Peptide sequences that target cytosolic proteins for lysosomal proteolysis

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897

An Overview of Autophagy: Morphology, Mechanism, and Regulation

Parzych, K. R., & Klionsky, D. J. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5371 · Cited by 2,521

Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy

Cuervo, A. M., Stefanis, L., Fredenburg, R., Lansbury, P. T., & Sulzer, D. (2004) · Science · doi:10.1126/science.1101738 · Cited by 2,024

Molecular definitions of autophagy and related processes

Galluzzi, L., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo‐San Pedro, J. M., Cecconi, F., Choi, A. M., Chu, C. T., Codogno, P., Colombo, M. I., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201796697 · Cited by 1,646

The coming of age of chaperone-mediated autophagy

Kaushik, S., & Cuervo, A. M. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0001-6 · Cited by 1,407

Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells

Mizushima, N., Yamamoto, A., Hatano, M., Kobayashi, Y., Kabeya, Y., Suzuki, K., Tokuhisa, T., Ohsumi, Y., & Yoshimori, T. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.4.657 · Cited by 1,361

Oxidative Stress in Aging Human Skin

Rinnerthaler, M., Bischof, J., Streubel, M., Trost, A., & Richter, K. (2015) · Biomolecules · doi:10.3390/biom5020545 · Cited by 1,053

Microautophagy of Cytosolic Proteins by Late Endosomes

Sahu, R., Kaushik, S., Clement, C. C., Cannizzo, E. S., Scharf, B., Follenzi, A., Potolicchio, I., Nieves, E., Cuervo, A. M., & Santambrogio, L. (2011) · Developmental Cell · doi:10.1016/j.devcel.2010.12.003 · Cited by 902

Autophagy and aging: The importance of maintaining "clean" cells

Cuervo, A. M., Bergamini, E., Brunk, U. T., Dröge, W., Ffrench, M., & Terman, A. (2005) · Autophagy · doi:10.4161/auto.1.3.2017 · Cited by 792

The lysosome: from waste bag to potential therapeutic target

Appelqvist, H., Wäster, P., Kågedal, K., & Öllinger, K. (2013) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjt022 · Cited by 772

A brief history of autophagy from cell biology to physiology and disease

Mizushima, N. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0092-5 · Cited by 696

Age-related decline in chaperone-mediated autophagy

Cuervo, A. M., & Dice, J. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002102200 · Cited by 665

Methods for Monitoring Autophagy from Yeast to Human

Klionsky, D. J., Cuervo, A. M., & Seglen, P. O. (2007) · Autophagy · doi:10.4161/auto.3678 · Cited by 656

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

Wang, Y., Martinez-Vicente, M., Krüger, U., Kaushik, S., Wong, E., Mandelkow, E.-M., Cuervo, A. M., & Mandelkow, E. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp367 · Cited by 617

Interplay of LRRK2 with chaperone-mediated autophagy

Orenstein, S. J., Kuo, S.-H., Tasset, I., Arias, E., Koga, H., Fernandez-Carasa, I., Cortes, E., Honig, L. S., Dauer, W., Consiglio, A., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3350 · Cited by 588

Consequences of the selective blockage of chaperone-mediated autophagy

Massey, A. C., Kaushik, S., Sovak, G., Kiffin, R., & Cuervo, A. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507436103 · Cited by 529

Protein Homeostasis and Aging: the importance of exquisite quality control

Koga, H., Kaushik, S., & Cuervo, A. M. (2011) · Ageing research reviews · doi:10.1016/j.arr.2010.02.001 · Cited by 476

Autophagy and the ubiquitin-proteasome system: Collaborators in neuroprotection

Nedelsky, N. B., Todd, P. K., & Taylor, J. P. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.002 · Cited by 351

Aging and Immune Function: Molecular Mechanisms to Interventions

Ponnappan, S., & Ponnappan, U. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3228 · Cited by 339

Targeted protein degradation: advances in drug discovery and clinical practice

Zhong, G., Chang, X., Xie, W., & Zhou, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02004-x · Cited by 326

Chaperone-mediated autophagy in aging and disease

Massey, A. C., Zhang, C., & Cuervo, A. M. (2006) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(05)73007-6 · Cited by 315

Chaperone-mediated autophagy: selectivity pays off

Cuervo, A. M. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.10.003 · Cited by 260

Chaperone-mediated autophagy. Molecular mechanisms and physiological relevance

Orenstein, S. J., & Cuervo, A. M. (2010) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2010.02.005 · Cited by 260

Proteome-wide analysis of chaperone-mediated autophagy targeting motifs

Kirchner, P., Bourdenx, M., Madrigal-Matute, J., Tiano, S., Diaz, A., Bartholdy, B. A., Will, B., & Cuervo, A. M. (2019) · PLOS Biology · doi:10.1371/journal.pbio.3000301 · Cited by 257

Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation

Valdor, R., Mocholi, E., Botbol, Y., Guerrero-Ros, I., Chandra, D., Koga, H., Gravekamp, C., Cuervo, A. M., & Macian, F. (2014) · Nature Immunology · doi:10.1038/ni.3003 · Cited by 244

Aberrant Interaction between Parkinson Disease-associated Mutant UCH-L1 and the Lysosomal Receptor for Chaperone-mediated Autophagy

Kabuta, T., Furuta, A., Aoki, S., Furuta, K., & Wada, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801918200 · Cited by 227

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice

Caballero, B., Bourdenx, M., Luengo, E., Diaz, A., Sohn, P. D., Chen, X., Wang, C., Juste, Y. R., Wegmann, S., Patel, B., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22501-9 · Cited by 223

Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives

Anguiano, J., Garner, T. P., Mahalingam, M., Das, B. C., Gavathiotis, E., & Cuervo, A. M. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1230 · Cited by 222

You say lipofuscin, we say ceroid: Defining autofluorescent storage material

Seehafer, S. S., & Pearce, D. A. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.12.006 · Cited by 212

Autophagy in Alzheimer’s disease

Zare-shahabadi, A., Masliah, E., Johnson, G. V. W., & Rezaei, N. (2015) · Reviews in the Neurosciences · doi:10.1515/revneuro-2014-0076 · Cited by 204

Lysosome: The metabolic signaling hub

Lamming, D. W., & Bar‐Peled, L. (2019) · Traffic · doi:10.1111/tra.12617 · Cited by 173

Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model

Xu, X., Sun, Y., Cen, X., Shan, B., Zhao, Q., Xie, T., Wang, Z., Hou, T., Xue, Y., Zhang, M., et al. (2021) · Protein & Cell · doi:10.1007/s13238-021-00858-3 · Cited by 171

Chaperone‐mediated autophagy: Molecular mechanisms, biological functions, and diseases

Yao, R., & Shen, J. (2023) · MedComm · doi:10.1002/mco2.347 · Cited by 111

Pathogenic Mechanisms of Neurodegeneration in Parkinson Disease

Mullin, S., & Schapira, A. H. V. (2015) · Neurologic Clinics · doi:10.1016/j.ncl.2014.09.010 · Cited by 108

Protective role of chaperone-mediated autophagy against atherosclerosis

Madrigal-Matute, J., de Bruijn, J., van Kuijk, K., Riascos-Bernal, D. F., Diaz, A., Tasset, I., Martín-Segura, A., Gijbels, M. J. J., Sander, B., Kaushik, S., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2121133119 · Cited by 107

Selective Uptake of Cytosolic, Peroxisomal, and Plasma Membrane Proteins into the Yeast Lysosome for Degradation

Chiang, H.-L., Schekman, R., & Hamamoto, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.17.9934 · Cited by 104

Identification of Novel Vesicles in the Cytosol to Vacuole Protein Degradation Pathway

Huang, P.-H., & Chiang, H.-L. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.4.803 · Cited by 98

Small molecule therapeutics for tauopathy in Alzheimer’s disease: Walking on the path of most resistance

Wang, L., Bharti, Kumar, R., Pavlov, P. F., & Winblad, B. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112915 · Cited by 92

Chaperone mediated autophagy degrades TDP-43 protein and is affected by TDP-43 aggregation

Ormeño, F., Hormazabal, J., Moreno, J., Riquelme, F., Rios, J., Criollo, A., Albornoz, A., Alfaro, I. E., & Budini, M. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00019 · Cited by 80

Primary cilia and autophagic dysfunction in Huntington’s disease

Kaliszewski, M., Knott, A. B., & Bossy-Wetzel, E. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2015.80 · Cited by 55

The endolysosomal system in conventional and unconventional protein secretion

Néel, E., Chiritoiu-Butnaru, M., Fargues, W., Denus, M., Colladant, M., Filaquier, A., Stewart, S. E., Lehmann, S., Zurzolo, C., Rubinsztein, D. C., et al. (2024) · Journal of Cell Biology · doi:10.1083/jcb.202404152 · Cited by 50

“Get the Balance Right”: Pathological Significance of Autophagy Perturbation in Neuromuscular Disorders

Castets, P., Frank, S., Sinnreich, M., & Rüegg, M. A. (2016) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-160153 · Cited by 49

Hsp70 inhibition induces myeloma cell death via the intracellular accumulation of immunoglobulin and the generation of proteotoxic stress

Zhang, L., Fok, J. J. L., Mirabella, F., Aronson, L. I., Fryer, R. A., Workman, P., Morgan, G. J., & Davies, F. E. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.07.023 · Cited by 32

Leupeptin-Induced Appearance of Partial Fragment of Betaine Homocysteine Methyltransferase during Autophagic Maturation in Rat Hepatocytes

Furuya, N., Kanazawa, T., Fujimura, S., Ueno, T., Kominami, E., & Kadowaki, M. (2001) · Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a002859 · Cited by 25