desaphy, J., Rolland, J., Pierno, S., Liantonio, A., Giannuzzi, V., Camerino, C., Didonna, M. P., Cocchi, D., Luca, A. D., et al. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.07.012 · Cited by 60 · see citing works

Mitochondrial DNA shifting in older adults following resistance exercise trainingThis paper article is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.

Tarnopolsky, M. A. (2009) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h09-022 · Cited by 59 · see citing works

Mitochondrial DNA deletion mutations increase exponentially with age in human skeletal muscle

Herbst, A. J., Lee, C. C., Vandiver, A. R., Aiken, J. M., McKenzie, D. I., Hoang, A. N., Allison, D. B., Liu, N., & Wanagat, J. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-020-01698-7 · Cited by 61 · see citing works

Low serum carotenoids and development of severe walking disability among older women living in the community: the Women's Health and Aging Study I

Semba, R. D., Varadhan, R., Bartali, B., Ferrucci, L., Ricks, M. O., Blaum, C. S., & Fried, L. P. (2006) · Age and Ageing · doi:10.1093/ageing/afl122 · Cited by 59 · see citing works

Exercise-induced mitochondrial biogenesis in skeletal muscle

Hood, D. A., & Saleem, A. (2007) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.02.009 · Cited by 56 · see citing works

Calorie restriction limits the generation but not the progression of mitochondrial abnormalities in aging skeletal muscle

Bua, E. A., McKiernan, S. H., & Aiken, J. M. (2004) · The FASEB Journal · doi:10.1096/fj.03-0668fje · Cited by 57 · see citing works

Short-term caloric restriction, resveratrol, or combined treatment regimens initiated in late-life alter mitochondrial protein expression profiles in a fiber-type specific manner in aged animals

Joseph, A.-M., Malamo, A. G., Silvestre, J. G. O., Wawrzyniak, N., Carey‐Love, S., Nguyen, L. M. ‐., Dutta, D., Xu, J., Leeuwenburgh, C., & Adhihetty, P. J. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.05.061 · Cited by 55 · see citing works

Somatic Mitochondrial DNA Deletions Accumulate to High Levels in Aging Human Extraocular Muscles

Yu‐Wai‐Man, P., Lai‐Cheong, J. E., Borthwick, G. M., He, L., Taylor, G. A., Greaves, L. C., Taylor, R. W., Griffiths, P. G., & Turnbull, D. M. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4660 · Cited by 54 · see citing works

Vitamin D Ameliorates Fat Accumulation with AMPK/SIRT1 Activity in C2C12 Skeletal Muscle Cells

Chang, E., & Kim, Y. (2019) · Nutrients · doi:10.3390/nu11112806 · Cited by 54 · see citing works

Skeletal muscle fiber size and fiber type distribution in human cancer: Effects of weight loss and relationship to physical function

Toth, M. J., Callahan, D. M., Miller, M. S., Tourville, T. W., Hackett, S. B., Couch, M. E., & Dittus, K. L. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.02.016 · Cited by 53 · see citing works

Sarcopenia--A Critical Perspective

Hepple, R. T. (2003) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2003.46.pe31 · Cited by 52 · see citing works

The relationships between sarcopenic skeletal muscle loss during ageing and macronutrient metabolism, obesity and onset of diabetes

Welch, A. A., Hayhoe, R. P. G., & Cameron, D. (2019) · Proceedings of The Nutrition Society · doi:10.1017/s0029665119001150 · Cited by 52 · see citing works

Contractile dysfunction and altered metabolic profile of the aging rat thyroarytenoid muscle

McMullen, C. A., & Andrade, F. H. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01066.2005 · Cited by 50 · see citing works

Fiber Atrophy and Hypertrophy in Skeletal Muscles of Late Middle-Aged Fischer 344 x Brown Norway F1-Hybrid Rats

Hepple, R. T., Ross, K. D., & Rempfer, A. B. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.2.b108 · Cited by 50 · see citing works

Chronic disuse and skeletal muscle structure in older adults: sex-specific differences and relationships to contractile function

Callahan, D. M., Tourville, T. W., Miller, M. S., Hackett, S. B., Sharma, H., Cruickshank, N. C., Slauterbeck, J. R., Savage, P. D., Ades, P. A., Maughan, D. W., et al. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00014.2015 · Cited by 49 · see citing works

Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy

Lee, C. M., Lopez, M. E., Weindruch, R. H., & Aiken, J. M. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00185-3 · Cited by 121 · see citing works

Mitochondrial DNA deletion mutations and sarcopenia

AIKEN, J., BUA, E., CAO, Z., LOPEZ, M., WANAGAT, J., McKENZIE, D., & McKIERNAN, S. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02111.x · Cited by 85 · see citing works

Cellular phenotypes of age-associated skeletal muscle mitochondrial abnormalities in rhesus monkeys

Lopez, M. E., Zeeland, N. L. V., Dahl, D. B., Weindruch, R. H., & Aiken, J. M. (2000) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(00)00059-2 · Cited by 74 · see citing works

This Month in the Journal

Williamson, R. E. (2006) · The American Journal of Human Genetics · doi:10.1086/507713

The Role of Apoptosis and Necrosis in Age-Dependent Enzymatic Mitochondrial Abnormalities in Individual Skeletal Muscle Fibers

Cheema, N. (2017) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r33r0q585