Berberine modulates deacetylation of PPARγ to promote adipose tissue remodeling and thermogenesis via AMPK/SIRT1 pathway
Open accessAbstract
Pharmacological stimulation of adipose tissue remodeling and thermogenesis to increase energy expenditure is expected to be a viable therapeutic strategy for obesity. Berberine has been reported to have pharmacological activity in adipose tissue to anti-obesity, while the mechanism remains unclear. Here, we observed that berberine significantly reduced the body weight and insulin resistance of high-fat diet mice by promoting the distribution of brown adipose tissue and thermogenesis. We have further demonstrated that berberine activated energy metabolic sensing pathway AMPK/SIRT1 axis to increase the level of PPARγ deacetylation, which leads to promoting adipose tissue remodeling and increasing the expression of the thermogenic protein UCP-1. These findings suggest that berberine that enhances the AMPK/SIRT1 pathway can act as a selective PPARγ activator to promote adipose tissue remodeling and thermogenesis. This study proposes a new mechanism for the regulation of berberine in adipose tissue and offers a great prospect for berberine in obesity treatment.
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Berberine supplementation ameliorates chronic inflammation by lowering serum CRP.
“A meta-analysis proved that berberine supplementation ameliorates the state of chronic inflammation by lowering the serum level of CRP [74].”
From The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials (2021) · cites this paper as [74]
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- Authors
- Xu, Y., Yu, T., Ma, G., Zheng, L., Jiang, X., Yang, F., Wang, Z., Li, N., He, Z., Song, X., Wen, D., Kong, J., Yu, Y., & Cao, L.
- Affiliations
- Sheng Jing Hospital (CN)
- China Medical University (CN)
- First Hospital of China Medical University (CN)
- Corresponding author
- Wen, Deliang
- Kong, Juan
- Yu, Yang
- Cao, Liu
- ORCID
- Venue
- International Journal of Biological Sciences
- Publisher
- Ivyspring International Publisher
- Published
- 2021
- Volume
- 17
- Issue
- 12
- Pages
- 3173-3187
- ISSN
- 1449-2288 (ISSN-L)
- PMC
- PMC8375237
- OpenAlex
- W3189716214
- Cited by
- 110
- References
- 78
- Citations by year
- 2026: 21 · 2025: 37 · 2024: 27 · 2023: 17 · 2022: 6 · 2021: 2
- FWCI
- 7.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- International Journal of Biological Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81770001, 2018225083, 2018YFC1311600, 82073545, 82000827, 82030091)
- Natural Science Foundation of Liaoning Province
- China Medical University
- Shengjing Hospital
- Topics
- Health Sciences › Medicine › Pharmacology › Berberine and alkaloids research
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- berberine, adipose tissue remodeling, thermogenesis, brown adipose tissue, AMPK/SIRT1 pathway, UCP1, obesity, insulin resistance, energy expenditure, high-fat diet
- MeSH terms
- Animals, Berberine, Body Weight, Adipose Tissue, Brown, Energy Metabolism, Glucose Tolerance Test, Insulin Resistance, Male, Mice, Inbred C57BL, Tomography, X-Ray Computed, Blotting, Western, Weight Gain, Thermogenesis, Microscopy, Electron, Transmission, PPAR gamma, Mice, AMP-Activated Protein Kinases, Sirtuin 1, Diet, High-Fat, Real-Time Polymerase Chain Reaction
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