Developmental Toxicity of Perfluorooctanesulfonate (PFOS) and Its Chlorinated Polyfluoroalkyl Ether Sulfonate Alternative F-53B in the Domestic Chicken
Open accessAbstract
The chlorinated polyfluoroalkyl ether sulfonate F-53B is used as a mist suppressant in the Chinese electroplating industry. Because of the regulations on perfluorooctanesulfonate (PFOS), its use is expected to increase. Until now, F-53B toxicity data have been scarce and are, to our knowledge, lacking for birds. This study therefore investigated the effects of PFOS and F-53B, separately and as mixtures, on the development of the chicken ( Gallus gallus domesticus). Compounds were injected in ovo, before incubation, at 150 and 1500 ng/g egg. At embryonic day 20, a significantly lower heart rate was observed in all treated groups compared to the control group and hatchlings exposed to the high dose of F-53B had a significantly enlarged liver (8%). Embryonic survival was not affected and no significant effects on hatchling body mass or oxidative stress parameters were found. Our results suggest that these compounds likely have different toxicity thresholds for the investigated endpoints, and/or different modes of action. This study thereby underlines the potential developmental toxicity of PFOS and F-53B at environmentally relevant concentrations. Assessment of PFOS alternatives should therefore continue, preferably prior to their large scale use, as they should be ensured to be less harmful than PFOS itself.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Other sulfonated ether acids, such as F-53B, have shown equivalent bioaccumulation potential as the regulated perfluorinated sulfonic acid PFOS.
“Further, other sulfonated ether acids, such as F-53B, have shown equivalent bioaccumulation potential as the regulated perfluorinated sulfonic acid PFOS.(70,71)”
From Identification of Per- and Polyfluoroalkyl Substances in the Cape Fear River by High Resolution Mass Spectrometry and Nontargeted Screening (2019) · cites this paper as [71]
Cites
Free Radicals in Biology and Medicine
Halliwell, B., & Gutteridge, J. M. C. (2015) · doi:10.1093/acprof:oso/9780198717478.001.0001 · Cited by 8,990 · see citing works
Global Distribution of Perfluorooctane Sulfonate in Wildlife
Giesy, J. P., & Kannan, K. (2001) · Environmental Science & Technology · doi:10.1021/es001834k · Cited by 2,750 · see citing works
A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)?
Wang, Z., DeWitt, J. C., Higgins, C. P., & Cousins, I. T. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.6b04806 · Cited by 1,921 · see citing works
Biomarkers of Environmental Contamination
McCarthy, J. F., & Shugart, L. R. (2018) · CRC Press eBooks · doi:10.1201/9781351070263 · Cited by 921 · see citing works
Wang, S., Huang, J., Yang, Y., Hui, Y., Ge, Y., Larssen, T., Yu, G., Deng, S., Wang, B., & Harman, C. (2013) · Environmental Science & Technology · doi:10.1021/es401525n · Cited by 620 · see citing works
Subchronic Toxicity Studies on Perfluorooctanesulfonate Potassium Salt in Cynomolgus Monkeys
Seacat, A. M. (2002) · Toxicological Sciences · doi:10.1093/toxsci/68.1.249 · Cited by 564 · see citing works
Exposure to Perfluorooctane Sulfonate during Pregnancy in Rat and Mouse. II: Postnatal Evaluation
Lau, C., Thibodeaux, J. R., Hanson, R. G., Rogers, J. M., Grey, B. E., Stanton, M. E., Butenhoff, J. L., & Stevenson, L. A. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfg122 · Cited by 549 · see citing works
Thibodeaux, J. R., Hanson, R. G., Rogers, J. M., Grey, B. E., Barbee, B. D., Richards, J. H., Butenhoff, J. L., Stevenson, L. A., & Lau, C. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfg121 · Cited by 445 · see citing works
Effects of oxidative stress on embryonic development
Dennery, P. A. (2007) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20098 · Cited by 433 · see citing works
Powley, C. R., George, S. W., Ryan, T. W., & Buck, R. C. (2005) · Analytical Chemistry · doi:10.1021/ac0508090 · Cited by 396 · see citing works
Developmental toxicity and alteration of gene expression in zebrafish embryos exposed to PFOS
Shi, X., Du, Y., Lam, P. K. S., Wu, R. S. S., & Zhou, B. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.01.043 · Cited by 384 · see citing works
Cui, L., Zhou, Q.-F., Liao, C.-Y., Fu, J.-J., & Jiang, G.-B. (2009) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-008-9194-6 · Cited by 368 · see citing works
Shi, Y., Vestergren, R., Xu, L., Zhou, Z., Li, C., Liang, Y., & Cai, Y. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.5b05849 · Cited by 361 · see citing works
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) in consumer products in Norway – A pilot study
Herzke, D., Olsson, E., & Posner, S. (2012) · Chemosphere · doi:10.1016/j.chemosphere.2012.03.035 · Cited by 349 · see citing works
Self-citationHuang, H., Huang, C., Wang, L., Ye, X., Bai, C., Simonich, M. T., Tanguay, R. L., & Dong, Q. (2010) · Aquatic Toxicology · doi:10.1016/j.aquatox.2010.02.003 · Cited by 283 · see citing works
Observation of emerging per- and polyfluoroalkyl substances (PFASs) in Greenland marine mammals
Gebbink, W. A., Bossi, R., Rigét, F. F., Rosing-Asvid, A., Sonne, C., & Dietz, R. (2016) · Chemosphere · doi:10.1016/j.chemosphere.2015.10.116 · Cited by 266 · see citing works
Shi, Y., Vestergren, R., Zhou, Z., Song, X., Xu, L., Liang, Y., & Cai, Y. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b04299 · Cited by 258 · see citing works
Wang, T., Vestergren, R., Herzke, D., Yu, J., & Cousins, I. T. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.6b03752 · Cited by 257 · see citing works
Self-citationCui, Q., Pan, Y., Zhang, H., Sheng, N., Wang, J., Guo, Y., & Dai, J. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.7b03662 · Cited by 228 · see citing works
14. United Nations Environment Program (UNEP)
Desai, B. H. (2015) · Yearbook of International Environmental Law · doi:10.1093/yiel/yvw063 · Cited by 214 · see citing works
Gomis, M. I., Wang, Z., Scheringer, M., & Cousins, I. T. (2015) · Science of The Total Environment · doi:10.1016/j.scitotenv.2014.10.062 · Cited by 211 · see citing works
Chang, S., Thibodeaux, J. R., Eastvold, M. L., Ehresman, D. J., Bjork, J. A., Froehlich, J. W., Lau, C. S., Singh, R. J., Wallace, K. B., & Butenhoff, J. L. (2007) · Toxicology · doi:10.1016/j.tox.2007.10.014 · Cited by 209 · see citing works
Chen, F., Yin, S., Kelly, B. C., & Liu, W. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.6b06049 · Cited by 168 · see citing works
Liu, Y., Ruan, T., Lin, Y., Liu, A., Yu, M., Liu, R., Meng, M., Wang, Y., Liu, J., & Jiang, G. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.6b06593 · Cited by 168 · see citing works
Shi, G., Cui, Q., Pan, Y., Sheng, N., Sun, S., Guo, Y., & Dai, J. (2017) · Aquatic Toxicology · doi:10.1016/j.aquatox.2017.02.002 · Cited by 162 · see citing works
Hanssen, L., Dudarev, A. A., Huber, S., Odland, J. Ø., Nieboer, E., & Sandanger, T. M. (2013) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2013.01.029 · Cited by 157 · see citing works
Li, C.-H., Ren, X., Ruan, T., Cao, L.-Y., Yan, X., Guo, L., & Jiang, G. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.7b06327 · Cited by 144 · see citing works
Berger, U. (2008) · Environmental Science & Technology · doi:10.1021/es800529h · Cited by 124 · see citing works
Gebbink, W. A., & Letcher, R. J. (2011) · Environmental Pollution · doi:10.1016/j.envpol.2011.10.011 · Cited by 121 · see citing works
Lin, Y., Ruan, T., Liu, A., & Jiang, G. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b02961 · Cited by 114 · see citing works
Newsted, J. L., Coady, K. K., Beach, S. A., Butenhoff, J. L., Gallagher, S., & Giesy, J. P. (2006) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2006.04.008 · Cited by 113 · see citing works
Molina, E. D., Balander, R. J., Fitzgerald, S. D., Giesy, J. P., Kannan, K., Mitchell, R. R., & Bursian, S. J. (2006) · Environmental Toxicology and Chemistry · doi:10.1897/04-414r.1 · Cited by 111 · see citing works
Avian wildlife as sentinels of ecosystem health
Smits, J. E. G., & Fernie, K. J. (2012) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2012.11.007 · Cited by 108 · see citing works
Deng, M., Wu, Y., Xu, C., Jin, Y., He, X., Wan, J., Yu, X., Rao, H., & Tu, W. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.12.101 · Cited by 103 · see citing works
Perfluorooctane sulfonate impairs the cardiac development of a marine medaka (Oryzias melastigma)
Huang, Q., Fang, C., Wu, X., Fan, J., & Dong, S. (2011) · Aquatic Toxicology · doi:10.1016/j.aquatox.2011.05.012 · Cited by 101 · see citing works
Custer, C. M., Custer, T. W., Dummer, P. M., Etterson, M. A., Thogmartin, W. E., Wu, Q., Kannan, K., Trowbridge, A. G., & McKann, P. C. (2013) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-013-9934-0 · Cited by 86 · see citing works
Peden-Adams, M. M., Stuckey, J. E., Gaworecki, K. M., Berger-Ritchie, J., Bryant, K., Jodice, P. G., Scott, T. R., Ferrario, J. B., Guan, B., Vigo, C., et al. (2009) · Reproductive Toxicology · doi:10.1016/j.reprotox.2008.10.009 · Cited by 84 · see citing works
Ahrens, L., Herzke, D., Huber, S., Bustnes, J. O., Bangjord, G., & Ebinghaus, R. (2011) · Environmental Science & Technology · doi:10.1021/es103473v · Cited by 76 · see citing works
Self-citationYin, N., Yang, R., Liang, S., Liang, S., Hu, B., Ruan, T., & Faiola, F. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.04.011 · Cited by 72 · see citing works
Influence of temperature and humidity manipulation on chicken embryonic development
da Noiva, R. G., Menezes, A. C., & Peleteiro, M. C. (2014) · BMC Veterinary Research · doi:10.1186/s12917-014-0234-3 · Cited by 71 · see citing works
Groffen, T., Lopez-Antia, A., D'Hollander, W., Prinsen, E., Eens, M., & Bervoets, L. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.05.007 · Cited by 66 · see citing works
Zhang, Q., Liu, W., Niu, Q. L., Wang, Y., Zhao, H., Zhang, H., Song, J., Tsuda, S., & Saito, N. (2016) · Toxicology Research · doi:10.1039/c5tx00184f · Cited by 55 · see citing works
Marteinson, S. C., Bird, D. M., Shutt, J. L., Letcher, R. J., Ritchie, I. J., & Fernie, K. J. (2010) · Environmental Toxicology and Chemistry · doi:10.1002/etc.200 · Cited by 55 · see citing works
Reproductive consequences of EDCs in birds
Ottinger, M. A., Abdelnabi, M. A., Quinn, M. A., Golden, N. H., Wu, J. M., & Thompson, N. (2002) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(01)00195-7 · Cited by 53 · see citing works
O’Brien, J. M., Kennedy, S. W., Chu, S., & Letcher, R. J. (2010) · Environmental Toxicology and Chemistry · doi:10.1002/etc.368 · Cited by 48 · see citing works
Neurobehavioral Teratogenicity of Perfluorinated Alkyls in an Avian Model
Pinkas, A., Slotkin, T. A., Brick-Turin, Y., Van der Zee, E. A., & Yanai, J. (2010) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2009.11.004 · Cited by 48 · see citing works
Henshel, D. S., Hehn, B. M., Wagey, R. T. E., Vo, M., & Steeves, J. D. (1997) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620160417 · Cited by 43 · see citing works
O’Brien, J. M., Carew, A. C., Chu, S., Letcher, R. J., & Kennedy, S. W. (2008) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2008.11.009 · Cited by 41 · see citing works
Nordén, M., Berger, U., & Engwall, M. (2016) · Environmental Science and Pollution Research · doi:10.1007/s11356-016-6285-1 · Cited by 40 · see citing works
Marasco, V., & Costantini, D. (2016) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2016.00095 · Cited by 37 · see citing works
Environmental Toxicity Studies Using Chickens as Surrogates for Wildlife: Effects of Injection Day
DeWitt, J. C., Meyer, E. B., & Henshel, D. S. (2005) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-004-2006-8 · Cited by 29 · see citing works
McKernan, M. A., Rattner, B. A., Hale, R. C., & Ottinger, M. A. (2007) · Environmental Toxicology and Chemistry · doi:10.1897/07-291.1 · Cited by 23 · see citing works
Strömqvist, M., Olsson, J., Kärrman, A., & Brunström, B. (2012) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2012.03.004 · Cited by 19 · see citing works
Perfluorooctane sulfonate increases β-oxidation of palmitic acid in chicken liver
Nordén, M., Westman, O., Venizelos, N., & Engwall, M. (2012) · Environmental Science and Pollution Research · doi:10.1007/s11356-012-0869-1 · Cited by 19 · see citing works
Parolini, M., Colombo, G., Valsecchi, S. M., Mazzoni, M., Possenti, C. D., Caprioli, M., Dalle‐Donne, I., Milzani, A., Saino, N., & Rubolini, D. (2015) · Environmental Science and Pollution Research · doi:10.1007/s11356-015-5248-2 · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ankley, G. T., Cureton, P., Hoke, R. A., Houde, M., Kumar, A., Kurias, J., Lanno, R., McCarthy, C., Newsted, J., Salice, C. J., et al. (2020) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4869 · Cited by 454 · see citing works
Schulz, K., Silva, M. R., & Klaper, R. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.139186 · Cited by 259 · see citing works
Per- and polyfluoroalkyl substances (PFAS) in livestock and game species: A review
Death, C. E., Bell, C., Champness, D., Milne, C. M., Reichman, S. M., & Hagen, T. G. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.144795 · Cited by 244 · see citing works
PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field
Bonato, M., Corrà, F., Bellio, M., Guidolin, L., Tallandini, L., Irato, P., & Santovito, G. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17218020 · Cited by 243 · see citing works
Nanofiltration for drinking water treatment: a review
Guo, H., Li, X., Yang, W., Yao, Z., Mei, Y., Peng, L. E., Yang, Z., Shao, S., & Tang, C. Y. (2021) · Frontiers of Chemical Science and Engineering · doi:10.1007/s11705-021-2103-5 · Cited by 221 · see citing works
McCord, J., & Strynar, M. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.8b06017 · Cited by 183 · see citing works
Human exposure to F-53B in China and the evaluation of its potential toxicity: An overview
He, Y., Lv, D., Li, C., Liu, X., Liu, W., & Han, W. (2022) · Environment International · doi:10.1016/j.envint.2022.107108 · Cited by 182 · see citing works
Li, Y., Yu, N., Du, L., Shi, W. F., Yu, H., Song, M., & Wei, S. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.9b06505 · Cited by 143 · see citing works
Are perfluorooctane sulfonate alternatives safer? New insights from a birth cohort study
Chu, C., Zhou, Y., Li, Q.-Q., Bloom, M. S., Lin, S., Yu, Y.-J., Chen, D., Yu, H.-Y., Hu, L.-W., Yang, B.-Y., et al. (2020) · Environment International · doi:10.1016/j.envint.2019.105365 · Cited by 117 · see citing works
Wen, Z.-J., Wei, Y.-J., Zhang, Y., & Zhang, Y. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03477-5 · Cited by 109 · see citing works
Yu, N., Wen, H.-Z., Wang, X., Yamazaki, E., Taniyasu, S., Yamashita, N., Yu, H., & Wei, S. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.9b05457 · Cited by 89 · see citing works
Jouanneau, W., Léandri‐Breton, D., Corbeau, A., Herzke, D., Moe, B., Nikiforov, V. A., Gabrielsen, G. W., & Chastel, O. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.1c03773 · Cited by 89 · see citing works
Self-citationTrifluoroacetic Acid: Toxicity, Sources, Sinks and Future Prospects
Garavagno, M. D. L. A., Holland, R., Khan, M. A. H., Orr-Ewing, A., & Shallcross, D. (2024) · Sustainability · doi:10.3390/su16062382 · Cited by 86 · see citing works
Lazcano, R. K., de Perre, C., Mashtare, M. L., & Lee, L. (2019) · Water Environment Research · doi:10.1002/wer.1174 · Cited by 72 · see citing works
Schiavone, C., & Portesi, C. (2023) · Applied Sciences · doi:10.3390/app13116696 · Cited by 70 · see citing works
Wang, J., Pan, Y., Wei, X., & Dai, J. (2020) · Environmental Science and Technology · doi:10.1021/acs.est.0c01877 · Cited by 61 · see citing works
Chen, Z., Hua, Z., & Guo, P. (2024) · Water Research · doi:10.1016/j.watres.2024.121878 · Cited by 65 · see citing works
Li, Y., Lu, X., Yu, N., Li, A., Zhuang, T., Du, L., Tang, S., Shi, W. F., Yu, H., Song, M., et al. (2021) · Environment International · doi:10.1016/j.envint.2021.106627 · Cited by 62 · see citing works
Yan, X., Wan, B., Yu, B., Fan, Y., Chen, D., & Guo, L. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.9b07708 · Cited by 61 · see citing works
Pan, C., Yu, K., Wang, Y., Zhang, W., Zhang, J., & Guo, J. K. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.01.019 · Cited by 60 · see citing works
Mi, X., Yang, Y.-Q., Zeeshan, M., Wang, Z.-B., Zeng, X., Zhou, Y., Yang, B., Hu, L., Yu, H.-Y., Zeng, X., et al. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.127691 · Cited by 60 · see citing works
Jin, Q., Ma, J., Shi, Y., Chen, C., Wang, Y., Zhao, E., Cai, Y., & Qu, G. (2020) · Environment International · doi:10.1016/j.envint.2020.106043 · Cited by 57 · see citing works
Zhang, Y.-T., Zeeshan, M., Su, F., Qian, Z.-M., Geiger, S. D., McMillin, S. E., Wang, Z.-B., Dong, P.-X., Ou, Y.-Q., Xiong, S.-M., et al. (2021) · Environment International · doi:10.1016/j.envint.2021.106913 · Cited by 54 · see citing works
Sheng, N., Wang, J., Guo, Y., Wang, J., & Dai, J. (2020) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.0c00075 · Cited by 53 · see citing works
Yu, S., Feng, W., Liang, Z.-M., Zeng, X., Bloom, M. S., Hu, G., Zhou, Y., Ou, Y., Chu, C., Li, Q., et al. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117078 · Cited by 52 · see citing works
Yang, W., Long, L., Guo, H., Wu, C., Zhou, S., Mei, Y., Peng, L. E., Liu, W., Yang, Z., Li, W., et al. (2022) · Journal of Membrane Science · doi:10.1016/j.memsci.2022.121038 · Cited by 51 · see citing works
Organofluorine Mass Balance Analysis of Whole Blood Samples in Relation to Gender and Age
Aro, R., Eriksson, U., Kärrman, A., & Yeung, L. W. Y. (2021) · Environmental Science and Technology · doi:10.1021/acs.est.1c04031 · Cited by 47 · see citing works
Microplastic Ingestion Induces Size-Specific Effects in Japanese Quail
Monclús, L., Smith, E. M., Ciesielski, T. M., Wagner, M., & Jaspers, V. L. B. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c03878 · Cited by 47 · see citing works
Self-citationGuo, J., Zhang, Y., Sun, Q., Qu, G., Wei, L. C., Wang, T., Jia, H., & Zhu, L. Y. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.132922 · Cited by 44 · see citing works
Home-produced eggs: An important human exposure pathway of perfluoroalkylated substances (PFAS)
Lasters, R., Groffen, T., Eens, M., Coertjens, D., Gebbink, W. A., Hofman, J., & Bervoets, L. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.136283 · Cited by 42 · see citing works
Novel and legacy per- and polyfluoroalkyl substances in bald eagle eggs from the Great Lakes region
Wu, Y., Simon, K. L., Best, D. A., Bowerman, W. W., & Venier, M. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.113811 · Cited by 42 · see citing works
Unravelling the magnitude and drivers of PFAS trophic magnification: a meta-analysis
Ricolfi, L., Yang, Y., Pottier, P., Morrison, K., Williams, C., Pollo, P., Hesselson, D., Neely, G. G., Taylor, M. D., Nakagawa, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65746-4 · Cited by 43 · see citing works
Wei, K.-N., Wang, X.-J., Zeng, Z.-C., Gu, R.-T., Deng, S.-Z., Jiang, J., Xu, C.-L., Li, W., & Wang, H. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112807 · Cited by 42 · see citing works
Lu, B., Qian, J., He, F., Wang, P.-F., He, Y., Tang, S., & Tian, X.-W. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.118684 · Cited by 36 · see citing works
Ding, D., Song, X., Wei, C., Hu, Z., & Liu, Z. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.126443 · Cited by 37 · see citing works
Combined effects of BPA and PFOS on fetal cardiac development: In vitro and in vivo experiments
Zhou, R., Cheng, W., Feng, Y., Wang, W., Liang, F., Luo, F., Yang, S., & Wang, Y. (2020) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2020.103434 · Cited by 36 · see citing works
Pan, Y. J., Wen, B., Zhang, H., & Zhang, S. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117332 · Cited by 33 · see citing works
Viada, B. N., Yudi, L. M., & Arrigan, D. W. M. (2020) · The Analyst · doi:10.1039/d0an00884b · Cited by 35 · see citing works
Li, C., Jiang, L., Zhang, D., Qi, Y., Wang, X., Jin, Y., Liu, X., Lin, Y., Luo, J., Xu, L., et al. (2023) · Environment International · doi:10.1016/j.envint.2023.107846 · Cited by 32 · see citing works
Li, X., Zhang, Q., Wang, A., Shan, S., Wang, X., Wang, Y., Wan, J., Ning, P., Chengjiao, H., Tian, H., et al. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.123544 · Cited by 32 · see citing works
Hong, S., Lee, S. H., Yang, J.-Y., Lee, J. H., Jung, K. K., Seok, J. H., Kim, S., Nam, K. T., Jeong, J., Lee, J. K., et al. (2020) · Toxics · doi:10.3390/toxics8030054 · Cited by 31 · see citing works
Zhu, Y., Yang, D., Duan, X., Zhang, Y., Chen, D., Gong, Z., & Liu, C. (2021) · Environmental Research · doi:10.1016/j.envres.2021.110962 · Cited by 31 · see citing works
Lu, B., Qian, J., Hu, J., Huang, Y., Wang, P.-H., Shen, J., He, Y., Tang, S., Liu, Y., & Zhang, Y. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130119 · Cited by 31 · see citing works
Photodegradation of F-53B in aqueous solutions through an UV/Iodide system.
Cao, H., Zhang, W., Wang, C.-P., Liang, Y., & Sun, H. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.133436 · Cited by 22 · see citing works
Kang, H., Calafat, A. M., Karvonen-Gutierrez, C. A., & Park, S. K. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c04501 · Cited by 21 · see citing works
Yadav, A., Verhaegen, S., Hadera, M. G., Berntsen, H. F., Berg, V., Lyche, J. L., Sabaredzovic, A., Haug, L. S., Myhre, O., Zimmer, K. E., et al. (2021) · NeuroToxicology · doi:10.1016/j.neuro.2021.10.013 · Cited by 19 · see citing works
Feng, Q.-J., Luo, X., Ye, M., Hu, K., Zeng, Y., & Mai, B. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.167008 · Cited by 19 · see citing works
F-53B mediated ROS affects uterine development in rats during puberty by inducing apoptosis
Nie, P., Lan, Y., You, T., Jia, T., & Xu, H. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116399 · Cited by 19 · see citing works
Smith, E. M., Bartošová, Z., Wagner, M., Jaspers, V. L. B., & Monclús, L. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.169019 · Cited by 18 · see citing works
Self-citationPartitioning of PFAS to serum, tissues, eggs, and hatchlings of an Australian freshwater turtle
Vardy, S., Baddiley, B., Braun, C., Limpus, C. J., Limpus, D. J., Plessis, M. D., Nilsson, S., González-Astudillo, V., & Beale, D. J. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.133885 · Cited by 18 · see citing works
Li, Z.-Y., Li, M., Liu, B., Zhang, X., Yi, S., Zhuang, W., Wang, W., Sun, Y., & Wang, A.-J. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.138372 · Cited by 14 · see citing works
Sun, J., Cheng, Y., Song, Z., Ma, S., Xing, L., Wang, K., Huang, C., Li, D., Chu, J., & Liu, Y. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115946 · Cited by 15 · see citing works
Luo, J., Luo, F., Li, H., Mao, C., Pan, Y., Fang, Z., Yu, D., Liu, H., & Fu, K. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202514746 · Cited by 13 · see citing works
Yang, Y., Wang, X., Yang, M., Wei, S., & Li, Y. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.3c09014 · Cited by 13 · see citing works
Zhang, J., Xu, Z., Deng, X., Zhang, Q., Ruan, Y., & Ji, X.-M. (2024) · Bioresource Technology · doi:10.1016/j.biortech.2024.130500 · Cited by 13 · see citing works
Zeng, Y., Dai, Y., Yin, L., Huang, J. H., & Hoffmann, M. R. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.174200 · Cited by 14 · see citing works
Pan, Y., Qin, H., Liu, W., Zhang, Q., Zheng, L., Zhou, C., & Quan, X. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.124402 · Cited by 13 · see citing works
Chen, L., Xie, Y., Li, M., Mortimer, M., Li, F., & Guo, L. (2023) · Toxicology · doi:10.1016/j.tox.2023.153566 · Cited by 12 · see citing works
Zhang, R., Yu, G.-Q., Luo, T., Zeng, X.-J., Sun, Y., Huang, B., Liu, Y.-J., & Zhang, J. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115862 · Cited by 8 · see citing works
Flaxseed Oil Alleviates PFOS-Induced Liver Injury by Regulating Hepatic Cholesterol Metabolism
Ren, J., Zuo, J., Yin, B., Huang, D., Wen, R., Pei, H., Liu, J., Zhang, Y., Zhu, S., Zhen, S., et al. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c04438 · Cited by 12 · see citing works
Rotondo, D., Gualandris, D., Lorusso, C., Braeuning, A., Calisi, A., & Dondero, F. (2024) · Journal of Xenobiotics · doi:10.3390/jox15010002 · Cited by 11 · see citing works
Per- and poly-fluoroalkyl substances in Tawny Owl (Strix aluco) feathers from Trøndelag, Norway
Zhang, J., Jaspers, V. L. B., Røe, J., Castro, G., Kroglund, I. B., González, S. V., Østnes, J. E., & Asimakopoulos, A. G. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.166213 · Cited by 12 · see citing works
Self-citationShurson, G. C. (2025) · Sustainability · doi:10.3390/su17156957 · Cited by 12 · see citing works
Lu, B., Wang, P., Zhu, Y., Hu, J., Qian, J., Huang, Y., Shen, J., Tang, S., & Liu, Y. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.125324 · Cited by 10 · see citing works
Shen, J., Xu, Y., Qian, J., Lu, B., Liu, F., Liu, Y., He, Y., & Zhao, S. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.135676 · Cited by 7 · see citing works
Sun, L., Chen, Y., Chen, J., Mao, G., Feng, W., & Wu, X. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-04093-1 · Cited by 6 · see citing works
Paddayuman, J. Z., Wijayahena, M. K., Aguilar, J. M. N., Gernold, Z. A., Wallace, J. S., & Aga, D. S. (2025) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.5c00219 · Cited by 6 · see citing works
Evaluating perfluorooctanesulfonate oxidation in permanganate systems
Park, S., Lee, L., Ross, I., & Hurst, J. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-07803-7 · Cited by 6 · see citing works
Qiu, M., Chen, J., Liu, M., Nie, Z., Ke, M.-L., Dong, G., Zhao, H., Zhou, C., Zeng, H., He, B., et al. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.115945 · Cited by 5 · see citing works
Brand, A., Peterson, S., Günzel, L. M. S., Yap, K. N., Ciesielski, T. M., Arzel, C., & Jaspers, V. L. B. (2025) · Environmental Toxicology and Chemistry · doi:10.1093/etojnl/vgaf213 · Cited by 5 · see citing works
Self-citationZhong, C., Zeng, H., Deng, J., Li, Q., Li, Z., Zhai, J., Li, X., & Luan, T. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.4c06345 · Cited by 4 · see citing works
Treatment of PFAS-laden solids via fluidized bed gliding arc plasmatron
Murillo‐Gelvez, J., Rabinovich, A., Sales, C. M., Fridman, A., Fridman, G., & McKenzie, E. R. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.138678 · Cited by 5 · see citing works
Khan, E. A., Greve, M., Russell, I., Ciesielski, T. M., Lundregan, S. L., Jensen, H., Rønning, B., Bones, A. M., Asimakopoulos, A. G., Waugh, C. A., et al. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.123443 · Cited by 4 · see citing works
Self-citationJouanneau, W., Boulinier, T., Herzke, D., Nikiforov, V. A., Gabrielsen, G. W., & Chastel, O. (2025) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2025.117941 · Cited by 4 · see citing works
Self-citationLiang, F., Li, Z., Wang, Z., Ke, X., Wu, L., Christie, P., & Luo, Y. (2024) · Soil Ecology Letters · doi:10.1007/s42832-024-0253-3 · Cited by 3 · see citing works
Ross, T. A., Zhang, J., Skaalvik, T. G., Atkinson, R., Jessop, R., Asimakopoulos, A. G., Jaspers, V. L. B., & Klaassen, M. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.176790 · Cited by 3 · see citing works
Self-citationStreckenbach, F., Schön, H., König, J., Frank, M., Langner, I., Stachs, O., Jonitz‐Heincke, A., Langner, S., Lindner, T., & Schätzel, J. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1450572 · Cited by 3 · see citing works
Cheng, Q., Lv, C., Li, Y., Song, H., Li, S., Li, D., Han, Y., Zhao, F., & Lin, Q. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118496 · Cited by 2 · see citing works
Comparative neurotoxicities of PFOS and its alternative F-53B based on acetylcholinesterase
Zhao, Y., Weng, L., & Chi, Z. (2025) · Journal of Environmental Sciences · doi:10.1016/j.jes.2025.08.063 · Cited by 2 · see citing works
Luo, J., Luo, F., Li, H., Mao, C., Pan, Y., Fang, Z., Yu, D., Liu, H., & Fu, K. (2025) · Angewandte Chemie · doi:10.1002/ange.202514746 · Cited by 2 · see citing works
Lu, Y., Yang, Z., Zou, Y., Deng, Y., Liu, L., Zhao, J., Luo, Q., Liu, H., Fei, S., Chen, K., et al. (2026) · Antioxidants · doi:10.3390/antiox15030368 · Cited by 2 · see citing works
Trypidaki, E., Gudmundsen, S. M. B., Karris, G., Xirouchakis, S. M., González, S. V., Zhang, J., Jaspers, V. L. B., Ciesielski, T. M., Tsangaris, C., & Asimakopoulos, A. G. (2024) · Diversity · doi:10.3390/d16090541 · Cited by 2 · see citing works
Self-citationSun, M., & Li, Y. (2025) · Water · doi:10.3390/w17111589 · Cited by 2 · see citing works
Yang, M., Chu, C., Huang, J.-W., Dong, G., Jin, N.-X., Roponen, M., & Jalava, P. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.5c05377 · Cited by 1 · see citing works
Liu, H., Chen, Y., Hu, W., Luo, Y., Zhu, P. S., You, S., Li, Y., Jiang, Z., Xi, Y., Su, Z. M., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4002343
Luo, X., Feng, Q.-J., Ye, M., Hu, K., Zeng, Y., & Mai, B. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4500465
Khan, E. A., Greve, M., Russell, I., Ciesielski, T. M., Lundregan, S. L., Jensen, H., Rønning, B., Bones, A. M., Asimakopoulos, A. G., Waugh, C. A., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4610216
Self-citationJouanneau, W. (2022) · theses.fr (ABES) · doi:10.70675/e97ccda4z438dz4cddzb54cz12df5cf693ed
Hache, G. C., Harris, T. R., Pichette, A. M., Fung, V. Y., Lamberti, G. A., Peaslee, G. F., Silva, A. O. D., Miranda, D. A., & Rand, A. A. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.6827838
Xiao, L., Xu, H., Zhang, Q., Wang, J., & ZHAO, Y. (2026) · Journal of Environmental Sciences · doi:10.1016/j.jes.2026.05.041
Lu, B., Wang, P., Hu, J., Qian, J., Shen, J., Tang, S., & Zong, Y. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.128638
Su, A., Zhai, Y., Zhang, C., Duan, H., & Rajan, K. (2026) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.6c00925
Paultre, C.-B., Mebel, A. M., & Ο'Shea, K. Ε. (2026) · The Journal of Physical Chemistry A · doi:10.1021/acs.jpca.6c02120
- Authors
- Briels, N., Ciesielski, T. M., Herzke, D., & Jaspers, V. L. B.
- Affiliations
- Norwegian University of Science and Technology (NO)
- The FRAM Centre (NO)
- Corresponding author
- Briels, Nathalie
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-10-10
- Volume
- 52
- Issue
- 21
- Pages
- 12859-12867
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W2897307424
- Cited by
- 93
- References
- 55
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 18 · 2023: 11 · 2022: 8 · 2021: 14 · 2020: 15 · 2019: 6
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Environmental Science & Technology (publishedVersion)
- PubMed (publishedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- Funders
- Norges Forskningsr?d (230465/F20)
- Norges Teknisk-Naturvitenskapelige Universitet
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Keywords
- PFOS, PFOS alternatives, F-53B, developmental toxicity, chickens, in ovo injection, embryonic development, heart rate, hepatomegaly, oxidative stress, toxic equivalents
- MeSH terms
- Animals, Chickens, Ether, Fluorocarbons, Water Pollutants, Chemical, Zebrafish, Alkanesulfonic Acids
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review