Cited by 110Berberine and alkaloids researchAdipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Berberine modulates deacetylation of PPARγ to promote adipose tissue remodeling and thermogenesis via AMPK/SIRT1 pathway

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Xu, Yingxi, Yu, Tianhao, Ma, Guojing, Zheng, Lixia, Jiang, Xuehan, Yang, Fan, Wang, Zhuo, Li, Na +6 more·2021·International Journal of Biological Sciences

Abstract

Pharmacological stimulation of adipose tissue remodeling and thermogenesis to increase energy expenditure is expected to be a viable therapeutic strategy for obesity. Berberine has been reported to have pharmacological activity in adipose tissue to anti-obesity, while the mechanism remains unclear. Here, we observed that berberine significantly reduced the body weight and insulin resistance of high-fat diet mice by promoting the distribution of brown adipose tissue and thermogenesis. We have further demonstrated that berberine activated energy metabolic sensing pathway AMPK/SIRT1 axis to increase the level of PPARγ deacetylation, which leads to promoting adipose tissue remodeling and increasing the expression of the thermogenic protein UCP-1. These findings suggest that berberine that enhances the AMPK/SIRT1 pathway can act as a selective PPARγ activator to promote adipose tissue remodeling and thermogenesis. This study proposes a new mechanism for the regulation of berberine in adipose tissue and offers a great prospect for berberine in obesity treatment.

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Authors
Xu, Y., Yu, T., Ma, G., Zheng, L., Jiang, X., Yang, F., Wang, Z., Li, N., He, Z., Song, X., Wen, D., Kong, J., Yu, Y., & Cao, L.
Affiliations
  • Sheng Jing Hospital (CN)
  • China Medical University (CN)
  • First Hospital of China Medical University (CN)
Corresponding author
  • Wen, Deliang
  • Kong, Juan
  • Yu, Yang
  • Cao, Liu
Venue
International Journal of Biological Sciences
Published
2021
Volume
17
Issue
12
Pages
3173-3187
ISSN
1449-2288 (ISSN-L)
OpenAlex
W3189716214
Cited by
110
References
78
Citations by year
2026: 21 · 2025: 37 · 2024: 27 · 2023: 17 · 2022: 6 · 2021: 2
FWCI
7.74
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • International Journal of Biological Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (81770001, 2018225083, 2018YFC1311600, 82073545, 82000827, 82030091)
  • Natural Science Foundation of Liaoning Province
  • China Medical University
  • Shengjing Hospital
Topics
  • Health Sciences › Medicine › Pharmacology › Berberine and alkaloids research
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords
berberine, adipose tissue remodeling, thermogenesis, brown adipose tissue, AMPK/SIRT1 pathway, UCP1, obesity, insulin resistance, energy expenditure, high-fat diet
MeSH terms
Animals, Berberine, Body Weight, Adipose Tissue, Brown, Energy Metabolism, Glucose Tolerance Test, Insulin Resistance, Male, Mice, Inbred C57BL, Tomography, X-Ray Computed, Blotting, Western, Weight Gain, Thermogenesis, Microscopy, Electron, Transmission, PPAR gamma, Mice, AMP-Activated Protein Kinases, Sirtuin 1, Diet, High-Fat, Real-Time Polymerase Chain Reaction

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