The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Complex History of Admixture between Modern Humans and Neandertals
Open accessAbstract
Recent analyses have found that a substantial amount of the Neandertal genome persists in the genomes of contemporary non-African individuals. East Asians have, on average, higher levels of Neandertal ancestry than do Europeans, which might be due to differences in the efficiency of purifying selection, an additional pulse of introgression into East Asians, or other unexplored scenarios. To better define the scope of plausible models of archaic admixture between Neandertals and anatomically modern humans, we analyzed patterns of introgressed sequence in whole-genome data of 379 Europeans and 286 East Asians. We found that inferences of demographic history restricted to neutrally evolving genomic regions allowed a simple one-pulse model to be robustly rejected, suggesting that differences in selection cannot explain the differences in Neandertal ancestry. We show that two additional demographic models, involving either a second pulse of Neandertal gene flow into the ancestors of East Asians or a dilution of Neandertal lineages in Europeans by admixture with an unknown ancestral population, are consistent with the data. Thus, the history of admixture between modern humans and Neandertals is most likely more complex than previously thought.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Thus, FAs could have acted as a population that diluted NE ancestry in western Eurasia (text S4), as previously suggested (16, 17).”
From Past human expansions shaped the spatial pattern of Neanderthal ancestry (2023) · cites this paper as [17]
In the citing paper
“In Europeans, archaic ancestry is consistent with contributions by a single population of Neanderthals 3 through one or more pulses [4][5][6][7] .”
From The nature of Neanderthal introgression revealed by 27,566 Icelandic genomes (2020) · cites this paper as [6]
In the citing paper
“It has been proposed that the early FAs are partly genetically derived from the previously identified “basal Eurasian” lineage (16, 17, 51).”
From Past human expansions shaped the spatial pattern of Neanderthal ancestry (2023) · cites this paper as [17]
In the citing paper
“This lineage is thought to have diverged from other Eurasian HG populations before the latter mixed with the NE, and therefore had a lower NE ancestry (16, 17, 51).”
From Past human expansions shaped the spatial pattern of Neanderthal ancestry (2023) · cites this paper as [17]
Citations
Cites
A draft sequence of the Neandertal genome
Green, R. E., Krause, J., Briggs, A. W., Maricic, T., Stenzel, U., Kircher, M., Patterson, N., Li, H., Zhai, W., Fritz, M. H.-Y., et al. (2010) · Science · doi:10.1126/science.1188021 · Cited by 4,318
Generating samples under a Wright–Fisher neutral model of genetic variation
Hudson, R. R. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.2.337 · Cited by 2,397
The complete genome sequence of a Neanderthal from the Altai Mountains
Prüfer, K., Racimo, F., Patterson, N., Jay, F., Sankararaman, S., Sawyer, S., Heinze, A., Renaud, G., Sudmant, P. H., de Filippo, C., et al. (2014) · Nature · doi:10.1038/nature12886 · Cited by 2,254
A high-coverage genome sequence from an archaic denisovan individual
Meyer, M., Kircher, M., Gansauge, M.-T., Li, H., Racimo, F., Mallick, S., Schraiber, J. G., Jay, F., Prüfer, K., de Filippo, C., et al. (2012) · Science · doi:10.1126/science.1224344 · Cited by 1,967
Evolution and functional impact of rare coding variation from deep sequencing of human exomes
Tennessen, J. A., Bigham, A. W., O’Connor, T. D., Fu, W., Kenny, E. E., Gravel, S., McGee, S., Do, R., Liu, X., Jun, G., et al. (2012) · Science · doi:10.1126/science.1219240 · Cited by 1,613
Self-citationAncient human genomes suggest three ancestral populations for present-day Europeans
Lazaridis, I., Patterson, N., Mittnik, A., Renaud, G., Mallick, S., Kirsanow, K., Sudmant, P. H., Schraiber, J. G., Castellano, S., Lipson, M., et al. (2014) · Nature · doi:10.1038/nature13673 · Cited by 1,357
Approximate Bayesian Computation (ABC) in practice
Csilléry, K., Blum, M. G. B., Gaggiotti, O. E., & François, O. (2010) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2010.04.001 · Cited by 1,302
The genomic landscape of Neanderthal ancestry in present-day humans
Sankararaman, S., Mallick, S., Dannemann, M., Prüfer, K., Kelso, J., Pääbo, S., Patterson, N., & Reich, D. (2014) · Nature · doi:10.1038/nature12961 · Cited by 1,107
abc: an R package for approximate Bayesian computation (ABC)
Csilléry, K., François, O., & Blum, M. G. B. (2012) · Methods in Ecology and Evolution · doi:10.1111/j.2041-210x.2011.00179.x · Cited by 709
Siva, N. (2008) · Nature Biotechnology · doi:10.1038/nbt0308-256b · Cited by 629
Cited by
Sorted by citations
Ancient DNA and the rewriting of human history: be sparing with Occam’s razor
Haber, M., Mezzavilla, M., Xue, Y., & Tyler-Smith, C. (2016) · Genome Biology · doi:10.1186/s13059-015-0866-z · Cited by 1,924
An early modern human from Romania with a recent Neanderthal ancestor
Fu, Q., Hajdinjak, M., Moldovan, O. T., Constantin, S., Mallick, S., Skoglund, P., Patterson, N., Rohland, N., Lazaridis, I., Nickel, B., et al. (2015) · Nature · doi:10.1038/nature14558 · Cited by 802
Tracing the peopling of the world through genomics
Nielsen, R., Akey, J. M., Jakobsson, M., Pritchard, J. K., Tishkoff, S., & Willerslev, E. (2017) · Nature · doi:10.1038/nature21347 · Cited by 728
Self-citationA high-coverage Neandertal genome from Vindija Cave in Croatia
Prüfer, K., de Filippo, C., Grote, S., Mafessoni, F., Korlević, P., Hajdinjak, M., Vernot, B., Skov, L., Hsieh, P., Peyrégne, S., et al. (2017) · Science · doi:10.1126/science.aao1887 · Cited by 719
Self-citationGenetic adaptation and Neandertal admixture shaped the immune system of human populations
Quach, H., Rotival, M., Pothlichet, J., Loh, Y.-H. E., Dannemann, M., Zidane, N., Laval, G., Patin, E., Harmant, C., Lopez, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.09.024 · Cited by 475
The Combined Landscape of Denisovan and Neanderthal Ancestry in Present-Day Humans
Sankararaman, S., Mallick, S., Patterson, N., & Reich, D. (2016) · Current Biology · doi:10.1016/j.cub.2016.03.037 · Cited by 465
Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals
Vernot, B., Tucci, S., Kelso, J., Schraiber, J. G., Wolf, A. B., Gittelman, R. M., Dannemann, M., Grote, S., McCoy, R. C., Norton, H., et al. (2016) · Science · doi:10.1126/science.aad9416 · Cited by 459
Self-citationOrigins of modern human ancestry
Bergström, A., Stringer, C. B., Hajdinjak, M., Scerri, E. M. L., & Skoglund, P. (2021) · Nature · doi:10.1038/s41586-021-03244-5 · Cited by 445
Analysis of Human Sequence Data Reveals Two Pulses of Archaic Denisovan Admixture
Browning, S. R., Browning, B. L., Zhou, Y., Tucci, S., & Akey, J. M. (2018) · Cell · doi:10.1016/j.cell.2018.02.031 · Cited by 381
Self-citationA high-coverage Neandertal genome from Chagyrskaya Cave
Mafessoni, F., Grote, S., de Filippo, C., Slon, V., Kolobova, K. A., Viola, B., Markin, S. V., Chintalapati, M., Peyrégne, S., Skov, L., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2004944117 · Cited by 309
The Strength of Selection against Neanderthal Introgression
Juric, I., Aeschbacher, S., & Coop, G. (2016) · PLOS Genetics · doi:10.1371/journal.pgen.1006340 · Cited by 309
Slatkin, M., & Racimo, F. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1524306113 · Cited by 265
Identifying and Interpreting Apparent Neanderthal Ancestry in African Individuals
Chen, L., Wolf, A. B., Fu, W., Li, L., & Akey, J. M. (2020) · Cell · doi:10.1016/j.cell.2020.01.012 · Cited by 254
Self-citationDannemann, M., Andrés, A. M., & Kelso, J. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2015.11.015 · Cited by 249
Population Stratification in Genetic Association Studies
Hellwege, J. N., Keaton, J. M., Giri, A., Gao, X., Edwards, D. R. V., & Edwards, T. L. (2017) · Current Protocols in Human Genetics · doi:10.1002/cphg.48 · Cited by 232
Limits of long-term selection against Neandertal introgression
Petr, M., Pääbo, S., Kelso, J., & Vernot, B. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1814338116 · Cited by 211
Self-citationEvidence that RNA Viruses Drove Adaptive Introgression between Neanderthals and Modern Humans
Enard, D., & Petrov, D. A. (2018) · Cell · doi:10.1016/j.cell.2018.08.034 · Cited by 208
Signatures of Archaic Adaptive Introgression in Present-Day Human Populations
Racimo, F., Marnetto, D., & Huerta-Sánchez, E. (2016) · Molecular Biology and Evolution · doi:10.1093/molbev/msw216 · Cited by 200
Multiple episodes of interbreeding between Neanderthal and modern humans
Villanea, F. A., & Schraiber, J. G. (2018) · Nature Ecology & Evolution · doi:10.1038/s41559-018-0735-8 · Cited by 192
Detecting Long-Term Balancing Selection Using Allele Frequency Correlation
Siewert, K. M., & Voight, B. F. (2017) · Molecular Biology and Evolution · doi:10.1093/molbev/msx209 · Cited by 166
Denisovan Ancestry in East Eurasian and Native American Populations
Qin, P., & Stoneking, M. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv141 · Cited by 157
The nature of Neanderthal introgression revealed by 27,566 Icelandic genomes
Skov, L., Coll Macià, M., Sveinbjörnsson, G., Mafessoni, F., Lucotte, E. A., Einarsdóttir, M. S., Jonsson, H., Halldorsson, B., Gudbjartsson, D. F., Helgason, A., et al. (2020) · Nature · doi:10.1038/s41586-020-2225-9 · Cited by 125
Sams, A. J., Dumaine, A., Nédélec, Y., Yotova, V., Alfieri, C., Tanner, J. E., Messer, P. W., & Barreiro, L. B. (2016) · Genome Biology · doi:10.1186/s13059-016-1098-6 · Cited by 140
Mondal, M., Bertranpetit, J., & Lao, O. (2019) · Nature Communications · doi:10.1038/s41467-018-08089-7 · Cited by 124
An ancestral recombination graph of human, Neanderthal, and Denisovan genomes
Schaefer, N. K., Shapiro, B., & Green, R. E. (2021) · Science Advances · doi:10.1126/sciadv.abc0776 · Cited by 106
“However, there is debate over whether this elevated Neanderthal ancestry is due to smaller past population size relative to other groups and the resulting stronger effect of genetic drift (22) or to additional pulses of Neanderthal admixture specific to these populations (9, 29).”
BackgroundEarly history of Neanderthals and Denisovans
Rogers, A. R., Bohlender, R. J., & Huff, C. D. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1706426114 · Cited by 108
Hsieh, P., Woerner, A. E., Wall, J. D., Lachance, J., Tishkoff, S. A., Gutenkunst, R. N., & Hammer, M. F. (2016) · Genome Research · doi:10.1101/gr.196634.115 · Cited by 105
Human evolution: a tale from ancient genomes
Llamas, B., Willerslev, E., & Orlando, L. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0484 · Cited by 100
Understanding rare and common diseases in the context of human evolution
Quintana‐Murci, L. (2016) · Genome biology · doi:10.1186/s13059-016-1093-y · Cited by 103
Pimenoff, V. N., de Oliveira, C. M., & Bravo, I. G. (2016) · Molecular Biology and Evolution · doi:10.1093/molbev/msw214 · Cited by 101
A Comprehensive Map of Genetic Variation in the World’s Largest Ethnic Group—Han Chinese
Chiang, C. W. K., Mangul, S., Robles, C. R., Kretzschmar, W. W., Cai, N., Kendler, K. S., Sankararam, S., & Flint, J. (2018) · Molecular Biology and Evolution · doi:10.1093/molbev/msy170 · Cited by 89
Something old, something borrowed: admixture and adaptation in human evolution
Dannemann, M., & Racimo, F. (2018) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2018.05.009 · Cited by 87
Recurrent gene flow between Neanderthals and modern humans over the past 200,000 years
Li, L., Comi, T. J., Bierman, R., & Akey, J. M. (2024) · Science · doi:10.1126/science.adi1768 · Cited by 94
Self-citationKim, B. Y., & Lohmueller, K. E. (2015) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.12.029 · Cited by 82
The contribution of Neanderthal introgression to modern human traits
Reilly, P. F., Tjahjadi, A., Miller, S. L., Akey, J. M., & Tucci, S. (2022) · Current Biology · doi:10.1016/j.cub.2022.08.027 · Cited by 89
Self-citationSmall Amounts of Archaic Admixture Provide Big Insights into Human History
Vattathil, S., & Akey, J. M. (2015) · Cell · doi:10.1016/j.cell.2015.09.042 · Cited by 74
Self-citationSignatures of archaic adaptive introgression in present-day human populations
Racimo, F., Marnetto, D., & Huerta-Sánchez, E. (2016) · doi:10.1101/045237 · Cited by 200
Model‐based detection and analysis of introgressed Neanderthal ancestry in modern humans
Steinrücken, M., Spence, J. P., Kamm, J. A., Wieczorek, E., & Song, Y. S. (2018) · Molecular Ecology · doi:10.1111/mec.14565 · Cited by 73
Outstanding questions in the study of archaic hominin admixture
Wolf, A. B., & Akey, J. M. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007349 · Cited by 68
Self-citationInsights into Modern Human Prehistory Using Ancient Genomes
Yang, M. A., & Fu, Q. (2018) · Trends in Genetics · doi:10.1016/j.tig.2017.11.008 · Cited by 66
More than a decade of genetic research on the Denisovans
Peyrégne, S., Slon, V., & Kelso, J. F. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-023-00643-4 · Cited by 75
Detecting hybridization using ancient DNA
Schaefer, N. K., Shapiro, B., & Green, R. E. (2016) · Molecular Ecology · doi:10.1111/mec.13556 · Cited by 66
Toward high-resolution population genomics using archaeological samples
Морозова, И., Flegontov, P., Mikheyev, A. S., Bruskin, S. A., Asgharian, H., Пономаренко, П. М., Klyuchnikov, V., GaneshPrasad, A., Prokhortchouk, E., Gankin, Y. V., et al. (2016) · DNA Research · doi:10.1093/dnares/dsw029 · Cited by 59
Advancements and Challenges in Ancient DNA Research: Bridging the Global North–South Divide
Dalal, V., Pasupuleti, N., Chaubey, G., Rai, N., & Shinde, V. S. (2023) · Genes · doi:10.3390/genes14020479 · Cited by 63
The success of failed Homo sapiens dispersals out of Africa and into Asia
Rabett, R. (2018) · Nature Ecology & Evolution · doi:10.1038/s41559-017-0436-8 · Cited by 59
Meltzer, D. J. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108632867 · Cited by 64
Kim, B. Y., Wei, X., Fitz‐Gibbon, S. T., Lohmueller, K. E., Ortego, J., Gugger, P. F., & Sork, V. L. (2018) · Molecular Ecology · doi:10.1111/mec.14869 · Cited by 48
Genomic signatures of sex-biased demography: progress and prospects
Webster, T. H., & Sayres, M. A. W. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.08.002 · Cited by 44
Yew, C.-W., Lu, D., Deng, L., Wong, L.-P., Ong, R. T., Lü, Y., Wang, X., Yunus, Y., Aghakhanian, F. F., Mokhtar, S. S., et al. (2018) · Human Genetics · doi:10.1007/s00439-018-1869-0 · Cited by 43
Out of Africa and into Asia: Fossil and genetic evidence on modern human origins and dispersals
Reyes‐Centeno, H. (2016) · Quaternary International · doi:10.1016/j.quaint.2015.11.063 · Cited by 40
Hominin interbreeding and the evolution of human variation
Ko, K. H. (2016) · Journal of Biological Research - Thessaloniki · doi:10.1186/s40709-016-0054-7 · Cited by 45
Harris, A. M., & DeGiorgio, M. (2017) · Human Biology · doi:10.13110/humanbiology.89.1.02 · Cited by 31
Our Tangled Family Tree: New Genomic Methods Offer Insight into the Legacy of Archaic Admixture
Ahlquist, K. D., Bañuelos, M. M., Funk, A., Lai, J., Rong, S., Villanea, F. A., & Witt, K. E. (2021) · Genome Biology and Evolution · doi:10.1093/gbe/evab115 · Cited by 36
The Spatial Signature of Introgression After a Biological Invasion With Hybridization
Quilodrán, C. S., Tsoupas, A., & Currat, M. (2020) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2020.569620 · Cited by 31
Esteller-Cucala, P., Maceda, I., Børglum, A. D., Demontis, D., Faraone, S. V., Cormand, B., & Lao, Ó. (2020) · Scientific Reports · doi:10.1038/s41598-020-65322-4 · Cited by 35
The Impact of Modern Admixture on Archaic Human Ancestry in Human Populations
Witt, K. E., Funk, A., Añorve-Garibay, V., Fang, L. L., & Huerta-Sánchez, E. (2023) · Genome Biology and Evolution · doi:10.1093/gbe/evad066 · Cited by 25
“These signals of admixture can also be indicative of selection (Tang et al. 2007), past demographic events (Vernot and Akey 2015; Wang et al. 2020), and even disease susceptibility (Rudan 2006; Mautz et al. 2019), demonstrating the value of analyzing admixed individuals.”
BackgroundArchaic admixture in human history
Wall, J. D., & Brandt, D. Y. C. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.07.002 · Cited by 29
Evolution, systematics, and the unnatural history of mitochondrial DNA
Schwartz, J. H. (2021) · Mitochondrial DNA Part A · doi:10.1080/24701394.2021.1899165 · Cited by 29
Inferences of African evolutionary history from genomic data
Beltrame, M. H., Rubel, M., & Tishkoff, S. A. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.10.002 · Cited by 26
Were Neanderthals and Homo sapiens ‘good species’?
Meneganzin, A., & Bernardi, M. (2023) · Quaternary Science Reviews · doi:10.1016/j.quascirev.2023.107975 · Cited by 29
On the Distribution of Tract Lengths During Adaptive Introgression
Shchur, V., Svedberg, J., Medina, P., Corbett-Detig, R. B., & Nielsen, R. (2020) · G3 Genes Genomes Genetics · doi:10.1534/g3.120.401616 · Cited by 27
Predicting Archaic Hominin Phenotypes from Genomic Data
Brand, C. M., Colbran, L. L., & Capra, J. A. (2022) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-111521-121903 · Cited by 24
A Genomic View of the Pleistocene Population History of Asia
Sikora, M. (2017) · Current Anthropology · doi:10.1086/694422 · Cited by 24
Apportioning archaic variants among modern populations
Witt, K. E., Villanea, F. A., Loughran, E., Zhang, X., & Huerta‐Sánchez, E. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2020.0411 · Cited by 27
Warren, K. A., Ritzman, T. B., Humphreys, R. A., Percival, C. J., Hallgrímsson, B., & Ackermann, R. (2018) · Journal of Human Evolution · doi:10.1016/j.jhevol.2017.12.002 · Cited by 24
Sellayah, D. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2018-00363 · Cited by 21
Taskent, O., Lin, Y. L., Patramanis, I., Pavlidis, P., & Gokcumen, O. (2020) · Genetics · doi:10.1534/genetics.120.303167 · Cited by 20
Dispersals Out of Africa and Back to Africa: Modern origins in North Africa
Garcea, E. A. A. (2016) · Quaternary International · doi:10.1016/j.quaint.2016.02.024 · Cited by 21
An evolutionary medicine perspective on Neandertal extinction
Sullivan, A., de Manuel, M., Marquès‐Bonet, T., & Perry, G. H. (2016) · Journal of Human Evolution · doi:10.1016/j.jhevol.2017.03.004 · Cited by 23
Introgression Makes Waves in Inferred Histories of Effective Population Size
Hawks, J. D. (2017) · Human Biology · doi:10.13110/humanbiology.89.1.04 · Cited by 19
Fourcade, T., Goñi, M. F. S., Lahaye, C., Rossignol, L., & Philippe, A. (2022) · Quaternary Research · doi:10.1017/qua.2022.21 · Cited by 15
An Extended Admixture Pulse Model Reveals the Limitations to Human–Neandertal Introgression Dating
Iasi, L. N. M., Ringbauer, H., & Peter, B. M. (2021) · Molecular Biology and Evolution · doi:10.1093/molbev/msab210 · Cited by 18
Archaic hominin admixture and its consequences for modern humans
Tagore, D., & Akey, J. M. (2024) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2024.102280 · Cited by 15
Self-citationThe contribution of ancient hominin genomes from Siberia to our understanding of human evolution
Pääbo, S. (2015) · Herald of the Russian Academy of Sciences · doi:10.1134/s1019331615050081 · Cited by 13
Past human expansions shaped the spatial pattern of Neanderthal ancestry
Quilodrán, C. S., Rio, J., Tsoupas, A., & Currat, M. (2023) · Science Advances · doi:10.1126/sciadv.adg9817 · Cited by 12
Denisovan admixture facilitated environmental adaptation in Papua New Guinean populations
Yermakovich, D., André, M., Brucato, N., Kariwiga, J., Leavesley, M., Pankratov, V., Mondal, M., Ricaut, F.-X., & Dannemann, M. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2405889121 · Cited by 12
First Peoples in a New World: Populating Ice Age America
Meltzer, D. J. (2021) · Cited by 12
The genetic structure of the world’s first farmersPreprint
Lazaridis, I., Nadel, D., Rollefson, G. O., Merrett, D. C., Rohland, N., Mallick, S., Fernandes, D., Novak, M., Gamarra, B., Sirak, K. A., et al. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/059311 · Cited by 12
Midfacial Morphology and Neandertal–Modern Human Interbreeding
Churchill, S. E., Keys, K., & Ross, A. H. (2022) · Biology · doi:10.3390/biology11081163 · Cited by 11
Further consideration of the curvature of the Neandertal Femur
Chapman, T. J., Sholukha, V. A., Semal, P., Louryan, S., & Jan, S. V. S. (2017) · American Journal of Physical Anthropology · doi:10.1002/ajpa.23334 · Cited by 9
IBD Sharing between Africans, Neandertals, and Denisovans
Povysil, G., & Hochreiter, S. (2016) · Genome Biology and Evolution · doi:10.1093/gbe/evw234 · Cited by 9
The Search for Ice Age Americans
Meltzer, D. J. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108632867.005 · Cited by 9
RNA viruses drove adaptive introgressions between Neanderthals and modern humansPreprint
Enard, D., & Petrov, D. A. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/120477 · Cited by 9
Smith, O., & Gilbert, M. T. P. (2018) · Population genomics · doi:10.1007/13836_2018_17 · Cited by 8
AD-LIBS: inferring ancestry across hybrid genomes using low-coverage sequence data
Schaefer, N. K., Shapiro, B., & Green, R. E. (2017) · BMC Bioinformatics · doi:10.1186/s12859-017-1613-0 · Cited by 8
Vernot, B., & Pääbo, S. (2018) · Cell · doi:10.1016/j.cell.2018.03.023 · Cited by 7
Self-citationLan, T., & Lindqvist, C. (2018) · Population genomics · doi:10.1007/13836_2017_7 · Cited by 7
Prat, S., Péan, S., Crépin, L., Puaud, S., Drucker, D. G., Lázničková‐Galetová, M., van der Plicht, J., Valladas, H., Verna, C., Patou‐Mathis, M., et al. (2018) · Bulletins et Mémoires de la Société d anthropologie de Paris · doi:10.3166/bmsap-2018-0032 · Cited by 8
A regulatory variant impacting TBX1 expression contributes to basicranial morphology in Homo sapiens
Funato, N., Heliövaara, A., & Boeckx, C. A. (2024) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2024.03.012 · Cited by 4
Conceiving of “Them” When Before There Was Only “Us”
Chang, M. L., & Nowell, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-36350-5_13 · Cited by 5
Underrepresented Populations at the Archaic Introgression Frontier
Villanea, F. A., & Witt, K. E. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.821170 · Cited by 5
Bosman, A. M., & Harvati, K. (2019) · American Journal of Physical Anthropology · doi:10.1002/ajpa.23844 · Cited by 5
A field theoretic approach to non-equilibrium population genetics in the strong selection regimePreprint
Balick, D. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.16.524324 · Cited by 5
Archaic adaptive introgression in modern human reproductive genes
Kendall, C., Nooranikhojasteh, A., Parra, E. J., Schillaci, M. A., & Viola, B. (2025) · Communications Biology · doi:10.1038/s42003-025-08682-9 · Cited by 6
Santo, L. N. D., Quilodrán, C. S., & Currat, M. (2023) · Molecular Biology and Evolution · doi:10.1093/molbev/msad252 · Cited by 4
Applications of Bayesian Skyline Plots and Approximate Bayesian Computation for Human Demography
Villanea, F. A., Kitchen, A., & Kemp, B. M. (2019) · Human Biology · doi:10.13110/humanbiology.91.4.04 · Cited by 4
Palaeogenetics: Dirt, what is it good for? Everything
Linderholm, A. E. (2021) · Current Biology · doi:10.1016/j.cub.2021.06.074 · Cited by 4
A new approach to exploratory data analysis in hominin phylogenetic reconstruction
Gautney, J. R. (2023) · Journal of Human Evolution · doi:10.1016/j.jhevol.2023.103412 · Cited by 4
Metadata
- Authors
- Vernot, B., & Akey, J. M.
- Affiliations
- University of Washington (US)
- Corresponding author
- Vernot, Benjamin
- Akey, Joshua M.
- Venue
- The American Journal of Human Genetics
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 96
- Issue
- 3
- Pages
- 448-453
- ISSN
- 0002-9297 (ISSN-L)
- PMC
- PMC4375686
- OpenAlex
- W2056921607
- Cited by
- 149
- References
- 19
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 11 · 2023: 10 · 2022: 8 · 2021: 30 · 2020: 9 · 2019: 6 · 2018: 19 · 2017: 15 · 2016: 26 · 2015: 6
- FWCI
- 92.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The American Journal of Human Genetics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (R01GM110068)
- Topics
- Social Sciences › Anthropology › Pleistocene-Era Hominins and Archaeology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- purifying selection, demographic history, gene flow
- MeSH terms
- Animals, Genetics, Population, Humans, Models, Genetic, Genome, White People, Asian People, Gene Flow, Neanderthals
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
