Modification of lipoprotein metabolism and function driving atherogenesis in diabetes

Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge

Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423

2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk

Mach, F., Baigent, C., Catapano, A. L., Koskinas, K. C., Casula, M., Badimon, L., Chapman, M. J., De Backer, G. G., Delgado, V., Ference, B. A., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz455 · Cited by 8,961

Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies

The Emerging Risk Factors Collaboration (2010) · The Lancet · doi:10.1016/s0140-6736(10)60484-9 · Cited by 5,125

2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.

Arnett, D. K., Blumenthal, R. S., Albert, M. A., Buroker, A. B., Goldberger, Z. D., Hahn, E. J., Himmelfarb, C. D., Khera, A., Lloyd-Jones, D., McEvoy, J. W., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000678 · Cited by 4,536

Pathophysiology of type 2 diabetes mellitus

Galicia-Garcia, U., Benito-Vicente, A., Jebari, S., Larrea-Sebal, A., Siddiqi, H., Uribe, K. B., Ostolaza, H., & Martín, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176275 · Cited by 3,360

Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia

Bhatt, D. L., Steg, P. G., Miller, M., Brinton, E. A., Jacobson, T. A., Ketchum, S. B., Doyle, R. T., Juliano, R. A., Jiao, L., Granowitz, C., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1812792 · Cited by 3,317

Vascular smooth muscle cells in atherosclerosis

Bennett, M. R., Sinha, S., & Owens, G. K. (2016) · Circulation Research · doi:10.1161/circresaha.115.306361 · Cited by 2,179

Inflammation in obesity, diabetes, and related disorders

Rohm, T. V., Meier, D. T., Olefsky, J. M., & Donath, M. Y. (2022) · Immunity · doi:10.1016/j.immuni.2021.12.013 · Cited by 2,066

SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe

SCORE2 working group and ESC Cardiovascular risk collaboration, Hageman, S., Pennells, L., Ojeda, F., Kaptoge, S., Kuulasmaa, K., de Vries, T., Xu, Z., Kee, F., Chung, R., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab309 · Cited by 1,810

Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel

Borén, J., Chapman, M. J., Krauss, R. M., Packard, C. J., Bentzon, J. F., Binder, C. J., Daemen, M. J., Demer, L. L., Hegele, R. A., Nicholls, S. J., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz962 · Cited by 1,601

The Response-to-Retention Hypothesis of Early Atherogenesis

Williams, K. J., & Tabas, I. (1995) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.15.5.551 · Cited by 1,413

Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management

Chapman, M. J., Ginsberg, H. N., Amarenco, P., Andreotti, F., Borén, J., Catapano, A. L., Descamps, O. S., Fisher, E., Kovanen, P. T., Kuivenhoven, J. A., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr112 · Cited by 1,227

CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior

Silverstein, R. L., & Febbraio, M. (2009) · Science Signaling · doi:10.1126/scisignal.272re3 · Cited by 1,141

Subendothelial retention of atherogenic lipoproteins in early atherosclerosis

Skålén, K., Gustafsson, M., Rydberg, E. K., Hultén, L. M., Wiklund, O., Innerarity, T. L., & Borén, J. (2002) · Nature · doi:10.1038/nature00804 · Cited by 1,019

Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies—a consensus statement from the European Atherosclerosis Society

Ginsberg, H. N., Packard, C. J., Chapman, M. J., Borén, J., Aguilar-Salinas, C. A., Averna, M., Ference, B. A., Gaudet, D., Hegele, R. A., Kersten, S., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab551 · Cited by 979

Comparison of a Novel Method vs the Friedewald Equation for Estimating Low-Density Lipoprotein Cholesterol Levels From the Standard Lipid Profile

Martin, S. S., Blaha, M. J., Elshazly, M. B., Toth, P. P., Kwiterovich, P. O., Blumenthal, R. S., & Jones, S. R. (2013) · JAMA · doi:10.1001/jama.2013.280532 · Cited by 883

Global epidemiology of dyslipidaemias

Pirillo, A., Casula, M., Olmastroni, E., Norata, G. D., & Catapano, A. L. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00541-4 · Cited by 882

Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice

Shimomura, I., Matsuda, M., Hammer, R. E., Bashmakov, Y. K., Brown, M. S., & Goldstein, J. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00010-9 · Cited by 860

Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome

Adiels, M., Olofsson, S.-O., Taskinen, M.-R., & Borén, J. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.160192 · Cited by 820

LOX-1, OxLDL, and Atherosclerosis

Pirillo, A., Norata, G. D., & Catapano, A. L. (2013) · Mediators of Inflammation · doi:10.1155/2013/152786 · Cited by 793

Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease

Smith, G. I., Shankaran, M., Yoshino, M., Schweitzer, G. G., Chondronikola, M., Beals, J. W., Okunade, A. L., Patterson, B. W., Nyangau, E., Field, T., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci134165 · Cited by 771

Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk

Das Pradhan, A., Glynn, R. J., Fruchart, J.-C., MacFadyen, J. G., Zaharris, E. S., Everett, B. M., Campbell, S. E., Oshima, R., Amarenco, P., Blom, D. J., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2210645 · Cited by 749

Vascular Cell Adhesion Molecule-1 Expression and Signaling During Disease: Regulation by Reactive Oxygen Species and Antioxidants

Cook‐Mills, J. M., Marchese, M. E., & Abdala‐Valencia, H. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3522 · Cited by 597

A New Equation for Calculation of Low-Density Lipoprotein Cholesterol in Patients With Normolipidemia and/or Hypertriglyceridemia

Sampson, M. L., Ling, C., Sun, Q., Harb, R., Ashmaig, M., Warnick, R., Sethi, A. A., Fleming, J. K., Otvos, J. D., Meeusen, J. W., et al. (2020) · JAMA Cardiology · doi:10.1001/jamacardio.2020.0013 · Cited by 593

Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review

Sniderman, A. D., Thanassoulis, G., Glavinovic, T., Navar, A. M., Pencina, M., Catapano, A., & Ference, B. A. (2019) · JAMA Cardiology · doi:10.1001/jamacardio.2019.3780 · Cited by 593

Calcium signaling in platelets

Varga-Szabó, D., Braun, A., & Nieswandt, B. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03455.x · Cited by 575

Pathology of human coronary and carotid artery atherosclerosis and vascular calcification in diabetes mellitus

Yahagi, K., Kolodgie, F. D., Lutter, C., Mori, H., Romero, M. E., Finn, A. V., & Virmani, R. (2017) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.116.306256 · Cited by 573

Increased Activation of the Mammalian Target of Rapamycin Pathway in Liver and Skeletal Muscle of Obese Rats: Possible Involvement in Obesity-Linked Insulin Resistance

Khamzina, L., Veilleux, A., Bergeron, S., & Marette, A. (2005) · Endocrinology · doi:10.1210/en.2004-0921 · Cited by 562

Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction

Darenskaya, M. A., Колесникова, Л. И., & Kolesnikov, S. I. (2021) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-021-05191-7 · Cited by 504

Hepatic uptake of chylomicron remnants

Cooper, A. D. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34932-4 · Cited by 499

Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets

Schwarz, J.-M., Linfoot, P., Dare, D., & Aghajanian, K. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.1.43 · Cited by 496

Cardiovascular risk in diabetes mellitus: Epidemiology, assessment and prevention

Wong, N. D., & Sattar, N. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00877-z · Cited by 495

Inhibition of lipoprotein lipase by an apoprotein of human very low density lipoprotein

Brown, W. V., & Baginsky, M. L. (1972) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(72)80149-9 · Cited by 493

VLDL, apolipoproteins B, CIII, and E, and risk of recurrent coronary events in the Cholesterol and Recurrent Events (CARE) trial

Sacks, F. M., Alaupovic, P., Moye, L. A., Cole, T. G., Sussex, B., Stampfer, M. J., Pfeffer, M. A., & Braunwald, E. (2000) · Circulation · doi:10.1161/01.cir.102.16.1886 · Cited by 490

Morphologic Findings of Coronary Atherosclerotic Plaques in Diabetics

BURKE, A. P., Kolodgie, F. D., Zieske, A. W., Fowler, D. R., Weber, D. K., Varghese, P. J., Farb, A. A., & Virmani, R. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000131783.74034.97 · Cited by 490

Genetic and metabolic determinants of plasma PCSK9 levels

Lakoski, S. G., Lagace, T. A., Cohen, J. C., Horton, J. D., & Hobbs, H. H. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0141 · Cited by 475

New insights into the pathophysiology of dyslipidemia in type 2 diabetes

Taskinen, M.-R., & Borén, J. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.01.039 · Cited by 440

Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models

Kim, K., Shim, D., Lee, J. S., Zaitsev, K., Williams, J. W., Kim, K.-W., Jang, M.-Y., Seok Jang, H., Yun, T. J., Lee, S. H., et al. (2018) · Circulation Research · doi:10.1161/circresaha.118.312804 · Cited by 434

Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription

Ishii, S., Iizuka, K., Miller, B. C., & Uyeda, K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405238101 · Cited by 424

Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease

Nielsen, T. S., Jessen, N., Jørgensen, J. O. L., Møller, N., & Lund, S. A. (2014) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0277 · Cited by 399

Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men.

Fried, S. K., Russell, C. D., Grauso, N. L., & Brolin, R. E. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116821 · Cited by 364

Apolipoprotein B and Non-HDL Cholesterol Better Reflect Residual Risk Than LDL Cholesterol in Statin-Treated Patients

Johannesen, C. D. L., Mortensen, M. B., Langsted, A., & Nordestgaard, B. G. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.01.027 · Cited by 359

The effect of metformin on blood pressure, plasma cholesterol and triglycerides in type 2 diabetes mellitus: a systematic review

Wulffelé, M. G., Kooy, A., de Zeeuw, D., Stehouwer, C. D. A., & Gansevoort, R. T. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01328.x · Cited by 359

Nonenzymatic Glucosylation of Low-Density Lipoprotein Alters Its Biologic Activity

Witztum, J. L., Mahoney, E. M., Branks, M. J., Fisher, M., Elam, R. L., & Steinberg, D. H. (1982) · Diabetes · doi:10.2337/diab.31.4.283 · Cited by 352

Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins.

Schissel, S. L., Tweedie-Hardman, J., Rapp, J. H., Graham, G., Williams, K. J., & Tabas, I. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118934 · Cited by 342

Triglyceride-rich lipoproteins isolated by selected-affinity anti-apolipoprotein B immunosorption from human atherosclerotic plaque

Rapp, J. H., Lespine, A., Hamilton, R. L., Colyvas, N., Chaumeton, A. H., Tweedie-Hardman, J., Kotite, L., Kunitake, S. T., Havel, R. J., & Kane, J. P. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.11.1767 · Cited by 340

Selective Retention of VLDL, IDL, and LDL in the Arterial Intima of Genetically Hyperlipidemic Rabbits In Vivo: Molecular Size as a Determinant of Fractional Loss From the Intima–Inner Media

Nordestgaard, B. G., Wootton, R., & Lewis, B. (1995) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.15.4.534 · Cited by 334

Identification of the principal proteoglycan-binding site in LDL. A single-point mutation in apo-B100 severely affects proteoglycan interaction without affecting LDL receptor binding.

Borén, J., Olin, K., Lee, I., Chait, A., Wight, T. N., & Innerarity, T. L. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2265 · Cited by 331

Lysophosphatidylcholine transcriptionally induces growth factor gene expression in cultured human endothelial cells.

Kume, N., & Gimbrone, M. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117047 · Cited by 329

SCORE2-Diabetes: 10-year cardiovascular risk estimation in type 2 diabetes in Europe

SCORE2-Diabetes Working Group and the ESC Cardiovascular Risk Collaboration, Pennells, L., Kaptoge, S., Østergaard, H. B., Read, S. H., Carinci, F., Franch-Nadal, J., Petitjean, C., Taylor, O., Hageman, S. H. J., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad260 · Cited by 329

Discrete subspecies of human low density lipoproteins are heterogeneous in their interaction with the cellular LDL receptor.

Nigon, F., Lesnik, P., Rouis, M., & Chapman, M. J. (1991) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41629-3 · Cited by 325

Secretory Sphingomyelinase, a Product of the Acid Sphingomyelinase Gene, Can Hydrolyze Atherogenic Lipoproteins at Neutral pH

Schissel, S. L., Jiang, X., Tweedie-Hardman, J., Jeong, T., Hurt‐Camejo, E., Najïb, J., Rapp, J. H., Williams, K. J., & Tabas, I. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.5.2738 · Cited by 322

Defective regulation of triglyceride metabolism by insulin in the liver in NIDDM.

Malmström, R., Packard, C. J., Caslake, M., Bedford, D., Stewart, P., Yki-Järvinen, H., Shepherd, J., & Taskinen, M.-R. (1997) · Diabetologia · doi:10.1007/s001250050700 · Cited by 319

Increased Small Low-Density Lipoprotein Particle Number

Kathiresan, S., Otvos, J. D., SULLIVAN, L. M., Keyes, M. J., Schaefer, E. J., Wilson, P. W. F., D’Agostino, R. B., Vasan, R. S., & Robins, S. J. (2005) · Circulation · doi:10.1161/circulationaha.105.567107 · Cited by 318

Hepatic PCSK9 Expression Is Regulated by Nutritional Status via Insulin and Sterol Regulatory Element-binding Protein 1c

Costet, P., Cariou, B., Lambert, G. C., Lalanne, F., Lardeux, B. R., Jarnoux, A. L., Grefhorst, A., Staels, B., & Krempf, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508582200 · Cited by 315

Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver.

Windler, E. E. T., & Havel, R. J. (1985) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34342-x · Cited by 314

Foxo1 mediates insulin action on apoC-III and triglyceride metabolism

Altomonte, J., Lin, C., Harbaran, S., Richter, A. M., Xu, J., Meseck, M. L., & Dong, H. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19992 · Cited by 312

Glycation impairs high-density lipoprotein function

Hedrick, C. C., Thorpe, S. R., Fu, M.-X., Harper, C. M., Yoo, J. H., Kim, S.-M., Wong, H., & Peters, A. L. (2000) · Diabetologia · doi:10.1007/s001250050049 · Cited by 310

Apolipoprotein CIII Induces Expression of Vascular Cell Adhesion Molecule-1 in Vascular Endothelial Cells and Increases Adhesion of Monocytic Cells

Kawakami, A., Aikawa, M., Alcaide, P., Luscinskas, F. W., Libby, P., & Sacks, F. M. (2006) · Circulation · doi:10.1161/circulationaha.106.622514 · Cited by 305

Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized FFAs that induce endothelial cell inflammation

Wang, L., Gill, R., Pedersen, T. L., Higgins, L. J., Newman, J. W., & Rutledge, J. C. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m700505-jlr200 · Cited by 303

Insulin sensitivity in subjects with type 2 diabetes. Relationship to cardiovascular risk factors: the Insulin Resistance Atherosclerosis Study.

Haffner, S. M., D'Agostino, R., Mykkänen, L. M., Tracy, R. P., Howard, B. V., Rewers, M., Selby, J. V., Savage, P. J., & Saad, M. F. (1999) · Diabetes Care · doi:10.2337/diacare.22.4.562 · Cited by 297

Visualization of the binding, endocytosis, and transcytosis of low-density lipoprotein in the arterial endothelium in situ.

Vasile, E., Simionescu, M., & Simionescu, N. (1983) · The Journal of cell biology · doi:10.1083/jcb.96.6.1677 · Cited by 294

Insulin stimulation of adipose tissue lipoprotein lipase. Use of the euglycemic clamp technique.

Sadur, C. N., & Eckel, R. H. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110547 · Cited by 288

Overproduction of VLDL 1 Driven by Hyperglycemia Is a Dominant Feature of Diabetic Dyslipidemia

Adiels, M., Borén, J., CASLAKE, M. J., Stewart, P., Soro, A., Westerbacka, J., Wennberg, B., Olofsson, S., Packard, C. J., & Taskinen, M. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000172689.53992.25 · Cited by 275

ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors

Gordts, P. L. S. M., Nock, R., Son, N.-H., Ramms, B., Lew, I., Gonzales, J. C., Thacker, B. E., Basu, D., Lee, R. G., Mullick, A. E., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86610 · Cited by 274

Oxidation of Low-Density Lipoprotein by Hypochlorite Causes Aggregation That is Mediated by Modification of Lysine Residues Rather Than Lipid Oxidation

Hazell, L. J., van den Berg, J. J. M., & Stocker, R. (1994) · Biochemical Journal · doi:10.1042/bj3020297 · Cited by 267

A review of CETP and its relation to atherosclerosis

de Grooth, G. J., Klerkx, A. H. E. M., Stroes, E. S. G., Stalenhoef, A. F. H., Kastelein, J. J. P., & Kuivenhoven, J. A. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r400007-jlr200 · Cited by 264

Foam Cells in Atherosclerosis: Novel Insights Into Its Origins, Consequences, and Molecular Mechanisms

Gui, Y., Zheng, H., & Cao, R. Y. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.845942 · Cited by 258

Intracellular Trafficking and Secretion of VLDL

Tiwari, S., & Siddiqi, S. A. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.241471 · Cited by 257

Remnant cholesterol as a cause of ischemic heart disease: Evidence, definition, measurement, atherogenicity, high risk patients, and present and future treatment

Varbo, A., Benn, M., & Nordestgaard, B. G. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.11.008 · Cited by 251

Inhibition of Angiopoietin-Like Protein 3 With a Monoclonal Antibody Reduces Triglycerides in Hypertriglyceridemia

Ahmad, Z., Banerjee, P., Hamon, S., Chan, K., Bouzelmat, A., Sasiela, W. J., Pordy, R. C., Mellis, S. J., Dansky, H. M., Gipe, D. A., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.039107 · Cited by 251

Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E3.

Weisgraber, K. H., Rall, S. C., Mahley, R. W., Milne, R. W., Marcel, Y. L., & Sparrow, J. T. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35898-2 · Cited by 240

Influence of plasma lipid and LDL-subfraction profile on the interaction between low density lipoprotein with human arterial wall proteoglycans

Anber, V., Griffin, B. A., McConnell, M., Packard, C. J., & Shepherd, J. (1996) · Atherosclerosis · doi:10.1016/0021-9150(96)05842-x · Cited by 237

Hepatic Very Low Density Lipoprotein-ApoB Overproduction Is Associated with Attenuated Hepatic Insulin Signaling and Overexpression of Protein-tyrosine Phosphatase 1B in a Fructose-fed Hamster Model of Insulin Resistance

Taghibiglou, C., Rashid-Kolvear, F., Iderstine, S. C. V., Le‐Tien, H., Fantus, I. G., Lewis, G. F., & Adeli, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106737200 · Cited by 236

Apolipoprotein B, the major protein component of triglyceride-rich and low density lipoproteins.

Chan, L. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35646-1 · Cited by 231

Oxidized LDL and anti-oxidized LDL antibodies in atherosclerosis – Novel insights and future directions in diagnosis and therapy,

Hartley, A., Haskard, D. O., & Khamis, R. (2018) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2018.05.010 · Cited by 219

Diabetic Hypertriglyceridemia: Evidence for Three Clinical Syndromes

Reaven, G. M., & Greenfield, M. S. (1981) · Diabetes · doi:10.2337/diab.30.2.s66 · Cited by 214

Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk

Tardif, J.-C., Karwatowska-Prokopczuk, E., Amour, E. S., Ballantyne, C. M., Shapiro, M. D., Moriarty, P. M., Baum, S. J., Hurh, E., Bartlett, V. J., Kingsbury, J., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehab820 · Cited by 210

The Evolving Understanding and Approach to Residual Cardiovascular Risk Management

Dhindsa, D. S., Sandesara, P. B., Shapiro, M. D., & Wong, N. D. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00088 · Cited by 208

Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression

Williams, J. W., Zaitsev, K., Kim, K.-W., Ivanov, S., Saunders, B. T., Schrank, P. R., Kim, K., Elvington, A., Kim, S. H., Tucker, C., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0768-4 · Cited by 206

The oxidative modification hypothesis of atherosclerosis: the comparison of atherogenic effects on oxidized LDL and remnant lipoproteins in plasma.

Nakajima, K., Nakano, T., & Tanaka, A. (2006) · Clinica chimica acta; international journal of clinical chemistry · doi:10.1016/j.cca.2005.12.013 · Cited by 205

The regulation of ApoB metabolism by insulin

Haas, M. E., Attie, A., & Biddinger, S. B. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.04.001 · Cited by 202

Serum Level of Triglycerides Is a Potent Risk Factor Comparable to LDL Cholesterol for Coronary Heart Disease in Japanese Patients with Type 2 Diabetes: Subanalysis of the Japan Diabetes Complications Study (JDCS)

Sone, H., Tanaka, S., Tanaka, S., Iimuro, S., Oida, K., Yamasaki, Y., Oikawa, S., Ishibashi, S., Katayama, S., Ohashi, Y., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0622 · Cited by 201

Anti-inflammatory and Antioxidant Properties of HDLs Are Impaired in Type 2 Diabetes

Morgantini, C., Natali, A., Boldrini, B., Imaizumi, S., Navab, M., Fogelman, A. M., Ferrannini, E., & Reddy, S. T. (2011) · Diabetes · doi:10.2337/db11-0378 · Cited by 200

Regulation of lipid metabolism by angiopoietin-like proteins

Dijk, W., & Kersten, S. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000290 · Cited by 197

Fasting and Postprandial Overproduction of Intestinally Derived Lipoproteins in an Animal Model of Insulin Resistance

Haidari, M., Leung, N., Mahbub, F., Uffelman, K., Kohen-Avramoglu, R., Lewis, G., & Adeli, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200544200 · Cited by 191

Plasma Apolipoproteins AI, AII, B, CI, and E Are Glucosylated in Hyperglycemic Diabetic Subjects

Curtiss, L. K., & Witztum, J. L. (1985) · Diabetes · doi:10.2337/diab.34.5.452 · Cited by 188

Effect of arterial proteoglycans and glycosaminoglycans on low density lipoprotein oxidation and its uptake by human macrophages and arterial smooth muscle cells.

Hurt‐Camejo, E., Camejo, G., Rosengren, B. E., López, F., Ahlström, C., Fager, G., & Bondjers, G. (1992) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.12.5.569 · Cited by 184

Triglyceride-rich lipoprotein remnants, low-density lipoproteins, and risk of coronary heart disease: a UK Biobank study

Björnson, E., Adiels, M., Taskinen, M.-R., Burgess, S., Rawshani, A., Borén, J., & Packard, C. J. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad337 · Cited by 183

Discordance Between Apolipoprotein B and LDL-Cholesterol in Young Adults Predicts Coronary Artery Calcification

Wilkins, J. T., Li, R. C., Sniderman, A., Chan, C., & Lloyd-Jones, D. M. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.10.055 · Cited by 181

A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis

Armstrong, S. M., Sugiyama, M. G., Fung, K., Gao, Y. K., Wang, C., Levy, A. S., Azizi, P., Roufaiel, M., Zhu, S.-N., Neculai, D., et al. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv218 · Cited by 178

Scavenger receptors for oxidized and glycated proteins

Horiuchi, S., Sakamoto, Y., & Sakai, M. (2003) · Amino Acids · doi:10.1007/s00726-003-0029-5 · Cited by 178

Metabolic Dyslipidemia and Cardiovascular Outcomes in Type 2 Diabetes Mellitus: Findings From the Look AHEAD Study

Kazé, A. D., Santhanam, P., Musani, S. K., Ahima, R. S., & Echouffo-Tcheugui, J. B. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.016947 · Cited by 177

Expression of apolipoprotein C-III in McA-RH7777 cells enhances VLDL assembly and secretion under lipid-rich conditions

Sundaram, M., Zhong, S., Khalil, M. B., Links, P. H., Zhao, Y., Iqbal, J., Hussain, M. M., Parks, R. J., Wang, Y., & Yao, Z. (2009) · Journal of Lipid Research · doi:10.1194/m900346-jlr200 · Cited by 176

Localization of Nonpancreatic Secretory Phospholipase A 2 in Normal and Atherosclerotic Arteries

Hurt‐Camejo, E., Andersen, S. B., Standal, R., Rosengren, B. E., Sartipy, P., Stadberg, E., & Johansen, B. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.2.300 · Cited by 170

Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice

Ai, D., Chen, C., Han, S., Ganda, A., Murphy, A. J., Haeusler, R. A., Thorp, E. B., Accili, D., Horton, J. D., & Tall, A. R. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61919 · Cited by 169

Transcriptional Activation of Apolipoprotein CIII Expression by Glucose May Contribute to Diabetic Dyslipidemia

Caron, S., Verrijken, A., Mertens, I. L., Samanez, C. H., Mautino, G., Haas, J. T., Duran-Sandoval, D., Prawitt, J., Francque, S., Vallez, E., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.220723 · Cited by 168

Glycation of LDL by Methylglyoxal Increases Arterial Atherogenicity

Rabbani, N., Godfrey, L., Xue, M., Shaheen, F., Geoffrion, M., Milne, R. W., & Thornalley, P. J. (2011) · Diabetes · doi:10.2337/db11-0085 · Cited by 167

The Atherogenic Role of Circulating Modified Lipids in Atherosclerosis

Summerhill, V. I., Grechko, A. V., Yet, S., Sobenin, I. A., & Orekhov, A. N. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143561 · Cited by 167

Cellular Consequences of the Association of ApoB Lipoproteins With Proteoglycans

Hurt‐Camejo, E., Olsson, U., Wiklund, O., Bondjers, G., & Camejo, G. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.6.1011 · Cited by 165

Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells

Kraehling, J. R., Chidlow, J. H., Rajagopal, C., Sugiyama, M. G., Fowler, J. W., Lee, M. Y., Zhang, X., Ramírez, C. M., Park, E. J., Tao, B., et al. (2016) · Nature Communications · doi:10.1038/ncomms13516 · Cited by 165

Exenatide, a Glucagon-like Peptide-1 Receptor Agonist, Acutely Inhibits Intestinal Lipoprotein Production in Healthy Humans

Xiao, C., Bandsma, R. H. J., Dash, S., Szeto, L., & Lewis, G. F. (2012) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.112.246207 · Cited by 164

Apolipoprotein B improves risk assessment of future coronary heart disease in the Framingham Heart Study beyond LDL-C and non-HDL-C

Pencina, M. J., D’Agostino, R. B., Zdrojewski, T., Williams, K., Thanassoulis, G., Furberg, C. D., Peterson, E. D., Vasan, R. S., & Sniderman, A. D. (2015) · European Journal of Preventive Cardiology · doi:10.1177/2047487315569411 · Cited by 164

Differential uptake of proteoglycan-selected subfractions of low density lipoprotein by human macrophages.

Hurt‐Camejo, E., Camejo, G., Rosengren, B. E., Lopez, F., Wiklund, O., & Bondjers, G. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42610-0 · Cited by 162

Large lipoproteins are excluded from the arterial wall in diabetic cholesterol-fed rabbits

Nordestgaard, B. G., & Zilversmit, D. B. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38428-5 · Cited by 156

Identification of a New Functional Domain in Angiopoietin-like 3 (ANGPTL3) and Angiopoietin-like 4 (ANGPTL4) Involved in Binding and Inhibition of Lipoprotein Lipase (LPL)

Lee, E.-C., Desai, U., Gololobov, G., Hong, S., Feng, X., Yu, X.-C., Gay, J., Wilganowski, N., Gao, C., Du, L.-L., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807899200 · Cited by 151

Differences in LDL subspecies involve alterations in lipid composition and conformational changes in apolipoprotein B

McNamara, J. R., Small, D. M., Li, Z., & Schaefer, E. J. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37557-x · Cited by 147

Postprandial Hyperlipidemia and Remnant Lipoproteins

Masuda, D., & Yamashita, S. (2017) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.rv16003 · Cited by 145

Oxidized Low Density Lipoprotein and Lysophosphatidylcholine Stimulate Cell Cycle Entry in Vascular Smooth Muscle Cells

Chai, Y.-C., Howe, P. H., DiCorleto, P. E., & Chisolm, G. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.17791 · Cited by 142

ApoCIII-Enriched LDL in Type 2 Diabetes Displays Altered Lipid Composition, Increased Susceptibility for Sphingomyelinase, and Increased Binding to Biglycan

Hiukka, A., Ståhlman, M., Pettersson, C., Levin, M. C., Adiels, M., Teneberg, S., Leinonen, E. S., Hultén, L. M., Wiklund, O., Orešič, M., et al. (2009) · Diabetes · doi:10.2337/db09-0206 · Cited by 141

Discordance analysis of apolipoprotein B and non-high density lipoprotein cholesterol as markers of cardiovascular risk in the INTERHEART study

Sniderman, A. D., Islam, S., Yusuf, S., & McQueen, M. J. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.08.039 · Cited by 138

Sphingomyelinase Induces Aggregation and Fusion, but Phospholipase A2 Only Aggregation, of Low Density Lipoprotein (LDL) Particles

Öörni, K., Hakala, J. K., Annila, A., Ala‐Korpela, M., & Kovanen, P. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.44.29127 · Cited by 137

Impact of advanced glycation end products (AGEs) signaling in coronary artery disease

Kosmopoulos, M., Drekolias, D., Zavras, P. D., Piperi, C., & Papavassiliou, A. G. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.01.006 · Cited by 136

New insight into the pathophysiology of lipid abnormalities in type 2 diabetes

Vergès, B. L. (2005) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70213-6 · Cited by 134

Glycoxidation of biological macromolecules: A critical approach to halt the menace of glycation

Ahmad, S., Khan, M. S., Akhter, F., Khan, M. S., Khan, M. S., Ashraf, J. M., Pandey, R. P., & Shahab, U. (2014) · Glycobiology · doi:10.1093/glycob/cwu057 · Cited by 133

Lysophosphatidylcholine Promotes P-Selectin Expression in Platelets and Endothelial Cells

Murohara, T., Scalia, R. G., & Lefer, A. M. (1996) · Circulation Research · doi:10.1161/01.res.78.5.780 · Cited by 132

Retention of atherogenic lipoproteins in the artery wall and its role in atherogenesis

Fogelstrand, P., & Borén, J. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.09.007 · Cited by 127

Intimal Retention of Cholesterol Derived From Apolipoprotein B100– and Apolipoprotein B48–Containing Lipoproteins in Carotid Arteries of Watanabe Heritable Hyperlipidemic Rabbits

Proctor, S. D., & Mamo, J. C. L. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000084638.14534.0a · Cited by 124

Receptor-mediated uptake of remnant lipoproteins by cholesterol-loaded human monocyte-macrophages.

Lenten, B. J. V., Fogelman, A. M., Jackson, R. L., Shapiro, S., Haberland, M. E., & Edwards, P. A. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39420-6 · Cited by 122

A Multicenter, Prospective, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of Saroglitazar 2 and 4 mg Compared with Placebo in Type 2 Diabetes Mellitus Patients Having Hypertriglyceridemia Not Controlled with Atorvastatin Therapy (PRESS VI)

Jani, R. H., Pai, V., Jha, P. R., Jariwala, G., Mukhopadhyay, S., Bhansali, A. K., & Joshi, S. (2013) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2013.0253 · Cited by 120

A Multicenter, Prospective, Randomized, Double-blind Study to Evaluate the Safety and Efficacy of Saroglitazar 2 and 4 mg Compared to Pioglitazone 45 mg in Diabetic Dyslipidemia (PRESS V)

Pai, V., Paneerselvam, A., Mukhopadhyay, S., Bhansali, A. K., Kamath, D., Shankar, V., Gambhire, D., Jani, R. H., Joshi, S., & Patel, P. (2014) · Journal of Diabetes Science and Technology · doi:10.1177/1932296813518680 · Cited by 119

Lipid modification in type 2 diabetes: the role of LDL and HDL

Vergès, B. (2009) · Fundamental & Clinical Pharmacology · doi:10.1111/j.1472-8206.2009.00739.x · Cited by 117

Delayed secretory pathway contributions to VLDL-triglycerides from plasma NEFA, diet, and de novo lipogenesis in humans

Vedala, A., Wang, W., Neese, R. A., Christiansen, M. P., & Hellerstein, M. K. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600200-jlr200 · Cited by 117

ApoC-III content of apoB-containing lipoproteins is associated with binding to the vascular proteoglycan biglycan

Olin-Lewis, K., Krauss, R. M., La Belle, M., Blanche, P. J., Barrett, P. H. R., Wight, T. N., & Chait, A. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200322-jlr200 · Cited by 114

Dysfunctional HDL in diabetes mellitus and its role in the pathogenesis of cardiovascular disease

Srivastava, R. A. K. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3165-z · Cited by 113

Oxford Textbook of Endocrinology and Diabetes

LATROFA, F., VITTI, P., & PINCHERA, A. (2011) · doi:10.1093/med/9780199235292.001.1 · Cited by 111

Analysis of plasma lipids and apolipoproteins in insulin-dependent and noninsulin-dependent diabetics

BRIONES, E. R., Mao, S. J. T., Palumbo, P. J., O’Fallon, W. M., CHENOWETH, W. L., & Kottke, B. A. (1984) · Metabolism · doi:10.1016/0026-0495(84)90160-4 · Cited by 107

Identification of the Proteoglycan Binding Site in Apolipoprotein B48

Flood, C., Gustafsson, M. V., Richardson, P. E., Harvey, S. C., Segrest, J. P., & Borén, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204053200 · Cited by 107

Lysophosphatidyl Choline, a Chemotactic Factor for Monocytes/T-Lymphocytes Is Elevated in Endometriosis

Murphy, A. A., Santanam, N., Morales, A. J., & Parthasarathy, S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4823 · Cited by 107

Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance

Laatsch, A., Merkel, M., Talmud, P. J., Grewal, T., Beisiegel†, U., & Heeren, J. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.07.046 · Cited by 106

Activation of NADPH oxidase is required for macrophage-mediated oxidation of low-density lipoprotein

Aviram, M., Rosenblat, M., Etzioni, A., & Lévy, R. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90005-0 · Cited by 105

Abnormal hepatic apolipoprotein B metabolism in type 2 diabetes

Vergès, B. L. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.01.028 · Cited by 105

RNA interference targeting ANGPTL3 for triglyceride and cholesterol lowering: phase 1 basket trial cohorts

Watts, G. F., Schwabe, C., Scott, R., Gladding, P. A., Sullivan, D., Baker, J., Clifton, P., Hamilton, J., Given, B., Melquist, S., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02494-2 · Cited by 105

Discordance between circulating atherogenic cholesterol mass and lipoprotein particle concentration in relation to future coronary events in women

Lawler, P. R., Akinkuolie, A. O., Ridker, P. M., Sniderman, A. D., Buring, J. E., Glynn, R. J., Chasman, D. I., & Mora, S. (2017) · Clinical Chemistry · doi:10.1373/clinchem.2016.264515 · Cited by 104

Glycation of LDL in non-diabetic people: Small dense LDL is preferentially glycated both in vivo and in vitro

Younis, N. N., Charlton-Menys, V., Sharma, R., Soran, H., & Durrington, P. N. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.04.036 · Cited by 104

Arterial Permeability and Efflux of Apolipoprotein B–Containing Lipoproteins Assessed by In Situ Perfusion and Three-Dimensional Quantitative Confocal Microscopy

Proctor, S. D., Vine, D. F., & Mamo, J. C. L. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000143859.75035.5a · Cited by 103

Advanced Glycation End Products-Induced Gene Expression of Scavenger Receptors in Cultured Human Monocyte-Derived Macrophages

Iwashima, Y., Eto, M., Hata, A., Kaku, K., Horiuchi, S., Ushikubi, F., & Sano, H. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3685 · Cited by 102

Glycation as an atherogenic modification of LDL

Younis, N. N., Sharma, R., Soran, H., Charlton-Menys, V., Elseweidy, M. M., & Durrington, P. N. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328306a057 · Cited by 102

Reduced Na(+)-K(+)-ATPase activity and plasma lysophosphatidylcholine concentrations in diabetic patients

Rabini, R. A., Galassi, R., Fumelli, P., Dousset, N., Solera, M. L., Valdiguié, P. M., CURATOLA, G., Ferretti, G., Taus, M., & Mazzanti, L. (1994) · Diabetes · doi:10.2337/diab.43.7.915 · Cited by 102

Glycated Low Density Lipoproteins Modify Platelet Properties: A Compositional and Functional Study

Ferretti, G., Rabini, R. A., Bacchetti, T., Vignini, A., Salvolini, E., Ravaglia, F., CURATOLA, G., & Mazzanti, L. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8466 · Cited by 99

Non-enzymatic glycation of apolipoprotein B in the sera of diabetic and non-diabetic subjects.

Tames, F., Mackness, M., Arrol, S., Laing, I., & Durrington, P. (1992) · Atherosclerosis · doi:10.1016/0021-9150(92)90260-n · Cited by 98

Liposome-like particles isolated from human atherosclerotic plaques are structurally and compositionally similar to surface remnants of triglyceride-rich lipoproteins.

Chung, B. H., Tallis, G. A., Yalamoori, V., Anantharamaiah, G. M., & Segrest, J. P. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.4.622 · Cited by 97

Effects of APOC3 Heterozygous Deficiency on Plasma Lipid and Lipoprotein Metabolism

Reyes-Soffer, G., Sztalryd, C., Horenstein, R. B., Holleran, S., Matveyenko, A., Thomas, T., Nandakumar, R., Ngai, C., Karmally, W., Ginsberg, H. N., et al. (2019) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.118.311476 · Cited by 97

‘Lipoproteins, glycoxidation and diabetic angiopathy’

Jenkins, A. J., Best, J. D., Klein, R. L., & Lyons, T. J. (2004) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.491 · Cited by 96

New insights into angiopoietin-like proteins in lipid metabolism and cardiovascular disease risk

Kersten, S. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000600 · Cited by 95

Colocalisation of intraplaque C reactive protein, complement, oxidised low density lipoprotein, and macrophages in stable and unstable angina and acute myocardial infarction

Meuwissen, M., van der Wal, A. C., Niessen, H. W. M., Koch, K. T., de Winter, R. J., van der Loos, C. M., Rittersma, S. Z. H., Chamuleau, S. A. J., Tijssen, J. G. P., Becker, A. E., et al. (2006) · Journal of Clinical Pathology · doi:10.1136/jcp.2005.027235 · Cited by 94

Possible functional interactions of apolipoprotein B-100 segments that associate with cell proteoglycans and the ApoB/E receptor

Olsson, U., Camejo, G., Hurt-Camejo, E., Elfsber, K., Wiklund, O., & Bondjers, G. (1997) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.17.1.149 · Cited by 94

Glycation Reduces the Stability of ApoAI and Increases HDL Dysfunction in Diet-Controlled Type 2 Diabetes

Kashyap, S. R., Ösme, A., Ilchenko, S., Golizeh, M., Lee, K., Wang, S., Bena, J., Previs, S. F., Smith, J. D., & Kasumov, T. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01551 · Cited by 92

Susceptibility of LDL and its subfractions to glycation

Soran, H., & Durrington, P. N. (2011) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328348a43f · Cited by 91

Expression of Class A Scavenger Receptor Is Enhanced by High Glucose in Vitro and under Diabetic Conditions in Vivo

Takaki, K., Sakai, M., Sakamoto, Y.-I., Takeya, M., & Horiuchi, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408715200 · Cited by 91

Foamy Monocytes Form Early and Contribute to Nascent Atherosclerosis in Mice With Hypercholesterolemia

Lu, X., Perrard, X. D., Perrard, J. L., Yang, D., Xiao, X., Teng, B.-B., Simon, S. I., Ballantyne, C. M., & Wu, H. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305609 · Cited by 91

Elevated remnant cholesterol and atherosclerotic cardiovascular disease in diabetes: a population-based prospective cohort study

Wadström, B. N., Pedersen, K. M., Wulff, A. B., & Nordestgaard, B. G. (2023) · Diabetologia · doi:10.1007/s00125-023-06016-0 · Cited by 91

Scavenger Receptor CD36 Directs Nonclassical Monocyte Patrolling Along the Endothelium During Early Atherogenesis

Marcovecchio, P., Thomas, G. D., Mikulski, Z., Ehinger, E., Mueller, K. A. L., Blatchley, A., Wu, R., Miller, Y. I., Nguyen, A. T., Taylor, A. M., et al. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309123 · Cited by 89

Uptake of chylomicron remnants causes cholesterol accumulation in cultured human arterial smooth muscle cellS

Florén, C., Albers, J. J., & Bierman, E. L. (1981) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(81)90219-8 · Cited by 88

Delayed catabolism of apoB-48 lipoproteins due to decreased heparan sulfate proteoglycan production in diabetic mice

Ebara, T., Conde, K., Kako, Y., Liu, Y., Xu, Y., Ramakrishnan, R., Goldberg, I. J., & Shachter, N. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8283 · Cited by 86

Binding of Human Phospholipase A2 Type II to Proteoglycans

Sartipy, P., Johansen, B., Camejo, G., Rosengren, B. E., Bondjers, G., & Hurt‐Camejo, E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.42.26307 · Cited by 86

Pathophysiology of type 1 diabetes mellitus

Kolb, H. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1212158 · Cited by 85

Role of Group IIa and Group V Secretory Phospholipases A2 in the Metabolism of Lipoproteins. Substrate Specificities of the Enzymes and the Regulation of Their Activities by Sphingomyelin

Gesquiere, L. R., Cho, W., & Subbaiah, P. V. (2002) · Biochemistry · doi:10.1021/bi015757x · Cited by 82

Plasma low density lipoprotein transport kinetics in noninsulin-dependent diabetes mellitus.

Kissebah, A. H., Alfarsi, S., Evans, D. J., & Adams, P. W. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110812 · Cited by 82

Glucosylated Glycerophosphoethanolamines are the Major LDL Glycation Products and Increase LDL Susceptibility to Oxidation

Ravandi, A., Kuksis, A., & Shaikh, N. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.2.467 · Cited by 81

Regulation of Hepatic ApoC3 Expression by PGC-1β Mediates Hypolipidemic Effect of Nicotinic Acid

Hernandez, C., Molusky, M. M., Li, Y., Li, S., & Lin, J. D. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.09.001 · Cited by 79

Cell Surface Expression of LDL Receptor Is Decreased in Type 2 Diabetic Patients and Is Normalized by Insulin Therapy

Duvillard, L., Florentin, E., Lizard, G., Petit, J., Galland, F., Monier, S., Gambert, P., & Vergès, B. L. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1540 · Cited by 79

Glycation of low-density lipoproteins by methylglyoxal and glycolaldehyde gives rise to the in vitro formation of lipid-laden cells

Brown, B. E., Dean, R. T., & Davies, M. J. (2005) · Diabetologia · doi:10.1007/s00125-004-1648-4 · Cited by 78

Glycation Accelerates the Oxidation of Low Density Lipoprotein by Copper Ions.

Kobayashi, K., WATANABE, J., Umeda, F., & Nawata, H. (1995) · Endocrine Journal · doi:10.1507/endocrj.42.461 · Cited by 78

Associations between Small Dense LDL, HDL Subfractions (HDL2, HDL3) and Risk of Atherosclerosis in Japanese-Americans

Maeda, S., Nakanishi, S., Yoneda, M., Awaya, T., Yamane, K., Hirano, T., & Kohno, N. (2011) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.11445 · Cited by 76

Uptake of Remnant Like Particles (RLP) in Diabetic Patients from Mouse Peritoneal Macrophages

Tomono, S., Kawazu, S., Kato, N., Ono, T., Ishii, C., Ito, Y., Shimizu, M., Shimoyama, M., Nakano, T., & Nakajima, K. (1994) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat1994.1.98 · Cited by 76

Influence of Glycation on LDL-Induced Generation of Fibrinolytic Regulators in Vascular Endothelial Cells

Zhang, J., Ren, S., Sun, D., & Shen, G. X. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.7.1140 · Cited by 76

Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin

Nidhina Haridas, P. A., Soronen, J., Sädevirta, S., Mysore, R., Quagliarini, F., Pasternack, A., Metso, J., Perttilä, J., Leivonen, M., Smas, C. M., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1254 · Cited by 75

Lipid-lowering in diabetes: An update

Chait, A., Eckel, R. H., Vrablı́k, M., & Zambon, A. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.117313 · Cited by 71

RNA Interference Therapy Targeting Apolipoprotein C-III in Hypertriglyceridemia

Gaudet, D., Clifton, P., Sullivan, D., Baker, J., Schwabe, C., Thackwray, S., Scott, R., Hamilton, J., Given, B., Melquist, S., et al. (2023) · NEJM Evidence · doi:10.1056/evidoa2200325 · Cited by 71

The Classification and Diagnosis of Diabetes Mellitus

Alberti, K. G. M. M. (2010) · Wiley eBooks · doi:10.1002/9781444324808.ch2 · Cited by 70

The pathophysiology of intestinal lipoprotein production

Giammanco, A., Cefalu, A. B., Noto, D., & Averna, M. R. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00061 · Cited by 68

Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma triglyceride-increasing factor

Shimamura, M., Matsuda, M., Ando, Y., Koishi, R., Yasumo, H., Furukawa, H., & Shimomura, I. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.024 · Cited by 67

Small dense LDL is more susceptible to glycation than more buoyant LDL in Type 2 diabetes

Younis, N. N., Soran, H., Pemberton, P. W., Charlton-Menys, V., Elseweidy, M. M., & Durrington, P. N. (2012) · Clinical Science · doi:10.1042/cs20120304 · Cited by 66

In vivo and in vitro evidence for the glycoxidation of low density lipoprotein in human atherosclerotic plaques

Imanaga, Y., Sakata, N., Takebayashi, S., Matsunaga, A., Sasaki, J., Arakawa, K., Nagai, R., Horiuchi, S., Itabe, H., & Takano, T. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00396-2 · Cited by 65

Modification of copper-catalyzed oxidation of low density lipoprotein by proteoglycans and glycosaminoglycans.

Camejo, G., Hurt‐Camejo, E., Rosengren, B. E., Wiklund, O., López, F., & Bondjers, G. (1991) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41901-7 · Cited by 65

The extracellular matrix on atherogenesis and diabetes-associated vascular disease

Camejo, G., Olsson, U., Hurt‐Camejo, E., Baharamian, N., & Bondjers, G. (2002) · Atherosclerosis Supplements · doi:10.1016/s1567-5688(01)00005-8 · Cited by 63

Serum concentrations of human angiopoietin-like protein 3 in patients with nonalcoholic fatty liver disease: association with insulin resistance

Yilmaz, Y. N., Ulukaya, E., Atuğ, Ö., & Dolar, E. (2009) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32832b77ae · Cited by 63

AGEs promote atherosclerosis by increasing LDL transcytosis across endothelial cells via RAGE/NF-κB/Caveolin-1 pathway

Shu, M., Cheng, W., Jia, X., Bai, X., Zhao, Y., Lu, Y., Zhu, L., Zhu, Y. S., Wang, L., Shu, Y., et al. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00715-5 · Cited by 63

Irreversibly glycated LDL induce oxidative and inflammatory state in human endothelial cells; added effect of high glucose

Toma, L., Stancu, C. S., Botez, G. M., Sima, A. V., & Simionescu, M. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.10.066 · Cited by 62

Regulation of low‐density‐lipoprotein‐receptro mRNA by insulin in human hepatoma Hep G2 cells

Wade, D. P., Knight, B. L., & Soutar, A. K. (1989) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1989.tb14784.x · Cited by 61

Induction of macrophage growth by advanced glycation end products of the Maillard reaction.

Yui, S., Sasaki, T., Araki, N., Horiuchi, S., & Yamazaki, M. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.4.1943 · Cited by 61

Metabolic Syndrome and Diabetic Atherothrombosis: Implications in Vascular Complications

Meerarani, P., Badimón, J. J., Zias, E. A., Fuster, V., & Moreno, P. (2006) · Current Molecular Medicine · doi:10.2174/156652406778018680 · Cited by 60

Uptake of type III hypertriglyceridemic VLDL by macrophages is enhanced by oxidation, especially after remnant formation

Whitman, S. C., Miller, D. B., Wolfe, B. M., Hegele, R. A., & Huff, M. W. (1997) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.17.9.1707 · Cited by 59

ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance

Ramms, B., Patel, S., Nora, C., Pessentheiner, A. R., Chang, M. W., Green, C. R., Golden, G. J., Secrest, P., Krauss, R. M., Metallo, C. M., et al. (2019) · Journal of Lipid Research · doi:10.1194/jlr.m093740 · Cited by 59

Type 2 Diabetes in Mice Induces Hepatic Overexpression of Sulfatase 2, a Novel Factor That Suppresses Uptake of Remnant Lipoproteins

Chen, K., Liu, M., Schaffer, L., Li, M., Boden, G. H., Wu, X., & Williams, K. J. (2010) · Hepatology · doi:10.1002/hep.23916 · Cited by 58

Increased capillary permeability in diabetes mellitus and its relationship to microvascular angiopathy

Viberti, G. C. (1983) · The American Journal of Medicine · doi:10.1016/0002-9343(83)90257-7 · Cited by 58

The Reciprocal Relationship between LDL Metabolism and Type 2 Diabetes Mellitus

Bonilha, I., Hajduch, É., Luchiari, B., Nadruz, W., Goff, W. L., & Sposito, A. C. (2021) · Metabolites · doi:10.3390/metabo11120807 · Cited by 58

Intestinal lipid absorption and transport in type 2 diabetes

Vergès, B. L. (2022) · Diabetologia · doi:10.1007/s00125-022-05765-8 · Cited by 58

Proteoglycan mediated lipoprotein retention: A mechanism of diabetic atherosclerosis

Tannock, L. R., & King, V. L. (2008) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-008-9078-0 · Cited by 57

Impact of metabolic syndrome and its components on cardiovascular disease event rates in 4900 patients with type 2 diabetes assigned to placebo in the field randomised trial

Scott, R. S., Donoghoe, M. W., Watts, G. F., O’Brien, R. C., Pardy, C. J., Taskinen, M., Davis, T. M. E., Colman, P. G., Manning, P. J., Fulcher, G. R., et al. (2011) · Cardiovascular Diabetology · doi:10.1186/1475-2840-10-102 · Cited by 56

Role of apolipoprotein C-III overproduction in diabetic dyslipidaemia

Adiels, M., Taskinen, M., Björnson, E., Andersson, L., Matikainen, N., Söderlund, S., Kahri, J., Hakkarainen, A., Lundbom, N., Sihlbom, C., et al. (2019) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13744 · Cited by 55

Involvement of RAGE, NADPH Oxidase, and Ras/Raf-1 Pathway in Glycated LDL-Induced Expression of Heat Shock Factor-1 and Plasminogen Activator Inhibitor-1 in Vascular Endothelial Cells

Sangle, G. V., Zhao, R., Mizuno, T. M., & Shen, G. X. (2010) · Endocrinology · doi:10.1210/en.2010-0323 · Cited by 55

Advanced Glycation End Product-Induced Peroxisome Proliferator-Activated Receptor γ Gene Expression in the Cultured Mesangial Cells

Iwashima, Y., Eto, M., Horiuchi, S., & Sano, H. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1539 · Cited by 53

Glycated LDL increases monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated chemotaxis

Isoda, K., Folco, E. J. E., Marwali, M. R., Ohsuzu, F., & Libby, P. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.10.035 · Cited by 53

Glycated Phosphatidylethanolamine Promotes Macrophage Uptake of Low Density Lipoprotein and Accumulation of Cholesteryl Esters and Triacylglycerols

Ravandi, A., Kuksis, A., & Shaikh, N. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.16494 · Cited by 52

Diabetes alters LDL receptor and PCSK9 expression in rat liver

Niesen, M. I., Bedi, M., & Lopez, D. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.11.009 · Cited by 51

Effect of alpha-tocopherol on LDL oxidation and glycation: in vitro and in vivo studies

Li, D., Devaraj, S., Fuller, C., Bucala, R., & Jialal, I. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37563-5 · Cited by 50

Kringle IV Type 2, Not Low Lipoprotein(a), as a Cause of Diabetes: A Novel Genetic Approach Using SNPs Associated Selectively with Lipoprotein(a) Concentrations or with Kringle IV Type 2 Repeats

Tolbus, A., Mortensen, M. B., Nielsen, S. F., Kamstrup, P. R., Bojesen, S. E., & Nordestgaard, B. G. (2017) · Clinical Chemistry · doi:10.1373/clinchem.2017.277103 · Cited by 50

Glycolaldehyde-Modified Low Density Lipoprotein Leads Macrophages to Foam Cells via the Macrophage Scavenger Receptor

Jinnouchi, Y., Sano, H., Nagai, R., Hakamata, H., Kodama, T., Suzuki, H., Yoshida, M., Ueda, S., & Horiuchi, S. (1998) · Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a022062 · Cited by 48

Metabolic syndrome

Neeland, I. J., Lim, S., Tchernof, A., Gastaldelli, A., Rangaswami, J., Ndumele, C. E., Powell-Wiley, T. M., & Després, J.-P. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00563-5 · Cited by 463

Nutrition and Lifestyle Interventions in Managing Dyslipidemia and Cardiometabolic Risk

Berisha, H., Hattab, R., Comi, L., Giglione, C., Migliaccio, S., & Magni, P. (2025) · Nutrients · doi:10.3390/nu17050776 · Cited by 85

The link between diabetes and cardiovascular disease

Borén, J., Öörni, K., & Catapano, A. L. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.117607 · Cited by 44

[Incisional hernia after surgery for abdominal aortic aneurysm].

Augestad, K. M., Wilsgaard, T., & Solberg, S. K. (2002) · PubMed · Cited by 29

Association of insulin resistance-related indicators with cardiovascular disease in Chinese people with different glycemic states

Zhang, Z., & Tan, L. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1515559 · Cited by 25

Effect of Lipid Management on Coronary Heart Disease Risk in Persons With Type 2 Diabetes

Brandts, J., & Ray, K. K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-323-87862-3.00019-7

New insights into the pathophysiology of dyslipidemia in type 2 diabetes

Taskinen, M.-R., & Borén, J. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.01.039 · Cited by 440

Distinct compositional alterations in plasma lipoproteins in type 2 diabetes: a cross-sectional study of healthy individuals and diabetics with and without cardiovascular comorbidities

Tsay, E., Kurmaeva, D., Nuriddinov, S., Tsoy, V., Abduxalimova, S., Bozorov, S. S., Khalimova, Z., Engelsen, S. B., Magkos, F., Akbarovna, D. D., et al. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-03039-2

Atherogenic Dyslipoproteinemia in Type 2 Diabetes Mellitus

Arungovind, G., Kamalanathan, A. S., & Venkataraman, K. (2017) · Springer eBooks · doi:10.1007/978-3-319-60324-7_20 · Cited by 1

Investigating the Atherogenic Risk of Lipoprotein(a) in Type 2 Diabetic Patients

Peela, J. R., Latiwesh, O. B., Elshaari, F. A., Hussain, A., Tabrez, E. S., Viglianco, E., Edwards, A., Ali, F., & Rawal, A. K. (2018) · Cureus · doi:10.7759/cureus.3030 · Cited by 9