Western diet induces dysbiosis with increased E coli in CEABAC10 mice , alters host barrier function favouring AIEC colonisation
Abstract
OBJECTIVE: Western diet is a risk factor for Crohn's disease (CD). Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is abnormally expressed in CD patients. This allows adherent-invasive Escherichia coli (AIEC) to colonise the gut mucosa and leads to inflammation. We assessed the effects of a high fat/high sugar (HF/HS) Western diet on gut microbiota composition, barrier integrity and susceptibility to infection in transgenic CEABAC10 mice expressing human CEACAMs. DESIGN: Colonic microbiota composition and susceptibility of CEABAC10 mice to AIEC LF82 bacteria infection were determined in mice fed a conventional or HF/HS diet. Barrier function and inflammatory response were assessed by studying intestinal permeability, tight junction protein and mucin expression and localisation, and by determining histological score and levels of cytokine release. RESULTS: HF/HS diet led to dysbiosis in WT and transgenic CEABAC10 mice, with a particular increase in E coli population in HF/HS-fed CEABAC10 mice. These mice showed decreased mucus layer thickness, increased intestinal permeability, induction of Nod2 and Tlr5 gene transcription, and increased TNFα secretion. These modifications led to a higher ability of AIEC bacteria to colonise the gut mucosa and to induce inflammation. CONCLUSIONS: Western diet induces changes in gut microbiota composition, alters host homeostasis and promotes AIEC gut colonisation in genetically susceptible mice. These results support the multifactorial aetiology of CD and highlight the importance of diet in CD pathogenesis.
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Ruminococcus torques was recently found at increased levels in mice consuming a high fat and sugar diet and in association with susceptibility to Crohn's disease.
“Consistently, Ruminococcus torques (Lachnospiraceae) was recently found at increased levels in mice consuming a high fat and sugar diet and with susceptibility to Crohn's disease.66”
From High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome (2016) · cites this paper as [66]
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- Authors
- Martinez-Medina, M., Denizot, J., Dreux, N., Robin, F., Billard, E., Bonnet, R., Darfeuille-Michaud, A., & Barnich, N.
- Affiliations
- Clermont Université, ‘Microbe intestin inflammation et Susceptibilité de l'Hôte’, UMR1071 Inserm/Université d'Auvergne M2iSH, Clermont-Ferrand, France
- Inserm (FR)
- Corresponding author
- Barnich, Nicolas
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2013-04-18
- Volume
- 63
- Issue
- 1
- Pages
- 116-124
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2097855460
- Cited by
- 539
- References
- 51
- Citations by year
- 2026: 16 · 2025: 40 · 2024: 44 · 2023: 47 · 2022: 58 · 2021: 54 · 2020: 74 · 2019: 52 · 2018: 33 · 2017: 31 · 2016: 22 · 2015: 29 · 2014: 32 · 2013: 6
- FWCI
- 13.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Western diet, high-fat high-sugar diet, Crohn's disease, gut dysbiosis, adherent-invasive Escherichia coli, CEACAM6, intestinal barrier function, intestinal permeability, mucus layer, NOD2, TLR5, TNF-α, gut microbiota, diet and inflammation
- MeSH terms
- Animals, Colon, Crohn Disease, Escherichia coli, Escherichia coli Infections, Female, Homeostasis, Intestinal Mucosa, Mice, Inbred C57BL, Mice, Transgenic, Biomarkers, Cell Adhesion Molecules, Cytokines, Dietary Sucrose, Genetic Predisposition to Disease, Mice, Host-Pathogen Interactions, Diet, High-Fat, Microbiota, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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