Cited by 65Seaweed-derived Bioactive CompoundsOral microbiology and periodontitis researchAntimicrobial agents and applications

Synergistic effect of fucoidan with antibiotics against oral pathogenic bacteria

Lee, Kyung-Yeol, Jeong, Mi-Ran, Choi, Sung-Mi, Na, Seong-Sook, Cha, Jeong-Dan·2013·Archives of Oral Biology

Abstract

Background Fucoidan is a sulphated polysaccharide that is primarily extracted from brown seaweeds; it has been broadly studied in recent years due to its numerous biological properties, including anticoagulant, antithrombotic, antitumour and antiviral activities.Objective and design In this study, fucoidan was evaluated against oral bacteria, either alone or with antibiotics, via the broth dilution method and chequerboard and time-kill assay.Results Minimum inhibitory concentration/minimum bactericidal concentration (MIC/MBC) values for the fucoidan against all the tested bacteria ranged between 0.125 and 0.50/0.25 and 1.00mgml(-1), for ampicillin 0.125 and 64/0.5 and 64μgml(-1) and for gentamicin 2 and 256/4 and 512μgml(-1), respectively. Furthermore, the MIC and MBC were reduced to one half-eighth as a result of the combination of the fucoidan with antibiotics. One to 3h of treatment with MIC50 of fucoidan with MIC50 of antibiotics resulted from an increase of the rate of killing in colony forming units (CFUs) ml(-1) to a greater degree than was observed with alone.Conclusion These results suggest that fucoidan is important in the antibacterial actions of the agents.

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Crossref · 10.1016/j.archoralbio.2012.11.002

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Authors
Lee, K.-Y., Jeong, M.-R., Choi, S.-M., Na, S.-S., & Cha, J.-D.
Affiliations
  • Jeonbuk National University (KR)
  • Daegu Health College (KR)
Corresponding author
Cha, Jeong-Dan
Venue
Archives of Oral Biology
Publisher
Elsevier BV
Published
2013-05
Volume
58
Issue
5
Pages
482-492
ISSN
0003-9969 (ISSN-L)
OpenAlex
W1979516644
Cited by
65
References
47
Citations by year
2026: 1 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 14 · 2020: 7 · 2019: 7 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 1 · 2013: 2
FWCI
5.59
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Oral Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Chonbuk National University
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
Keywords
fucoidan, sulfated polysaccharides, brown algae, oral pathogens, antibiotic synergy, ampicillin, gentamicin, minimum inhibitory concentration, minimum bactericidal concentration, antibacterial activity, time-kill kinetics
MeSH terms
Ampicillin, Anti-Bacterial Agents, Bacteria, Anaerobic, Dental Plaque, Drug Synergism, Gentamicins, Gram-Negative Bacteria, Polysaccharides, Colony Count, Microbial, Biofilms, Plant Preparations, Fucus

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