Cited by 258Extracellular vesicles in diseaseNanoparticle-Based Drug DeliveryRNA Interference and Gene Delivery

The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.

Approaches to surface engineering of extracellular vesicles

Open access

Richter, Maximilian, Vader, Pieter, Fuhrmann, Gregor·2021·Advanced Drug Delivery Reviews

DOI 10.1016/j.addr.2021.03.020

Open this paper in CoChat — free account

Abstract

Extracellular vesicles (EVs) are cell-derived nanoparticles that are important mediators in intercellular communication. This function makes them auspicious candidates for therapeutic and drug-delivery applications. Among EVs, mammalian cell derived EVs and outer membrane vesicles (OMVs) produced by gram-negative bacteria are the most investigated candidates for pharmaceutical applications. To further optimize their performance and to utilize their natural abilities, researchers have strived to equip EVs with new moieties on their surface while preserving the integrity of the vesicles. The aim of this review is to give a comprehensive overview of techniques that can be used to introduce these moieties to the vesicle surface. Approaches can be classified in regards to whether they take place before or after the isolation of EVs. The producing cells can be subjected to genetic manipulation or metabolic engineering to produce surface modified vesicles or EVs are engineered after their isolation by physical or chemical means. Here, the advantages and disadvantages of these processes and their applicability for the development of EVs as therapeutic agents are discussed.

Integrity signals

Registry

Crossref · 10.1016/j.addr.2021.03.020

Cites

109 of 109 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Shedding light on the cell biology of extracellular vesicles
van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369
Biological properties of extracellular vesicles and their physiological functions
Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930
PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
Suk, J. S., Xu, Q., Kim, N., Hanes, J., & Ensign, L. M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.09.012 · Cited by 4,523
Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication
Mathieu, M., Jaular, L. M., Lavieu, G., & Théry, C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0250-9 · Cited by 3,863
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715
Current knowledge on exosome biogenesis and release
Hessvik, N. P., & Llorente, A. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2595-9 · Cited by 2,362
Progress in Exosome Isolation Techniques
Li, P., Kaslan, M., Lee, S. H., Yao, J. D., & Gao, Z. (2017) · Theranostics · doi:10.7150/thno.18133 · Cited by 2,019
Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions
Schwechheimer, C., & Kuehn, M. J. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3525 · Cited by 2,009
Exosomes as drug delivery vehicles for Parkinson’s disease therapy
Haney, M. J., Klyachko, N. L., Zhao, Y., Gupta, R., Plotnikova, E. G., He, Z., Patel, T., Piroyan, A., Sokolsky, M., Kabanov, A. V., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.033 · Cited by 2,009
Optimized exosome isolation protocol for cell culture supernatant and human plasma
Lobb, R. J., Becker, M., Wen, S., Wong, C. S. F., Wiegmans, A. P., Leimgruber, A., & Möller, A. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27031 · Cited by 1,763
Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting
Wiklander, O. P. B., Nordin, J. Z., O'Loughlin, A., Gustafsson, Y., Corso, G., Mäger, I., Vader, P., Lee, Y., Sork, H., Seow, Y., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.26316 · Cited by 1,730
Self-citation
Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells
Ohno, S.-I., Takanashi, M., Sudo, K., Ueda, S., Ishikawa, A., Matsuyama, N., Fujita, K., Mizutani, T., Ohgi, T., Ochiya, T., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2012.180 · Cited by 1,666
Biological Functions and Biogenesis of Secreted Bacterial Outer Membrane Vesicles
Kulp, A., & Kuehn, M. J. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.091208.073413 · Cited by 1,540
Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi
Brown, L. C., Wolf, J. M., Prados‐Rosales, R., & Casadevall, A. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3480 · Cited by 1,412
Extracellular vesicles as drug delivery systems: Why and how?
Elsharkasy, O. M., Nordin, J. Z., Hagey, D. W., de Jong, O. G., Schiffelers, R. M., Andaloussi, S. E., & Vader, P. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.04.004 · Cited by 1,235
Self-citation
Single‐step isolation of extracellular vesicles by size‐exclusion chromatography
Böing, A. N., van der Pol, E., Grootemaat, A. E., Coumans, F. A. W., Sturk, A., & Nieuwland, R. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.23430 · Cited by 1,228
Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy
Tian, T., Zhang, H.-X., He, C.-P., Fan, S., Zhu, Y.-L., Qi, C., Huang, N.-P., Xiao, Z.-D., Lu, Z.-H., Tannous, B. A., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2017.10.012 · Cited by 1,154
Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey
Gardiner, C., Vizio, D. D., Sahoo, S., Théry, C., Witwer, K. W., Wauben, M. H. M., & Hill, A. F. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.32945 · Cited by 1,113
Advances in therapeutic applications of extracellular vesicles
Wiklander, O. P. B., Brennan, M. Á., Lötvall, J., Breakefield, X. O., & EL Andaloussi, S. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aav8521 · Cited by 1,039
Mechanism of hard-nanomaterial clearance by the liver
Tsoi, K. M., MacParland, S. A., Ma, X., Spetzler, V. N., Echeverri, J. A., Ouyang, B., Fadel, S. M., Sykes, E. A., Goldaracena, N., Kaths, J. M., et al. (2016) · Nature Materials · doi:10.1038/nmat4718 · Cited by 1,035
Minimal "Self" Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles
Rodriguez, P. L., Harada, T., Christian, D. A., Pantano, D. A., Tsai, R. K., & Discher, D. E. (2013) · Science · doi:10.1126/science.1229568 · Cited by 1,001
The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling
Deun, J. V., Mestdagh, P., Sormunen, R. T., Cocquyt, V., Vermaelen, K., Vandesompele, J., Bracke, M., Wever, O. D., & Hendrix, A. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24858 · Cited by 987
A Review of Exosomal Isolation Methods: Is Size Exclusion Chromatography the Best Option?
Sidhom, K., Obi, P. O., & Saleem, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186466 · Cited by 940
Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter
Lai, C. P., Mardini, O., Ericsson, M., Prabhakar, S., Maguire, C. A., Chen, J. W., Tannous, B. A., & Breakefield, X. O. (2014) · ACS Nano · doi:10.1021/nn404945r · Cited by 913
Membrane vesicles traffic signals and facilitate group activities in a prokaryote
Mashburn, L. M., & Whiteley, M. (2005) · Nature · doi:10.1038/nature03925 · Cited by 844
Membrane Vesicle Release in Bacteria, Eukaryotes, and Archaea: a Conserved yet Underappreciated Aspect of Microbial Life
Deatherage, B. L., & Cookson, B. T. (2012) · Infection and Immunity · doi:10.1128/iai.06014-11 · Cited by 765
Engineering hybrid exosomes by membrane fusion with liposomes
Sato, Y. T., Umezaki, K., Sawada, S., Mukai, S.-A., Sasaki, Y., Harada, N., Shiku, H., & Akiyoshi, K. (2016) · Scientific Reports · doi:10.1038/srep21933 · Cited by 744
Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection
Takahashi, Y., Nishikawa, M., Shinotsuka, H., Matsui, Y., Ohara, S., Imai, T., & Takakura, Y. (2013) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2013.03.013 · Cited by 743
Biodistribution and delivery efficiency of unmodified tumor-derived exosomes
Smyth, T., Kullberg, M., Malik, N., Smith-Jones, P. M., Graner, M. W., & Anchordoquy, T. J. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.12.013 · Cited by 738
Copper-free click chemistry in living animals
Chang, P. V., Prescher, J. A., Sletten, E. M., Baskin, J. M., Miller, I. A., Agard, N. J., Lo, A., & Bertozzi, C. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911116107 · Cited by 673
Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles
Kooijmans, S. A. A., Stremersch, S., Braeckmans, K., de Smedt, S. C., Hendrix, A., Wood, M. J. A., Schiffelers, R. M., Raemdonck, K., & Vader, P. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.08.014 · Cited by 663
Self-citation
PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time
Kooijmans, S. A. A., Fliervoet, L. A. L., van der Meel, R., Fens, M. H. A. M., Heijnen, H. F. G., Henegouwen, P. M. P. V. B. E., Vader, P., & Schiffelers, R. M. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.009 · Cited by 645
Self-citation
Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response
Kim, O. Y., Park, H. T., Dinh, N. T. H., Choi, S. J., Lee, J., Kim, J. H., Lee, S.-W., & Gho, Y. S. (2017) · Nature Communications · doi:10.1038/s41467-017-00729-8 · Cited by 616
High‐speed centrifugation induces aggregation of extracellular vesicles
Linares, R., Tan, S., Gounou, C., Arraud, N., & Brisson, A. R. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.29509 · Cited by 601
Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes
Katsuda, T., Tsuchiya, R., Kosaka, N., Yoshioka, Y., Takagaki, K., Oki, K., Takeshita, F., Sakai, Y., Kuroda, M., & Ochiya, T. (2013) · Scientific Reports · doi:10.1038/srep01197 · Cited by 579
Bioorthogonal Reactions for Labeling Proteins
Lang, K., & Chin, J. W. (2014) · ACS Chemical Biology · doi:10.1021/cb4009292 · Cited by 566
Surface Functionalization of Exosomes Using Click Chemistry
Smyth, T., Petrova, K., Payton, N. M., Persaud, I., Redzic, J. S., Graner, M. W., Smith-Jones, P., & Anchordoquy, T. J. (2014) · Bioconjugate Chemistry · doi:10.1021/bc500291r · Cited by 532
A novel affinity-based method for the isolation of highly purified extracellular vesicles
Nakai, W., Yoshida, T., Díez, D., Miyatake, Y., Nishibu, T., Imawaka, N., Naruse, K., Sadamura, Y., & Hanayama, R. (2016) · Scientific Reports · doi:10.1038/srep33935 · Cited by 504
Exosome-mediated delivery of hydrophobically modified siRNA for huntingtin mRNA silencing
Didiot, M.-C., Hall, L. M., Coles, A. H., Haraszti, R. A., Godinho, B. M., Chase, K., Sapp, E., Ly, S., Alterman, J. F., Hassler, M. R., et al. (2016) · Molecular Therapy · doi:10.1038/mt.2016.126 · Cited by 483
Modification of Extracellular Vesicles by Fusion with Liposomes for the Design of Personalized Biogenic Drug Delivery Systems
Piffoux, M., Silva, A., Wilhelm, C., Gazeau, F., & Tareste, D. C. (2018) · ACS Nano · doi:10.1021/acsnano.8b02053 · Cited by 474
Display of GPI‐anchored anti‐EGFR nanobodies on extracellular vesicles promotes tumour cell targeting
Kooijmans, S. A. A., Gomez‐Aleza, C., Roffler, S. R., van Solinge, W. W., Vader, P., & Schiffelers, R. M. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.31053 · Cited by 447
Self-citation
Acute Inflammatory Response to Endotoxin in Mice and Humans
Copeland, S., Warren, H. S., Lowry, S. F., Calvano, S. E., & Remick, D. G. (2005) · Clinical and Vaccine Immunology · doi:10.1128/cdli.12.1.60-67.2005 · Cited by 427
Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy
Gao, X., Ran, N., Dong, X., Zuo, B., Yang, R., Zhou, Q., Moulton, H. M., Seow, Y., & Yin, H. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat0195 · Cited by 426
Outer membrane vesicles as platform vaccine technology
van der Pol, L., Stork, M., & van der Ley, P. (2015) · Biotechnology Journal · doi:10.1002/biot.201400395 · Cited by 394
Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells
Lindenbergh, M. F. S., & Stoorvogel, W. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055700 · Cited by 379
Stabilization of Exosome-targeting Peptides via Engineered Glycosylation
Hung, M. E., & Leonard, J. N. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.621383 · Cited by 368
Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth
Bellavia, D., Raimondo, S., Calabrese, G., Forte, S., Cristaldi, M., Patinella, A., Memeo, L., Manno, M., Raccosta, S., Diana, P., et al. (2017) · Theranostics · doi:10.7150/thno.17092 · Cited by 368
PKH26 labeling of extracellular vesicles: Characterization and cellular internalization of contaminating PKH26 nanoparticles
Dominkuš, P. P., Stenovec, M., Sitar, S., Lasič, E., Zorec, R., Plemenitaš, A., Žagar, E., Kreft, M., & Lenassi, M. (2018) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2018.03.013 · Cited by 364
Extracellular Vesicles—Connecting Kingdoms
Woith, E., Fuhrmann, G., & Melzig, M. F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225695 · Cited by 341
Self-citation
Insertion of poly(ethylene glycol) derivatized phospholipid into pre‐formed liposomes results in prolonged in vivo circulation time
Uster, P. S., Allen, T. M., Daniel, B. E., Mendez, C. J., Newman, M. S., & Zhu, G. Z. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00452-8 · Cited by 298
Reprogramming Exosomes as Nanoscale Controllers of Cellular Immunity
Cheng, Q., Shi, X., Han, M., Smbatyan, G., Lenz, H., & Zhang, Y. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b10047 · Cited by 294
Targeting Tumor Antigens to Secreted Membrane Vesicles In vivo Induces Efficient Antitumor Immune Responses
Zeelenberg, I. S., Ostrowski, M., Krumeich, S., Bobrie, A., Jancic, C. C., Boissonnas, A., Delcayre, A. X., Pecq, J. L., Combadière, B., Amigorena, S., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-3163 · Cited by 286
Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets
Szabó, G., & Momen‐Heravi, F. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.71 · Cited by 286
Quantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice
Morishita, M., Takahashi, Y., Nishikawa, M., Sano, K., Kato, K., Yamashita, T., Imai, T., Saji, H., & Takakura, Y. (2014) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24251 · Cited by 285
Aptamer-Conjugated Extracellular Nanovesicles for Targeted Drug Delivery
Wan, Y., Wang, L., Zhu, C., Zheng, Q., Wang, G., Tong, J., Fang, Y., Xia, Y., Cheng, G., He, X., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-2880 · Cited by 261
Isolation of High-Purity Extracellular Vesicles by the Combination of Iodixanol Density Gradient Ultracentrifugation and Bind-Elute Chromatography From Blood Plasma
Onódi, Z., Pelyhe, C., Nagy, C. T., Brenner, G. B., Almási, L., Kittel, Á., Manček‐Keber, M., Ferdinandy, P., Buzás, E. I., & Giricz, Z. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01479 · Cited by 255
Regulation of Postsynaptic Retrograde Signaling by Presynaptic Exosome Release
Korkut, C., Li, Y., Koles, K., Brewer, C., Ashley, J., Yoshihara, M., & Budnik, V. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.013 · Cited by 250
Membrane Vesicle Formation as a Multiple-Stress Response Mechanism Enhances Pseudomonas putida DOT-T1E Cell Surface Hydrophobicity and Biofilm Formation
Baumgarten, T., Sperling, S., Seifert, J., von Bergen�, M., Steiniger, F., Wick, L. Y., & Heipieper, H. J. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.01525-12 · Cited by 250
Confounding factors in vesicle uptake studies using fluorescent lipophilic membrane dyes
Takov, K., Yellon, D. M., & Davidson, S. M. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1388731 · Cited by 248
Exosomes Engineered to Express a Cardiomyocyte Binding Peptide Demonstrate Improved Cardiac Retention in Vivo
Mentkowski, K. I., & Lang, J. K. (2019) · Scientific Reports · doi:10.1038/s41598-019-46407-1 · Cited by 244
Intestinal Anti-inflammatory Effects of Outer Membrane Vesicles from Escherichia coli Nissle 1917 in DSS-Experimental Colitis in Mice
Fábrega, M.-J., Rodríguez-Nogales, A., Garrido-Mesa, J., Algieri, F., Badía, J., Giménez, R., Gálvez, J., & Baldomà, L. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01274 · Cited by 240
Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer’s and Parkinson’s Disease
Vella, L. J., Hill, A. F., & Cheng, L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020173 · Cited by 238
New insights into extracellular vesicle biogenesis and function
Latifkar, A., Hur, Y. H., Sanchez, J. C., Cerione, R. A., & Antonyak, M. A. (2019) · Journal of Cell Science · doi:10.1242/jcs.222406 · Cited by 230
Modification of Lipid A Biosynthesis in Neisseria meningitidis lpxL Mutants: Influence on Lipopolysaccharide Structure, Toxicity, and Adjuvant Activity
van der Ley, P., Steeghs, L., Hamstra, H.-J., ten Hove, J., Zomer, B., & van Alphen, L. (2001) · Infection and Immunity · doi:10.1128/iai.69.10.5981-5990.2001 · Cited by 215
Aptamer-Functionalized Exosomes: Elucidating the Cellular Uptake Mechanism and the Potential for Cancer-Targeted Chemotherapy
Zou, J., Shi, M., Liu, X., Jin, C. Y., Xing, X., Qiu, L., & Tan, W. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.8b05204 · Cited by 215
Development of exosome surface display technology in living human cells
Stickney, Z., Losacco, J., McDevitt, S., Zhang, Z., & Lü, B. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.02.058 · Cited by 209
The application of exosomes as a nanoscale cancer vaccine
Seifalian, A. M. (2010) · International Journal of Nanomedicine · doi:10.2147/ijn.s13402 · Cited by 206
Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles
O’Loughlin, A. J., Mäger, I., de Jong, O. G., Varela, M. A., Schiffelers, R. M., Andaloussi, S. E., Wood, M. J. A., & Vader, P. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.03.021 · Cited by 200
Self-citation
TRAIL delivery by MSC‐derived extracellular vesicles is an effective anticancer therapy
Yuan, Z., Kolluri, K. K., Gowers, K. H. C., & Janes, S. M. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1265291 · Cited by 197
Increasing vaccine potency through exosome antigen targeting
Hartman, Z. C., Wei, J., Glass, O. K., Guo, H., Lei, G., Yang, X.-Y., Osada, T., Hobeika, A., Delcayre, A., Le Pecq, J.-B., et al. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.09.133 · Cited by 196
Augmented liver targeting of exosomes by surface modification with cationized pullulan
Tamura, R., Üemoto, S., & Tabata, Y. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.05.013 · Cited by 190
Therapeutic and diagnostic applications of extracellular vesicles
Stremersch, S., Smedt, S. C. D., & Raemdonck, K. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.07.054 · Cited by 189
Systematic characterization of extracellular vesicle sorting domains and quantification at the single molecule – single vesicle level by fluorescence correlation spectroscopy and single particle imaging
Corso, G., Heusermann, W., Trojer, D., Görgens, A., Steib, E., Voshol, J., Graff, A., Genoud, C., Lee, Y., Hean, J., et al. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1663043 · Cited by 180
Integrating Protein Engineering and Bioorthogonal Click Conjugation for Extracellular Vesicle Modulation and Intracellular Delivery
Wang, M., Altınoglu, S., Takeda, Y. S., & Xu, Q. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141860 · Cited by 171
The roles of extracellular vesicles in cancer biology: Toward the development of novel cancer biomarkers
Katsuda, T., Kosaka, N., & Ochiya, T. (2013) · PROTEOMICS · doi:10.1002/pmic.201300389 · Cited by 171
Recombinant phosphatidylserine-binding nanobodies for targeting of extracellular vesicles to tumor cells: a plug-and-play approach
Kooijmans, S. A. A., Gitz-Francois, J. J., Schiffelers, R. M., & Vader, P. (2018) · Nanoscale · doi:10.1039/c7nr06966a · Cited by 169
Self-citation
Clinical potential of mesenchymal stem/stromal cell-derived extracellular vesicles
Giebel, B., Kordelas, L., & Börger, V. (2017) · Stem Cell Investigation · doi:10.21037/sci.2017.09.06 · Cited by 161
Cellular Engineering with Membrane Fusogenic Liposomes to Produce Functionalized Extracellular Vesicles
Lee, J., Lee, H., Goh, U., Kim, J., Jeong, M., Lee, J. Y. H., & Park, J. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b01315 · Cited by 154
Pitfalls associated with lipophilic fluorophore staining of extracellular vesicles for uptake studies
Simonsen, J. B. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1582237 · Cited by 152
Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs
Stremersch, S., Vandenbroucke, R. E., Wonterghem, E. V., Hendrix, A., Smedt, S. C. D., & Raemdonck, K. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.04.005 · Cited by 147
Membrane Radiolabelling of Exosomes for Comparative Biodistribution Analysis in Immunocompetent and Immunodeficient Mice - A Novel and Universal Approach
Faruqu, F. N., Wang, J. T.-W., Xu, L., McNickle, L., Chong, E. M.-Y., Walters, A. A., Gurney, M., Clayton, A., Smyth, L. A., Hider, R. C., et al. (2019) · Theranostics · doi:10.7150/thno.27891 · Cited by 146
Exosomes Mediate Epithelium–Mesenchyme Crosstalk in Organ Development
Jiang, N., Xiang, L., He, L., Yang, G., Zheng, J., Wang, C., Zhang, Y., Wang, S., Zhou, Y., Sheu, T.-J., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b01087 · Cited by 142
Exosomes as a novel way of interneuronal communication
Chivet, M., Javalet, C., Hemming, F. J., Pernet‐Gallay, K., Laulagnier, K., Fraboulet, S., & Sadoul, R. (2013) · Biochemical Society Transactions · doi:10.1042/bst20120266 · Cited by 141
Recombinant M2e outer membrane vesicle vaccines protect against lethal influenza A challenge in BALB/c mice
Rappazzo, C. G., Watkins, H. C., Guarino, C., Chau, A., Lopez, J. L., DeLisa, M. P., Leifer, C. A., Whittaker, G. R., & Putnam, D. A. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.01.028 · Cited by 141
Systematic review of targeted extracellular vesicles for drug delivery – Considerations on methodological and biological heterogeneity
Gudbergsson, J. M., Jønsson, K., Simonsen, J. B., & Johnsen, K. B. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.06.006 · Cited by 139
Factors influencing the retention and chemical stability of poly(ethylene glycol)-lipid conjugates incorporated into large unilamellar vesicles
Parr, M. J., Ansell, S. M., Choi, L. S. L., & Cullis, P. R. (1994) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(94)90004-3 · Cited by 134
The Therapeutic Benefit of Bacterial Membrane Vesicles
Bitto, N. J., & Kaparakis‐Liaskos, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061287 · Cited by 133
Biocompatible bacteria-derived vesicles show inherent antimicrobial activity
Schulz, E., Goes, A., Garcia, R., Panter, F., Koch, M., Müller, R., Fuhrmann, K., & Fuhrmann, G. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.09.030 · Cited by 133
Self-citation
Employing Escherichia coli-derived outer membrane vesicles as an antigen delivery platform elicits protective immunity against Acinetobacter baumannii infection
Huang, W., Wang, S., Yao, Y., Xia, Y., Xu, Y., Li, K., Sun, P., Liu, C., Sun, W., Bai, H., et al. (2016) · Scientific Reports · doi:10.1038/srep37242 · Cited by 130
Liposome triggering of innate immune responses: A perspective on benefits and adverse reactions
Szebeni, J., & Moghimi, S. M. (2009) · Journal of Liposome Research · doi:10.1080/08982100902792855 · Cited by 128
Structural modifications of outer membrane vesicles to refine them as vaccine delivery vehicles
Kim, S., Kim, K. S., Lee, S., Kim, E., Kim, M.-S., Lee, E., Gho, Y. S., Kim, J.-W., Bishop, R. E., & Chang, K. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2009.08.001 · Cited by 121
Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles
Gupta, D., Wiklander, O. P. B., Görgens, A., Conceição, M., Corso, G., Liang, X., Seow, Y., Balusu, S., Feldin, U., Bostancıoğlu, R. B., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00792-z · Cited by 119
Mannose‐Modified Serum Exosomes for the Elevated Uptake to Murine Dendritic Cells and Lymphatic Accumulation
Choi, E. S., Song, J., Kang, Y. Y., & Mok, H. (2019) · Macromolecular Bioscience · doi:10.1002/mabi.201900042 · Cited by 112
The Role of Cancer-Derived Exosomes in Tumorigenicity & Epithelial-to-Mesenchymal Transition
Blackwell, R. H., Foreman, K. E., & Gupta, G. N. (2017) · Cancers · doi:10.3390/cancers9080105 · Cited by 84
General Approach to Engineering Extracellular Vesicles for Biomedical Analysis
Di, H., Zeng, E., Zhang, P., Liu, X., Zhang, C., Yang, J. A., & Liu, D. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b02268 · Cited by 82
Annexin I-mediated vesicular aggregation: mechanism and role in human neutrophils
Meers, P. R., Mealy, T. R., Pavlotsky, N., & Tauber, A. I. (1992) · Biochemistry · doi:10.1021/bi00143a003 · Cited by 80
Next-generation outer membrane vesicle vaccines againstNeisseria meningitidisbased on nontoxic LPS mutants
van der Ley, P., & van den Dobbelsteen, G. (2011) · Human Vaccines · doi:10.4161/hv.7.8.16086 · Cited by 75
Adjuvant effect of bacterial outer membrane vesicles with penta-acylated lipopolysaccharide on antigen-specific T cell priming
Lee, D. H., Kim, S., Kang, W., Choi, Y. S., Lee, S. H., Lee, S., You, S., Lee, H. K., Chang, K.-T., & Shin, E. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.08.102 · Cited by 74
Quantum Dot Labeling and Visualization of Extracellular Vesicles
Zhang, M., Vojtech, L. N., Ye, Z., Hladik, F., & Nance, E. A. (2020) · ACS Applied Nano Materials · doi:10.1021/acsanm.0c01553 · Cited by 63
Extracellular vesicles expressing a single-chain variable fragment of an HIV-1 specific antibody selectively target Env+ tissues
Zou, X., Yuan, M., Zhang, T., Wei, H., Xu, S., Jiang, N., Zheng, N., & Wu, Z. (2019) · Theranostics · doi:10.7150/thno.33925 · Cited by 63
Myxobacteria-Derived Outer Membrane Vesicles: Potential Applicability Against Intracellular Infections
Goes, A., Lapuhs, P., Kuhn, T., Schulz, E., Richter, R., Panter, F., Dahlem, C., Koch, M., Garcia, R., Kiemer, A. K., et al. (2020) · Cells · doi:10.3390/cells9010194 · Cited by 47
Self-citation
Extracellular Vesicles as Therapeutic Agents for Cardiac Fibrosis
Rogers, R. G., Ciullo, A., Marbán, E., & Ibrahim, A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00479 · Cited by 41
Induced fusion and aggregation of bacterial outer membrane vesicles: Experimental and theoretical analysis
Gnopo, Y. M. D., Misra, A., Hsu, H.-L., DeLisa, M. P., Daniel, S., & Putnam, D. A. (2020) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2020.04.068 · Cited by 38
Within-species variation in OMV cargo proteins: the Myxococcus xanthus OMV pan-proteome
Zwarycz, A. S., Livingstone, P. G., & Whitworth, D. E. (2020) · Molecular Omics · doi:10.1039/d0mo00027b · Cited by 38
Tresylated PEG-sterols for coupling of proteins to preformed plain or PEGylated liposomes
Steenpaß, T., Lung, A., & Schubert, R. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.12.010 · Cited by 30
Hemifusion in Synaptic Vesicle Cycle
Kweon, D., Kong, B., & Shin, Y. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00065 · Cited by 29
Neisseria meningitidis Native Outer Membrane Vesicles Containing Different Lipopolysaccharide Glycoforms as Adjuvants for Meningococcal and Nonmeningococcal Antigens
Nagaputra, J. C., Rollier, C. S., Sadarangani, M., Hoe, J. C., Mehta, O. H., Norheim, G., Saleem, M. S., Chan, H., Derrick, J. P., Feavers, I. M., et al. (2013) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00561-13 · Cited by 27
Insertion stability of poly(ethylene glycol)-cholesteryl-based lipid anchors in liposome membranes
Molnar, D., Linders, J., Mayer, C., & Schubert, R. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.03.023 · Cited by 23

Flagged first, then by citations

Research works printed but not linked: 1

D. Gupta, O.P.B. Wiklander, A. Görgens, M. Conceição, G. Corso, X. Liang, Y. Seow, S. Balsu, U. Felldin, B. Bostancioglu, Y.X. Fiona Lee, J. Hean, I. Mäger, T.C. Roberts, M. Gustafsson, D.K. Mohammad, H. Sork, A. Bäcklund, C.I. Edvard Smith, M.J.A. Wood, R. Vandenbroucke, J.Z. Nordin, S.E.L. Andaloussi, Engineering of extracellular vesicles for display of protein biotherapeutics, bioRxiv, (2020) 2020.2006.2014.149823. · DOI

Sorted by citations

Immunogenicity of Extracellular Vesicles
Xia, Y., Zhang, J., Liu, G., & Wolfram, J. (2024) · Advanced Materials · doi:10.1002/adma.202403199 · Cited by 274
Engineered Exosome for Drug Delivery: Recent Development and Clinical Applications
Tian, J., Han, Z., Song, D., Peng, Y., Xiong, M., Chen, Z., Duan, S., & Zhang, L. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s444582 · Cited by 246
Development of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities
Claridge, B., Lozano, J., Poh, Q. H., & Greening, D. W. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.734720 · Cited by 243
Guidelines for clinical translation and commercialization of extracellular vesicles and exosomes based therapeutics
Cheng, K., & Kalluri, R. (2023) · Extracellular Vesicle · doi:10.1016/j.vesic.2023.100029 · Cited by 231
Harnessing extracellular vesicle heterogeneity for diagnostic and therapeutic applications
Carney, R. P., Mizenko, R. R., Bozkurt, B. T., Lowe, N. M., Henson, T., Arizzi, A., Wang, A., Tan, C., & George, S. C. (2024) · Nature Nanotechnology · doi:10.1038/s41565-024-01774-3 · Cited by 248

See all 258

Authors: Richter, M., Vader, P., & Fuhrmann, G.
Affiliations: Helmholtz Centre for Infection Research (DE)
University Medical Center Utrecht (NL)
Corresponding author: Fuhrmann, Gregor
ORCID: Richter, Maximilian
Vader, Pieter
Fuhrmann, Gregor
Venue: Advanced Drug Delivery Reviews
Publisher: Elsevier BV
Published: 2021-06
Volume: 173
Pages: 416-426
ISSN: 0169-409X (ISSN-L)
DOI: 10.1016/j.addr.2021.03.020
OpenAlex: W3150047560
Cited by: 258
References: 109
Citations by year: 2026: 46 · 2025: 66 · 2024: 55 · 2023: 56 · 2022: 29 · 2021: 6
FWCI: 3.83
Type: journal article
Language: en
Open access: green
dspace.library.uu.nl
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Advanced Drug Delivery Reviews (publishedVersion)
PubMed (publishedVersion)
Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
HZI (Helmholtz Centre for Infection Research) (submittedVersion, cc-by-nc-nd)
Funders: Studienstiftung des deutschen Volkes eV
European Research Council
Bundesministerium fur Bildung und Forschung Dienststelle Berlin
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords: extracellular vesicles, surface engineering, outer membrane vesicles, bacterial vesicles, vesicle isolation, metabolic engineering, drug delivery, therapeutic vesicles, intercellular communication
MeSH terms: Extracellular Vesicles, Animals, Cell Communication, Humans, Surface Properties, Tissue Engineering

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Approaches to surface engineering of extracellular vesicles

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks