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Cited by 59Pituitary Gland Disorders and TreatmentsAdrenal Hormones and DisordersAdrenal and Paraganglionic Tumors

Consensus statement by the French Society of Endocrinology (SFE) and French Society of Pediatric Endocrinology & Diabetology (SFEDP) on diagnosis of Cushing's syndrome

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Tabarin, Antoine, Assié, Guillaume, Barat, Pascal, Bonnet, Fidéline, Bonneville, Jean François, Borson-Chazot, Françoise, Bouligand, Jérôme, Boulin, Anne +30 more·2022·Annales d Endocrinologie
DOI 10.1016/j.ando.2022.02.001
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Abstract

Cushing's syndrome is defined by prolonged exposure to glucocorticoids, leading to excess morbidity and mortality. Diagnosis of this rare pathology is difficult due to the low specificity of the clinical signs, the variable severity of the clinical presentation, and the difficulties of interpretation associated with the diagnostic methods. The present consensus paper by 38 experts of the French Society of Endocrinology and the French Society of Pediatric Endocrinology and Diabetology aimed firstly to detail the circumstances suggesting diagnosis and the biologic diagnosis tools and their interpretation for positive diagnosis and for etiologic diagnosis according to ACTH-independent and -dependent mechanisms. Secondly, situations making diagnosis complex (pregnancy, intense hypercortisolism, fluctuating Cushing's syndrome, pediatric forms and genetically determined forms) were detailed. Lastly, methods of surveillance and diagnosis of recurrence were dealt with in the final section.

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Authors
Tabarin, A., Assié, G., Barat, P., Bonnet, F., Bonneville, J. F., Borson-Chazot, F., Bouligand, J., Boulin, A., Brue, T., Caron, P., Castinetti, F., Chabre, O., Chanson, P., Corcuff, J. B., Cortet, C., Coutant, R., Dohan, A., Drui, D., Espiard, S., Gaye, D., Grunenwald, S., Guignat, L., Hindie, E., Illouz, F., Kamenicky, P., Lefebvre, H., Linglart, A., Martinerie, L., North, M. O., Raffin-Samson, M. L., Raingeard, I., Raverot, G., Raverot, V., Reznik, Y., Taieb, D., Vezzosi, D., Young, J., & Bertherat, J.
Affiliations
  • Centre Hospitalier Universitaire de Bordeaux (FR)
  • Université Paris Cité (FR)
  • Centre Hospitalier Universitaire de Liège (BE)
  • Inserm (FR)
  • Hôpital Foch (FR)
  • Hôpital Larrey (FR)
  • Université de Bordeaux (FR)
  • Centre Hospitalier Universitaire de Lille (FR)
  • Centre Hospitalier Universitaire d'Angers (FR)
  • Hôpital Cochin (FR)
  • Centre Hospitalier Universitaire de Nantes (FR)
  • Hôpital Lapeyronie (FR)
  • Hospices Civils de Lyon (FR)
  • Centre Hospitalier Universitaire de Caen Normandie (FR)
  • Centre Hospitalier Universitaire de Toulouse (FR)
  • Assistance Publique – Hôpitaux de Paris (FR)
Corresponding author
Tabarin, Antoine
ORCID
Venue
Annales d Endocrinologie
Publisher
Elsevier BV
Published
2022-04
Volume
83
Issue
2
Pages
119-141
ISSN
0003-4266 (ISSN-L)
DOI
10.1016/j.ando.2022.02.001
OpenAlex
W4213216879
Cited by
59
References
328
Citations by year
2026: 8 · 2025: 15 · 2024: 14 · 2023: 16 · 2022: 6
FWCI
9.44
Type
journal article
Language
en
Open access
Licence
Locations
  • Annales d Endocrinologie (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
Keywords
Cushing's syndrome, diagnosis, glucocorticoid excess, ACTH-independent Cushing's syndrome, ACTH-dependent Cushing's syndrome, etiological diagnosis, hypercortisolism, pregnancy, recurrence monitoring, diagnostic biomarkers
MeSH terms
Child, Cushing Syndrome, Endocrinology, Female, Glucocorticoids, Humans, Pregnancy, Consensus

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