Synergistic effect of fucoidan with antibiotics against oral pathogenic bacteria
Abstract
Background Fucoidan is a sulphated polysaccharide that is primarily extracted from brown seaweeds; it has been broadly studied in recent years due to its numerous biological properties, including anticoagulant, antithrombotic, antitumour and antiviral activities.Objective and design In this study, fucoidan was evaluated against oral bacteria, either alone or with antibiotics, via the broth dilution method and chequerboard and time-kill assay.Results Minimum inhibitory concentration/minimum bactericidal concentration (MIC/MBC) values for the fucoidan against all the tested bacteria ranged between 0.125 and 0.50/0.25 and 1.00mgml(-1), for ampicillin 0.125 and 64/0.5 and 64μgml(-1) and for gentamicin 2 and 256/4 and 512μgml(-1), respectively. Furthermore, the MIC and MBC were reduced to one half-eighth as a result of the combination of the fucoidan with antibiotics. One to 3h of treatment with MIC50 of fucoidan with MIC50 of antibiotics resulted from an increase of the rate of killing in colony forming units (CFUs) ml(-1) to a greater degree than was observed with alone.Conclusion These results suggest that fucoidan is important in the antibacterial actions of the agents.
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Dental plaque biofilms cause dental caries, periodontitis and gingivitis.
“In dental disease, dental plaque biofilms are known to cause dental caries, periodontitis and gingivitis, though the biofilms are also present on healthy teeth [10].”
From Antimicrobial and Antibiofilm Activities of Sulfated Polysaccharides from Marine Algae against Dental Plaque Bacteria (2018) · cites this paper as [10]
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Fucoidan exerts anti-cancer activity in a 3D prostate spheroid cell culture modelPreprint
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Self-citation
- Authors
- Lee, K.-Y., Jeong, M.-R., Choi, S.-M., Na, S.-S., & Cha, J.-D.
- Affiliations
- Jeonbuk National University (KR)
- Daegu Health College (KR)
- Corresponding author
- Cha, Jeong-Dan
- ORCID
- Choi, Sung-Mi
- Venue
- Archives of Oral Biology
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 58
- Issue
- 5
- Pages
- 482-492
- ISSN
- 0003-9969 (ISSN-L)
- OpenAlex
- W1979516644
- Cited by
- 65
- References
- 47
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 14 · 2020: 7 · 2019: 7 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 1 · 2013: 2
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Oral Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chonbuk National University
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Keywords
- fucoidan, sulfated polysaccharides, brown algae, oral pathogens, antibiotic synergy, ampicillin, gentamicin, minimum inhibitory concentration, minimum bactericidal concentration, antibacterial activity, time-kill kinetics
- MeSH terms
- Ampicillin, Anti-Bacterial Agents, Bacteria, Anaerobic, Dental Plaque, Drug Synergism, Gentamicins, Gram-Negative Bacteria, Polysaccharides, Colony Count, Microbial, Biofilms, Plant Preparations, Fucus
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