Cited by 699Genomics, phytochemicals, and oxidative stressNF-κB Signaling PathwaysNuclear Receptors and Signaling

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NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

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Liu, Guang-Hui, Qu, Jing, Shen, Xun·2008·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

DOI 10.1016/j.bbamcr.2008.01.002

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Abstract

Constitutively activated NF-kappaB occurs in many inflammatory and tumor tissues. Does it interfere with anti-inflammatory or anti-tumor signaling pathway? Here, we report that NF-kappaB p65 subunit repressed the Nrf2-antioxidant response element (ARE) pathway at transcriptional level. In the cells where NF-kappaB and Nrf2 were simultaneously activated, p65 unidirectionally antagonized the transcriptional activity of Nrf2. In the p65-overexpressing cells, the ARE-dependent expression of heme oxygenase-1 was strongly suppressed. However, p65 inhibited the ARE-driven gene transcription in a way that was independent of its own transcriptional activity. Two mechanisms were found to coordinate the p65-mediated repression of ARE: (1) p65 selectively deprives CREB binding protein (CBP) from Nrf2 by competitive interaction with the CH1-KIX domain of CBP, which results in inactivation of Nrf2. The inactivation depends on PKA catalytic subunit-mediated phosphorylation of p65 at S276. (2) p65 promotes recruitment of histone deacetylase 3 (HDAC3), the corepressor, to ARE by facilitating the interaction of HDAC3 with either CBP or MafK, leading to local histone hypoacetylation. This investigation revealed the participation of NF-kappaB p65 in the negative regulation of Nrf2-ARE signaling, and might provide a new insight into a possible role of NF-kappaB in suppressing the expression of anti-inflammatory or anti-tumor genes.

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Cytokines suppress adipogenesis and PPAR-γ function through the TAK1/TAB1/NIK cascade
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Signaling to NF-κB
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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
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“Nrf2 is amember of theCNC-basic leucine zipper (CNC-bZIP) family of transcription factors, which coordinately regulates the constitutive and inducible expression of antioxidant and phase 2 detoxification enzymes, such as heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1), via a cis-acting DNA element…”
Background
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Background
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Background
In vivo rescue of alveolar macrophages from SP-A knockout mice with exogenous SP-A nearly restores a wild type intracellular proteome; actin involvement
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“40 In the case of inﬂammation, NRF2 also has another mechanism with NF-k B. Studies have shown that up-regulation of NRF2 can enhance the clearance of a -synuclein, which is a proinﬂammatory protein promoting the activation of NF-k B, to reduce inﬂammation.”
Background
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Ansari, N., Khodagholi, F., Amini, M., & Shaerzadeh, F. (2011) · Biochimie · doi:10.1016/j.biochi.2011.01.012 · Cited by 35
Bixin protects against particle-induced long-term lung injury in an NRF2-dependent manner
Xue, L., Zhang, H., Zhang, J., Li, B., Zhang, Z., & Tao, S. (2018) · Toxicology Research · doi:10.1039/c7tx00304h · Cited by 35
Lymphocyte Levels of Redox-Sensitive Transcription Factors and Antioxidative Enzymes as Indicators of Pro-Oxidative State in Depressive Patients
Lukić, I., Mitić, M., Djordjevic, J., Tatalović, N., Bozovic, N., Soldatović, I., Mihaljevic, M. M., Pavlović, Z., Radojcic, M. B., Marić, N. P., et al. (2014) · Neuropsychobiology · doi:10.1159/000362841 · Cited by 37
Molecular signaling pathways in doxorubicin-induced nephrotoxicity and potential therapeutic agents
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The Attenuation of Chronic Ulcerative Colitis by (R)‐salbutamol in Repeated DSS‐Induced Mice
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“Furthermore, CREB binding protein (CBP) is a transcription factor between Nrf-2 and NF-κB, which means that there is competition betweenNrf-2 and NF-κB, namely, negative feedback regulation [48].”
Background
Phillygenin inhibits inflammation in chondrocytes via the Nrf2/NF-κB axis and ameliorates osteoarthritis in mice
Zhang, P., Jin, Y., Xia, W., Wang, X., & Zhou, Z. (2023) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2023.03.002 · Cited by 34
Dietary oxidized fat activates the oxidative stress-responsive transcription factors NF-κB and Nrf2 in intestinal mucosa of mice
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Nrf2–Keap1 Pathway and NLRP3 Inflammasome in Parkinson’s Disease: Mechanistic Crosstalk and Therapeutic Implications
Jain, R., Vora, L. K., Nathiya, D., & Khatri, D. K. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05389-0 · Cited by 36
“Interference between p65 and Nrf2 diminishes the ability of cells to neutralize ROS and cause oxidative damage [128].”
Need (more than) two to Tango: Multiple tools to adapt to changes in oxygen availability
Fratantonio, D., Cimino, F., Speciale, A., & Virgili, F. (2018) · BioFactors · doi:10.1002/biof.1419 · Cited by 34
“Its transcriptional activity can be triggered by many different stimuli, including bacterial lipopolysaccharide (LPS), viral pathogens, cytokines, or growth factors [114].”
Background
Antineuroinflammatory therapy: potential treatment for autism spectrum disorder by inhibiting glial activation and restoring synaptic function
Li, Y., Zhang, X., & Li, Y. (2019) · CNS Spectrums · doi:10.1017/s1092852919001603 · Cited by 33
“The NF-κB subunit p65 could downregulate Nrf2 activation either by cAMP-response element binding protein (CREBP) or histone deacetylase 3 (HDAC3)-related pathways.(86) Also, p65may decrease Nrf2 binding to its cognate DNA sequences and enhanceNrf2 ubiquitination.”
Method
MiR-139-5p negatively regulates PMP22 to repress cell proliferation by targeting the NF-κB signaling pathway in gastric cancer
Hou, J., Zhuo, H., Chen, X., Cheng, J. R., Zheng, W., Zhong, M., & Cai, J. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.40338 · Cited by 33
“In response to numerous stimuli including tumor necrosis factor alpha (TNF-α) and bacterial lipopolysaccharide (LPS), NF-κB is activated and translocated into the nucleus from the cytoplasm, where it acts as a transcription factor to regulate its downstream target genes [35, 36, 41-43].”
Background
NRF2 immunobiology in cancer: implications for immunotherapy and therapeutic targeting
Panda, H., Rowland, N. G., Krall, C. M., Bowman, B. M., Major, M. B., & Zolkind, P. (2025) · Oncogene · doi:10.1038/s41388-025-03560-4 · Cited by 39
The Biofunctions of Phytochemicals and Their Applications in Farm Animals: The Nrf2/Keap1 System as a Target
Qin, S., & Hou, D. (2017) · Engineering · doi:10.1016/j.eng.2017.03.011 · Cited by 34
Berry-Derived Polyphenols in Cardiovascular Pathologies: Mechanisms of Disease and the Role of Diet and Sex
Najjar, R. S., Turner, C. G., Wong, B. J., & Feresin, R. G. (2021) · Nutrients · doi:10.3390/nu13020387 · Cited by 33
“Under conditions of inflammation and oxidative stress, NF-κB appears to bind 10-fold greater to CBP than Nrf2 as observed in HepG2 cells treated with 12-O-tetradecanoylphorbol-13-acetate (PMA; a protein kinase C activator) [247].”
The Nrf2 pathway in psychiatric disorders: pathophysiological role and potential targeting
Bhandari, R., Kaur, J., Kaur, S., & Kuhad, A. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1887141 · Cited by 32
“erythroid2 – antioxidant responsive element (Nrf2-ARE) signaling [40].”
Background
The Protective Effect of Polysaccharide SAFP from Sarcodon aspratus on Water Immersion and Restraint Stress-Induced Gastric Ulcer and Modulatory Effects on Gut Microbiota Dysbiosis
Zhang, D., Xiang, M., Jiang, Y., Wu, F., Chen, H., Sun, M., Zhang, L., Du, X., & Chen, L. (2022) · Foods · doi:10.3390/foods11111567 · Cited by 32
“Previous studies have demonstrated that TLR4 and Nrf2 pathways maintain a redox homeostasis and further modulate the key redox modulators by individually affecting various signaling cascades to interact with each other [43].”
Background
The anti-inflammatory effect of melatonin in SH-SY5Y neuroblastoma cells exposed to sublethal dose of hydrogen peroxide
Nopparat, C., Chantadul, V., Permpoonputtana, K., & Govitrapong, P. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.04.001 · Cited by 35
“and Nrf2 has been demonstrated that NF-κ B could interfere with Nrf2 at the transcriptional level via the withdrawal of CREB binding protein (CBP) from Nrf2 and via promoting the recruitment of histone deacetylase 3 (HDAC3), the co-repressor, to the antioxidant response element (ARE) region (Liu et al., 2008).”
Background
Exercise training upregulates Nrf2 protein in the rostral ventrolateral medulla of mice with heart failure
Wafi, A. M., Yu, L., Gao, L., & Zucker, I. H. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00469.2019 · Cited by 31
“Previous data from the literature show that the prooxidant NF-kB and antioxidant Nrf2 transcription factors compete for binding to the nuclear creb binding protein (30); as such, both transcription factors are critical for regulating intracellular oxidative stress.”
Background
Lipin proteins form homo- and hetero-oligomers
Liu, G., Qu, J. T., Carmack, A. E., Kim, H. B., Chen, C., Ren, H., Morris, A. J., Finck, B. N., & Harris, T. E. (2010) · Biochemical Journal · doi:10.1042/bj20100584 · Cited by 31
Oxidative stress and NRF2 signaling in kidney injury
Ng, C., Kim, I., Yanti, Y., & Kwak, M. (2024) · Toxicological Research · doi:10.1007/s43188-024-00272-x · Cited by 31
“Furthermore, NRF2 suppresses the transcriptional activity of NF-κB by competing for and diminishing the availability of cAMP-responsive-element-binding protein (CBP), a transcriptional co-activator for both NRF2 and NF-κB [108, 109].”
Blueberry Polyphenols Increase Nitric Oxide and Attenuate Angiotensin II-Induced Oxidative Stress and Inflammatory Signaling in Human Aortic Endothelial Cells
Najjar, R. S., Mu, S., & Feresin, R. G. (2022) · Antioxidants · doi:10.3390/antiox11040616 · Cited by 33
“However, under conditions of inflammation and oxidative stress, NF-κB appears to bind 10-fold greater to CBP than NRF2 as observed in HepG2 cells treated with 12-O-tetradecanoylphorbol-13-acetate [53].”
Background
Cellular adaptive response to glutathione depletion modulates endothelial dysfunction triggered by TNF-α
Speciale, A., Anwar, S., Ricciardi, E., Chirafisi, J., Saija, A., & Cimino, F. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.09.017 · Cited by 30
Interplay between HSP90 and Nrf2 pathways in diabetes-associated atherosclerosis
Lázaro, I., Oguiza, A., Recio, C., Lopez‐Sanz, L., Bernal, S., Egido, J., & Gómez‐Guerrero, C. (2017) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2016.10.003 · Cited by 32
Effects of Mycoplasmas on the Host Cell Signaling Pathways
Borchsenius, S. N., Vishnyakov, I. E., Chernova, O. A., Chernov, V. M., & Barlev, N. A. (2020) · Pathogens · doi:10.3390/pathogens9040308 · Cited by 29
“Importantly, forced overexpression of p300 was shown to alleviate the p53-mediated repression of RelA, emphasizing the fact that p300/CBP is likely a restricting influence for both transcription factors.”
BackgroundInfluential
Schisantherin A attenuates sepsis-induced acute kidney injury by suppressing inflammation via regulating the NRF2 pathway
Gui, Y., Yang, Y., Xu, D., Tao, S., & Li, J. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118161 · Cited by 29
tBHQ-Induced HO-1 Expression Is Mediated by Calcium through Regulation of Nrf2 Binding to Enhancer and Polymerase II to Promoter Region of HO-1
Cheung, K. L., Yu, S., Pan, Z., Ma, J., Wu, T.-Y., & Kong, A. T. (2011) · Chemical Research in Toxicology · doi:10.1021/tx1004369 · Cited by 29
NFkB and Nrf2 in esophageal epithelial barrier function
Chen, H. H., Yu, F., Li, W., Orlando, R. C., Shaheen, N. J., & Chen, X. L. (2013) · Tissue Barriers · doi:10.4161/tisb.27463 · Cited by 28
“p65 also represses the Nrf2 pathway at the transcriptional level through HDAC3 and CBP.(48) On the other hand, NFkB and Nrf2 both regulate a subset of target genes, including HO1, GCLC, Gαi2, and IL8.”
Background
Vinpocetine reduces cisplatin-induced acute kidney injury through inhibition of NF–κB pathway and activation of Nrf2/ARE pathway in rats
Song, W., Yin, W., Ding, L., Gao, Y., Xu, J., Yang, Y., He, X., Gong, P., Wei, L., Chen, W., et al. (2020) · International Urology and Nephrology · doi:10.1007/s11255-020-02485-z · Cited by 28
Perspectives on the Clinical Development of NRF2-Targeting Drugs
Lastra, D., Fernández-Ginés, R., Manda, G., & Cuadrado, A. (2020) · Handbook of experimental pharmacology · doi:10.1007/164_2020_381 · Cited by 29
hPMSCs inhibit the expression of PD-1 in CD4+IL-10+ T cells and mitigate liver damage in a GVHD mouse model by regulating the crosstalk between Nrf2 and NF-κB signaling pathway
Zhang, A., Zhang, J., Li, X., Zhang, H., Xiong, Y., Wang, Z., Zhao, N., Wang, F., & Luan, X. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02407-5 · Cited by 28
Nrf2-Independent Anti-Inflammatory Effects of Dimethyl Fumarate: Challenges and Prospects in Developing Electrophilic Nrf2 Activators for Neurodegenerative Diseases
Izumi, Y., & Kōyama, Y. (2024) · Antioxidants · doi:10.3390/antiox13121527 · Cited by 31
Peroxiredoxin I plays a protective role against UVA irradiation through reduction of oxidative stress
Ito, T., Kimura, S., Seto, K., Warabi, E., Kawachi, Y., Shoda, J., Tabuchi, K., Yamagata, K., Hasegawa, S., Bukawa, H., et al. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.12.002 · Cited by 27
“NFkB was found to compete with Nrf2 for the co-activator CREB binding protein (CBP) and to recruit histone deacetylase 3 (HDAC3), resulting in local hypoacetylation and the repression of Nrf2 signaling [24].”
Background
CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells
Wang, P., Liu, Z., Zhang, X., Li, J., Sun, L., Ju, Z., Li, J., Chan, P., Liu, G., Zhang, W., et al. (2018) · Protein & Cell · doi:10.1007/s13238-018-0560-5 · Cited by 28
“Upon stimulations, the degradation of IκB releases NF-κB, which subsequently translocates to the nucleus to modulate genes for the maintenance of cellular homeostasis (Liu et al., 2008; Perkins, 2007).”
Scutellarin Attenuates the IL-1β-Induced Inflammation in Mouse Chondrocytes and Prevents Osteoarthritic Progression
Luo, Z., Hu, Z., Bian, Y., Su, W., Li, X., Li, S., Wu, J., Li, S., Song, Y., Zheng, G., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00107 · Cited by 27
“Nrf2/NF-kB cross talk is also known to be a key pathway regulating downstream protein expression (Liu et al., 2008; Lee et al., 2009).”
Background
Changes of KEAP1/NRF2 and IKB/NF‐κB Expression Levels Induced by Cell‐Free DNA in Different Cell Types
Kostyuk, S. V., Porokhovnik, L. N., Ershova, E. S., Malinovskaya, E. M., Konkova, M. S., Kameneva, L. V., Dolgikh, O. А., Вейко, В. П., Писарев, В. М., Martynov, A. V., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1052413 · Cited by 27
“Seemingly, NF-κB can repress the NRF2 gene transcription by a mechanism connected with CREB: NF-κB competes with NRF2 for a transcription coactivator CREB-binding protein (a protein that binds to CREB) [66].”
Background
The Lipoxin Receptor/FPR2 Agonist BML-111 Protects Mouse Skin Against Ultraviolet B Radiation
Martinez, R. M., Fattori, V., Saito, P., Pinto, I. C., Rodrigues, C. C. A., Melo, C. P. B., Bussmann, A. J. C., Staurengo‐Ferrari, L., Bezerra, J. R., Vignoli, J. A., et al. (2020) · Molecules · doi:10.3390/molecules25122953 · Cited by 30
“That mechanism dampens antioxidant response [54,55].”
Background
Repurposing Dimethyl Fumarate for Cardiovascular Diseases: Pharmacological Effects, Molecular Mechanisms, and Therapeutic Promise
Thomas, S. D., Jha, N. K., Sadek, B. S., & Ojha, S. K. (2022) · Pharmaceuticals · doi:10.3390/ph15050497 · Cited by 27
Sanguinarine protects against indomethacin-induced small intestine injury in rats by regulating the Nrf2/NF-κB pathways
Lin, X.-L., Shi, Y., Cao, Y., Tan, X., Zeng, Y., Luo, S.-T., Li, Y., Li, Q., Xia, B., Fu, R.-G., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.960140 · Cited by 26
“The most well-established negative cross-talk between Nrf2 and NF-κB is a competitive combination with CBP–p300 complex (Liu et al., 2008).”
Background
NRF2 , a crucial modulator of skin cells protection against vitiligo, psoriasis, and cancer
Panieri, E., Telkoparan‐Akillilar, P., & Saso, L. (2022) · BioFactors · doi:10.1002/biof.1912 · Cited by 27
Lithium co-administration with rutin improves post-stroke neurological outcomes via suppressing Gsk-3β activity in a rat model
Rana, A. K., Kumar, R., Shukla, D. N., & Singh, D. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.07.004 · Cited by 26
JSH-23 prevents depressive-like behaviors in mice subjected to chronic mild stress: Effects on inflammation and antioxidant defense in the hippocampus
Wang, Q., Dong, X., Li, N., Wang, Y., Guan, X., Lin, Y., Kang, J., Zhang, X., Zhang, Y., Li, X., et al. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.04.005 · Cited by 25
“SOD is a key endogenous antioxidant enzyme and is a component of first line defense system against reactive oxygen species (Alscher et al., 2002).”
Influential
Resveratrol modulates the inflammatory response in hPDLSCs via the NRF2 / HO ‐1 and NF‐κB pathways and promotes osteogenic differentiation
Ma, Y., Qian, Y., Chen, Y., Ruan, X., Peng, X., Sun, Y., Zhang, J., Luo, J., Zhou, S., & Deng, C. (2023) · Journal of Periodontal Research · doi:10.1111/jre.13200 · Cited by 25
Interaction between TSPO—a neuroimmune marker—and redox status in clinical high risk for psychosis: a PET–MRS study
Hafizi, S., Silva, T. M. S., Meyer, J. H., Kiang, M., Houle, S., Remington, G. J., Prce, I., Wilson, A. A., Rusjan, P., Sailasuta, N., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0061-5 · Cited by 25
NRF2 Is One of the Players Involved in Bone Marrow Mediated Drug Resistance in Multiple Myeloma
Yen, C., & Hsiao, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113503 · Cited by 25
“Conversely, activated NRF2 suppresses NF-κB signaling [184,185].”
Oxidative stress and redox signaling in CRPC progression: therapeutic potential of clinically-tested Nrf2-activators
Mondal, D., Narwani, D., Notta, S., Ghaffar, D., Mardhekar, N. M., & Quadri, S. S. A. (2020) · Cancer Drug Resistance · doi:10.20517/cdr.2020.71 · Cited by 25
“Nuclear translocated NF-κB can directly inhibit Nrf-2 at the transcriptional level([194]) and vice versa([195]).”
Background
Nrf2/ARE axis signalling in hepatocyte cellular death
Ghanim, B. Y., & Qinna, N. A. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07125-6 · Cited by 32
“However, it has been reported that persistent induction of Nrf2 through aggregation of p62 causes growth of hepatocellular carcinomas (HCCs) and could be worsened with Keap1 deficiency [49, 50].”
BackgroundInfluential
Targeting NRF2 in Type 2 diabetes mellitus and depression: Efficacy of natural and synthetic compounds
Subba, R., Ahmad, M. H., Ghosh, B., & Mondal, A. C. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174993 · Cited by 26
The Protective Effect of α-Lipoic Acid against Gold Nanoparticles (AuNPs)-Mediated Liver Damage Is Associated with Upregulating Nrf2 and Suppressing NF-κB
Alshammari, G. M., Abdelhalim, M. A. K., Al-Ayed, M. S., Al‐Harbi, L. N., & Yahya, M. A. (2022) · Nutrients · doi:10.3390/nu14163327 · Cited by 25

Authors: Liu, G.-H., Qu, J., & Shen, X.
Affiliations: Chinese Academy of Sciences (CN)
Corresponding author: Shen, Xun
ORCID: Liu, Guang-Hui
Qu, Jing
Shen, Xun
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Publisher: Elsevier BV
Published: 2008-05
Volume: 1783
Issue: 5
Pages: 713-727
ISSN: 0167-4889 (ISSN-L)
DOI: 10.1016/j.bbamcr.2008.01.002
OpenAlex: W2113024198
Cited by: 697
References: 77
Citations by year: 2026: 54 · 2025: 45 · 2024: 51 · 2023: 47 · 2022: 68 · 2021: 51 · 2020: 59 · 2019: 59 · 2018: 47 · 2017: 38 · 2016: 32 · 2015: 33 · 2014: 15 · 2013: 28 · 2012: 13
FWCI: 7.82
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1904 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (30330250, 30570462)
Shanghai Municipal Education Commission (E-04010)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: NF-κB p65, Nrf2, antioxidant response element, CBP, HDAC3, MafK, heme oxygenase-1, transcriptional repression, histone deacetylation, histone hypoacetylation, PKA phosphorylation, corepressor recruitment, anti-inflammatory signaling
MeSH terms: Histone Deacetylase 3, Antioxidants, Cell Line, Gene Expression Regulation, Histone Deacetylases, Humans, Transcription, Genetic, Trans-Activators, NF-kappa B, Response Elements, CREB-Binding Protein, MafK Transcription Factor, NF-E2-Related Factor 2, Transcription Factor RelA

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NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

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