Cited by 37Circadian rhythm and melatoninGut microbiota and healthDietary Effects on Health

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Therapeutic potential of melatonin in colorectal cancer: Focus on lipid metabolism and gut microbiota

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Pan, Shijia, Guo, Yuan, Hong, Fan, Xu, Pengfei, Zhai, Yonggong·2022·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI 10.1016/j.bbadis.2021.166281

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Abstract

Colorectal cancer (CRC) is one of the most common gastrointestinal malignancies. The occurrence and development of CRC are complicated processes. Obesity and dysbacteriosis have been increasingly regarded as the main risk factors for CRC. Understanding the etiology of CRC from multiple perspectives is conducive to screening for some potential drugs or new treatment strategies to limit the serious side effects of conventional treatment and prolong the survival of CRC patients. Melatonin, a natural indoleamine, is mainly produced by the pineal gland, but it is also abundant in other tissues, including the gastrointestinal tract, retina, testes, lymphocytes, and Harder's glands. Melatonin could participate in lipid metabolism by regulating adipogenesis and lipolysis. Additionally, many studies have focused on the potential beneficial effects of melatonin in CRC, such as promotion of apoptosis; inhibition of cell proliferation, migration, and invasion; antioxidant activity; and immune regulation. Meaningfully, gut microbiota is the main determinant of all aspects of health and disease (including obesity and tumorigenesis). The gut microbiota is of great significance for understanding the relationship between obesity and increased risk of CRC. Although the current understanding of how the melatonin-mediated gut microbiota coordinates a variety of physiological and pathological activities is fairly comprehensive, there are still many unknown topics to be explored in the face of a complex nutritional status and a changeable microbiota. This review summarizes the potential links among melatonin, lipid metabolism, gut microbiota, and CRC to promote the development of melatonin as a preventive and therapeutic agent for CRC.

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Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells
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Non-adrenergic control of lipolysis and thermogenesis in adipose tissues
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Pinealectomy Reduces Melatonin Levels in the Serum but Not in the Gastrointestinal Tract of Rats
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Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice
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Phospholipase D2-Dependent Inhibition of the Nuclear Hormone Receptor PPARγ by Cyclic Phosphatidic Acid
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Impact of Melatonin on Skeletal Muscle and Exercise
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Targeting Dietary and Microbial Tryptophan-Indole Metabolism as Therapeutic Approaches to Colon Cancer
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Cellular mechanisms involved in the melatonin inhibition of HT‐29 human colon cancer cell proliferation in culture
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Melatonin, Immune Function and Cancer
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SREBP1 promotes the invasion of colorectal cancer accompanied upregulation of MMP7 expression and NF-κB pathway activation
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The gut microbiota at the intersection of bile acids and intestinal carcinogenesis: An old story, yet mesmerizing
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Localization of Aa-nat mRNA in the rat retina by fluorescence in situ hybridization and laser capture microdissection
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Melatonin Orchestrates Lipid Homeostasis through the Hepatointestinal Circadian Clock and Microbiota during Constant Light Exposure
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Self-citation
Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis‐associated colon carcinogenesis
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Melatonin reduces endothelin‐1 expression and secretion in colon cancer cells through the inactivation of FoxO‐1 and NF ‐ κβ
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Loss of Abhd5 Promotes Colorectal Tumor Development and Progression by Inducing Aerobic Glycolysis and Epithelial-Mesenchymal Transition
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Chemotherapy: induction of stress responses
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Melatonin/PGC1A/UCP1 promotes tumor slimming and represses tumor progression by initiating autophagy and lipid browning
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Biochemotherapy with standard chemotherapies plus the pineal hormone melatonin in the treatment of advanced solid neoplasms
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Melatonin induces apoptosis of colorectal cancer cells through HDAC 4 nuclear import mediated by C a MKII inactivation
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Melatonin reduces inflammatory response in human intestinal epithelial cells stimulated by interleukin‐1β
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Consequences of Essential Fatty Acids
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Melatonin and enterochromaffine cells
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Biomodulation of cancer chemotherapy for metastatic colorectal cancer: a randomized study of weekly low-dose irinotecan alone versus irinotecan plus the oncostatic pineal hormone melatonin in metastatic colorectal cancer patients progressing on 5-fluorouracil-containing combinations.
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Light-at-Night-Induced Circadian Disruption, Cancer and Aging
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Melatonin concentrations in serum and tissues of porcine gastrointestinal tract and their relationship to the intake and passage of food
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EXPRESSION OF CONCERN: Adipocyte differentiation is inhibited by melatonin through the regulation of C/EBPβ transcriptional activity
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Ocular Clocks: Adapting Mechanisms for Eye Functions and Health
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Melatonin, an inhibitory agent in breast cancer
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Melatonin Treatment Alleviates Spinal Cord Injury-Induced Gut Dysbiosis in Mice
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Melatonin synthesis in chicken retina: Effect of kainic acid-induced lesions on the diurnal rhythm and D2-dopamine receptor-mediated regulation of serotonin N-acetyltransferase activity
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Rhythmic changes in colonic motility are regulated by period genes
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Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome
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Decreased High-Density Lipoprotein Cholesterol and Increased Low-Density Cholesterol Levels in Patients with Colorectal Adenomas
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Melatonin, A Natural Programmed Cell Death Inducer in Cancer
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Melatonin inhibits Warburg-dependent cancer by redirecting glucose oxidation to the mitochondria: a mechanistic hypothesis
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The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas
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Light pollution, reproductive function and cancer risk.
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Phagocytic Activity of Cultured Retinal Pigment Epithelial Cells from Chick Embryo: Inhibition by Melatonin and Cyclic AMP, and Its Reversal by Taurine and Cyclic GMP
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Effects of Melatonin on Intestinal Microbiota and Oxidative Stress in Colitis Mice
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Melatonin reduces intramuscular fat deposition by promoting lipolysis and increasing mitochondrial function
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Melatonin Supplementation Decreases Hypertrophic Obesity and Inflammation Induced by High-Fat Diet in Mice
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Mechanisms Underlying Tumor Suppressive Properties of Melatonin
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Melatonin promotes adipogenesis and mitochondrial biogenesis in 3T3‐L1 preadipocytes
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Melatonin and Vitamin D Interfere with the Adipogenic Fate of Adipose-Derived Stem Cells
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Characteristics of fecal gut microbiota in patients with colorectal cancer at different stages and different sites
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Anti-Warburg Effect of Melatonin: A Proposed Mechanism to Explain its Inhibition of Multiple Diseases
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Effects of phenylhydrazine or phlebotomy on peripheral blood, bone marrow and erythropoietin in Wistar rats
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Fatty acid synthase enhances colorectal cancer cell proliferation and metastasis via regulating AMPK/mTOR pathway
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Blockage of melatonin receptors impairs p53-mediated prevention of DNA damage accumulation
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Possible Involvement of the Nuclear RZR/ROR-Alpha Receptor in the Antitumor Action of Melatonin on Murine Colon 38 Cancer
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Cholesterol metabolism and colorectal cancers
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Melatonin: A Molecule for Reducing Breast Cancer Risk
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Melatonin Inhibits Reactive Oxygen Species‐Driven Proliferation, Epithelial‐Mesenchymal Transition, and Vasculogenic Mimicry in Oral Cancer
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The melatonin-producing system is fully functional in retinal pigment epithelium (ARPE-19)
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Immunotherapy with subcutaneous low-dose interleukin-2 and the pineal indole melatonin as a new effective therapy in advanced cancers of the digestive tract
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Melatonin suppresses thyroid cancer growth and overcomes radioresistance via inhibition of p65 phosphorylation and induction of ROS
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Melatonin promotes differentiation of 3T3‐L1 fibroblasts
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Gastrointestinal melatonin: cellular identification and biological role.
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Melatonin attenuates (‐)‐epigallocatehin‐3‐gallate‐triggered hepatotoxicity without compromising its downregulation of hepatic gluconeogenic and lipogenic genes in mice
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Helicobacter pyloriand serum kynurenine-tryptophan ratio in patients with colorectal cancer
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Melatonin content in plasma and large intestine of patients with colorectal carcinoma before and after surgery
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Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits
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EXPRESSION OF CONCERN: Melatonin prevents cadmium‐induced bone damage: First evidence on an improved osteogenic/adipogenic differentiation balance of mesenchymal stem cells as underlying mechanism
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Shift work and colorectal cancer risk in the MCC-Spain case–control study
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Participation of MT3 melatonin receptors in the synergistic effect of melatonin on cytotoxic and apoptotic actions evoked by chemotherapeutics
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Does the use of melatonin overcome drug resistance in cancer chemotherapy?
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Melatonin and colon carcinogenesis
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Effect of Lactobacillus rhamnosus hsryfm 1301 on the Gut Microbiota and Lipid Metabolism in Rats Fed a High-Fat Diet
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Plasma Melatonin Levels in Patients Suffering From Colorectal Carcinoma
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Melatonin and RZR/ROR receptor ligand CGP 52608 induce apoptosis in the murine colonic cancer
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Melatonin-Induced Changes in Cytosolic Calcium Might be Responsible for Apoptosis Induction in Tumour Cells
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New Issues About Melatonin and its Effects on the Digestive System
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Melatonin Decreases Glucose Metabolism in Prostate Cancer Cells: A 13C Stable Isotope-Resolved Metabolomic Study
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Melatonin Improves Fatty Liver Syndrome by Inhibiting the Lipogenesis Pathway in Hamsters with High-Fat Diet-Induced Hyperlipidemia
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Melatonin promotes triacylglycerol accumulation via MT2 receptor during differentiation in bovine intramuscular preadipocytes
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Intestinal microorganisms involved in colorectal cancer complicated with dyslipidosis
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Authors: Pan, S., Guo, Y., Hong, F., Xu, P., & Zhai, Y.
Affiliations: Beijing Normal University (CN)
University of Pittsburgh (US)
ORCID: Guo, Yuan
Hong, Fan
Xu, Pengfei
Zhai, Yonggong
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
Published: 2022-01
Volume: 1868
Issue: 1
Pages: 166281
ISSN: 0925-4439 (ISSN-L)
DOI: 10.1016/j.bbadis.2021.166281
OpenAlex: W3204951023
Cited by: 37
References: 241
Citations by year: 2026: 6 · 2025: 7 · 2024: 9 · 2023: 7 · 2022: 6
FWCI: 0.73
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (31571164, 82070901)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Keywords: melatonin, colorectal cancer, lipid metabolism, gut microbiota, obesity, dysbiosis, adipogenesis, lipolysis, apoptosis, cell proliferation, antioxidant activity, immune regulation, cancer prevention, cancer therapy
MeSH terms: Gastrointestinal Microbiome, Cell Movement, Humans, Melatonin, Neoplasm Invasiveness, Colorectal Neoplasms, Apoptosis, Cell Proliferation, Lipid Metabolism, Carcinogenesis

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Therapeutic potential of melatonin in colorectal cancer: Focus on lipid metabolism and gut microbiota

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