Cationic lipids activate intracellular signaling pathways
Abstract
Cationic liposomes are commonly used as a transfection reagent for DNA, RNA or proteins and as a co-adjuvant of antigens for vaccination trials. A high density of positive charges close to cell surface is likely to be recognized as a signal of danger by cells or contribute to trigger cascades that are classically activated by endogenous cationic compounds. The present review provides evidence that cationic liposomes activate several cellular pathways like pro-apoptotic and pro-inflammatory cascades. An improved knowledge of the relationship between the cationic lipid properties (nature of the lipid hydrophilic moieties, hydrocarbon tail, mode of organization) and the activation of these pathways opens the way to the use and design of cationic tailored for a specific application (e.g. for gene transport or as adjuvants).
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Cationic lipids have been associated with activation of several cellular pathways such as pro-apoptotic and pro-inflammatory cascades.
“Cationic lipids have been associated with the activation of several cellular pathways like pro-apoptotic and pro-inflammatory cascades [65]”
From The dawn of mRNA vaccines: the COVID-19 case (2021) · cites this paper as [65]
Cites
Boussif, O., Lezoualc’h, F., Zanta, M. A., Djavaheri‐Mergny, M., Scherman, D., DEMENEIX, B. A., & Behr, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7297 · Cited by 6,256 · see citing works
Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors
Cros, J. F., Cagnard, N., Woollard, K. J., Patey, N., Zhang, S., Sénéchal, B., Puel, A., Biswas, S. K., Moshous, D., Pïcard, C., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.012 · Cited by 1,251 · see citing works
Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery
Khalil, I. A., Kogure, K., Akita, H., & Harashima, H. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.1.8 · Cited by 1,241 · see citing works
Mechanism of DNA Release from Cationic Liposome/DNA Complexes Used in Cell Transfection,
Xu, Y., & Szoka, F. C. (1996) · Biochemistry · doi:10.1021/bi9602019 · Cited by 1,136 · see citing works
CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4
Zanoni, I., Ostuni, R., Marek, L. R., Barresi, S., Barbalat, R., Barton, G. M., Granucci, F., & Kagan, J. C. (2011) · Cell · doi:10.1016/j.cell.2011.09.051 · Cited by 997 · see citing works
The Vaccine Adjuvant Monophosphoryl Lipid A as a TRIF-Biased Agonist of TLR4
Mata‐Haro, V., Cekic, C., Martin, M., Chilton, P. M., Casella, C. R., & Mitchell, T. C. (2007) · Science · doi:10.1126/science.1138963 · Cited by 901 · see citing works
The inflammasome: an integrated view
Gross, O., Thomas, C. J., Guarda, G., & Tschopp, J. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01046.x · Cited by 778 · see citing works
Progress in developing cationic vectors for non-viral systemic gene therapy against cancer
Morille, M., Passirani, C., Vonarbourg, A., Clavreul, A., & Benoît, J. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.04.036 · Cited by 769 · see citing works
CD14 is required for MyD88-independent LPS signaling
Jiang, Z., Georgel, P., Du, X., Shamel, L., Sovath, S., Mudd, S., Huber, M., Kalis, C., Keck, S., Galanos, C., et al. (2005) · Nature Immunology · doi:10.1038/ni1207 · Cited by 671 · see citing works
Gringhuis, S. I., Kaptein, T. M., Wevers, B. A., Theelen, B., van der Vlist, M., Boekhout, T., & Geijtenbeek, T. B. H. (2012) · Nature Immunology · doi:10.1038/ni.2222 · Cited by 612 · see citing works
Recent Advances in Nonviral Vectors for Gene Delivery
Guo, X., & Huang, L. (2011) · Accounts of Chemical Research · doi:10.1021/ar200151m · Cited by 585 · see citing works
Cationic lipids, lipoplexes and intracellular delivery of genes.
Wasungu, L., & Hoekstra, D. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.06.024 · Cited by 575 · see citing works
Kedmi, R., Ben-Arie, N., & Peer, D. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.027 · Cited by 546 · see citing works
Formation and Intracellular Trafficking of Lipoplexes and Polyplexes
Elouahabi, A., & Ruysschaert, J. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2004.12.006 · Cited by 464 · see citing works
Self-citationFilion, M. C., & Phillips, N. C. (1997) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(97)00126-0 · Cited by 428 · see citing works
Cationic lipids and polymers mediated vectors for delivery of siRNA
Zhang, S., Zhao, B., Jiang, H., Wang, B., & Ma, B. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.07.016 · Cited by 421 · see citing works
Kaiser, W. J., & Offermann, M. K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4942 · Cited by 374 · see citing works
Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8
Maelfait, J., Vercammen, E., Janssens, S., Schotte, P., Haegman, M., Magez, S., & Beyaert, R. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071632 · Cited by 327 · see citing works
Cationic compounds used in lipoplexes and polyplexes for gene delivery
Zhang, S., Xu, Y., Wang, B., Qiao, W., Liu, D., & Li, Z. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.08.019 · Cited by 320 · see citing works
CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation
Zanoni, I., Ostuni, R., Capuano, G., Collini, M., Caccia, M., Ronchi, A. E., Rocchetti, M., Mingozzi, F., Foti, M., Chirico, G. G., et al. (2009) · Nature · doi:10.1038/nature08118 · Cited by 319 · see citing works
The Design of Cationic Lipids for Gene Delivery
Martin, B., Sainlos, M., Aissaoui, A., Oudrhiri, N., Hauchecorne, M., VIGNERON, J. ‐., Lehn, J., & Lehn, P. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053382133 · Cited by 304 · see citing works
Karmali, P. P., & Chaudhuri, A. (2006) · Medicinal Research Reviews · doi:10.1002/med.20090 · Cited by 289 · see citing works
Sensing damage by the NLRP3 inflammasome
Leemans, J. C., Cassel, S. L., & Sutterwala, F. S. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01043.x · Cited by 281 · see citing works
Crystal Structure of CD14 and Its Implications for Lipopolysaccharide Signaling
Kim, J.-I., Lee, C. J., Jin, M. S., Lee, C.-H., Paik, S., Lee, H., & Lee, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414607200 · Cited by 278 · see citing works
Mitochondrial ROS fuel the inflammasome
Sorbara, M. T., & Girardin, S. E. (2011) · Cell Research · doi:10.1038/cr.2011.20 · Cited by 274 · see citing works
Cationic liposomes as vaccine adjuvants
Christensen, D., Korsholm, K. S., Andersen, P. L., & Agger, E. M. (2011) · Expert Review of Vaccines · doi:10.1586/erv.11.17 · Cited by 262 · see citing works
Calcium and Mitochondrial Reactive Oxygen Species Generation: How to Read the Facts
Ádám‐Vizi, V., & Starkov, A. A. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100465 · Cited by 250 · see citing works
Erridge, C., Kennedy, S., Spickett, C. M., & Webb, D. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800352200 · Cited by 229 · see citing works
Lipopolysaccharide binding protein and soluble CD14 catalyze exchange of phospholipids.
Yu, B., Hailman, E., & Wright, S. D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119160 · Cited by 225 · see citing works
CD14 is a coreceptor of Toll-like receptors 7 and 9
Baumann, C., Aspalter, I. M., Sharif, O., Pichlmair, A., Blüml, S., Grebien, F., Brückner, M., Pasierbek, P., Aumayr, K., Planyavsky, M., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101111 · Cited by 220 · see citing works
Intracellular Delivery of Proteins with a New Lipid-mediated Delivery System
Zelphati, O., Wang, Y., Kitada, S., Reed, J. C., Felgner, P. L., & Corbeil, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104920200 · Cited by 214 · see citing works
Cationic liposomal lipids: From gene carriers to cell signaling
Lonez, C., Vandenbranden, M., & Ruysschaert, J. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.03.002 · Cited by 208 · see citing works
Self-citationThe adjuvant mechanism of cationic dimethyldioctadecylammonium liposomes
Korsholm, K. S., Agger, E. M., Foged, C., Christensen, D., Dietrich, J., Andersen, C. S., Geisler, C., & Andersen, P. L. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02560.x · Cited by 188 · see citing works
Gene delivery by cationic lipids: in and out of an endosome
Hoekstra, D., Rejman, J., Wasungu, L., Shi, F., & Zuhorn, I. S. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350068 · Cited by 186 · see citing works
Immunostimulation of dendritic cells by cationic liposomes
Vangasseri, D. P., Cui, Z., Chen, W., Hokey, D. A., Falo, L. D., & Huang, L. (2006) · Molecular Membrane Biology · doi:10.1080/09687860600790537 · Cited by 183 · see citing works
Yan, W., Chen, W., & Huang, L. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.04.009 · Cited by 178 · see citing works
Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonists
Peri, F., & Piazza, M. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.05.014 · Cited by 162 · see citing works
Zuhorn, I. S., & Hoekstra, D. (2002) · The Journal of Membrane Biology · doi:10.1007/s00232-002-1015-7 · Cited by 156 · see citing works
Major limitations in the use of cationic liposomes for DNA delivery
Filion, M. C., & Phillips, N. C. (1998) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(97)00423-7 · Cited by 155 · see citing works
Deciphering the complexity of Toll-like receptor signaling
Ostuni, R., Zanoni, I., & Granucci, F. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0464-x · Cited by 154 · see citing works
Altering the immune response with lipid-based nanoparticles
Landesman‐Milo, D., & Peer, D. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.12.034 · Cited by 139 · see citing works
Cationic liposomes as vaccine adjuvants
Christensen, D., Korsholm, K. S., Rosenkrands, I., Lindenstrøm, T., Andersen, P. L., & Agger, E. M. (2007) · Expert Review of Vaccines · doi:10.1586/14760584.6.5.785 · Cited by 138 · see citing works
Two Faces of Protein Kinase Cδ: The Contrasting Roles of PKCδ in Cell Survival and Cell Death
Basu, A., & Pal, D. (2010) · The Scientific World JOURNAL · doi:10.1100/tsw.2010.214 · Cited by 130 · see citing works
Montier, T., Benvegnu, T. J., Jaffrès, P., Yaouanc, J., & Lehn, P. (2008) · Current Gene Therapy · doi:10.2174/156652308786070989 · Cited by 129 · see citing works
A simple but effective cancer vaccine consisting of an antigen and a cationic lipid
Chen, W., Yan, W., & Huang, L. (2007) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-007-0390-4 · Cited by 126 · see citing works
Yan, W., Chen, W., & Huang, L. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.05.005 · Cited by 125 · see citing works
Redox regulation of calcium ion channels: Chemical and physiological aspects
Bogeski, I., Kappl, R., Kummerow, C., Gulaboski, R., Hoth, M., & Niemeyer, B. A. (2011) · Cell Calcium · doi:10.1016/j.ceca.2011.07.006 · Cited by 121 · see citing works
DiC14‐amidine cationic liposomes stimulate myeloid dendritic cells through Toll‐like receptor 4
Tanaka, T., Legat, A., Adam, E., Steuve, J., Gatot, J., Vandenbranden, M., Ulianov, L., Lonez, C., Ruysschaert, J., Muraille, É., et al. (2008) · European Journal of Immunology · doi:10.1002/eji.200737998 · Cited by 98 · see citing works
Self-citationCationic lipid-mediated nucleic acid delivery: beyond being cationic
Rao, N. M. (2010) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2010.01.001 · Cited by 98 · see citing works
Induction of apoptosis in macrophages by cationic liposomes
Aramaki, Y., Takano, S., & Tsuchiya, S. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01386-1 · Cited by 97 · see citing works
Iwaoka, S., Nakamura, T., Takano, S., Tsuchiya, S., & Aramaki, Y. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0405181 · Cited by 91 · see citing works
Takano, S., Aramaki, Y., & Tsuchiya, S. (2003) · Pharmaceutical Research · doi:10.1023/a:1024441702398 · Cited by 87 · see citing works
Complex Formation with Plasmid DNA Increases the Cytotoxicity of Cationic Liposomes
Nguyen, L. T., Atobe, K., Barichello, J. M., Ishida, T., & Kiwada, H. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.751 · Cited by 87 · see citing works
Regen, T., van Rossum, D., Scheffel, J., Kastriti, M. E., Revelo, N. H., Prinz, M., Brück, W., & Hanisch, U. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.10.009 · Cited by 68 · see citing works
Interactions between Cationic Vesicles and Cultured Mammalian Cells
Carmona‐Ribeiro, A. M., Ortis, F., Schumacher, R. I., & Armelin, M. C. S. (1997) · Langmuir · doi:10.1021/la960759h · Cited by 67 · see citing works
Piazza, M., Rossini, C., Fiorentina, S. D., Pozzi, C., Comelli, F., Bettoni, I., Fusi, P. A., Costa, B., & Peri, F. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm801333m · Cited by 66 · see citing works
Weber, C., Müller, C., Podszuweit, A., Montino, C., Vollmer, J., & Forsbach, A. (2012) · Immunology · doi:10.1111/j.1365-2567.2012.03559.x · Cited by 60 · see citing works
Cationic Liposomes Induce Macrophage Apoptosis through Mitochondrial Pathway
Aramaki, Y., Takano, S., & Tsuchiya, S. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2458 · Cited by 58 · see citing works
L-Arginine and Atherothrombosis
Loscalzo, J. (2004) · Journal of Nutrition · doi:10.1093/jn/134.10.2798s · Cited by 55 · see citing works
Evidence of a Specific Interaction between New Synthetic Antisepsis Agents and CD14
Piazza, M., Yu, L. P., Teghanemt, A., Gioannini, T. L., Weiss, J. P., & Peri, F. (2009) · Biochemistry · doi:10.1021/bi901601b · Cited by 55 · see citing works
CD14 but not MD2 transmit signals from DAMP
Chun, K., & Seong, S. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2009.10.002 · Cited by 54 · see citing works
Induction of Apoptosis in WEHI 231 Cells by Cationic Liposomes
Aramaki, Y., Takano, S., Arima, H., & Tsuchiya, S. (2000) · Pharmaceutical Research · doi:10.1023/a:1007552529280 · Cited by 45 · see citing works
Caspase-containing complexes in the regulation of cell death and inflammation
Festjens, N., Cornelis, S., Lamkanfi, M., & Vandenabeele, P. (2006) · Biological Chemistry · doi:10.1515/bc.2006.124 · Cited by 45 · see citing works
David, S. A., Bechtel, B., Cariappa, A., Mathan, V. I., & Balaram, P. (1994) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(94)90250-x · Cited by 42 · see citing works
Kongkaneramit, L., Sarisuta, N., Azad, N., Lu, Y., Iyer, A. K. V., Wang, L., & Rojanasakul, Y. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.136077 · Cited by 42 · see citing works
Gregory, C. D., & Devitt, A. (1999) · APOPTOSIS · doi:10.1023/a:1009673914340 · Cited by 40 · see citing works
Adhesion Receptors Mediate Efficient Non-viral Gene Delivery
Zuhorn, I. S., Kalicharan, D., Robillard, G. T., & Hoekstra, D. (2007) · Molecular Therapy · doi:10.1038/mt.sj.6300139 · Cited by 40 · see citing works
Polyamine effects on cell function: Possible central role of plasma membrane PI(4,5)P2
Coburn, R. F. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21899 · Cited by 39 · see citing works
Interaction of Cationic Colloids at the Surface of J774 Cells: A Kinetic Analysis
Chenevier, P., Veyret, B., Roux, D., & Henry, N. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76383-1 · Cited by 39 · see citing works
Kusumoto, K.-I., & Ishikawa, T. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.07.114 · Cited by 36 · see citing works
Dalkara, D., Chandrashekhar, C., & Zuber, G. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.10.005 · Cited by 32 · see citing works
Polycationic lipids inhibit the pro-inflammatory response to LPS
Leon‐Ponte, M., Kirchhof, M. G., Sun, T., Stephens, T. A., Singh, B., Sandhu, S., & Madrenas, J. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.07.019 · Cited by 31 · see citing works
Piazza, M., Calabrese, V., Baruffa, C., Gioannini, T. L., Weiss, J. P., & Peri, F. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.06.019 · Cited by 31 · see citing works
Interactions between cationic liposomes and drugs or biomolecules
Carmona‐Ribeiro, A. M. (2000) · Anais da Academia Brasileira de Ciências · doi:10.1590/s0001-37652000000100005 · Cited by 31 · see citing works
Asai, Y., Makimura, Y., Kawabata, A., & Ogawa, T. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.11.7674 · Cited by 31 · see citing works
Cationic Type I Amphiphiles As Modulators of Membrane Curvature Elastic Stress in Vivo
Dymond, M. K., & Attard, G. S. (2008) · Langmuir · doi:10.1021/la8017612 · Cited by 29 · see citing works
Arisaka, M., Nakamura, T., Yamada, A., Negishi, Y., & Aramaki, Y. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.055 · Cited by 28 · see citing works
Polyamines protect against radiation-induced oxidative stress.
von Deutsch, A. W., Mitchell, C. D., Williams, C. E., Dutt, K., Silvestrov, N. A., Klement, B. J., Abukhalaf, I. K., & von Deutsch, D. A. (2005) · PubMed · Cited by 26 · see citing works
Wilmar, A., Lonez, C., Vermeersch, M., Andrianne, M., Pérez-Morga, D. L., Ruysschaert, J., Vandenbranden, M., Léo, O., & Temmerman, S. T. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.10.071 · Cited by 24 · see citing works
Self-citationJacquet, A., Vanderschrick, J.-F., Vandenbranden, M., Elouahabi, A., Magi, M., Garcia, L., & Ruysschaert, J. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2004.12.024 · Cited by 23 · see citing works
Self-citationSpermine, a molecular switch regulating EGFR, integrin β3, Src, and FAK scaffolding
Ray, R. M., Li, C., Bhattacharya, S., Naren, A. P., & Johnson, L. R. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.12.016 · Cited by 22 · see citing works
Cationic lipids activate cellular cascades. Which receptors are involved?
Lonez, C., Lensink, M. F., Vandenbranden, M., & Ruysschaert, J. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.02.015 · Cited by 22 · see citing works
Self-citationTagami, T., Hirose, K., Barichello, J. M., Ishida, T., & Kiwada, H. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9663-7 · Cited by 22 · see citing works
Lipoxygenase May Be Involved in Cationic Liposome-Induced Macrophage Apoptosis
Takano, S., Aramaki, Y., & Tsuchiya, S. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5731 · Cited by 21 · see citing works
Lysine triggers apoptosis through a NADPH oxidase‐dependent mechanism in human renal tubular cells
Verzola, D., Famà, A., Villaggio, B., Rocco, M. D., Simonato, A., D’Amato, E., Gianiorio, F., & Garibotto, G. (2012) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-012-9468-z · Cited by 20 · see citing works
Efficient Protein Transduction Method Using Cationic Peptides and Lipids
Yamaguchi, K., Inoue, M., & Goshima, N. (2011) · BioMed Research International · doi:10.1155/2011/872065 · Cited by 15 · see citing works
Cationic lipids involved in gene transfer mobilize intracellular calcium
Ouali, M., Ruysschaert, J., Lonez, C., & Vandenbranden, M. (2007) · Molecular Membrane Biology · doi:10.1080/09687860601108911 · Cited by 14 · see citing works
Self-citationInvolvement of lipid rafts in macrophage apoptosis induced by cationic liposomes
Arisaka, M., Takano, K., Negishi, Y., Arima, H., & Aramaki, Y. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.02.003 · Cited by 13 · see citing works
Involvement of actin cytoskeleton in macrophage apoptosis induced by cationic liposomes
Takano, K., Sato, K., Negishi, Y., & Aramaki, Y. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.12.009 · Cited by 11 · see citing works
Phosphatidyl inositol-3-phosphate kinase mediates CD14 dependent signaling
O’Toole, T. G., & Peppelenbosch, M. P. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.10.010 · Cited by 9 · see citing works
Arima, H., Aramaki, Y., & Tsuchiya, S. (1997) · Journal of Pharmaceutical Sciences · doi:10.1021/js960530m · Cited by 9 · see citing works
Toxicogenomics of Nonviral Cationic Gene Delivery Nanosystems
Omidi, Y., Kafil, V., & Barar, J. (2011) · InTech eBooks · doi:10.5772/19035 · Cited by 4 · see citing works
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Chaudhary, N., Weissman, D., & Whitehead, K. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00283-5 · Cited by 1,555 · see citing works
Ndeupen, S., Qin, Z., Jacobsen, S., Bouteau, A., Estanbouli, H., & Igyártó, B. Z. (2021) · iScience · doi:10.1016/j.isci.2021.103479 · Cited by 678 · see citing works
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Zhang, Y., Sun, C., Wang, C., Jankovic, K. E., & Dong, Y. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00244 · Cited by 638 · see citing works
Liposomes as vaccine delivery systems: a review of the recent advances
Schwendener, R. A. (2014) · Therapeutic Advances in Vaccines · doi:10.1177/2051013614541440 · Cited by 524 · see citing works
The dawn of mRNA vaccines: the COVID-19 case
Verbeke, R., Lentacker, I., De Smedt, S. C., & Dewitte, H. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.03.043 · Cited by 504 · see citing works
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Xu, S., Yang, K., Li, R., & Zhang, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186582 · Cited by 368 · see citing works
Circular RNA vaccine in disease prevention and treatment
Niu, D., Wu, Y., & Lian, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01561-x · Cited by 273 · see citing works
mRNA vaccines in disease prevention and treatment
Zhang, G., Tang, T., Chen, Y., Huang, X., & Liang, T. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01579-1 · Cited by 253 · see citing works
Recent advances on thermosensitive and pH-sensitive liposomes employed in controlled release
Aghdam, M. A., Bagheri, R., Mosafer, J., Baradaran, B., Hashemzaei, M., Baghbanzadeh, A., de la Guárdia, M., & Mokhtarzadeh, A. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.09.018 · Cited by 242 · see citing works
Lipid Nanoparticles as Delivery Systems for RNA-Based Vaccines
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Mechanism of action of mRNA-based vaccines
Iavarone, C., O’hagan, D. T., Yu, D., Delahaye, N. F., & Ulmer, J. B. (2017) · Expert Review of Vaccines · doi:10.1080/14760584.2017.1355245 · Cited by 234 · see citing works
Xi, K., Gu, Y., Tang, J., Chen, H., Xu, Y., Wu, L., Cai, F., Deng, L., Yang, H., Shi, Q., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18265-3 · Cited by 231 · see citing works
Lindsay, K. E., Bhosle, S. M., Zurla, C., Beyersdorf, J., Rogers, K. A., Vanover, D., Xiao, P., Araínga, M., Shirreff, L. M., Pitard, B., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0378-3 · Cited by 218 · see citing works
Shields, C. W., Wang, L., Evans, M. A., & Mitragotri, S. (2019) · Advanced Materials · doi:10.1002/adma.201901633 · Cited by 190 · see citing works
Merging the best of both worlds: hybrid lipid-enveloped matrix nanocomposites in drug delivery
Raemdonck, K., Braeckmans, K., Demeester, J., & Smedt, S. C. D. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60299k · Cited by 190 · see citing works
How cationic lipids transfer nucleic acids into cells and across cellular membranes: Recent advances
Rehman, Z. U., Zuhorn, I. S., & Hoekstra, D. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.12.014 · Cited by 186 · see citing works
Clinical and immunological effects of mRNA vaccines in malignant diseases
Heine, A., Juranek, S., & Brossart, P. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01339-1 · Cited by 185 · see citing works
Correlation of the cytotoxic effects of cationic lipids with their headgroups
Cui, S., Wang, Y., Gong, Y., Lin, X., Zhao, Y., Zhi, D., Zhou, Q., & Zhang, S. (2018) · Toxicology Research · doi:10.1039/c8tx00005k · Cited by 180 · see citing works
Developing Biodegradable Lipid Nanoparticles for Intracellular mRNA Delivery and Genome Editing
Qiu, M., Li, Y., Bloomer, H., & Xu, Q. (2021) · Accounts of Chemical Research · doi:10.1021/acs.accounts.1c00500 · Cited by 168 · see citing works
Granot-Matok, Y., & Peer, D. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.08.015 · Cited by 154 · see citing works
Kheraldine, H., Rachid, O., Habib, A. M., Moustafa, A. A., Benter, I. F., & Akhtar, S. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113908 · Cited by 152 · see citing works
Weijer, R., Broekgaarden, M., Kos, M., van Vught, R., Rauws, E. A., Breukink, E. J., van Gulik, T. M., Storm, G., & Heger, M. (2015) · Journal of Photochemistry and Photobiology C Photochemistry Reviews · doi:10.1016/j.jphotochemrev.2015.05.002 · Cited by 139 · see citing works
Knife’s edge: Balancing immunogenicity and reactogenicity in mRNA vaccines
Lee, J., Woodruff, M. C., Kim, E. H., & Nam, J. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-00999-x · Cited by 137 · see citing works
Yuba, E. (2020) · Journal of Materials Chemistry B · doi:10.1039/c9tb02470k · Cited by 133 · see citing works
Cationic lipid nanocarriers activate Toll-like receptor 2 and NLRP3 inflammasome pathways
Lonez, C., Bessodes, M., Scherman, D., Vandenbranden, M., Escriou, V., & Ruysschaert, J. (2013) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2013.12.003 · Cited by 129 · see citing works
Self-citationThe immunostimulatory nature of mRNA lipid nanoparticles
Sharma, P., Hoorn, D., Aitha, A., Breier, D., & Peer, D. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115175 · Cited by 132 · see citing works
Nanovaccine: an emerging strategy
Das, A., & Ali, N. (2021) · Expert Review of Vaccines · doi:10.1080/14760584.2021.1984890 · Cited by 131 · see citing works
Yoshizaki, Y., Yuba, E., Sakaguchi, N., Koiwai, K., Harada, A., & Kono, K. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.05.077 · Cited by 121 · see citing works
Swaminathan, G., Thoryk, E. A., Cox, K. S., Meschino, S., Dubey, S. A., Vora, K. A., Celano, R., Gindy, M. E., Casimiro, D. R., & Bett, A. J. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.10.132 · Cited by 118 · see citing works
Evading innate immunity in nonviral mRNA delivery: don't shoot the messenger.
Devoldere, J., Dewitte, H., De Smedt, S. C., & Remaut, K. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2015.07.009 · Cited by 112 · see citing works
Future considerations for the mRNA-lipid nanoparticle vaccine platform
Igyártó, B. Z., Jacobsen, S., & Ndeupen, S. (2021) · Current Opinion in Virology · doi:10.1016/j.coviro.2021.03.008 · Cited by 109 · see citing works
Mucosal Vaccine Development Based on Liposome Technology
Bernasconi, V., Norling, K., Bally, M., Höök, F., & Lycke, N. Y. (2016) · Journal of Immunology Research · doi:10.1155/2016/5482087 · Cited by 108 · see citing works
Nanotools for Sepsis Diagnosis and Treatment
Papafilippou, L., Claxton, A., Dark, P., Kostarelos, K., & Hadjidemetriou, M. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202001378 · Cited by 118 · see citing works
Lipid nanocarriers for microRNA delivery
Scheideler, M., Vidaković, I., & Prassl, R. (2019) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2019.104837 · Cited by 107 · see citing works
Recent Developments in mRNA-Based Protein Supplementation Therapy to Target Lung Diseases
Sahu, I., Haque, A. K. M. A., Weidensee, B., Weinmann, P., & Kormann, M. S. D. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.02.019 · Cited by 104 · see citing works
Modulation of Immune Response Using Engineered Nanoparticle Surfaces
Moyano, D. F., Liu, Y., Peer, D., & Rotello, V. M. (2015) · Small · doi:10.1002/smll.201502273 · Cited by 103 · see citing works
Zelkoski, A. E., Lu, Z., Sukumar, G., Dalgard, C. L., Said, H., Alameh, M., Mitre, E. E. S., & Malloy, A. M. W. (2025) · npj Vaccines · doi:10.1038/s41541-025-01124-x · Cited by 113 · see citing works
Li, Y., Ye, Z., Yang, H., & Xu, Q. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.04.013 · Cited by 99 · see citing works
Recent progress in gene therapy to deliver nucleic acids with multivalent cationic vectors
Junquera, E., & Aicart, E. (2015) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2015.07.003 · Cited by 99 · see citing works
Yoshizaki, Y., Yuba, E., Sakaguchi, N., Koiwai, K., Harada, A., & Kono, K. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.07.001 · Cited by 90 · see citing works
Axial pharmaceutical properties of liposome in cancer therapy: Recent advances and perspectives
Kiaie, S. H., Mojarad-Jabali, S., Khaleseh, F., Allahyari, S., Taheri, E., Zakeri-Milani, P., & Valizadeh, H. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119269 · Cited by 87 · see citing works
Micro/nanoparticle adjuvants for antileishmanial vaccines: Present and future trends
Badiee, A., Shargh, V. H., Khamesipour, A., & Jaafari, M. R. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.11.068 · Cited by 86 · see citing works
Increasing the Chemical Variety of Small-Molecule-Based TLR4 Modulators: An Overview
Romerio, A., & Peri, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01210 · Cited by 84 · see citing works
Catenacci, L., Rossi, R., Sechi, F., Buonocore, D., Sorrenti, M., Perteghella, S., Peviani, M., & Bonferoni, M. C. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16121521 · Cited by 83 · see citing works
Microfluidic self-assembly of folate-targeted monomolecular siRNA-lipid nanoparticles
Krzysztoń, R., Salem, B., Lee, D.-J., Schwake, G., Wagner, E., & Rädler, J. O. (2017) · Nanoscale · doi:10.1039/c7nr01593c · Cited by 81 · see citing works
Markov, O. V., Mironova, N. L., Shmendel, E. V., Serikov, R. N., Morozova, N. G., Maslov, M. A., Vlassov, V. V., & Аркадьевна, З. М. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.06.028 · Cited by 78 · see citing works
Li, Z., Zhang, X., Ho, W., Li, F., Gao, M., Bai, X., & Xu, X. (2022) · ACS Nano · doi:10.1021/acsnano.2c07822 · Cited by 75 · see citing works
Hwang, T., Aljuffali, I. A., Hung, C., Chen, C., & Fang, J. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.04.011 · Cited by 72 · see citing works
Kumar, K., Rani, V., Mishra, M., & Chawla, R. (2022) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2022.100103 · Cited by 71 · see citing works
Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Driessche, E. V., Nielsen, H. M., Franzyk, H., & Foged, C. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.07.014 · Cited by 71 · see citing works
Vhora, I., Lalani, R., Bhatt, P., Patil, S., & Misra, A. R. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.04.006 · Cited by 70 · see citing works
Endosomal Escape and Nuclear Localization: Critical Barriers for Therapeutic Nucleic Acids
Allen, R., & Yokota, T. (2024) · Molecules · doi:10.3390/molecules29245997 · Cited by 62 · see citing works
Moreno, E., Schwartz, J., Larrea, E., Conde, I., Font, M., Sanmartín, C., Irache, J. M., & Espuelas, S. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.07.011 · Cited by 62 · see citing works
Liposome-based immunity-inducing systems for cancer immunotherapy
Yuba, E. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.11.001 · Cited by 62 · see citing works
Bernard, M., Bazin, E., Petiot, N., Lemdani, K., Commandeur, S., Verdelet, C., Margot, S., Perkov, V., Ripoll, M., Garinot, M., et al. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.05.004 · Cited by 62 · see citing works
RNA vaccines for cancer: Principles to practice
Guasp, P., Reiche, C., Sethna, Z. M., & Balachandran, V. P. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.05.005 · Cited by 60 · see citing works
Development and applications of mRNA treatment based on lipid nanoparticles
Wang, Z., Ma, W., Fu, X., Qi, Y., Zhao, Y., & Zhang, S. (2023) · Biotechnology Advances · doi:10.1016/j.biotechadv.2023.108130 · Cited by 57 · see citing works
Korzun, T., Moses, A. S., Jozić, A., Grigoriev, V., Newton, S., Kim, J., Diba, P., Sattler, A. L., Levasseur, P. R., Le, N., et al. (2024) · ACS Nano · doi:10.1021/acsnano.4c05088 · Cited by 58 · see citing works
Ndeupen, S., Qin, Z., Jacobsen, S., Estanbouli, H., Bouteau, A., & Igyártó, B. Z. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.04.430128 · Cited by 57 · see citing works
O’Mahony, A., Godinho, B. M. D. C., Cryan, J. F., & O’Driscoll, C. M. (2013) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.23672 · Cited by 55 · see citing works
Recent advancements in lipid–mRNA nanoparticles as a treatment option for cancer immunotherapy
Karmacharya, P., Patil, B. R., & Kim, J. O. (2022) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-022-00569-9 · Cited by 54 · see citing works
Nano-bio interactions in mRNA nanomedicine: Challenges and opportunities for targeted mRNA delivery
Saiding, Q., Zhang, Z., Chen, S., Xiao, F., Chen, Y., Li, Y., Zhen, X., Khan, M. M., Chen, W., Koo, S., et al. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115116 · Cited by 57 · see citing works
Systemic tumor-specific gene delivery
Kullberg, M., McCarthy, R., & Anchordoquy, T. J. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.08.300 · Cited by 51 · see citing works
He, Z., Wei, X., Luo, M., Luo, S., Yang, Y., Yu, Y.-Y., Chen, Y., Ma, C., Liang, X., Guo, F., et al. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.10.015 · Cited by 52 · see citing works
PLGA nanoparticles loaded with KMP-11 stimulate innate immunity and induce the killing of Leishmania
Santos, D. M., Carneiro, M. W., de Moura, T. R., Soto, M., Luz, N. F., Prates, D. B., Irache, J. M., Brodskyn, C. I., Barral, A. M. P., Barral‐Netto, M., et al. (2013) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2013.04.003 · Cited by 50 · see citing works
Michel, T., Luft, D., Abraham, M.-K., Reinhardt, S., Medina, M. L. S., Kurz, J., Schaller, M., Avci‐Adali, M., Schlensak, C., Peter, K., et al. (2017) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2017.07.013 · Cited by 50 · see citing works
Nascimento, T. L., Hillaireau, H., Vergnaud, J., Rivano, M., Deloménie, C., Courilleau, D., Arpicco, S., Suk, J. S., Hanes, J. S., & Fattal, E. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.06.125 · Cited by 49 · see citing works
Protein adsorption determines pulmonary cell uptake of lipid-based nanoparticles
Subramaniam, S., Joyce, P., Donnellan, L., Young, C., Wignall, A. D., Hoffmann, P., & Prestidge, C. A. (2023) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2023.03.048 · Cited by 48 · see citing works
Ruyra, À., Cano‐Sarabia, M., MacKenzie, S. A., Maspoch, D., & Roher, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076338 · Cited by 48 · see citing works
Lonez, C., Irvine, K. L., Pizzuto, M., Schmidt, B. I., Gay, N. J., Ruysschaert, J., Gangloff, M., & Bryant, C. E. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1915-1 · Cited by 46 · see citing works
Self-citationCationic Nanoparticle-Based Cancer Vaccines
Heuts, J., Jiskoot, W., OSSENDORP, F. A., & van der Maaden, K. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13050596 · Cited by 46 · see citing works
Wong, P. T., Leroueil, P. R., Smith, D. M., Ciotti, S., Bielinska, A. U., Janczak, K. W., Mullen, C. H., Groom, J. V., Taylor, E. M., Passmore, C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126120 · Cited by 46 · see citing works
Nanoparticle Platforms for Antigen-Specific Immune Tolerance
Thorp, E. B., Boada, C., Jarbath, C., & Luo, X. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00945 · Cited by 45 · see citing works
Nanoparticles as multifunctional devices for the topical treatment of cutaneous leishmaniasis
Moreno, E., Schwartz, J., Fernández-Rubio, C., Sanmartín, C., Nguewa, P., Irache, J. M., & Espuelas, S. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.885500 · Cited by 45 · see citing works
COVID-19 mRNA Vaccines: The Molecular Basis of Some Adverse Events
Giannotta, G., Murrone, A., & Giannotta, N. (2023) · Vaccines · doi:10.3390/vaccines11040747 · Cited by 43 · see citing works
Huggins, C., Pearce, S. W. A., Peri, F., Neumann, F., COCKERILL, G. W., & Pirianov, G. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.08.010 · Cited by 45 · see citing works
Decationized crosslinked polyplexes for redox-triggered gene delivery
Novo, L., van Gaal, E. V. B., Mastrobattista, E., van Nostrum, C. F., & Hennink, W. E. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.03.035 · Cited by 44 · see citing works
Lu, T., Hu, F., Yue, H., Yang, T., & Ma, G. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.02.039 · Cited by 44 · see citing works
Novo, L., Rizzo, L. Y., Golombek, S. K., Dakwar, G. R., Lou, B., Remaut, K., Mastrobattista, E., van Nostrum, C. F., Jahnen‐Dechent, W., Kiessling, F. M., et al. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.08.028 · Cited by 43 · see citing works
Regulation of vascular smooth muscle cell autophagy by DNA nanotube-conjugated mTOR siRNA
You, Z., Qian, H., Wang, C., He, B., Yan, J., Mao, C., & Wang, G. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.07.015 · Cited by 42 · see citing works
Rohde, C. M., Lindemann, C., Giovanelli, M. A., Sellers, R. S., Diekmann, J., Choudhary, S., Ramaiah, L., Vogel, A. B., Chervona, Y., Muik, A., et al. (2023) · Vaccines · doi:10.3390/vaccines11020417 · Cited by 44 · see citing works
de Groot, A. M., Thanki, K., Gangloff, M., Falkenberg, E., Zeng, X., Bijnen, D. C. J. V., van Eden, W., Franzyk, H., Nielsen, H. M., Broere, F., et al. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.02.003 · Cited by 42 · see citing works
Strong Immune Responses Induced by Direct Local Injections of Modified mRNA-Lipid Nanocomplexes
Arya, S., Lin, Q., Zhou, N., Gao, X., & Huang, J.-D. (2020) · Molecular Therapy - Nucleic Acids · doi:10.1016/j.omtn.2019.12.044 · Cited by 39 · see citing works
Molecular simplification of lipid A structure: TLR4-modulating cationic and anionic amphiphiles
Calabrese, V., Cighetti, R., & Peri, F. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.05.011 · Cited by 37 · see citing works
Vhora, I., Lalani, R., Bhatt, P., Patil, S., Patel, H., Patel, V., & Misra, A. R. (2018) · AAPS PharmSciTech · doi:10.1208/s12249-018-1161-6 · Cited by 37 · see citing works
Is the oral microbiome a source to enhance mucosal immunity against infectious diseases?
Zenobia, C., Herpoldt, K., & Freire, M. (2021) · npj Vaccines · doi:10.1038/s41541-021-00341-4 · Cited by 37 · see citing works
Fraix, A., Gall, T. L., Berchel, M., Denis, C., Lehn, P., Montier, T., & Jaffrès, P. (2013) · Organic & Biomolecular Chemistry · doi:10.1039/c3ob27261c · Cited by 36 · see citing works
Ando, H., Kobayashi, S., Lila, A. S. A., Eldin, N. E., Kato, C., Shimizu, T., Ukawa, M., Kawazoe, K., & Ishida, T. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.10.019 · Cited by 36 · see citing works
Nonviral Gene Delivery with Dendritic Self-Assembling Architectures
Tschiche, A., Malhotra, S., & Haag, R. (2014) · Nanomedicine · doi:10.2217/nnm.14.32 · Cited by 34 · see citing works
Yuba, E. (2016) · Polymer Journal · doi:10.1038/pj.2016.31 · Cited by 34 · see citing works
Cationic Nanostructures for Vaccines Design
Carmona‐Ribeiro, A. M., & Pérez-Betancourt, Y. (2020) · Biomimetics · doi:10.3390/biomimetics5030032 · Cited by 33 · see citing works
Li, T., He, J., Horvath, G. L., Próchnicki, T., Latz, E., & Takeoka, S. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.10.011 · Cited by 34 · see citing works
Dual Approaches in Oncology: The Promise of siRNA and Chemotherapy Combinations in Cancer Therapies
Sousa, C., & Videira, M. (2025) · Onco · doi:10.3390/onco5010002 · Cited by 34 · see citing works
The Current Landscape of mRNA Vaccines Against Viruses and Cancer–A Mini Review
Ladak, R. J., He, A. J., Huang, Y.-H., & Ding, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.885371 · Cited by 33 · see citing works
Subharat, S., Shu, D., Zheng, T., Buddle, B. M., Kaneko, K., Hook, S., Janssen, P. H., & Wedlock, D. N. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159861 · Cited by 32 · see citing works
Rodríguez-Lavado, J., Sestito, S. E., Cighetti, R., Moncayo, E. M. A., Oblak, A., Lainšček, D., Blanco, J. L. J., Fernández, J. M. G., Mellet, C. O., Jerala, R., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm501182w · Cited by 32 · see citing works
Hwang, T., Hsu, C., Aljuffali, I. A., Chen, C.-H., Chang, Y.-T., & Fang, J. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.02.022 · Cited by 32 · see citing works
Liposomal celecoxib combined with dendritic cell therapy enhances antitumor efficacy in melanoma
Jahani, V., Yazdani, M., Badiee, A., Jaafari, M. R., & Arabi, L. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.01.034 · Cited by 31 · see citing works
Călina, D. C., Hernández, A. F., Härtung, T., Egorov, A. M., Izotov, B. N., Νikolouzakis, Τ. Κ., Tsatsakis, A. M., Vlachoyiannopoulos, P. G., & Docea, A. O. (2021) · Life · doi:10.3390/life11090907 · Cited by 31 · see citing works
Self-assembled triangular DNA nanoparticles are an efficient system for gene delivery
Wang, Y., You, Z., Du, J., Li, H., Chen, H., Li, J., Dong, W., He, B., Mao, C., & Wang, G. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.038 · Cited by 30 · see citing works
- Authors
- Lonez, C., Vandenbranden, M., & Ruysschaert, J.-M.
- Affiliations
- Université Libre de Bruxelles (BE)
- Corresponding author
- Lonez, Caroline
- ORCID
- Lonez, Caroline
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 64
- Issue
- 15
- Pages
- 1749-1758
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2055351480
- Cited by
- 221
- References
- 92
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 20 · 2023: 18 · 2022: 21 · 2021: 21 · 2020: 14 · 2019: 10 · 2018: 11 · 2017: 14 · 2016: 16 · 2015: 20 · 2014: 19 · 2013: 12 · 2012: 4
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- cationic liposomes, cationic lipids, intracellular signaling, apoptosis, inflammation, liposome transfection, vaccine adjuvants, gene delivery, lipid structure
- MeSH terms
- Adjuvants, Immunologic, Animals, Antigens, Cations, Humans, Inflammation, Lipids, Liposomes, Transfection, Vaccines, Drug Design, Signal Transduction, Apoptosis
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