Cited by 222RNA Interference and Gene DeliveryImmune Response and InflammationNanoparticle-Based Drug Delivery

Cationic lipids activate intracellular signaling pathways

Lonez, Caroline, Vandenbranden, Michel, Ruysschaert, Jean-Marie·2012·Advanced Drug Delivery Reviews

Abstract

Cationic liposomes are commonly used as a transfection reagent for DNA, RNA or proteins and as a co-adjuvant of antigens for vaccination trials. A high density of positive charges close to cell surface is likely to be recognized as a signal of danger by cells or contribute to trigger cascades that are classically activated by endogenous cationic compounds. The present review provides evidence that cationic liposomes activate several cellular pathways like pro-apoptotic and pro-inflammatory cascades. An improved knowledge of the relationship between the cationic lipid properties (nature of the lipid hydrophilic moieties, hydrocarbon tail, mode of organization) and the activation of these pathways opens the way to the use and design of cationic tailored for a specific application (e.g. for gene transport or as adjuvants).

Integrity signals

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Crossref · 10.1016/j.addr.2012.05.009

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  • Cationic lipids have been associated with activation of several cellular pathways such as pro-apoptotic and pro-inflammatory cascades.

    “Cationic lipids have been associated with the activation of several cellular pathways like pro-apoptotic and pro-inflammatory cascades [65]”

    From The dawn of mRNA vaccines: the COVID-19 case (2021) · cites this paper as [65]

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Authors
Lonez, C., Vandenbranden, M., & Ruysschaert, J.-M.
Affiliations
Université Libre de Bruxelles (BE)
Corresponding author
Lonez, Caroline
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2012-12
Volume
64
Issue
15
Pages
1749-1758
ISSN
0169-409X (ISSN-L)
OpenAlex
W2055351480
Cited by
221
References
92
Citations by year
2026: 7 · 2025: 13 · 2024: 20 · 2023: 18 · 2022: 21 · 2021: 21 · 2020: 14 · 2019: 10 · 2018: 11 · 2017: 14 · 2016: 16 · 2015: 20 · 2014: 19 · 2013: 12 · 2012: 4
FWCI
1.60
Type
journal article
Language
en
Open access
closed
Locations
  • Advanced Drug Delivery Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
cationic liposomes, cationic lipids, intracellular signaling, apoptosis, inflammation, liposome transfection, vaccine adjuvants, gene delivery, lipid structure
MeSH terms
Adjuvants, Immunologic, Animals, Antigens, Cations, Humans, Inflammation, Lipids, Liposomes, Transfection, Vaccines, Drug Design, Signal Transduction, Apoptosis

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