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The endolysosomal system in conventional and unconventional protein secretion

Néel, Eloïse, Chiritoiu-Butnaru, Marioara, Fargues, William, Denus, Morgane, Colladant, Maëlle, Filaquier, Aurore, Stewart, Sarah E., Lehmann, Sylvain, Zurzolo, Chiara, Rubinsztein, David C., Marin, Philippe, Parmentier, Marie-Laure, Villeneuve, Julien·2024·Journal of Cell Biology
DOI 10.1083/jcb.202404152PMC PMC11318669
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Abstract

Most secreted proteins are transported through the “conventional” endoplasmic reticulum–Golgi apparatus exocytic route for their delivery to the cell surface and release into the extracellular space. Nonetheless, formative discoveries have underscored the existence of alternative or “unconventional” secretory routes, which play a crucial role in exporting a diverse array of cytosolic proteins outside the cell in response to intrinsic demands, external cues, and environmental changes. In this context, lysosomes emerge as dynamic organelles positioned at the crossroads of multiple intracellular trafficking pathways, endowed with the capacity to fuse with the plasma membrane and recognized for their key role in both conventional and unconventional protein secretion. The recent recognition of lysosomal transport and exocytosis in the unconventional secretion of cargo proteins provides new and promising insights into our understanding of numerous physiological processes.

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Metadata

Authors
Néel, E., Chiritoiu-Butnaru, M., Fargues, W., Denus, M., Colladant, M., Filaquier, A., Stewart, S. E., Lehmann, S., Zurzolo, C., Rubinsztein, D. C., Marin, P., Parmentier, M.-L., & Villeneuve, J.
Venue
Journal of Cell Biology
Publisher
Rockefeller University Press
Published
2024-08-12
Volume
223
Issue
9
ISSN
  • 0021-9525
  • 1540-8140
DOI
10.1083/jcb.202404152
PMC
PMC11318669
Cited by
50
References
10
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • Centre National de la Recherche Scientifique
  • Institut National de la Santé et de la Recherche Médicale
  • University of Montpellier
  • Fondation Vaincre Alzheimer
  • Association France Alzheimer et maladies apparentées
  • Association France Parkinson
  • Fédération pour la Recherche sur le Cerveau
  • Agence Nationale de la Recherche (ANR-23-CE16-0012)
  • Romanian Academy (155/GAR2023)
  • Australian Research Council
  • Centre of Excellence in Neurodegeneration
  • UK Dementia Research Institute
  • UK Medical Research Council
  • National Institute for Health Research Cambridge Biomedical Research Centre

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