Yeast growth in raffinose results in resistance to acetic acid induced programmed cell death mostly due to the activation of the mitochondrial retrograde pathway
Open accessAbstract
In order to investigate whether and how a modification of mitochondrial metabolism can affect yeast sensitivity to programmed cell death (PCD) induced by acetic acid (AA-PCD), yeast cells were grown on raffinose, as a sole carbon source, which, differently from glucose, favours mitochondrial respiration. We found that, differently from glucose-grown cells, raffinose-grown cells were mostly resistant to AA-PCD and that this was due to the activation of mitochondrial retrograde (RTG) response, which increased with time, as revealed by the up-regulation of the peroxisomal isoform of citrate synthase and isocitrate dehydrogenase isoform 1, RTG pathway target genes. Accordingly, the deletion of RTG2 and RTG3, a positive regulator and a transcription factor of the RTG pathway, resulted in AA-PCD, as shown by TUNEL assay. Neither deletion in raffinose-grown cells of HAP4, encoding the positive regulatory subunit of the Hap2,3,4,5 complex nor constitutive activation of the RTG pathway in glucose-grown cells due to deletion of MKS1, a negative regulator of RTG pathway, had effect on yeast AA-PCD. The RTG pathway was found to be activated in yeast cells containing mitochondria, in which membrane potential was measured, capable to consume oxygen in a manner stimulated by the uncoupler CCCP and inhibited by the respiratory chain inhibitor antimycin A. AA-PCD resistance in raffinose-grown cells occurs with a decrease in both ROS production and cytochrome c release as compared to glucose-grown cells en route to AA-PCD.
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Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
The Role of Mitochondria in Apoptosis
Wang, C., & Youle, R. J. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134850 · Cited by 1,987 · see citing works
Yeast Carbon Catabolite Repression
Gancedo, J. M. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.2.334-361.1998 · Cited by 1,278 · see citing works
Measurement of Mitochondrial Membrane Potential Using Fluorescent Rhodamine Derivatives
Scaduto, R. C., & Grotyohann, L. W. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)77214-0 · Cited by 1,232 · see citing works
Mitochondrial Membrane Potential Probes and the Proton Gradient: A Practical Usage Guide
Perry, S. W., Norman, J. P., Barbieri, J., Brown, E. B., & Gelbard, H. A. (2011) · BioTechniques · doi:10.2144/000113610 · Cited by 1,196 · see citing works
Butow, R. A., & Avadhani, N. G. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00179-0 · Cited by 882 · see citing works
Mitochondrial retrograde signaling
Liu, Z., & Butow, R. A. (2006) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.110405.090613 · Cited by 680 · see citing works
Self-citationApoptosis in yeast: triggers, pathways, subroutines
Carmona‐Gutiérrez, D., Eisenberg, T., Büttner, S., Meisinger, C., Kroemer, G., & Madeo, F. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2009.219 · Cited by 483 · see citing works
Glucose-sensing and -signalling mechanisms in yeast
Rolland, F., Winderickx, J., & Thevelein, J. M. (2002) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2002.tb00084.x · Cited by 475 · see citing works
Genome-wide responses to mitochondrial dysfunction
Epstein, C. B., Waddle, J. A., Hale, W., Davé, V., Thornton, J., Macatee, T. L., Garner, H. R., & Butow, R. A. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.2.297 · Cited by 389 · see citing works
Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae
Kirchman, P. A., Kim, S., Lai, C.-Y., & Jazwinski, S. M. (1999) · Genetics · doi:10.1093/genetics/152.1.179 · Cited by 328 · see citing works
Occurrence and Biocatalytic Potential of Carbohydrate Oxidases
van Hellemond, E. W., Leferink, N. G. H., Heuts, D. P. H. M., Fraaije, M. W., & van Berkel, W. J. H. (2006) · Advances in applied microbiology · doi:10.1016/s0065-2164(06)60002-6 · Cited by 325 · see citing works
The Mitochondrial Genotype Can Influence Nuclear Gene Expression in Yeast
Parikh, V. S., Morgan, M. M., Scott, R., Clements, L. S., & Butow, R. A. (1987) · Science · doi:10.1126/science.3027892 · Cited by 324 · see citing works
Liu, Z., & Butow, R. A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.10.6720 · Cited by 290 · see citing works
Self-citationTranscriptional regulation of nonfermentable carbon utilization in budding yeast
Turcotte, B., Liang, X. B., Robert, F., & Soontorngun, N. (2009) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2009.00555.x · Cited by 282 · see citing works
Sekito, T., Thornton, J., & Butow, R. A. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.6.2103 · Cited by 251 · see citing works
Formentini, L., Sánchez‐Aragó, M., Sánchez-Cenizo, L., & Cuezva, J. M. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.01.008 · Cited by 240 · see citing works
Signaling pathways in mitochondrial dysfunction and aging
Mammucari, C., & Rizzuto, R. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.07.003 · Cited by 239 · see citing works
The Novel SLIK Histone Acetyltransferase Complex Functions in the Yeast Retrograde Response Pathway
Pray-Grant, M. G., Schieltz, D. M., McMahon, S. J., Wood, J., Kennedy, E. L., Cook, R. G., Workman, J. L., Yates, J. R., & Grant, P. A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.24.8774-8786.2002 · Cited by 237 · see citing works
Mechanism of Metabolic Control
Komeili, A., Wedaman, K. P., O'Shea, E. K., & Powers, T. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.4.863 · Cited by 230 · see citing works
Liao, X. S., Small, W. C., Srere, P. A., & Butow, R. A. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.1.38 · Cited by 218 · see citing works
Traven, A., Wong, J. M. S., Xu, D., Sopta, M., & Ingles, C. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006807200 · Cited by 213 · see citing works
The coordination of nuclear and mitochondrial communication during aging and calorie restriction
Finley, L. W. S., & Haigis, M. C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.03.003 · Cited by 207 · see citing works
Mitochondrial signaling pathways: A receiver/integrator organelle
Goldenthal, M. J., & Marı́n-Garcı́a, J. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000038228.85494.3b · Cited by 184 · see citing works
The retrograde response: When mitochondrial quality control is not enough
Jazwinski, S. M. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.02.010 · Cited by 172 · see citing works
Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p
Liu, Z., Sekito, T., Špı́rek, M., Thornton, J., & Butow, R. A. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00285-5 · Cited by 148 · see citing works
Self-citationDual targeting of yeast catalase A to peroxisomes and mitochondria
Petrova, V. Y., Drescher, D., Kujumdzieva, A. V., & Schmitt, M. (2004) · Biochemical Journal · doi:10.1042/bj20040042 · Cited by 140 · see citing works
Giannattasio, S., Guaragnella, N., Côrte‐Real, M., Passarella, S., & Marra, E. (2005) · Gene · doi:10.1016/j.gene.2005.03.030 · Cited by 133 · see citing works
Self-citationA yeast BH3-only protein mediates the mitochondrial pathway of apoptosis
Büttner, S., Ruli, D., Vögtle, F., Galluzzi, L., Moitzi, B., Eisenberg, T., Kepp, O., Habernig, L., Carmona‐Gutierrez, D., Rockenfeller, P., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.197 · Cited by 133 · see citing works
The Yeast Retrograde Response as a Model of Intracellular Signaling of Mitochondrial Dysfunction
Jazwinski, S. M., & Kriete, A. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00139 · Cited by 115 · see citing works
Rández‐Gil, F., Sanz, P., Entian, K., & Prieto, J. A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2940 · Cited by 115 · see citing works
Rtg2 Protein Links Metabolism and Genome Stability in Yeast Longevity
Borghouts, C., Benguría, A., Wawryn, J., & Jazwinski, S. M. (2004) · Genetics · doi:10.1534/genetics.166.2.765 · Cited by 101 · see citing works
Miceli, M. V., Jiang, J. C., Tiwari, A., Rodríguez-Quiñones, J. F., & Jazwinski, S. M. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2011.00102 · Cited by 96 · see citing works
Almeida, B., Ohlmeier, S., Almeida, A. J., Madeo, F., Leão, C., Rodrigues, F. J. S., & Ludovico, P. (2009) · PROTEOMICS · doi:10.1002/pmic.200700816 · Cited by 91 · see citing works
Aup1-mediated regulation of Rtg3 during mitophagy
Journo, D., Mor, A., & Abeliovich, H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.048140 · Cited by 90 · see citing works
Giannattasio, S., Liu, Z., Thornton, J., & Butow, R. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509187200 · Cited by 89 · see citing works
Self-citationMitochondria Autophagy in Yeast
Kanki, T., Klionsky, D. J., & Okamoto, K. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3762 · Cited by 75 · see citing works
Cardiolipin Mediates Cross-Talk between Mitochondria and the Vacuole
Chen, S., Tarsio, M., Kane, P. M., & Greenberg, M. L. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-05-0486 · Cited by 65 · see citing works
The role of mitochondria in yeast programmed cell death
Guaragnella, N., Ždralević, M., Antonacci, L., Passarella, S., Marra, E., & Giannattasio, S. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00070 · Cited by 65 · see citing works
Self-citationKulawiec, M., & Arnouk, H. (2006) · Cancer Biology & Therapy · doi:10.4161/cbt.5.8.2880 · Cited by 64 · see citing works
Ruiz‐Roig, C., Noriega, N., Duch, A., Posas, F., & de Nadal, E. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-04-0289 · Cited by 63 · see citing works
Giannattasio, S., Atlante, A., Antonacci, L., Guaragnella, N., Lattanzio, P., Passarella, S., & Marra, E. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.03.048 · Cited by 59 · see citing works
Self-citationGuaragnella, N., Bobba, A., Passarella, S., Marra, E., & Giannattasio, S. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.11.072 · Cited by 53 · see citing works
Self-citationPeroxisome biogenesis inSaccharomyces cerevisiae
Kunau, W., & Hartig, A. (1992) · Antonie van Leeuwenhoek · doi:10.1007/bf00584463 · Cited by 52 · see citing works
Guaragnella, N., Antonacci, L., Giannattasio, S., Marra, E., & Passarella, S. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.12.007 · Cited by 52 · see citing works
Self-citationAchievements and perspectives in yeast acetic acid-induced programmed cell death pathways
Guaragnella, N., Antonacci, L., Passarella, S., Marra, E., & Giannattasio, S. (2011) · Biochemical Society Transactions · doi:10.1042/bst0391538 · Cited by 50 · see citing works
Self-citationRosenkrantz, M. S., Keil, C. S., Pennell, E. A., & Devenish, L. J. (1994) · Molecular Microbiology · doi:10.1111/j.1365-2958.1994.tb00407.x · Cited by 47 · see citing works
Guaragnella, N., Antonacci, L., Passarella, S., Marra, E., & Giannattasio, S. (2007) · Folia Microbiologica · doi:10.1007/bf02931304 · Cited by 46 · see citing works
Self-citationAtlante, A., De Bari, L., Bobba, A., Marra, E., Calissano, P., & Passarella, S. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01863.x · Cited by 45 · see citing works
Self-citationZhang, F., Pracheil, T., Thornton, J., & Liu, Z. (2013) · Genes · doi:10.3390/genes4010086 · Cited by 45 · see citing works
Self-citationA Novel Degron-mediated Degradation of the RTG Pathway Regulator, Mks1p, by SCFGrr1
Liu, Z., Špı́rek, M., Thornton, J., & Butow, R. A. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-06-0516 · Cited by 43 · see citing works
Self-citationYeast as a Tool to Study Signaling Pathways in Mitochondrial Stress Response and Cytoprotection
Ždralević, M., Guaragnella, N., Antonacci, L., Marra, E., & Giannattasio, S. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/912147 · Cited by 38 · see citing works
Self-citationGuaragnella, N., Passarella, S., Marra, E., & Giannattasio, S. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.07.044 · Cited by 38 · see citing works
Self-citationJazwinski, S. M. (2011) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-2561-4_4 · Cited by 31 · see citing works
Pereira, H., Azevedo, F., Rego, A., Sousa, M. J., Chaves, S. R., & Côrte‐Real, M. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.11.025 · Cited by 26 · see citing works
Cellular responses to mitochondrial dysfunction: it's not always downhill
Butow, R. A. (2002) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401083 · Cited by 23 · see citing works
Tang, W., Chowdhury, A. R., Guha, M., Huang, L., Winkle, T. V., Rustgi, A. K., & Avadhani, N. G. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs190 · Cited by 22 · see citing works
Stress‐Related Mitochondrial Components and Mitochondrial Genome as Targets of Anticancer Therapy
Giannattasio, S., Guaragnella, N., Arbini, A., & Moro, L. (2012) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12057 · Cited by 18 · see citing works
Self-citationDilova, I., & Powers, T. (2006) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2005.00008.x · Cited by 16 · see citing works
Mitochondrial alterations and autofluorescent conversion of Candida albicans induced by histatins
Diaz, G., Polonelli, L., Conti, S., Messana, I., Cabras, T., Putzolu, M., Falchi, A. M., Fadda, M. E., Cosentino, S., & Isola, R. (2005) · Microscopy Research and Technique · doi:10.1002/jemt.20161 · Cited by 11 · see citing works
Antonacci, L., Guaragnella, N., Ždralević, M., Passarella, S., Marra, E., & Giannattasio, S. (2012) · Current Pharmaceutical Biotechnology · doi:10.2174/138920112804724819 · Cited by 5 · see citing works
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- P.W. Piper, Resistance of yeasts to wek organic acid food preservatives, in: A. Laskin, G. Gadd, S. Sariaslani (Eds.), Advances in Applied Microbiology, vol. 77, Academic Press, Burlington, 2011, pp. 97-113.
Cited by
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Mitochondrial Retrograde Signaling: Triggers, Pathways, and Outcomes
da Cunha, F. M., Torelli, N. Q., & Kowaltowski, A. J. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/482582 · Cited by 168 · see citing works
Palma, M., Guerreiro, J. F., & Sá‐Correia, I. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00274 · Cited by 147 · see citing works
Johnson, J. E., & Johnson, F. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097729 · Cited by 138 · see citing works
Mitochondrial stress signaling in longevity: A new role for mitochondrial function in aging
Hill, S., & Remmen, H. V. (2014) · Redox Biology · doi:10.1016/j.redox.2014.07.005 · Cited by 129 · see citing works
Acetic acid stress in budding yeast: From molecular mechanisms to applications
Guaragnella, N., & Bettiga, M. (2021) · Yeast · doi:10.1002/yea.3651 · Cited by 121 · see citing works
Self-citationMitochondrial dysfunction in cancer chemoresistance
Guaragnella, N., Giannattasio, S., & Moro, L. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.07.027 · Cited by 84 · see citing works
Self-citationRegulation of Cell Death Induced by Acetic Acid in Yeasts
Chaves, S. R., Rego, A., Martins, V. M., Santos‐Pereira, C., Sousa, M. J., & Côrte‐Real, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.642375 · Cited by 75 · see citing works
Mitochondria-cytosol-nucleus crosstalk: learning from Saccharomyces cerevisiae
Guaragnella, N., Coyne, L. P., Chen, X. J., & Giannattasio, S. (2018) · FEMS Yeast Research · doi:10.1093/femsyr/foy088 · Cited by 72 · see citing works
Self-citationKhan, K., Tran, H. C., Mansuroglu, B., Önsell, P., Buratti, S., Schwarzländer, M., Costa, A., Rasmusson, A. G., & Aken, O. V. (2024) · Current Biology · doi:10.1016/j.cub.2023.12.005 · Cited by 66 · see citing works
Mitochondrial Retrograde Signalling and Metabolic Alterations in the Tumour Microenvironment
Yang, D., & Kim, J. (2019) · Cells · doi:10.3390/cells8030275 · Cited by 64 · see citing works
Sousa, M., Duarte, A., Fernandes, T. R., Chaves, S. R., Pacheco, A., Leão, C., Côrte‐Real, M., & Sousa, M. J. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-838 · Cited by 64 · see citing works
Paulo, J. A., O’Connell, J. D., Gaun, A., & Gygi, S. P. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-07-0499 · Cited by 60 · see citing works
How do yeast sense mitochondrial dysfunction?
Кнорре, Д. А., Соколов, С. С., Zyrina, A. N., & Severin, F. F. (2016) · Microbial Cell · doi:10.15698/mic2016.11.537 · Cited by 39 · see citing works
Apoptosis-like cell death in unicellular photosynthetic organisms — A review
Kasuba, K. C., Vavilala, S. L., & D’Souza, J. S. (2015) · Algal Research · doi:10.1016/j.algal.2015.07.016 · Cited by 39 · see citing works
Guaragnella, N., Stirpe, M., Marzulli, D., Mazzoni, C., & Giannattasio, S. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/4651062 · Cited by 37 · see citing works
Self-citationOuyang, X., Cha, Y., Li, W., Zhu, C., Zhu, M., Li, S., Zhuo, M., Huang, S., & Li, J. (2019) · RSC Advances · doi:10.1039/c9ra05558d · Cited by 30 · see citing works
The Uprising of Mitochondrial DNA Biomarker in Cancer
Khair, S. Z. N. M., Radzak, S. M. A., & Yusoff, A. A. M. (2021) · Disease Markers · doi:10.1155/2021/7675269 · Cited by 29 · see citing works
Laera, L., Guaragnella, N., Ždralević, M., Marzulli, D., Liu, Z., & Giannattasio, S. (2016) · Microbial Cell · doi:10.15698/mic2016.12.549 · Cited by 25 · see citing works
Self-citationRole of Mitochondrial Retrograde Pathway in Regulating Ethanol-Inducible Filamentous Growth in Yeast
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Lis, P., Jurkiewicz, P., Cal, M., Ko, Y. H., Pedersen, P. L., Goffeau, A., & Ułaszewski, S. (2016) · Oncotarget · doi:10.18632/oncotarget.7174 · Cited by 22 · see citing works
The influence of mitochondrial dynamics on mitochondrial genome stability
Prevost, C. T., Peris, N., Seger, C., Pedeville, D., Wershing, K., Sia, E. A., & Sia, R. A. L. (2017) · Current Genetics · doi:10.1007/s00294-017-0717-4 · Cited by 21 · see citing works
Ruetenik, A., Ocampo, A., Ruan, K., Zhu, Y., Li, C. V., Zhai, R. G., & Barrientos, A. (2016) · Microbial Cell · doi:10.15698/mic2016.08.518 · Cited by 17 · see citing works
Inactivation of HAP4 accelerates RTG-dependent Osmoadaptation in Saccharomyces cerevisiae
Di Noia, M. A., Scarcia, P., Agrimi, G., Ocheja, O. B., Wahid, E., Pisano, I., Paradies, E., Palmieri, L., Guaragnella, C., & Guaragnella, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065320 · Cited by 17 · see citing works
Self-citationRTG signaling sustains mitochondrial respiratory capacity in HOG1-dependent osmoadaptation
Guaragnella, N., Agrimi, G., Scarcia, P., Suriano, C., Pisano, I., Bobba, A., Mazzoni, C., Palmieri, L., & Giannattasio, S. (2021) · Microorganisms · doi:10.3390/microorganisms9091894 · Cited by 16 · see citing works
Self-citationBayliak, M. M., Hrynkiv, O. V., Knyhynytska, R. V., & Lushchak, V. I. (2017) · Archives of Microbiology · doi:10.1007/s00203-017-1423-9 · Cited by 14 · see citing works
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Self-citationGuaragnella, N., Marra, E., Galli, A., Moro, L., & Giannattasio, S. (2014) · APOPTOSIS · doi:10.1007/s10495-014-1006-z · Cited by 7 · see citing works
Self-citationFujii, R., Katsukawa, R., Takeda, E., Itakura, E., & Matsuura, A. (2024) · iScience · doi:10.1016/j.isci.2024.111573 · Cited by 6 · see citing works
Takayama, C., Koga, A., Sakamoto, R., Arita, N., & Tani, M. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.03.061 · Cited by 6 · see citing works
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Shirvanyan, A. H., Primavera, A., Guaragnella, N., Ledesma‐Amaro, R., & Trchounian, K. A. (2026) · FEMS Yeast Research · doi:10.1093/femsyr/foag004 · Cited by 5 · see citing works
Self-citationPogoda, E., Tutaj, H., Pirog, A., Tomala, K., & Korona, R. (2021) · Biogerontology · doi:10.1007/s10522-021-09924-z · Cited by 5 · see citing works
Friis, R. M. N., & Schultz, M. C. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.07.029 · Cited by 3 · see citing works
Stokdyk, K., Berroyer, A., Grami, Z. A., & Kim, N. (2021) · Current Genetics · doi:10.1007/s00294-020-01141-4 · Cited by 3 · see citing works
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Guaragnella, N., Ždralević, M., Palková, Z., & Giannattasio, S. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1266-8_6 · Cited by 3 · see citing works
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Omini, J. J., Krassovskaya, I., Dele-Osibanjo, T. A., Pedersen, C., & Obata, T. (2025) · eLife · doi:10.7554/elife.107953 · Cited by 3 · see citing works
Primavera, A., Laera, L., Castegna, A., Scarcia, P., Palmieri, L., Noia, M. A. D., & Guaragnella, N. (2025) · Biochemical Journal · doi:10.1042/bcj20253414 · Cited by 2 · see citing works
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Self-citationŁabędzka-Dmoch, K., Bui, T. H. D., Piątkowski, J., Dilling, M., Jagiełło, P., Kabza, W., & Golik, P. (2026) · Molecular Biology and Evolution · doi:10.1093/molbev/msag005 · Cited by 1 · see citing works
Druseikis, M. E., & Covo, S. (2024) · Yeast · doi:10.1002/yea.3975 · Cited by 1 · see citing works
Saputro, S. S. T., Wahyunita, K., Nurhasanah, A., Nugraha, Y., Faizal, I., Pambudi, S., & Pramono, A. P. (2023) · F1000Research · doi:10.12688/f1000research.123181.1 · Cited by 1 · see citing works
Druseikis, M. E., & Covo, S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.21.481281
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Singh, M. K., Cavellini, L., Kunz, C., Lelek, M., Bomme, P., Belgareh‐Touzé, N., Mallet, A., Dietrich, L., Zimmer, C., & Cohen, M. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.21.582105
Saputro, S. S. T., Wahyunita, K., Nurhasanah, A., Nugraha, Y., Faizal, I., Pambudi, S., & Pramono, A. P. (2024) · F1000Research · doi:10.12688/f1000research.123181.2
Saputro, S. S. T., Wahyunita, K., Nurhasanah, A., Nugraha, Y., Faizal, I., Pambudi, S., Wibowo, S., & Pramono, A. P. (2024) · F1000Research · doi:10.12688/f1000research.123181.3
Dynamic assembly of malate dehydrogenase–citrate synthase multienzyme complex in the mitochondria
Omini, J. J., Krassovskaya, I., Dele-Osibanjo, T. A., Pedersen, C., & Obata, T. (2026) · eLife · doi:10.7554/elife.107953.3
Dynamic assembly of malate dehydrogenase-citrate synthase multienzyme complex in the mitochondriaPreprint
Omini, J. J., Krassovskaya, I., Dele-Osibanjo, T. A., Pedersen, C., & Obata, T. (2025) · eLife · doi:10.7554/elife.107953.1
Modeling premature aging in yeast via the expression of Progerin
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A 25+ Year Journey on Yeast-Regulated Cell Death Research
Sousa, M. J., Rego, A., Martins, V. M., Santos‐Pereira, C., Chaves, S. R., & Côrte‐Real, M. (2026) · Current topics in microbiology and immunology · doi:10.1007/82_2026_342
Druseikis, M., & Covo, S. (2026) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkag261
- Authors
- Guaragnella, N., Ždralević, M., Lattanzio, P., Marzulli, D., Pracheil, T., Liu, Z., Passarella, S., Marra, E., & Giannattasio, S.
- Affiliations
- Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IT)
- LSU New Orleans (US)
- University of Molise (IT)
- Corresponding author
- Giannattasio, Sergio
- ORCID
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 1833
- Issue
- 12
- Pages
- 2765-2774
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W2009721804
- Cited by
- 52
- References
- 62
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 6 · 2023: 2 · 2022: 3 · 2021: 7 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 4 · 2013: 1
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Funders
- FIRB-MERIT RBNE08HWLZ
- Italian Ministry of Economy and Finance
- University of Salento
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- raffinose, yeast, mitochondrial respiration, peroxisome biogenesis, citrate synthase, isocitrate dehydrogenase, HAP4, MKS1, reactive oxygen species, cytochrome c release, mitochondrial membrane potential, carbon source
- MeSH terms
- Glucose, Hydrogen-Ion Concentration, Mitochondria, Phosphorylation, Raffinose, Saccharomyces cerevisiae, Immunoblotting, Signal Transduction, Apoptosis, Gene Deletion, Reactive Oxygen Species, Acetic Acid, Saccharomyces cerevisiae Proteins, Intracellular Space, Cytochromes c, Membrane Potential, Mitochondrial
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