Cited by 283Per- and polyfluoroalkyl substances researchEnvironmental Toxicology and EcotoxicologyToxic Organic Pollutants Impact

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Toxicity, uptake kinetics and behavior assessment in zebrafish embryos following exposure to perfluorooctanesulphonicacid (PFOS)

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Huang, Haihua, Huang, Changjiang, Wang, Lijun, Ye, Xiaowei, Bai, Chenglian, Simonich, Michael T., Tanguay, Robert L., Dong, Qiaoxiang·2010·Aquatic Toxicology

DOI 10.1016/j.aquatox.2010.02.003PMC PMC4028132

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Abstract

Perfluorooctanesulphonicacid (PFOS), a persistent organic contaminant, has been widely detected in the environment, wildlife and humans, but few studies have assessed its effect on aquatic organisms. The present study evaluated the effect of PFOS on zebrafish embryos. Zebrafish embryos exhibited developmental toxicity of bent spine, uninflated swim bladder, decreased heart rate and affected spontaneous movement after exposure to various PFOS concentrations (0-8mg/L) from 6 to 120h post-fertilization (hpf). The LC(50) at 120hpf was 2.20mg/L and the EC(50) at 120hpf was 1.12mg/L. Continuous exposure to PFOS from 1 to 121hpf resulted in a steady accumulation with no evidence of elimination. PFOS induced cell death at 24hpf was consistently found in the brain, eye, and tail region of embryos. PFOS exposure induced lesions in the muscle fibers with histological examination. Behavior assessment of PFOS in zebrafish embryos elevated the basal rate of swimming after 4 days of exposure, and larvae exposed to PFOS (0.25-4mg/L) for only 1h at 6dpf swam faster with increasing PFOS concentration. Embryos/larvae exposed to 8mg/L PFOS for 24h periods from 1 to 121hpf showed the highest incidence of malformations in the 97-121hpf window. This is the first study to define uptake kinetics and to focus on behavioral consequences following PFOS exposure in zebrafish. Our results further the understanding of the toxicity of PFOS to aquatic organisms and suggest the need for additional research to identify the mode of PFOS toxicity.

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Stages of embryonic development of the zebrafish
Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B., & Schilling, T. F. (1995) · Developmental Dynamics · doi:10.1002/aja.1002030302 · Cited by 12,037
The zebrafish book : a guide for the laboratory use of zebrafish (Danio rerio)
Westerfield, M. (1995) · Medical Entomology and Zoology · Cited by 6,813
Global Distribution of Perfluorooctane Sulfonate in Wildlife
Giesy, J. P., & Kannan, K. (2001) · Environmental Science & Technology · doi:10.1021/es001834k · Cited by 2,750
Perfluoroalkyl Acids: A Review of Monitoring and Toxicological Findings
Lau, C., Anitole, K., Hodes, C., Lai, D., Pfahles-Hutchens, A., & Seed, J. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm128 · Cited by 2,620
Half-Life of Serum Elimination of Perfluorooctanesulfonate,Perfluorohexanesulfonate, and Perfluorooctanoate in Retired Fluorochemical Production Workers
Olsen, G. W., Burris, J. M., Ehresman, D. J., Froehlich, J. W., Seacat, A. M., Butenhoff, J. L., & Zobel, L. R. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10009 · Cited by 2,049
Fluorinated Surfactants and Repellents
(2001) · Textile Research Journal · doi:10.1177/004051750107100823 · Cited by 1,376
Biological Monitoring of Polyfluoroalkyl Substances: A Review
Houde, M., Martin, J. W., Letcher, R. J., Solomon, K. R., & Muir, D. C. G. (2006) · Environmental Science & Technology · doi:10.1021/es052580b · Cited by 1,280
Peer Reviewed: Perfluorochemical Surfactants in the Environment
Giesy, J. P., & Kannan, K. (2002) · Environmental Science & Technology · doi:10.1021/es022253t · Cited by 1,103
The Developmental Toxicity of Perfluoroalkyl Acids and Their Derivatives
Lau, C., Butenhoff, J. L., & Rogers, J. M. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.11.031 · Cited by 867
Fluorinated organics in the biosphere
Key, B. D., Howell, R. D., & Criddle, C. S. (1997) · Environmental Science & Technology · doi:10.1021/es961007c · Cited by 729

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Authors: Huang, H., Huang, C., Wang, L., Ye, X., Bai, C., Simonich, M. T., Tanguay, R. L., & Dong, Q.
Affiliations: Wenzhou Medical University (CN)
Oregon State University (US)
Corresponding author: Huang, Haihua
Huang, Changjiang
Dong, Qiaoxiang
ORCID: Huang, Haihua
Huang, Changjiang
Wang, Lijun
Simonich, Michael T.
Tanguay, Robert L.
Dong, Qiaoxiang
Venue: Aquatic Toxicology
Publisher: Elsevier BV
Published: 2010-06
Volume: 98
Issue: 2
Pages: 139-147
ISSN: 0166-445X (ISSN-L)
DOI: 10.1016/j.aquatox.2010.02.003
PMC: PMC4028132
OpenAlex: W2066635393
Cited by: 283
References: 49
Citations by year: 2026: 14 · 2025: 21 · 2024: 12 · 2023: 23 · 2022: 28 · 2021: 19 · 2020: 23 · 2019: 23 · 2018: 10 · 2017: 16 · 2016: 13 · 2015: 9 · 2014: 14 · 2013: 21 · 2012: 19
FWCI: 15.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Aquatic Toxicology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Wenzhou Municipal People's Government
National Institutes of Health
U.S. Public Health Service (P30 00210)
National Institute of Environmental Health Sciences (P30ES000210)
Science and Technology Department of Zhejiang Province
Topics: Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords: PFOS, zebrafish embryos, developmental toxicity, uptake kinetics, persistent organic pollutants, swimming behavior, malformations, cell death, LC50, EC50, aquatic toxicity
MeSH terms: Animals, Behavior, Animal, Dose-Response Relationship, Drug, Embryo, Nonmammalian, Fertilization, Fluorocarbons, Heart Rate, Kinetics, Larva, Water Pollutants, Chemical, Zebrafish, Alkanesulfonic Acids

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Toxicity, uptake kinetics and behavior assessment in zebrafish embryos following exposure to perfluorooctanesulphonicacid (PFOS)

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