Exosome-mediated delivery of hydrophobically modified siRNA for huntingtin mRNA silencing

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

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Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

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Functional delivery of viral miRNAs via exosomes

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Multivalent <i>N</i> -Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

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Export of microRNAs and microRNA-protective protein by mammalian cells

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Safety and efficacy of RNAi therapy for transthyretin amyloidosis

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Microvesicles: mediators of extracellular communication during cancer progression

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Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy

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A Novel Geneiba1in the Major Histocompatibility Complex Class III Region Encoding an EF Hand Protein Expressed in a Monocytic Lineage

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Sustained Therapeutic Reversal of Huntington's Disease by Transient Repression of Huntingtin Synthesis

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Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

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Axonal transport: cargo-specific mechanisms of motility and regulation

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RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

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Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

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Exosome-mediated delivery of siRNA in vitro and in vivo

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Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice

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Exosomes for targeted siRNA delivery across biological barriers

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Exosome mimetics: a novel class of drug delivery systems

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Systemic exosomal siRNA delivery reduced alpha‐synuclein aggregates in brains of transgenic mice

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Loss of normal huntingtin function: new developments in Huntington's disease research

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Extracellular vesicles as an emerging mechanism of cell-to-cell communication

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Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntington's Disease Mice

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Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

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Exosomes

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Competitive Interactions of Cancer Cells and Normal Cells via Secretory MicroRNAs

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The rough endoplasmatic reticulum is a central nucleation site of siRNA‐mediated RNA silencing

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Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity

Bryniarski, K., Ptak, W., Jayakumar, A., Püellmann, K., Caplan, M. J., Chairoungdua, A., Lü, J., Adams, B. D., Sikora, E., Nazimek, K., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.04.048 · Cited by 214 · see citing works

FedExosomes: Engineering Therapeutic Biological Nanoparticles that Truly Deliver

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Exosome derived from murine adipose-derived stromal cells: Neuroprotective effect on in vitro model of amyotrophic lateral sclerosis

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Hepatic cell-to-cell transmission of small silencing RNA can extend the therapeutic reach of RNA interference (RNAi)

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Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain

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The release of microparticles by apoptotic cells and their effects on macrophages

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Nucleoside modifications modulate activation of the protein kinase PKR in an RNA structure-specific manner

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Oligonucleotide therapeutic approaches for Huntington disease

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Exosomal RNA as biomarkers and the therapeutic potential of exosome vectors

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Extracellular Vesicles in Brain Tumor Progression

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The Development of Stem Cell-Derived Exosomes as a Cell-Free Regenerative Medicine

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Novel Hydrophobically Modified Asymmetric RNAi Compounds (sd-rxRNA) Demonstrate Robust Efficacy in the Eye

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Exosomes as a Potential Tool for a Specific Delivery of Functional Molecules

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Human Neural Progenitor Cell Engraftment Increases Neurogenesis and Microglial Recruitment in the Brain of Rats with Stroke

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Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitro

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Transfection of Neuronal Cultures

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Huntington Disease -- GeneReviews®

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Exosomes: biogenesis, biologic function and clinical potential

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RNA delivery by extracellular vesicles in mammalian cells and its applications

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Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine

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&lt;p&gt;Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications&lt;/p&gt;

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Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

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Advances in therapeutic applications of extracellular vesicles

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High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources

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Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy

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Approaches to surface engineering of extracellular vesicles

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Improved Loading of Plasma-Derived Extracellular Vesicles to Encapsulate Antitumor miRNAs

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Targeted therapy using engineered extracellular vesicles: principles and strategies for membrane modification

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Achieving the Promise of Therapeutic Extracellular Vesicles: The Devil is in Details of Therapeutic Loading

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Extracellular Vesicles in Brain Tumors and Neurodegenerative Diseases

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Strategies for the use of Extracellular Vesicles for the Delivery of Therapeutics

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RNA delivery biomaterials for the treatment of genetic and rare diseases

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Current advances in non‐viral gene delivery systems: Liposomes versus extracellular vesicles

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Exosome-mediated delivery of siRNA molecules in cancer therapy: triumphs and challenges

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Emerging prospects of extracellular vesicles for brain disease theranostics

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Exosome: The “Off-the-Shelf” Cellular Nanocomponent as a Potential Pathogenic Agent, a Disease Biomarker, and Neurotherapeutics

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Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntington's Disease Mice

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Sustained effects of nonallele‐specific Huntingtin silencing

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Double-mismatched siRNAs enhance selective gene silencing of a mutant ALS-causing allele

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High potency silencing by single-stranded boranophosphate siRNA

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