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Cited by 143Metabolomics and Mass Spectrometry StudiesNutrition, Genetics, and DiseaseHealth, Environment, Cognitive Aging

Paving the Way to Precision Nutrition Through Metabolomics

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Tebani, Abdellah, Bekri, Soumeya·2019·Frontiers in Nutrition
DOI 10.3389/fnut.2019.00041PMC PMC6465639
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Abstract

Nutrition is an interdisciplinary science that studies the interactions of nutrients with the body in relation to maintenance of health and well-being. Nutrition is highly complex due to the underlying various internal and external factors that could model it. Thus, hacking this complexity requires more holistic and network-based strategies that could unveil these dynamic system interactions at both time and space scales. The ongoing omics era with its high-throughput molecular data generation is paving the way to embrace this complexity and is deeply reshaping the whole field of nutrition. Understanding the future paths of nutrition science is of importance from both translational and clinical perspectives. Basic nutrients which might include metabolites are important in nutrition science. Moreover, metabolites are key biological communication channels and represent an appealing functional readout at the interface of different major influential factors that define health and disease. Metabolomics is the technology that enables holistic and systematic analyses of metabolites in a biological system. Hence, given its intrinsic functionality, its tight connection to metabolism and its high clinical actionability potential, metabolomics is a very appealing technology for nutrition science. The ultimate goal is to deliver a tailored and clinically relevant nutritional recommendations and interventions to achieve precision nutrition. This work intends to present an update on the applications of metabolomics to personalize nutrition in translational and clinical settings. It also discusses the current conceptual shifts that are remodeling clinical nutrition practices in this Precision Medicine era. Finally, perspectives of clinical nutrition in the ever-growing, data-driven healthcare landscape are presented.

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  • Permanent rather than transient changes to the core gut microbiota are likely required for long-term impact on health outcomes.

    “Permanent rather than transient changes to the core gut microbiota are likely required for long-term impact on health outcomes [16].”

    From Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration (2019) · cites this paper as [16]

  • Wide variations in individual responses to food intake contribute to many conflicting outcomes in this area of research with failures to find diet-specific effects.

    “These wide variations contribute to many conflicting outcomes in this area of research with failures to find diet-specific effects [16].”

    From Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration (2019) · cites this paper as [16]

  • Defining and stratifying those with a diet-responsive gut microbiota within an intervention cohort may enhance the predictable performance of dietary investigations and would likely reduce the number of conflicting observations between similar studies.

    “As seen in Figure 2, defining and stratifying those with a diet-responsive gut microbiota within an intervention cohort may enhance the predictable performance of these dietary investigations, and would likely reduce the number of conflicting observations between similar studies [16].”

    From Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration (2019) · cites this paper as [16]

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Cited by

Sorted by citations

Authors
Tebani, A., & Bekri, S.
Affiliations
  • Centre Hospitalier Universitaire de Rouen (FR)
  • Inserm (FR)
Corresponding author
Tebani, Abdellah
ORCID
Venue
Frontiers in Nutrition
Publisher
Frontiers Media SA
Published
2019-04-09
Volume
6
Pages
41-41
ISSN
2296-861X (ISSN-L)
DOI
10.3389/fnut.2019.00041
PMC
PMC6465639
OpenAlex
W2937827778
Cited by
143
References
17
Citations by year
2026: 10 · 2025: 23 · 2024: 19 · 2023: 22 · 2022: 25 · 2021: 20 · 2020: 20 · 2019: 4
FWCI
1.52
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Nutrition (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Keywords
personalized nutrition, metabolomics, metabolites, clinical nutrition, precision medicine, omics, dietary intervention, data-driven healthcare

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