Circadian rhythm and the gut microbiome

Voigt, R.M.; Forsyth, C.B.; Green, S.J.; Engen, P.A.; Keshavarzian, A.

doi:10.1016/bs.irn.2016.07.002

Cited by 281Circadian rhythm and melatoninGut microbiota and healthDietary Effects on Health

Circadian rhythm and the gut microbiome

Voigt, R.M., Forsyth, C.B., Green, S.J., Engen, P.A., Keshavarzian, A.·2016·International Review of Neurobiology

DOI 10.1016/bs.irn.2016.07.002

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Abstract

Circadian rhythms are 24-h patterns regulating behavior, organs, and cells in living organisms. These rhythms align biological functions with regular and predictable environmental patterns to optimize function and health. Disruption of these rhythms can be detrimental resulting in metabolic syndrome, cancer, or cardiovascular disease, just to name a few. It is now becoming clear that the intestinal microbiome is also regulated by circadian rhythms via intrinsic circadian clocks as well as via the host organism. Microbiota rhythms are regulated by diet and time of feeding which can alter both microbial community structure and metabolic activity which can significantly impact host immune and metabolic function. In this review, we will cover how host circadian rhythms are generated and maintained, how host circadian rhythms can be disrupted, as well as the consequences of circadian rhythm disruption. We will further highlight the newly emerging literature indicating the importance of circadian rhythms of the intestinal microbiota.

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The molecular mechanisms of circadian clocks are similar across all species and are regulated by genetic enhancer/repressor elements, epigenetic modulation by methylation and acetylation, post-translation modification of regulatory proteins, and a variety of hormonal and signaling molecules.
“The molecular mechanisms of circadian clocks are similar across all species and are regulated by genetic enhancer/repressor elements, epigenetic modulation by methylation and acetylation, post-translation modification of regulatory proteins, and a variety of hormonal and signaling molecules [220,229,231].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [229]
Circadian clocks exist in all cells, including the microbiome, and function as autonomous transcriptional-translational genetic feedback loops.
“Circadian clocks exist in all cells, including the microbiome, and function as autonomous transcriptional-translational genetic feedback loops [228,229].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [229]
These biologic rhythms are regulated by diet and time of feeding rather than environmental 24-hour light-dark cycles.
“regulated by diet and time of feeding rather than environmental 24-hour light-dark cycles (Voigt et al., 2016;Johnson et al., 2017).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Voigt et al., 2016
Microbial enzymatic activity may also be influenced by circadian rhythms.
“this may also be true of microbial enzymatic activity because gut microbiota community structure and metabolic activity also feature biologic rhythms”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Voigt et al., 2016
Gut microbiota community structure and metabolic activity feature biologic rhythms.
“gut microbiota community structure and metabolic activity also feature biologic rhythms”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Voigt et al., 2016

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Authors: Voigt, R. M., Forsyth, C. B., Green, S. J., Engen, P. A., & Keshavarzian, A.
Affiliations: Rush University Medical Center (US)
University of Illinois Chicago (US)
Corresponding author: Keshavarzian, A.
ORCID: Voigt, R.M.
Forsyth, C.B.
Green, S.J.
Engen, P.A.
Keshavarzian, A.
Venue: International Review of Neurobiology
Publisher: Elsevier
Published: 2016
Volume: 131
Pages: 193-205
ISSN: 0074-7742 (ISSN-L)
DOI: 10.1016/bs.irn.2016.07.002
OpenAlex: W2512637358
Cited by: 274
References: 56
Citations by year: 2026: 30 · 2025: 34 · 2024: 30 · 2023: 35 · 2022: 37 · 2021: 40 · 2020: 31 · 2019: 15 · 2018: 16 · 2017: 6
FWCI: 28.32
Type: book chapter
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: International review of neurobiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Physiology › Dietary Effects on Health
Keywords: circadian rhythm, gut microbiota, circadian clock, circadian rhythm disruption, meal timing, diet, microbial community structure, host-microbe interactions, immune function, metabolism, metabolic syndrome
MeSH terms: Gastrointestinal Microbiome, Animals, Circadian Rhythm, Humans

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